Cryptic t(15;17) acute promyelocytic leukemia with a karyotype of add(11)(p15) and t(13,20)- A case report with a literature review.

Abstract:

:Most acute promyelocytic leukemia (APL) are characterized by reciprocal translocations t(15;17)(q22;21), which results in the fusion of PML gene at 15q22 with RARα gene at 17q21. However, several complex variant translocations also have been reported. Here we report a 62-year-old man with typical morphology and clinical features of APL with a complex karyotype including add(11)(p15) and t(13,20)(q12;q11.2) without typical t(15;17) assayed by the G-banding analysis. FISH with a PML/RARα dual-color DNA probe showed an atypical fusion signal, RT-qPCR analysis showed PML/RARα fusion transcripts, and NGS detected FLT3, WT1, and KRAS mutations. The patient achieved complete remission after treatment with conventional chemotherapy combined ATRA and ATO. Although the mechanism of this kind of cryptic variant remains unknown, we conclude that the cryptic PML/RARα fusion with add(11)(p15), t(13,20)(q12;q11.2) seems not to alter the effectiveness of chemotherapy combined with ATRA and ATO.

journal_name

Bosn J Basic Med Sci

authors

Gu S,Zi J,Ma J,Ge Z

doi

10.17305/bjbms.2020.5106

subject

Has Abstract

pub_date

2020-10-09 00:00:00

eissn

1512-8601

issn

1840-4812

pub_type

杂志文章,评审
  • Effects of basal insulin analog and metformin on glycaemia control and weight as risk factors for endothelial dysfunction.

    abstract::Obese patients with type 2 diabetes and impaired glucose tolerance are at increased risk of development of cardiovascular diseases. Endothelial dysfunction may be a reason for development of atherosclerosis and cardiovascular diseases. Lifestyle modification, increased physical activity, weight reduction, energy restr...

    journal_title:Bosnian journal of basic medical sciences

    pub_type: 杂志文章

    doi:10.17305/bjbms.2008.2882

    authors: Ascić-Buturović B,Kacila M

    更新日期:2008-11-01 00:00:00

  • Fixed combination lisinopril plus hydro-chlorothiazide in the treatment of essential arterial hypertension: an opened, multi-centre, prospective clinical trial.

    abstract::The aim of this trial was to examine the efficacy and safety of antihypertensive fixed combination lisinopril plus hydrochlorothiazide (Lopril H, Bosnalijek dd) in the treatment of essential arterial hypertension. In our trial we included 297 patients, aged 54.65+/-9.6 years, with treated or untreated hypertension and...

    journal_title:Bosnian journal of basic medical sciences

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.17305/bjbms.2007.3031

    authors: Gerc V,Begović B,Vehabović M,Voronkov LG,Vataman E,Musić L,Buksa M,Kusljugić Z,Ilyash MG,Ena LM,Tchelujko VI,Dyaduk AI,Bagrij AE,Andrievskaja SA,Vehabović A,Knezević B,Hima F

    更新日期:2007-11-01 00:00:00

  • Comprehensive analysis of patients with neuromyelitis optica spectrum disorder (NMOSD) combined with chronic hepatitis B (CHB) infection and seropositive for anti-aquaporin-4 antibody.

    abstract::Previous research indicated the association between hepatitis B virus (HBV) infection/vaccination and the onset of demyelinating diseases. However, most of these studies were single case reports, and comprehensive data are still scarce. Here we present a comprehensive analysis of 10 patients with neuromyelitis optica ...

    journal_title:Bosnian journal of basic medical sciences

    pub_type: 杂志文章

    doi:10.17305/bjbms.2017.2255

    authors: Liu J,Xu L,Chen ZL,Li M,Yi H,Peng FH

    更新日期:2018-02-20 00:00:00

  • A three-dimensional computed tomography study to determine the ideal method for fluoroscopically-guided bone marrow aspiration from the iliac crest.

    abstract::Bone marrow aspiration (BMA) through the iliac crest is potentially unsafe due to the vicinity of neurovascular structures in the greater sciatic notch. Our objective was to investigate the safety of a recently described BMA technique, specifically a trajectory from the posterior superior iliac spine (PSIS) to the ant...

    journal_title:Bosnian journal of basic medical sciences

    pub_type: 杂志文章

    doi:10.17305/bjbms.2020.4744

    authors: D'Souza RS,Li L,Leng S,Hunt C,Law L,Muir C,Eldrige J,Bydon M,Chi M,Shapiro S,Mauck WD,Qu W

