Abstract:
:Stability testing of an active substance or finished product provides information of the variation of drug substance or final product with time influenced by a variety of environmental factors such as temperature, humidity and light. Knowledge gained from stability studies enables understanding of the effects of the environment on the drugs. The aim of our study was to determine the stability of cefuroxime axetil oral suspension at different temperature storage conditions (stored at room /20 degrees C/ and refrigerated /5 degrees C/ conditions). Determination of cefuroxime (as cefuroxime axetil) was performed by dissolution testing. Fractions of the released cefuroxime axetil were compared using f2 value. After interpolating data for dissolution profiles at room and refrigerated conditions the following f2values were obtained: 62,56; 56,32 and 36,18 on 3rd, 6th and 10th day, respectively. These values indicate similarities in drug release from analyzed cefuroxime axetil oral suspension on 3rd, 6th day, and differences on 10th day. Based on our results, we may assume that cefuroxime axetil oral suspension preserves its stability for 10 days after reconstitution under room and refrigerated conditions. It is obvious, according to the f2 value obtained on the 10th day, that there is a difference between the released cefuroxime axetil from oral suspension at room (87,68%) and refrigerated (92,35%) conditions. Concentration changes can be caused by the mechanisms associated with drug release and hydrolytical decomposition of the sample and higher temperatures during longer period of storage.
journal_name
Bosn J Basic Med Scijournal_title
Bosnian journal of basic medical sciencesauthors
Uzunović A,Vranić Edoi
10.17305/bjbms.2008.3005subject
Has Abstractpub_date
2008-02-01 00:00:00pages
93-7issue
1eissn
1512-8601issn
1840-4812journal_volume
8pub_type
杂志文章abstract::Nod-like receptor protein 3 (NLRP3) inflammasome has been implicated in alcoholic liver disease. Chronic alcohol consumption enhances gut permeability and causes microbial translocation. The present study explored the activation of the NLRP3 inflammasome by Escherichia coli RNA in hepatic stellate cells (HSCs), and th...
journal_title:Bosnian journal of basic medical sciences
pub_type: 杂志文章
doi:10.17305/bjbms.2016.699
更新日期:2016-01-14 00:00:00
abstract::Epileptic psychoses as the most complex psychopathological phenomena represent unexplored states for prognosis. Clinical trials, conveyed in order to found risk factors still are not consistent in their conclusions. By this research results of all biological, clinical, psychological and social, as well as demographic ...
journal_title:Bosnian journal of basic medical sciences
pub_type: 杂志文章
doi:10.17305/bjbms.2007.3069
更新日期:2007-05-01 00:00:00
abstract::We investigated serum concentration of C-reactive protein (CRP) and measures of adiposity in 30 patients with type 2 diabetes mellitus (15 male, 15 female) and 30 age and sex-matched apparently healthy subjects. CRP concentration was determined by laser nephelometry (BN II Analyzer) and CardioPhase high-sensitivity CR...
journal_title:Bosnian journal of basic medical sciences
pub_type: 杂志文章
doi:10.17305/bjbms.2007.3021
更新日期:2007-11-01 00:00:00
abstract::The diagnostic performance of the Liver Imaging Reporting and Data System (LI-RADS) in differentiating hepatocellular carcinoma (HCC) from other hepatic malignancies has not been investigated in Chinese patients with chronic liver disease from hepatitis B virus (HBV) infection. The aim of this study was to evaluate th...
journal_title:Bosnian journal of basic medical sciences
pub_type: 杂志文章
doi:10.17305/bjbms.2019.4576
更新日期:2020-08-03 00:00:00
abstract::There are numerous methods of administering drugs to the body, both passive and active. Active methods include the use of penetration enhancers and assisted drug delivery. One of them is sonophoresis (phonophoresis). This term is used to describe the effects of ultrasound on the movement of drugs through intact living...
