Abstract：
:(1) Background: Regular exercise induces physiological and morphological changes in the organisms, but excessive training loads may induce damage and impair recovery or muscle growth. The purpose of the study was to evaluate the impact of Silymarin (SM) consumption on endurance capacity, muscle/cardiac histological changes, bodyweight, and food intake in rats subjected to 60 min of regular exercise training (RET) five days per week. (2) Methods: Male Wistar rats were subjected to an eight-week RET treadmill program and were previously administered SM and vitamin C. Bodyweight and food consumption were measured and registered. The maximal endurance capacity (MEC) test was performed at weeks one and eight. After the last training session, the animals were sacrificed, and samples of quadriceps/gastrocnemius and cardiac tissue were obtained and process for histological analyzes. (3) Results: SM consumption improved muscle recovery, inflammation, and damaged tissue, and promoted hypertrophy, vascularization, and muscle fiber shape/appearance. MEC increased after eight weeks of RET in all trained groups; moreover, the SM-treated group was enhanced more than the group with vitamin C. There were no significant changes in bodyweight and in food and nutrient consumption along the study. (5) Conclusion: SM supplementation may enhance physical performance, recovery, and muscle hypertrophy during the eight-week RET program.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Vargas-Mendoza N,Ángeles-Valencia M,Madrigal-Santillán EO,Morales-Martínez M,Tirado-Lule JM,Solano-Urrusquieta A,Madrigal-Bujaidar E,Álvarez-González I,Fregoso-Aguilar T,Morales-González Á,Morales-González JAdoi
10.3390/ijms21207724subject
Has Abstractpub_date
2020-10-19 00:00:00issue
20issn
1422-0067pii
ijms21207724journal_volume
21pub_type
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