Abstract:
BACKGROUND:Little published research has shown the relationship between noninvasive US shear wave speed (SWS) measurements and degree of liver fibrosis as established by percutaneous biopsy in children. OBJECTIVE:To assess the relationship between liver US shear wave speed (SWS) measurements and parenchymal fibrosis in children. MATERIALS AND METHODS:Sixty-two children (0-18 years old) with known or suspected liver disease underwent same-day US shear wave elastography (SWE) and clinically ordered percutaneous core needle biopsy. SWE was performed just before the liver biopsy in the area targeted for sampling, using an Acuson S3000 US system with a 9L4 transducer; six SWS measurements were acquired using Virtual Touch Quantification (VTQ) and Virtual Touch IQ (VTIQ) modes. Biopsy specimens were scored for histological fibrosis and inflammation. Bivariate relationships were assessed using Pearson correlation, while multiple linear regression analysis was used to establish the relationship between SWS and predictor variables. Receiver operating characteristic (ROC) curves were created to assess the abilities of VTQ and VTIQ to discern low vs. high liver fibrosis (histological fibrosis scores 0-2 vs. 3-6). RESULTS:There were significant positive correlations between liver histological fibrosis score and VTQ (n = 49) and VTIQ (n = 48) mean shear wave speed measurements (r = 0.68 and r = 0.73; P-values <0.0001). There also were significant positive correlations between liver histological inflammation score and VTQ and VTIQ mean shear wave speed measurements (r = 0.47 and r = 0.44, and P = 0.0006 and P = 0.0016, respectively). For VTQ, both histological fibrosis (P < 0.0001) and inflammation (P = 0.04) scores were significant predictors of shear wave speed (model adjusted R (2) = 0.49). For VTIQ, only histological fibrosis score (P < 0.0001) was a significant predictor of shear wave speed (model adjusted R (2) = 0.56). ROC areas under the curve were 0.84 and 0.86 for VTQ and VTIQ, respectively. CONCLUSION:Liver US shear wave speed measurements increase with increasing parenchymal fibrosis in children.
journal_name
Pediatr Radioljournal_title
Pediatric radiologyauthors
Dillman JR,Heider A,Bilhartz JL,Smith EA,Keshavarzi N,Rubin JM,Lopez MJdoi
10.1007/s00247-015-3345-5subject
Has Abstractpub_date
2015-09-01 00:00:00pages
1480-8issue
10eissn
0301-0449issn
1432-1998journal_volume
45pub_type
杂志文章abstract::Contrast-enhanced ultrasound (CEUS) and diffusion-weighted imaging (DWI) are safe, repeatable imaging techniques. The aim of this paper is to discuss the advantages, technical factors and possible clinical applications of these imaging tools in focal renal lesions in children. ...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/s00247-019-04552-9
更新日期:2020-02-01 00:00:00
abstract:BACKGROUND:A pull-back tube esophagogram (PBTE) is widely accepted in the literature as the radiological investigation of choice for the diagnosis of tracheoesophageal fistula without esophageal atresia. However, PBTE is rarely performed in our institution, as we have been successful in confirming the presence of such ...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/s00247-006-0269-0
更新日期:2006-11-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:The neurocentral synchondrosis (NCS) is a cartilaginous growth plate that since the early 1900s has been implicated as a potential cause of adolescent idiopathic scoliosis (AIS). Previous studies have focused only on the closure age without characterizing normal NCS development. Using MRI, the...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/s00247-002-0771-y
更新日期:2002-11-01 00:00:00
abstract:BACKGROUND:Subglottic haemangioma causes progressive and life-threatening stridor, typically manifesting at age 2-3 months. Standard diagnosis is by laryngoscopy. Larynx sonography is rarely used but allows assessment of the presence and extension of a mass that impinges on the subglottic airway. The additional use of ...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/s00247-011-2213-1
更新日期:2011-11-01 00:00:00
abstract::Two adolescent girls with acquired vaginal occlusion and resultant hematometracolpos are presented. Both are long-term survivors of childhood malignancies, who prior to multiagent chemotherapy and pelvic irradiation had normal uteri by imaging. Both were amenorrheic post therapy. Routine follow-up computed tomography ...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/BF02011961
更新日期:1993-01-01 00:00:00
abstract::Paediatric cerebral sinovenous thrombosis (CSVT) is a rare but serious condition. The imaging signs may be subtle with a number of potential pitfalls. We present a pictorial essay of the pitfalls of diagnosis of CSVT on CT and MRI. We describe, using examples, potential pitfalls on both imaging modalities including an...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/s00247-012-2402-6
更新日期:2013-01-01 00:00:00
abstract::MRI is invaluable in assessing the neonatal brain following suspected perinatal injury. Good quality imaging requires adaptations to both the hardware and the sequences used for adults or older children. The perinatal and postnatal details often predict the pattern of lesions sustained and should be available to aid i...