journal_title:Bosnian journal of basic medical sciences
pub_type: 杂志文章
doi:10.17305/bjbms.2004.3410
更新日期:2004-05-01 00:00:00
abstract::Innocent heart murmurs are hearth murmurs that occur in patients with a normal heart structure. They do not represent a disease of the heart and vascular system, and should not be treated as such. Iron-deficiency anaemia often causes, along with other symptoms, systolic heart murmurs and tachycardia. It appears in chi...
journal_title:Bosnian journal of basic medical sciences
pub_type: 杂志文章
doi:10.17305/bjbms.2005.3269
更新日期:2005-08-01 00:00:00
abstract::Tranexamic acid (TXA) reduces blood loss and transfusion rates in unilateral total knee arthroplasty (TKA), but there is limited data regarding its efficacy in bilateral TKA. This study reports the impact TXA has on clinical outcomes and hospital cost of care in simultaneous, primary bilateral TKA. The 449 patients we...
journal_title:Bosnian journal of basic medical sciences
pub_type: 杂志文章
doi:10.17305/bjbms.2020.5060
更新日期:2020-10-27 00:00:00
abstract::The synergy and shared co-morbidity, certainly interplay between kidney and cardiovascular disease, where advanced renal failure influences on progression of cardiac disease in bi-direction relationship. Cardiovascular diseases are cause of death in almost 50% of uremic patients. Correction of uremia after successful ...
journal_title:Bosnian journal of basic medical sciences
pub_type: 杂志文章
doi:10.17305/bjbms.2009.2827
更新日期:2009-05-01 00:00:00
abstract::In parallel to technological advances in late twentieth century, medical diagnostics and therapeutic options greatly improved. A surge of evidence-based research in intensive care medicine provided additional opportunities and the "best" medical practice has been changing rapidly. However, the primary focus of Hippocr...
journal_title:Bosnian journal of basic medical sciences
pub_type: 杂志文章
doi:10.17305/bjbms.2009.2763
更新日期:2009-10-01 00:00:00
abstract::Aminoglycoside antibiotics are obligated nephrotoxins and inevitably cause renal failure during prolonged use. Experimental models of gentamicin-induced nephrotoxicity have shown histopathological, ultrastructural and functional alteration with blood urea nitrogen and serum creatinine increase leading to acute renal i...
journal_title:Bosnian journal of basic medical sciences
pub_type: 杂志文章
doi:10.17305/bjbms.2008.2977
更新日期:2008-05-01 00:00:00
abstract::Intracerebral hemorrhage is the deadliest, most disabling and least treatable form of stroke despite progression in medical science. The aim of the study was to analyze the frequency, risk factors, localization and 30-day prognosis in patients with intracerebral hemorrhage. We analyzed 352 patients with intracerebral ...
journal_title:Bosnian journal of basic medical sciences
pub_type: 杂志文章
doi:10.17305/bjbms.2008.2964
更新日期:2008-05-01 00:00:00
abstract::Non-small-cell lung cancer (NSCLC) with KRAS (Kirsten RAt Sarcoma 2 viral oncogene homolog) mutation has become a clinical challenge in cancer treatment as KRAS-mutant tumors are often resistant to conventional anti-tumor therapies. Activated CDC42-associated kinase 1 (ACK1), an activator of protein kinase B (AKT), is...
journal_title:Bosnian journal of basic medical sciences
pub_type: 杂志文章
doi:10.17305/bjbms.2020.4746
更新日期:2020-06-01 00:00:00
abstract::The aim of this study was to assess echocardiographic changes in female patients with untreated dysfunctional thyroid states and whether the therapy aimed to normalize the thyroid dysfunction could lead to improvement in cardiac systolic and diastolic function. The study included 90 female subjects who performed contr...
journal_title:Bosnian journal of basic medical sciences
pub_type: 杂志文章
doi:10.17305/bjbms.2010.2704
更新日期:2010-05-01 00:00:00
abstract::Most of today available non-invasive procedures cannot clearly determinate between benign and malignant solitary pulmonary nodules (SPN). The purpose of the study was to assess the possibility of using 99mTc labeled hexakis-2-methoxyisobutylisonitrile (99mTc-MIBI) to differentiate benign from malignant SPN. Sixty pati...
