Abstract:
BACKGROUND:Data suggest an increased risk of thyroid dysfunction following iodine-based contrast material (IBCM) in children. OBJECTIVE:To estimate the prevalence of thyroid stimulating hormone (TSH) abnormalities following exposure to a single dose of intravenous IBCM during computed tomography (CT) in young children. MATERIALS AND METHODS:Inpatients ≤24 months of age who underwent a single CT with intravenous IBCM (exposed cohort) or abdominal ultrasound (US) (unexposed cohort) examination and had a TSH value obtained within 90 days after imaging between January 2009 to November 2018 were identified. Propensity score matching with 20 variables was performed. Primary thyroid dysfunction was defined by abnormally high or low TSH value. Multivariable logistic regression identified risk factors, including intravenous IBCM, for thyroid dysfunction. RESULTS:From the eligible 4,215 imaging examinations, 114 unique patients were included in the propensity matched population (n=57 per group). Thyroid dysfunction was identified in 14% (8/57) and 7% (4/57) of the IBCM-exposed and IBCM-unexposed cohorts, respectively. No patient in either cohort was started on thyroid hormone supplementation within the 3 months after imaging. Intravenous IBCM exposure was not a significant predictor of thyroid dysfunction on univariable (odds ratio [OR]=2.16, 95% confidence interval [CI]=0.61-7.64, P=0.23) or multivariable (OR=2.61, 95% CI=0.65-10.55, P=0.18) analyses. Significant independent predictors of post-imaging thyroid dysfunction included height (OR=1.25, P=0.0095) and trisomy 21 (OR=4.04, P=0.019). CONCLUSION:Hospitalized children ≤24 months of age who received a single dose of intravenous IBCM for CT examination had a similar prevalence of TSH abnormalities compared to a propensity score matched group who underwent abdominal US. One dose of intravenous IBCM likely does not cause prolonged TSH abnormalities; however, larger studies are needed.
journal_name
Pediatr Radioljournal_title
Pediatric radiologyauthors
Gilligan LA,Dillman JR,Su W,Zhang B,Chuang J,Trout ATdoi
10.1007/s00247-020-04881-0subject
Has Abstractpub_date
2020-11-17 00:00:00eissn
0301-0449issn
1432-1998pii
10.1007/s00247-020-04881-0pub_type
杂志文章abstract::Intracerebral paragangliomas are rare because of the lack of paraganglial cells in the cerebral tissue. We report a rare case of melanotic paraganglioma arising from the temporal horn of the lateral ventricle in a patient with prior Langerhans cell histiocytosis (LCH) treated with chemotherapy and radiation. ...
journal_title:Pediatric radiology
pub_type: 杂志文章
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abstract:BACKGROUND:Urea cycle disorders encompass several enzyme deficiencies that can result in cerebral damage, with a wide clinical spectrum from asymptomatic to severe. OBJECTIVE:The goal of this study was to correlate brain MRI abnormalities in urea cycle disorders with clinical neurological sequelae to evaluate whether ...
journal_title:Pediatric radiology
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journal_title:Pediatric radiology
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更新日期:1981-02-01 00:00:00
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journal_title:Pediatric radiology
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abstract::Isolated, well-differentiated ectopic cerebellar tissue is extremely rare, with only eight cases in the literature. We describe a unique case of histopathologically proven ectopic cerebellar tissue presenting as a discrete extra-axial mass in the posterior cranial fossa. We describe the clinical, CT and MRI findings, ...
journal_title:Pediatric radiology
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abstract::Clavicle fractures are the most common bony injury that occurs during the delivery process. We present a case of medial clavicular physeal fracture mimicking sternoclavicular dislocation diagnosed by ultrasound (US) in a neonate. The infant presented to our clinic at 12 days old with improving left upper extremity pse...
journal_title:Pediatric radiology
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journal_title:Pediatric radiology
pub_type: 杂志文章
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journal_title:Pediatric radiology
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journal_title:Pediatric radiology
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journal_title:Pediatric radiology
pub_type: 杂志文章,评审
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abstract:BACKGROUND:Little published research has shown the relationship between noninvasive US shear wave speed (SWS) measurements and degree of liver fibrosis as established by percutaneous biopsy in children. OBJECTIVE:To assess the relationship between liver US shear wave speed (SWS) measurements and parenchymal fibrosis i...
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journal_title:Pediatric radiology
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更新日期:1994-01-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2019-10-01 00:00:00
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journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/s002470050728
更新日期:2000-04-01 00:00:00
abstract::Relapses of lymphoblastic leukaemia traditionally involve the central nervous system and testes in boys. Involvement of the female pelvic organs is frequently found at autopsy; however, involvement of the cervical uterus is rare and even less commonly symptomatic. A 13-cm uterine mass was discovered in a 15-year-old a...
journal_title:Pediatric radiology
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doi:10.1007/s00247-007-0661-4
更新日期:2008-03-01 00:00:00
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journal_title:Pediatric radiology
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更新日期:2018-05-01 00:00:00
abstract::Barium esophagrams were obtained in two patients with respiratory problems whose underlying congenital heart disease was pseudotruncus arteriosus type I. The esophagrams revealed vascular indentations on the esophagus, one posteriorly, and the other anteriorly. Both types of indentations were secondary to aorto-pulmon...
journal_title:Pediatric radiology
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journal_title:Pediatric radiology
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journal_title:Pediatric radiology
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journal_title:Pediatric radiology
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更新日期:2013-03-01 00:00:00
abstract::Sakoda complex is a rare but distinct combination of birth defects consisting of a basal cephalocele, agenesis of the corpus callosum, and midline cleft lip/palate. It has been reported in association with ophthalmologic abnormalities, cognitive deficits and severe epilepsy. Here we describe both prenatal and postnata...
journal_title:Pediatric radiology
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journal_title:Pediatric radiology
pub_type: 杂志文章
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更新日期:1999-12-01 00:00:00
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journal_title:Pediatric radiology
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