    更新日期:2020-05-11 00:00:00

  • Combined inhibition of ACK1 and AKT shows potential toward targeted therapy against KRAS-mutant non-small-cell lung cancer.

    abstract::Non-small-cell lung cancer (NSCLC) with KRAS (Kirsten RAt Sarcoma 2 viral oncogene homolog) mutation has become a clinical challenge in cancer treatment as KRAS-mutant tumors are often resistant to conventional anti-tumor therapies. Activated CDC42-associated kinase 1 (ACK1), an activator of protein kinase B (AKT), is...

    journal_title:Bosnian journal of basic medical sciences

    pub_type: 杂志文章

    doi:10.17305/bjbms.2020.4746

    authors: Yu X,Liu J,Qiu H,Hao H,Zhu J,Peng S

    更新日期:2020-06-01 00:00:00

  • Inhibition of Neutral red photolysis with different antioxidants.

    abstract::Neutral red is a dye the azine structure which has been used as an acido-base indicator and a dye in histochemistry. In 1960 Goldhaber introduced Neutral red into the medium of resorbing bone cultures to localize the osteoclast in the living cultures. Using time-lapse microcinematography in order to follow the osteocl...

    journal_title:Bosnian journal of basic medical sciences

    pub_type: 杂志文章

    doi:10.17305/bjbms.2007.3091

    authors: Rimpapa Z,Sofić E,Sapcanin A,Toromanović J,Tahirović I

    更新日期:2007-02-01 00:00:00

  • Assessment of relatedness between neurocan gene as bipolar disorder susceptibility locus and schizophrenia.

    abstract::Large scale genetic association meta-analyses showed that neurocan (NCAN) gene polymorphism rs1064395 is susceptibility locus for bipolar disorder. These studies also included patients with bipolar disorder originated from Bosnia and Herzegovina. Followed by theory of shared genetic elements between bipolar disorder a...

    journal_title:Bosnian journal of basic medical sciences

    pub_type: 杂志文章

    doi:10.17305/bjbms.2012.2446

    authors: Oruč L,Kapur-Pojskić L,Ramić J,Pojskić N,Bajrović K

    更新日期:2012-11-01 00:00:00

  • Epidemiologic genotyping of methicillin-resistant Staphylococcus aureus (MRSA) by pulsed-field gel electrophoresis (PFGE).

    abstract::Staphylococcus aureus has long been recognized as one of the leading cause of hospital infections all over the world. Increased frequency of methicillin-resistant Staphylococcus aureus (MRSA) in hospitalized patients and possibility of vancomycin resistance requires rapid and reliable characterization of isolates and ...

    journal_title:Bosnian journal of basic medical sciences

    pub_type: 杂志文章

    doi:10.17305/bjbms.2008.2930

    authors: Ostojić M

    更新日期:2008-08-01 00:00:00

  • Comparison of complications and dialysis adequacy between temporary and permanent tunnelled catheter for haemodialysis.

    abstract::Number of hemodialysis patients each day is increasing. The quality of their lives is largely determined by the quality of hemodialysis treatment. One of the most important factors is the type of applied blood approach. The type of blood approach in the most case is artery venous fistula, permanent, temporary catheter...

    journal_title:Bosnian journal of basic medical sciences

    pub_type: 杂志文章

    doi:10.17305/bjbms.2009.2776

    authors: Kukavica N,Resic H,Sahovic V

    更新日期:2009-11-01 00:00:00

  • Clinical applications of avian eggshell-derived hydroxyapatite.

    abstract::The search for bone reconstruction materials and methods is an ongoing challenge. The aim of this review is to systemically search the available literature concerning the clinical performance of eggshell as a substitute material in guided bone regeneration in oral surgery. Five databases (PubMed, Cochrane, Web of Scie...

    journal_title:Bosnian journal of basic medical sciences

    pub_type: 杂志文章,评审

    doi:10.17305/bjbms.2020.4888

    authors: Opris H,Bran S,Dinu C,Baciut M,Prodan DA,Mester A,Baciut G

    更新日期:2020-11-02 00:00:00

  • Body dissatisfaction: how is it related to stress and one's perception of individual and cultural ideal body? A comparison of Bosnian and American university students.

    abstract::Cultural differences in body dissatisfaction, the relationship of stress to body dissatisfaction and individual and cultural body ideals were investigated. Forty-eight United States women and 48 Bosnian women completed the Body Shape Questionnaire (BSQ), the Impact of Event Scale (IES), and a Body Figure Rating Scale....

