Abstract:
:Both poly(A) enrichment and ribosomal RNA depletion are commonly used for RNA sequencing. Either has its advantages and disadvantages that may lead to biases in the downstream analyses. To better access these effects, we carried out both ribosomal RNA-depleted and poly(A)-selected RNA-seq for CD4+ T naive cells isolated from 40 healthy individuals from the Blueprint Project. For these 40 individuals, the genomic and epigenetic data were also available. This dataset offers a unique opportunity to understand how library construction influences differential gene expression, alternative splicing and molecular QTL (quantitative loci) analyses for human primary cells.
journal_name
Sci Datajournal_title
Scientific dataauthors
Chen L,Yang R,Kwan T,Tang C,Watt S,Zhang Y,Bourque G,Ge B,Downes K,Frontini M,Ouwehand WH,Lin JW,Soranzo N,Pastinen T,Chen Ldoi
10.1038/s41597-020-00719-4subject
Has Abstractpub_date
2020-11-09 00:00:00pages
376issue
1issn
2052-4463pii
10.1038/s41597-020-00719-4journal_volume
7pub_type
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