Nigella A ameliorates inflammation and intestinal flora imbalance in DSS induced colitis mice.

Abstract:

:Nigella A, also named Sieboldianoside A, has been extracted from many kinds of Traditional Chinese Medicine (TCM), such as Nigella glandulifera, Stauntonia chinensis DC., and the leaves of Acanthopanax sieboldianus. Nigella A exhibited potential analgesic, anti-inflammatory, anti-tumor, and antioxidant activities. However, whether Nigella A could treat ulcerative colitis (UC) is still unknown. As saponins always be regarded as the kinds of ingredients that could regulate immunity and intestinal flora. This research aimed to investigate the therapeutic effect of Nigella A on UC and explore its effect on intestinal flora. We noted that Nigella A and Sulfasalazine (SASP) could significantly improve the signs and symptoms, alleviate colonic pathological injury in DSS-induced mice. The changing of many specific bacterial genus such as Lactobacillus, Porphyromonadaceae, Bacteroides and Escherichia might closely related to the recovery of intestinal inflammatory response. This study initially confirmed the therapeutic effect of Nigella A and SASP on DSS-induced colitis by improving the diversity of intestinal microbial composition. Nigella A has the potential to be developed for the treatment of UC and other disorders related to the imbalance of intestinal flora.

journal_name

AMB Express

journal_title

AMB Express

authors

Hu X,Xu N,Yang X,Hu X,Zheng Y,Zhang Q

doi

10.1186/s13568-020-01114-3

subject

Has Abstract

pub_date

2020-10-04 00:00:00

pages

179

issue

1

issn

2191-0855

pii

10.1186/s13568-020-01114-3

journal_volume

10

pub_type

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