    journal_title:Bosnian journal of basic medical sciences

    pub_type: 杂志文章

    doi:10.17305/bjbms.2005.3332

    authors: Serifović S,Dinnel DL,Sinanović O

    更新日期:2005-02-01 00:00:00

  • Diagnostic performance of LI-RADS version 2018 in differentiating hepatocellular carcinoma from other hepatic malignancies in patients with hepatitis B virus infection.

    abstract::The diagnostic performance of the Liver Imaging Reporting and Data System (LI-RADS) in differentiating hepatocellular carcinoma (HCC) from other hepatic malignancies has not been investigated in Chinese patients with chronic liver disease from hepatitis B virus (HBV) infection. The aim of this study was to evaluate th...

    journal_title:Bosnian journal of basic medical sciences

    pub_type: 杂志文章

    doi:10.17305/bjbms.2019.4576

    authors: Shao S,Liang Y,Kuang S,Chen J,Shan Q,Yang H,Zhang Y,Wang B,J Fowler K,Wang J,B Sirlin C

    更新日期:2020-08-03 00:00:00

  • MicroRNA-466 (miR-466) functions as a tumor suppressor and prognostic factor in colorectal cancer (CRC).

    abstract::MicroRNAs (miRNAs) have an important role in the regulation of tumor development and metastasis. In this study, we investigated the clinical and prognostic value as well as biological function of miR-466 in colorectal cancer (CRC). Tumor and adjacent healthy tissues were obtained from 100 patients diagnosed with CRC. ...

    journal_title:Bosnian journal of basic medical sciences

    pub_type: 杂志文章

    doi:10.17305/bjbms.2018.2376

    authors: Tong F,Ying Y,Pan H,Zhao W,Li H,Zhan X

    更新日期:2018-08-01 00:00:00

  • Treatment options for thoracolumbar spine fractures.

    abstract::A decision for operative versus nonoperative management of thoracolumbar fractures should NEVER be based solely on one factor. Only after a thorough physical, neurological, and spinal examination, and an assessment of a patient's prior activity, social and educational background and patient's expectations, one should ...

    journal_title:Bosnian journal of basic medical sciences

    pub_type: 杂志文章,评审

    doi:10.17305/bjbms.2005.3279

    authors: Karaiković EE,Pacheco HO

    更新日期:2005-05-01 00:00:00

  • Extracorporeal shock waves lithotripsy versus retrograde ureteroscopy: is radiation exposure a criterion when we choose which modern treatment to apply for ureteric stones?

    abstract::The aim of this study is to compare two major urological procedures in terms of patient exposure to radiation. We evaluated 175 patients, that were subjected to retrograde ureteroscopy (URS) and extracorporeal shock waves lithotripsy (ESWL) for lumbar or pelvic ureteral lithiasis, at two urological departments. The C-...

    journal_title:Bosnian journal of basic medical sciences

    pub_type: 杂志文章

    doi:10.17305/bjbms.2014.4.99

    authors: Pricop C,Maier A,Negru D,Malau O,Orsolya M,Radavoi D,Serban DR

    更新日期:2014-10-18 00:00:00

  • The neuroprotective effects of tocotrienol rich fraction and alpha tocopherol against glutamate injury in astrocytes.

    abstract::Tocotrienol rich fraction (TRF) is an extract of palm oil, which consists of 25% alpha tocopherol (α-TCP) and 75% tocotrienols. TRF has been shown to possess potent antioxidant, anti-inflammatory, anticancer, neuroprotection, and cholesterol lowering activities. Glutamate is the main excitatory amino acid neurotransmi...

    journal_title:Bosnian journal of basic medical sciences

    pub_type: 杂志文章

    doi:10.17305/bjbms.2014.4.91

    authors: Selvaraju TR,Khaza'ai H,Vidyadaran S,Abd Mutalib MS,Vasudevan R

    更新日期:2014-11-16 00:00:00

  • TFF1 inhibits proliferation and induces apoptosis of gastric cancer cells in vitro.

    abstract::Trefoil Factor Family (TFF) plays an essential role in the intestinal epithelial restitution, but the relationship between TFF1 and gastric cancer (GC) is still unclear. The present study aimed to determine the role of TFF1 in repairing gastric mucosa and in the pathogenesis of GC. The TFF1 expression in different ga...

