Abstract：
:In the present study, we evaluated the phytochemical compounds and antioxidant properties of chloroform, ethanol and acetone extracts for leaves and flowers of Leonutusleonurus (L.leonurus) alongside with their cytotoxic effects on human cervical carcinoma (HeLa) cell lines. The phytochemical compounds present in the leaves and flowers of L.leonurus included; phenolics, flavonoids and alkaloids. Their radicals scavenging effects against 2, 2-diphenyl-1-picrylhydrazyl [DPPH] 2,2'-azinobis-(3-ethylbenzothiazoline-6-sulphonate) [ABTS·+], hydrogen peroxide, nitric oxide as well as metal chelating activities showed dose-dependent activities. Gas chromatography-mass spectrometry (GCMS) analyses revealed the presence of important bioactive compounds, which are associated with antioxidant; and the extracts exhibited toxicity effect against HeLa cells. The findings from this study divulge extracts of L.leonurus as prospective sources of antioxidant and anticancer agents; and hence, further study on their neuroprotective potentials becomes imperative.
journal_name
3 Biotechjournal_title
3 Biotechauthors
Tonisi S,Okaiyeto K,Hoppe H,Mabinya LV,Nwodo UU,Okoh AIdoi
10.1007/s13205-020-2126-5subject
Has Abstractpub_date
2020-03-01 00:00:00pages
141issue
3eissn
2190-572Xissn
2190-5738pii
2126journal_volume
10pub_type
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