journal_title:Bosnian journal of basic medical sciences
pub_type: 杂志文章
doi:10.17305/bjbms.2011.2570
更新日期:2011-08-01 00:00:00
abstract::The lithium ions concentration in human serum was determined using Dry-slide technology Vitros 250 Analyser (Ortho Clinical Diagnostic), atomic absorption spectrometry (AAS) method Perkin Elmer 403 and ion-selective electrode (ISE) potentiometry AVL 9181. We compared lithium ions results in sample sera between these m...
journal_title:Bosnian journal of basic medical sciences
pub_type: 杂志文章
doi:10.17305/bjbms.2006.3191
更新日期:2006-05-01 00:00:00
abstract::Long non-coding RNAs (lncRNAs) are involved in a range of biological processes, such as cellular differentiation, migration, apoptosis, invasion, proliferation, and transcriptional regulation. The aberrant expression of lncRNAs plays a significant role in several cancer types. Aurora kinases are increasingly expressed...
journal_title:Bosnian journal of basic medical sciences
pub_type: 杂志文章
doi:10.17305/bjbms.2019.4155
更新日期:2020-02-05 00:00:00
abstract::The objective of our study was to evaluate bladder outlet obstruction number (BOON) in order to predict infravesical obstruction in patients with benign prostatic enlargement (BPE). Two hundred patients with proven BPE from daily urological practice at the Urology Department of the Sarajevo University Clinical Centre ...
journal_title:Bosnian journal of basic medical sciences
pub_type: 杂志文章
doi:10.17305/bjbms.2012.2459
更新日期:2012-08-01 00:00:00
abstract::Ebselen is an organoselenium compound which has strong antioxidant and anti-inflammatory effects. We investigated the neuroprotective role of ebselen pretreatment in rats with experimental sciatic nerve ischemia-reperfusion (I/R) injury. Adult male Sprague Dawley rats were divided into four groups (N = 7 in each group...
journal_title:Bosnian journal of basic medical sciences
pub_type: 杂志文章
doi:10.17305/bjbms.2015.521
更新日期:2015-08-26 00:00:00
abstract::Numerous studies conducted on acetylsalicylic acid (ASA, aspirin) confirmed that ASA inhibits proliferation and induces apoptosis in various types of human cells. Therefore, it was of interest to examine possible effects of different concentrations of ASA on viability and proliferation of lymphocytes in the cell cultu...
journal_title:Bosnian journal of basic medical sciences
pub_type: 杂志文章
doi:10.17305/bjbms.2008.2919
更新日期:2008-08-01 00:00:00
abstract::Lung cancer is responsible for 40% mortalities from malignant diseases in man and exhibits an extremely infiltrating way of growing. It does not respect the lobes' or the organs' borders and spreads by blood system, lymph system and per continuitatem. According to its biological characteristics and response to treatme...
journal_title:Bosnian journal of basic medical sciences
pub_type: 杂志文章
doi:10.17305/bjbms.2007.3052
更新日期:2007-08-01 00:00:00
abstract::The nonparasitic primary splenic cysts are very rare clinical entity. In the past, splenectomy was the treatment of choice but with the recognition of the spleen's important immunological function, spleen-preserving surgery is the preferred treatment modality. We hereby present a case of a large splenic mesothelial cy...
journal_title:Bosnian journal of basic medical sciences
pub_type: 杂志文章,评审
doi:10.17305/bjbms.2013.2395
更新日期:2013-05-01 00:00:00
abstract::MicroRNAs (miRNAs) have an important role in the regulation of tumor development and metastasis. In this study, we investigated the clinical and prognostic value as well as biological function of miR-466 in colorectal cancer (CRC). Tumor and adjacent healthy tissues were obtained from 100 patients diagnosed with CRC. ...