journal_title:Pediatric radiology
pub_type: 杂志文章,评审
doi:10.1007/s00247-010-1620-z
更新日期:2010-06-01 00:00:00
abstract::Ultrasound is a remarkably powerful and versatile modality for pediatric imaging, without requiring exposure to radiation or sedatives. By providing information on blood flow, Doppler sonography can reveal details about normal physiology and disease processes not discernable from gray-scale anatomic images alone. Howe...
journal_title:Pediatric radiology
pub_type: 杂志文章,评审
doi:10.1007/s00247-004-1228-2
更新日期:2004-10-01 00:00:00
abstract::One case of hemorrhage in the cavum septi pellucidi (CSP) is presented. This unusual location of intracranial hemorrhage was demonstrated by cranial sonography in a premature neonate. ...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/BF02386822
更新日期:1986-01-01 00:00:00
abstract::Historically, the first case of congenital prepyloric membrane in an infant was documented in 1933 [1]. Since then cases have been reported only sporadically in the literature [2-8]. This is a case of congenital antral web which was identified by real-time ultrasonography, confirmed by barium meal study, and proven at...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/BF02016251
更新日期:1992-01-01 00:00:00
abstract::Abnormal enlargement or malposition of any vascular structure or mass adjacent to the airway can cause extrinsic airway compression. In children with previous surgery for congenital heart disease, mass effect from prosthetic devices or alteration in the anatomic position of normal structures can lead to extrinsic airw...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/s002470050121
更新日期:1997-03-01 00:00:00
abstract::Ultrasound (US) has been proposed as an alternative first-line imaging modality to diagnose community-acquired pneumonia in children. Lung US has the potential benefits over chest radiography of being radiation free, subject to fewer regulatory requirements, relatively lower cost and with immediate bedside availabilit...
journal_title:Pediatric radiology
pub_type: 杂志文章,评审
doi:10.1007/s00247-017-3910-1
更新日期:2017-10-01 00:00:00
abstract::A case in which there was thallium-201 (201Tl) uptake in Langerhans cell histiocytosis (LCH) of the left femoral diaphysis is presented. The authors propose that 201Tl scintigraphy is potentially useful in the diagnosis and follow-up of patients with LCH. ...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/BF01383394
更新日期:1996-10-01 00:00:00
abstract::We report a neonate with antenatal imaging features suggestive of CLOVES syndrome. Postnatal clinical and imaging findings confirmed the diagnosis, with the constellation of truncal overgrowth, cutaneous capillary malformation, lymphatic and musculoskeletal anomalies. The clinical, radiological and histopathological f...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/s00247-010-1559-0
更新日期:2010-08-01 00:00:00
abstract::An unusual case is presented of a vascular ring due to a right arch with mirror-image branching and a left ligamentum arteriosum from the descending aorta to the left pulmonary artery. There have been only four previous reports of this rare arch anomaly. In addition, the patient had no underlying congenital heart lesi...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/BF02019065
更新日期:1995-01-01 00:00:00
abstract:BACKGROUND:Air enema under fluoroscopy is a well-accepted procedure for the treatment of childhood intussusception. However, the reported radiation doses of pneumatic reduction with conventional fluoroscopy units have been high in decades past. OBJECTIVE:To compare current radiation doses at our institution to past do...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/s00247-014-3218-3
更新日期:2015-04-01 00:00:00
abstract:BACKGROUND:Pediatric radiology fellowship web pages convey practical information and provide an opportunity to impress upon visitors the mission and principles that are core to the program. OBJECTIVE:The goal of the study was to assess pediatric radiology fellowship program websites and identify potential areas for im...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/s00247-019-04381-w
更新日期:2019-05-01 00:00:00
abstract::Pulmonary capillary haemangiomatosis (PCH) is a rare disorder characterized by widespread capillary proliferation in the lung, infiltrating the interstitium and the alveolar walls. We present the HRCT features of PCH in a surviving ex-premature infant. To our knowledge, this is a unique case of the radiological featur...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/s00247-004-1374-6
更新日期:2005-06-01 00:00:00
abstract::Shaken-baby syndrome (SBS) is a type of child abuse caused by violent shaking of an infant, with or without impact, and characterized by subdural hematomas, retinal hemorrhages, and occult bone fractures. Parenchymal brain lesions in SBS may be missed or underestimated on CT scans, but can be detected at an earlier st...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/s00247-003-1025-3
更新日期:2003-12-01 00:00:00
abstract:BACKGROUND:Infant videofluoroscopic swallow studies (VFSSs) require clinicians to make determinations about swallowing deficits based on a limited number of fluoroscopically observed swallows. Although airway protection is known to decline throughout a bottle-feed, the paucity of data regarding the timing of this degra...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/s00247-019-04527-w
更新日期:2020-02-01 00:00:00
abstract::Abnormalities of the fetal urinary tract, most commonly hydronephrosis of differing causes, can be detected by ultrasound (US). Prenatal measurements of the kidney can help to predict the postnatal outcome of hydronephrosis. About 20% of abnormalities evident in utero are not present after birth. After delivery, vario...
