Biodiscovery of antibacterial constituents from the endolichenic fungi isolated from Parmotrema rampoddense.

Abstract:

:A total of nine endolichenic fungi were isolated from the foliose lichen Parmotrema rampoddense (Nyl.) Hale. Of the nine endolichenic fungi, three taxa (Fusarium proliferatum, Nemania primolutea, Daldinia eschsholtzii) showed antibacterial activities as determined by the disk diffusion assay against ESKAPE bacterial pathogens. Fusarium proliferatum gave the most active fungal extract with zone of inhibition values of 15 mm and 19 mm against E. faecalis and S. aureus, respectively. Further chromatographic purification of the F. proliferatum ethyl acetate extract led to the isolation and identification of bis(2-ethylhexyl)terephthalate (1), acetyl tributyl citrate (2), and fusarubin (3). Acetyl tributyl citrate (2) exhibited moderate antibacterial activity against Klebsiella pneumoniae, Pseudomonas aeruginosa, and Staphylococcus aureus.

journal_name

3 Biotech

journal_title

3 Biotech

authors

Tan MA,Castro SG,Oliva PMP,Yap PRJ,Nakayama A,Magpantay HD,Dela Cruz TEE

doi

10.1007/s13205-020-02213-5

subject

Has Abstract

pub_date

2020-05-01 00:00:00

pages

212

issue

5

eissn

2190-572X

issn

2190-5738

pii

2213

journal_volume

10

pub_type

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