    journal_title:Bosnian journal of basic medical sciences

    pub_type: 杂志文章

    doi:10.17305/bjbms.2012.2499

    authors: Ge Y,Zhang J,Cao J,Wu Q,Sun L,Guo L,Wang Z

    更新日期:2012-05-01 00:00:00

  • Diagnostic usefulness of serum carcinoembryonic antigen determinations in breast cancer patients.

    abstract:BACKGROUND AND PURPOSE:Carcinoembryonic antigen (CEA) is used as a tumour marker in breast cancer (BC). In order to assess diagnostic value of CEA in BC we examined its serum levels and frequencies of its increase in breast cancer patients (BCP), and compared them to those in controls. We also determined CEA in patient...

    journal_title:Bosnian journal of basic medical sciences

    pub_type: 杂志文章

    doi:10.17305/bjbms.2003.3552

    authors: Mujagić Z,Mujagić H

    更新日期:2003-05-01 00:00:00

  • When less is more in the intensive care unit; lessons learned.

    abstract::In parallel to technological advances in late twentieth century, medical diagnostics and therapeutic options greatly improved. A surge of evidence-based research in intensive care medicine provided additional opportunities and the "best" medical practice has been changing rapidly. However, the primary focus of Hippocr...

    journal_title:Bosnian journal of basic medical sciences

    pub_type: 杂志文章

    doi:10.17305/bjbms.2009.2763

    authors: Festic E,Gajic O

    更新日期:2009-10-01 00:00:00

  • Introduction of the new analytical approaches to the doping control on the XIV Winter Olympic Games.

    abstract::In this paper we present introduction and development of some new analytical methods for identification of anabolic steroids, their metabolites and certain hormones, especially determination of exogenous testosterone by means of gas chromatography-mass spectrometry. Identification of central nervous stimulants and cor...

    journal_title:Bosnian journal of basic medical sciences

    pub_type: 杂志文章

    doi:10.17305/bjbms.2003.3528

    authors: Nikolin B,Lekić M,Sober M

    更新日期:2003-07-01 00:00:00

  • Effect of CCT137690 on long non-coding RNA expression profiles in MCF-7 and MDA-MB-231 cell lines.

    abstract::Long non-coding RNAs (lncRNAs) are involved in a range of biological processes, such as cellular differentiation, migration, apoptosis, invasion, proliferation, and transcriptional regulation. The aberrant expression of lncRNAs plays a significant role in several cancer types. Aurora kinases are increasingly expressed...

    journal_title:Bosnian journal of basic medical sciences

    pub_type: 杂志文章

    doi:10.17305/bjbms.2019.4155

    authors: Balcı Okcanoğlu T,Kayabaşı Ç,Gündüz C

    更新日期:2020-02-05 00:00:00

  • Localization of trefoil factor family peptide 3 (TFF3) in epithelial tissues originating from the three germ layers of developing mouse embryo.

    abstract::Trefoil factor family (TFF) peptides are involved in the maintenance of epithelial integrity and epithelial restitution. Mature epithelial tissues originate from different embryonic germ layers. The objective of this research was to explore the presence and localization of TFF3 peptide in mouse embryonic epithelia and...

    journal_title:Bosnian journal of basic medical sciences

    pub_type: 杂志文章

    doi:10.17305/bjbms.2017.1838

    authors: Bijelić N,Belovari T,Tolušić Levak M,Baus Lončar M

    更新日期:2017-08-20 00:00:00

  • Influence of Rho kinase inhibitor Fasudil on late endothelial progenitor cells in peripheral blood of COPD patients with pulmonary artery hypertension.

    abstract::The objective of our work was to investigate the influence of Fasudil, a Rho inhibitor on the number and function of the late endothelial progenitor cells in peripheral blood of chronic obstructive pulmonary diseases (COPD) patients with pulmonary artery hypertension. Eighty COPD patients with pulmonary artery hyperte...

    journal_title:Bosnian journal of basic medical sciences

    pub_type: 杂志文章,随机对照试验

    doi:10.17305/bjbms.2014.2295

    authors: Liu P,Zhang H,Tang Y,Sheng C,Liu J,Zeng Y

    更新日期:2014-02-01 00:00:00

  • Nitric oxide synthesis-promoting effects of valsartan in human umbilical vein endothelial cells via the Akt/adenosine monophosphate-activated protein kinase/endothelial nitric oxide synthase pathway.

