Abstract:
:A 35 kDa rabbit erythrocyte agglutinating lectin from the seeds of Cicer arietinum was purified and designated as CAL. The lectin was inhibited by fetuin and N-acetyl-d-galactosamine at a concentration of 20 and 50 mM respectively, but not by simple mono or oligosaccharides. CAL is active between pH 5 and 10 presented thermo stability up to 50 °C and demonstrated DNA damage inhibition at 30 µg concentration. The lectin elicited maximum mitogenic activity towards mice splenocytes at 7.5 µg ml- 1. CAL exerted an inhibitory activity on HIV-1 reverse transcriptase with IC50 of 180 µM. CAL abilities in animal bioassay resulted decreased levels of total triglyceride and creatinine. In vitro and in vivo studies revealed that CAL may constitute an important role impending biomedical applications.
journal_name
3 Biotechjournal_title
3 Biotechauthors
Gautam AK,Srivastava N,Nagar DP,Bhagyawant SSdoi
10.1007/s13205-018-1272-5subject
Has Abstractpub_date
2018-06-01 00:00:00pages
272issue
6eissn
2190-572Xissn
2190-5738pii
1272journal_volume
8pub_type
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