journal_title:Pediatric radiology
pub_type: 杂志文章,评审
doi:10.1007/s002470050434
更新日期:1998-08-01 00:00:00
abstract:OBJECTIVE:The purpose of this paper is to review and categorize the CT appearances of primary and secondary intraperitoneal neoplasms in children. MATERIALS AND METHODS:We retrospectively reviewed the CT images of 14 cases of intraperitoneal neoplasms. They were reviewed for bowel wall thickening, mesenteric nodules, ...
journal_title:Pediatric radiology
pub_type: 杂志文章,多中心研究
doi:10.1007/s002470050363
更新日期:1998-05-01 00:00:00
abstract::The spectrum of congenital anomalies of the male urethra is presented. The embryologic basis of each anomaly, when known, is discussed. Clinical and imaging features of each entity are presented. ...
journal_title:Pediatric radiology
pub_type: 杂志文章,评审
doi:10.1007/s00247-007-0495-0
更新日期:2007-09-01 00:00:00
abstract:BACKGROUND:Late-onset noninfectious pulmonary complications (LONIPCs) are life-threatening complications of bone marrow transplantation (BMT). Several pathological patterns are described in the literature with different prognoses, and with different relationships to graft-versus-host disease (GVHD). The role of high-re...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/s00247-008-0984-9
更新日期:2008-11-01 00:00:00
abstract::Neonatal goiter is a rare cause of a neck mass and stridor. Often, the diagnosis can be made on clinical grounds exclusively, but there may be times when a neck mass becomes a diagnostic dilemma. There are several different imaging modalities available to the clinician that are useful in the rapid diagnosis of neonata...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/BF01405300
更新日期:1996-01-01 00:00:00
abstract::Accurate diagnosis of non-accidental injury (NAI) can be reached in the majority of cases by careful appraisal of the social and family history, combined with painstaking clinical roentgenographic and other imaging evaluations. Careful review of the scientific literature clearly indicates that collagen analysis to exc...
journal_title:Pediatric radiology
pub_type: 杂志文章,评审
doi:10.1007/s002470050079
更新日期:1997-02-01 00:00:00
abstract::Imaging studies for sinusitis add little to the clinical management of the pediatric patient in most instances. The findings shown by paranasal sinus imaging are nonspecific and need to be correlated with clinical findings. Coronal CT is recommended for complications or for recurrent or persistent sinus disease. ...
journal_title:Pediatric radiology
pub_type: 杂志文章,评审
doi:10.1007/s002470050251
更新日期:1997-11-01 00:00:00
abstract::Congenital neutropenia is an uncommon entity which may be familial and has a wide spectrum of clinical expression. Three sisters with the severe form of the disease, that suffered from recurrent infections which lead to their demise, are described. Review of their radiographs revealed the presence of cortical thickeni...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/BF02388088
更新日期:1987-01-01 00:00:00
abstract::Neonatal cerebral MR imaging is a sensitive technique for evaluating brain injury in the term and preterm infant. In term encephalopathic infants, MR imaging reliably detects not only the pattern of brain injury but might also provide clues about the timing of injury. In premature infants, MR imaging has surpassed US ...
journal_title:Pediatric radiology
pub_type: 杂志文章,实务指引
doi:10.1007/s00247-007-0705-9
更新日期:2008-03-01 00:00:00
abstract::During halothane anaesthesia the hepatic blood flow may be reduced. This effect interferes with the angiographic investigation of the liver and this is demonstrated by the case presented. ...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/BF00973989
更新日期:1977-03-17 00:00:00