Abstract：
:Breast cancer is regarded worldwide as a severe human disease. Various genetic variations, including hereditary and somatic mutations, contribute to the initiation and progression of this disease. The diagnostic parameters of breast cancer are not limited to the conventional protein content and can include newly discovered genetic variants and even genetic modification patterns such as methylation and microRNA. In addition, breast cancer detection extends to detailed breast cancer stratifications to provide subtype-specific indications for further personalized treatment. One genome-wide expression-methylation quantitative trait loci analysis confirmed that different breast cancer subtypes have various methylation patterns. However, recognizing clinically applied (methylation) biomarkers is difficult due to the large number of differentially methylated genes. In this study, we attempted to re-screen a small group of functional biomarkers for the identification and distinction of different breast cancer subtypes with advanced machine learning methods. The findings may contribute to biomarker identification for different breast cancer subtypes and provide a new perspective for differential pathogenesis in breast cancer subtypes.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Chen L,Zeng T,Pan X,Zhang YH,Huang T,Cai YDdoi
10.3390/ijms20174269subject
Has Abstractpub_date
2019-08-31 00:00:00issue
17issn
1422-0067pii
ijms20174269journal_volume
20pub_type
杂志文章abstract：:Among classical BCR-ABL-negative myeloproliferative neoplasms (MPN), primary myelofibrosis (PMF) is the most aggressive subtype from a clinical standpoint, posing a great challenge to clinicians. Whilst the biological consequences of the three MPN driver gene mutations (JAK2, CALR, and MPL) have been well described, r...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21238885
更新日期：2020-11-24 00:00:00
abstract：:Neurons are structurally unique and have dendrites and axons that are vulnerable to injury. Some neurons in the peripheral nervous system (PNS) can regenerate their axons after injuries. However, most neurons in the central nervous system (CNS) fail to do so, resulting in irreversible neurological disorders. To unders...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
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更新日期：2021-01-06 00:00:00
abstract：:To learn more about the structure-activity relationships of (E)-3-(5-styryl-1,3,4-oxadiazol-2-yl)benzenesulfonamide derivatives, which in our previous research displayed promising in vitro anticancer activity, we have synthesized a group of novel (E)-5-[(5-(2-arylvinyl)-1,3,4-oxadiazol-2-yl)]-4-chloro-2-R1-benzenesulf...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21062235
更新日期：2020-03-23 00:00:00
abstract：:Several cellular insults can result in sperm DNA fragmentation either on one or both DNA strands. Oxidative damage, premature interruption of the apoptotic process and defects in DNA compaction during spermatogenesis are the main mechanisms that cause DNA breaks in sperm. The two-tailed Comet assay is the only techniq...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
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更新日期：2020-05-29 00:00:00
abstract：:Programmed cell death (PCD) is a crucial process required for the normal development and physiology of metazoans. The three major mechanisms that induce PCD are called type I (apoptosis), type II (autophagic cell death), and type III (necrotic cell death). Dysfunctional PCD leads to diseases such as cancer and neurode...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms15023145
更新日期：2014-02-21 00:00:00
abstract：:Neonatal seizures are one of the most common comorbidities of neonatal encephalopathy, with seizures aggravating acute injury and clinical outcomes. Current treatment can control early life seizures; however, a high level of pharmacoresistance remains among infants, with increasing evidence suggesting current anti-sei...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
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更新日期：2020-10-22 00:00:00
abstract：:In our ongoing research to discover natural products with neuroprotective effects, hyperoside (quercetin 3-O-galactoside) was isolated from Acer tegmentosum, which has been used in Korean traditional medicine to treat liver-related disorders. Here, we demonstrated that hyperoside protects cultured dopaminergic neurons...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20235832
更新日期：2019-11-20 00:00:00
abstract：:Hepatocyte growth factor (HGF) is an endogenously expressed bioactive substance that has a strong anti-apoptotic effect. In this study, we biochemically and histologically characterized the effects of rh-HGF on in vitro human hepatocyte injury and mouse acute liver failure (ALF) models, both of which were induced by a...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20081821
更新日期：2019-04-12 00:00:00
abstract：:Caspase-8 was originally identified as a central player of programmed cell death triggered by death receptor stimulation. In that context, its activity is tightly regulated through several mechanisms, with the best established being the expression of FLICE-like inhibitory protein (FLIP) family proteins and the Src-dep...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms19123798
更新日期：2018-11-29 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2014-05-12 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21228590
更新日期：2020-11-14 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms17060900