    abstract::Valsartan (VAL), an antagonist of angiotensin II receptor type 1, has antihypertensive and multiple cardiovascular protective effects. The pleiotropic functions of VAL are related to the increased synthesis and biological activity of intravascular nitric oxide (NO). In this study, the role and mechanisms of VAL in the...

    journal_title:Bosnian journal of basic medical sciences

    pub_type: 杂志文章

    doi:10.17305/bjbms.2017.1319

    authors: Zhao Y,Wang L,He S,Wang X,Shi W

    更新日期:2017-05-20 00:00:00

  • Analysis of risk factors, localization and 30-day prognosis of intracerebral hemorrhage.

    abstract::Intracerebral hemorrhage is the deadliest, most disabling and least treatable form of stroke despite progression in medical science. The aim of the study was to analyze the frequency, risk factors, localization and 30-day prognosis in patients with intracerebral hemorrhage. We analyzed 352 patients with intracerebral ...

    journal_title:Bosnian journal of basic medical sciences

    pub_type: 杂志文章

    doi:10.17305/bjbms.2008.2964

    authors: Smajlović D,Salihović D,C Ibrahimagić O,Sinanović O,Vidović M

    更新日期:2008-05-01 00:00:00

  • Spleen-preserving surgery in treatment of large mesothelial splenic cyst in children--a case report and review of the literature.

    abstract::The nonparasitic primary splenic cysts are very rare clinical entity. In the past, splenectomy was the treatment of choice but with the recognition of the spleen's important immunological function, spleen-preserving surgery is the preferred treatment modality. We hereby present a case of a large splenic mesothelial cy...

    journal_title:Bosnian journal of basic medical sciences

    pub_type: 杂志文章,评审

    doi:10.17305/bjbms.2013.2395

    authors: Zvizdić Z,Karavdić K

    更新日期:2013-05-01 00:00:00

  • Stability of cefuroxime axetil oral suspension at different temperature storage conditions.

    abstract::Stability testing of an active substance or finished product provides information of the variation of drug substance or final product with time influenced by a variety of environmental factors such as temperature, humidity and light. Knowledge gained from stability studies enables understanding of the effects of the e...

    journal_title:Bosnian journal of basic medical sciences

    pub_type: 杂志文章

    doi:10.17305/bjbms.2008.3005

    authors: Uzunović A,Vranić E

    更新日期:2008-02-01 00:00:00

  • Analysis of CYP2C9*2, CYP2C19*2, and CYP2D6*4 polymorphisms in patients with type 2 diabetes mellitus.

    abstract::This is the first study performed in population from Bosnia & Herzegovina (BH), in which we analysed a significance of genetic variations in drug-metabolising enzyme, cytochrome P450 (CYP), in pathogenesis of Type 2 diabetes. We have determined allele frequencies for CYP2C9*2, CYP2C19*2, and CYP2D6*4 in diabetic patie...

    journal_title:Bosnian journal of basic medical sciences

    pub_type: 杂志文章

    doi:10.17305/bjbms.2010.2662

    authors: Semiz S,Dujic T,Ostanek B,Prnjavorac B,Bego T,Malenica M,Marc J,Causevic A

    更新日期:2010-11-01 00:00:00

  • Structural changes in the rat placenta during the last third of gestation discovered by stereology.

    abstract::Structural changes in the rat placenta during the last third of gestation were for the first time assessed by stereology. Fischer female rats were euthanized on the day 16 or day 19 of gestation, and 35 placentas were collected. Three randomly selected placentas from each group were stereologically analyzed for the ab...

    journal_title:Bosnian journal of basic medical sciences

    pub_type: 杂志文章

    doi:10.17305/bjbms.2015.1.244

    authors: Serman L,Zunic I,Vrsaljko N,Grbesa D,Gjurcevic E,Matasin Z,Nikuseva Martic T,Bulic Jakus F,Tlak Gajger I,Serman A

    更新日期:2015-01-22 00:00:00

  • Treatment benefits on metabolic syndrome with diet and physical activity.

    abstract::The research has included 422 patients aged between 25 to 60, of whom 341 were men and 81 women. The purpose of research was to determine impact of diet and physical activity in the treatment of metabolic syndrome during the six month period. Processing of results through descriptive and discriminative analysis have i...

    journal_title:Bosnian journal of basic medical sciences

    pub_type: 杂志文章

    doi:10.17305/bjbms.2010.2718

    authors: Dragusha G,Elezi A,Dragusha S,Gorani D,Begolli L

    更新日期:2010-05-01 00:00:00