Abstract：
:We evaluated the potential of nine vitamin B3 scaffold-based derivatives as acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitors, as a starting point for the development of novel drugs for treating disorders with cholinergic neurotransmission-linked pathology. As the results indicate, all compounds reversibly inhibited both enzymes in the micromolar range pointing to the preference of AChE over BChE for binding the tested derivatives. Molecular docking studies revealed the importance of interactions with AChE active site residues Tyr337 and Tyr124, which dictated most of the observed differences. The most potent inhibitor of both enzymes with Ki of 4 μM for AChE and 8 μM for BChE was the nicotinamide derivative 1-(4'-phenylphenacyl)-3-carbamoylpyridinium bromide. Such a result places it within the range of several currently studied novel cholinesterase inhibitors. Cytotoxicity profiling did not classify this compound as highly toxic, but the induced effects on cells should not be neglected in any future detailed studies and when considering this scaffold for drug development.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Zandona A,Lihtar G,Maraković N,Miš K,Bušić V,Gašo-Sokač D,Pirkmajer S,Katalinić Mdoi
10.3390/ijms21218088subject
Has Abstractpub_date
2020-10-29 00:00:00issue
21issn
1422-0067pii
ijms21218088journal_volume
21pub_type
杂志文章abstract：:Chemotherapy is one of the most common strategies for tumor treatment but often associated with post-therapy tumor recurrence. While chemotherapeutic drugs are known to induce tumor cell senescence, the roles and mechanisms of senescence in tumor recurrence remain unclear. In this study, we used doxorubicin to induce ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
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更新日期：2021-01-15 00:00:00
abstract：:In inflammatory bowel diseases (IBD), the therapeutic benefit and mucosal healing from specific probiotics may relate to the modulation of dendritic cells (DCs). Herein, we assessed the immunomodulatory effects of four probiotic strains including Lactobacillus salivarius, Bifidobacterium bifidum, Bacillus coagulans an...
journal_title：International journal of molecular sciences
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abstract：:Many systems, including polymers and molecular liquids, when adequately cooled and/or compressed, solidify into a disordered solid, i.e., a glass. The transition is not abrupt, featuring progressive decrease of the microscopic mobility and huge slowing down of the relaxation. A distinctive aspect of glass-forming mate...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
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更新日期：2019-11-14 00:00:00
abstract：:Breast cancer is regarded worldwide as a severe human disease. Various genetic variations, including hereditary and somatic mutations, contribute to the initiation and progression of this disease. The diagnostic parameters of breast cancer are not limited to the conventional protein content and can include newly disco...
journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
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更新日期：2012-01-01 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2020-04-28 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2017-11-26 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2020-03-19 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2019-09-10 00:00:00
abstract：:Coffee is a popular drink consumed all over the world. Besides its long-recognized stimulant effect, it has important nutritional and health effects. However, the type of bean processing modifies the composition of brewed coffee and possibly its bioactivity. In this study, extracts obtained from green and roasted bean...
journal_title：International journal of molecular sciences
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doi：10.3390/ijms19113407
更新日期：2018-10-31 00:00:00
abstract：:Circulating tumour cells (CTCs) from liquid biopsies are under current investigation in several cancers, including epithelial ovarian cancer (EOC) but face significant drawbacks in terms of non-standardised methodology, low viable cell numbers and accuracy of CTC identification. In this pilot study, we report that che...
journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
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更新日期：2016-12-22 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2013-10-18 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2013-08-26 00:00:00
abstract：:Due to their large spectrum of bioactive properties, much attention has recently been drawn to phlorotannins-i.e., phenolic compounds characteristic from brown macroalgae. This study aimed to evaluate the antioxidant and anti-inflammatory properties of F. vesiculosus phlorotannin extracts and purified fractions. Overa...
journal_title：International journal of molecular sciences
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更新日期：2020-09-20 00:00:00
abstract：:Interferons (IFNs) are very powerful cytokines, which play a key role in combatting pathogen infections by controlling inflammation and immune response by directly inducing anti-pathogen molecular countermeasures. There are three classes of IFNs: type I, type II and type III. While type II IFN is specific for immune c...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
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更新日期：2019-03-21 00:00:00
abstract：:In the first trimester of pregnancy, placental development involves a wide range of cellular processes. These include trophoblast proliferation, fusion, and differentiation, which are dependent on tight cell cycle control. The intrauterine environment affects placental development, which also includes the trophoblast ...
journal_title：International journal of molecular sciences
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更新日期：2020-01-11 00:00:00
abstract：:Growing interest and recent evidence have identified long non-coding RNA (lncRNA) as the potential regulatory elements for eukaryotes. LncRNAs can activate various transcriptional and post-transcriptional events that impact cellular functions though multiple regulatory functions. Recently, a large number of lncRNAs ha...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21082659
更新日期：2020-04-11 00:00:00
abstract：BACKGROUND:Although particular matter (PM) increases incidence and severity of idiopathic pulmonary fibrosis, the underlying mechanism remains elusive. METHODS:The effects of PM were evaluated in a murine model of bleomycin-induced pulmonary fibrosis. Mice were divided into four groups, receiving: (1) Saline (control)...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21010227
更新日期：2019-12-28 00:00:00