更新日期：2016-06-08 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms19071991
更新日期：2018-07-08 00:00:00
abstract：:Sertoli cells are somatic supporting cells in spermatogenic niche and play critical roles in germ cell development, but it is yet to be understood how epigenetic modifiers regulate Sertoli cell development and contribution to spermatogenesis. BRG1 (Brahma related gene 1) is a catalytic subunit of the mammalian SWI/SNF...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21124358
更新日期：2020-06-19 00:00:00
abstract：:The 12-oxo-phytodienoic acid reductases (OPRs), which belong to the old yellow enzyme (OYE) family, are flavin mononucleotide (FMN)-dependent oxidoreductases with critical functions in plants. Despite the clear characteristics of growth and development, as well as the defense responses in Arabidopsis, tomato, rice, an...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20081914
更新日期：2019-04-18 00:00:00
abstract：:The MP2 and DFT/B3LYP methods at 6-311++G(d,p) and aug-cc-pdz basis sets have been used to probe the origin of relative stability preference for eclipsed acetaldehyde over its bisected counterpart. A relative energy stability range of 1.02 to 1.20 kcal/mol, in favor of the eclipsed conformer, was found and discussed. ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms131115360
更新日期：2012-11-20 00:00:00
abstract：:The effects of various inhibitors on crude, commercial and partially purified commercial mushroom tyrosinase were examined by comparing IC(50) values. Kojic acid, salicylhydroxamic acid, tropolone, methimazole, and ammonium tetrathiomolybdate had relatively similar IC(50) values for the crude, commercial and partially...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms10093811
更新日期：2009-09-02 00:00:00
abstract：:Polyester and/or polythioester grafted chitosan copolymers were synthesized. For that, poly(ε-caprolactone) (PCL), poly(ε-thiocaprolactone) (PTCL), and their copolymers were first synthesized by ring opening polymerization. Copolymers with caprolactone:thiocaprolactone (CL:TCL) molar ratios of 2:1, 1:1, 1:2 were synth...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19123799
更新日期：2018-11-29 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms19071928
更新日期：2018-06-30 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms19072030
更新日期：2018-07-12 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms16047112
更新日期：2015-03-30 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 历史文章,杂志文章
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更新日期：2015-07-03 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
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更新日期：2020-12-29 00:00:00
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journal_title：International journal of molecular sciences
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doi：10.3390/ijms21218326
更新日期：2020-11-06 00:00:00
abstract：:Understanding the composition and structure of the acquired enamel pellicle (AEP) has been a major goal in oral biology. Our lab has conducted studies on the composition of AEP formed on permanent enamel. The exhaustive exploration has provided a comprehensive identification of more than 100 proteins from AEP formed o...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms14010920
更新日期：2013-01-07 00:00:00
abstract：:As the worldwide application of nanomaterials in commercial products increases every year, various nanoparticles from industry might present possible risks to aquatic systems and human health. Presently, there are many unknowns about the toxic effects of nanomaterials, especially because the unique physicochemical pro...
journal_title：International journal of molecular sciences
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更新日期：2020-04-20 00:00:00
abstract：:To combat the escalating rise of antibacterial resistance, the development of antimicrobial peptides (AMPs) with a unique mode of action is considered an attractive strategy. However, proteolytic degradation of AMPs remains the greatest challenge in their transformation into therapeutics. Herein, we synthesized Fmoc-t...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21103602
更新日期：2020-05-20 00:00:00
abstract：:Recently, neuromediators such as substance P (SP) have been found to be important factors in tendon homeostasis. Some studies have found SP to be the cause of inflammation and tendinopathy, whereas others have determined it to be a critical component of tendon healing. As demonstrated by these conflicting findings, th...
journal_title：International journal of molecular sciences
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更新日期：2020-11-16 00:00:00
abstract：:In vivo inoculation of cells such as tumor cells and induced pluripotent stem (iPS)/embryonic stem (ES) cells into immunocompromised mice has been considered as a powerful technique to evaluate their potential to proliferate or differentiate into various cell types originating from three germ cell layers. Subcutaneous...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
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更新日期：2017-08-02 00:00:00
abstract：:Barley (Hordeum vulgare L.) is an important cereal crop grown for both the feed and malting industries. The allelic dwarfing gene sdw1/denso has been used throughout the world to develop commercial barley varieties. Proteomic analysis offers a new approach to identify a broad spectrum of genes that are expressed in th...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms130810410
更新日期：2012-01-01 00:00:00
