Abstract：
:Quorum sensing (QS) plays an important role in virulence of Pseudomonas aeruginosa, blocking of QS ability are viewed as viable antimicrobial chemotherapy and which may prove to be a safe anti-virulent drug. Bioactive components from Piper betle have been reported to possess antimicrobial ability. This study envisages on the anti-QS properties of ethanolic extract of P. betle leaf (PbLE) using P. aeruginosa PAO1 as a model organism. A marked reduction in swarming, swimming, and twitching ability of the bacteria is demonstrated in presence of PbLE. The biofilm and pyocyanin production also shows a marked reduction in presence of PbLE, though it does not affect the bacterial growth. Thus, the studies hint on the possible effect of the bioactive components of PbLE on reducing the virulent ability of the bacteria; identification of bioactive compounds should be investigated further.
journal_name
3 Biotechjournal_title
3 Biotechauthors
Datta S,Jana D,Maity TR,Samanta A,Banerjee Rdoi
10.1007/s13205-015-0348-8subject
Has Abstractpub_date
2016-06-01 00:00:00pages
18issue
1eissn
2190-572Xissn
2190-5738pii
10.1007/s13205-015-0348-8journal_volume
6pub_type
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