journal_title:Bosnian journal of basic medical sciences
pub_type: 杂志文章
doi:10.17305/bjbms.2018.2376
更新日期:2018-08-01 00:00:00
abstract::Non-coding RNAs play a critical role in gene regulation in cancer cells. Reduced expression of microRNA-192 (miR-192) has been detected in many cancers. In this study, we investigated the role of miR-192 in cell proliferation and cell cycle control in NALM-6 cell line, a model of acute lymphoblastic leukemia (ALL). Ce...
journal_title:Bosnian journal of basic medical sciences
pub_type: 杂志文章
doi:10.17305/bjbms.2017.1921
更新日期:2017-08-20 00:00:00
abstract::Large scale genetic association meta-analyses showed that neurocan (NCAN) gene polymorphism rs1064395 is susceptibility locus for bipolar disorder. These studies also included patients with bipolar disorder originated from Bosnia and Herzegovina. Followed by theory of shared genetic elements between bipolar disorder a...
journal_title:Bosnian journal of basic medical sciences
pub_type: 杂志文章
doi:10.17305/bjbms.2012.2446
更新日期:2012-11-01 00:00:00
abstract::The aim of study was to evaluate endocrine changes in PCOS women during metformin treatment. One hundred women with PCOS, aged 20-40 years were included. A complete hormonal and metabolic pattern was recorded for each subject every 6 months. Metformin treatment after 6 and 12 months significantly reduced weight, BMI, ...
journal_title:Bosnian journal of basic medical sciences
pub_type: 杂志文章
doi:10.17305/bjbms.2013.2359
更新日期:2013-08-01 00:00:00
abstract::The purpose of this study was to investigate trends in the incidence of upper tract urothelial carcinoma (UTUC) in patients and to establish a reliable and practical nomogram based on significant clinical factors to predict the overall survival (OS) and cancer-specific survival (CSS) of UTUC patients. The Surveillance...
journal_title:Bosnian journal of basic medical sciences
pub_type: 杂志文章
doi:10.17305/bjbms.2020.5345
更新日期:2020-12-18 00:00:00
abstract::Neurological outcome is an important determinant of death in admitted survivors after out-of-hospital cardiac arrest (OHCA). Studies demonstrated several significant pre-hospital predictors of ischemic brain injury (time to resuscitation, time of resuscitation, and cause of OHCA). Our aim was to evaluate the relations...
journal_title:Bosnian journal of basic medical sciences
pub_type: 杂志文章
doi:10.17305/bjbms.2020.4623
更新日期:2020-08-03 00:00:00
abstract:BACKGROUND AND PURPOSE:Clinical research of drugs is a researching step subsequent to the preclinical studies in experimental animals. The aim of our research was to evaluate animal model of wound healing process after the burn inducement and effects of the ointment containing natural plants on the process of burn heal...
journal_title:Bosnian journal of basic medical sciences
pub_type: 杂志文章
doi:10.17305/bjbms.2003.3495
更新日期:2003-11-01 00:00:00
abstract::Number of hemodialysis patients each day is increasing. The quality of their lives is largely determined by the quality of hemodialysis treatment. One of the most important factors is the type of applied blood approach. The type of blood approach in the most case is artery venous fistula, permanent, temporary catheter...
journal_title:Bosnian journal of basic medical sciences
pub_type: 杂志文章
doi:10.17305/bjbms.2009.2776
更新日期:2009-11-01 00:00:00
abstract::Thymic stromal lymphopoietin (TSLP) is a cytokine produced by epithelial cells in the lungs, skin, and intestinal mucosa and is involved in several physiological and pathological processes. In this study, we evaluated serum TSLP levels in patients with celiac disease (CD). The prospective study was conducted at a gast...
journal_title:Bosnian journal of basic medical sciences
pub_type: 杂志文章
doi:10.17305/bjbms.2019.4016
更新日期:2019-08-20 00:00:00