Abstract：
:For treatment individualisation of patients with locally advanced head and neck squamous cell carcinoma (HNSCC) treated with primary radiochemotherapy, we explored the capabilities of different deep learning approaches for predicting loco-regional tumour control (LRC) from treatment-planning computed tomography images. Based on multicentre cohorts for exploration (206 patients) and independent validation (85 patients), multiple deep learning strategies including training of 3D- and 2D-convolutional neural networks (CNN) from scratch, transfer learning and extraction of deep autoencoder features were assessed and compared to a clinical model. Analyses were based on Cox proportional hazards regression and model performances were assessed by the concordance index (C-index) and the model's ability to stratify patients based on predicted hazards of LRC. Among all models, an ensemble of 3D-CNNs achieved the best performance (C-index 0.31) with a significant association to LRC on the independent validation cohort. It performed better than the clinical model including the tumour volume (C-index 0.39). Significant differences in LRC were observed between patient groups at low or high risk of tumour recurrence as predicted by the model ([Formula: see text]). This 3D-CNN ensemble will be further evaluated in a currently ongoing prospective validation study once follow-up is complete.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Starke S,Leger S,Zwanenburg A,Leger K,Lohaus F,Linge A,Schreiber A,Kalinauskaite G,Tinhofer I,Guberina N,Guberina M,Balermpas P,von der Grün J,Ganswindt U,Belka C,Peeken JC,Combs SE,Boeke S,Zips D,Richter C,Troostdoi
10.1038/s41598-020-70542-9subject
Has Abstractpub_date
2020-09-24 00:00:00pages
15625issue
1issn
2045-2322pii
10.1038/s41598-020-70542-9journal_volume
10pub_type
杂志文章abstract：:The stochastic tunneling-basin hopping method (STUN-BH) was utilized to obtain the most stable peptide S7 configuration (Ac-Ser-Ser-Phe-Pro-Gln-Pro-Asn-CONH2) adsorbed on Au(111) facet. After the most stable S7 configuration was found, molecular dynamics (MD) simulation was conducted to investigate the thermal stabili...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-59144-7
更新日期：2020-02-07 00:00:00
abstract：:Heat shock protein 90 (HSP90) inhibition is an attractive strategy for cancer treatment. Several HSP90 inhibitors have shown promising effects in clinical oncology trials. However, little is known about HSP90 inhibition-mediated bladder cancer therapy. Here, we report a quantitative proteomic study that evaluates alte...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-00143-6
更新日期：2017-03-15 00:00:00
abstract：:Knee osteoarthritis (OA) is the most common musculoskeletal disorder. OA diagnosis is currently conducted by assessing symptoms and evaluating plain radiographs, but this process suffers from subjectivity. In this study, we present a new transparent computer-aided diagnosis method based on the Deep Siamese Convolution...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-20132-7
更新日期：2018-01-29 00:00:00
abstract：:BEST1 is a Ca2+-activated Cl- channel predominantly expressed in retinal pigment epithelium (RPE), and over 250 genetic mutations in the BEST1 gene have been identified to cause retinal degenerative disorders generally known as bestrophinopathies. As most BEST1 mutations are autosomal dominant, it is of great biomedic...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-54892-7
更新日期：2019-12-13 00:00:00
abstract：:The structural and magnetic properties of seven CeMn2Ge(2-x)Six compounds with x = 0.0-2.0 have been investigated in detail. Substitution of Ge with Si leads to a monotonic decrease of both a and c along with concomitant contraction of the unit cell volume and significant modifications of the magnetic states - a cross...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep11288
更新日期：2015-06-19 00:00:00
abstract：:Tetrandrine (Tet) could enhance the antitumor effect of Paclitaxel (Ptx) by increasing intracellular Reactive Oxygen Species (ROS) levels, which leads to the possibility of co-delivery of both drugs for synergistic antitumor effect. In the current study, we reported an efficient, local therapeutic strategy employing e...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep26546
更新日期：2016-05-26 00:00:00
abstract：:Alzheimer's disease (AD) is one of the most prevalent neurodegenerative diseases, yet current therapeutic treatments are inadequate due to a complex disease pathogenesis. The plant polyphenol apigenin has been shown to have anti-inflammatory and neuroprotective properties in a number of cell and animal models; however...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep31450
更新日期：2016-08-12 00:00:00
abstract：:A novel chemical absorption-biological reduction (CABR) integrated process, employing ferrous ethylenediaminetetraacetate (Fe(II)EDTA) as a solvent, is deemed as a potential option for NOx removal from the flue gas. Previous work showed that the Fe(II)EDTA concentration was critical for the NOx removal in the CABR pro...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep18876
更新日期：2016-01-08 00:00:00
abstract：:Understanding the rhizodeposited carbon (C) dynamics of winter wheat (Triticum aestivum L.), is crucial for soil fertility and C sequestration. Pot-grown winter wheat was pulse labelled with 14CO2 at the key growth stages. 14C in the shoots, roots and soil was measured at 5 or 2 days after 14C-labelling (DAL 5/2) at e...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-21547-y
更新日期：2018-02-16 00:00:00
abstract：:The Holocene drying trend in the northern Altai Mountains and the wetting trend in the southern Altai Mountains inferred from the paleoclimatic studies indicated it is needed to understand the modern climatic characters in this region. However, a detailed analysis of modern climate variations in the northern and south...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-21637-x
更新日期：2018-02-19 00:00:00
abstract：:We developed a spongy-like porous polymer (spongy monolith) consisting of poly(ethylene-co-glycidyl methacrylate) with continuous macropores that allowed efficient in situ reaction between the epoxy groups and proteins of interest. Immobilization of protein A on the spongy monolith enabled high-yield collection of imm...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-00264-y
更新日期：2017-03-14 00:00:00
abstract：:The overproduction of hydrogen peroxide is an inherent feature of some tumour cells and inflamed tissues. We took advantage of this peculiarity to eliminate cells using chemiluminescent peroxyoxalate reaction. We designed dispersions containing polyoxalate and tetramethylhematoporhyrin (TMHP) in dimethylphthalate drop...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-03527-w
更新日期：2017-06-13 00:00:00
abstract：:We report a water decomposition mode called 'Aquaionic Splitting (AiS)' by means of iron corrosion in aqueous solution. In this paper, we investigated the phenomenon by controlling the reaction between iron and water. A pseudo-sacrificial protection method with oil paint was employed to select the anode and cathode fo...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-58707-y
更新日期：2020-02-03 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-019-48627-x
更新日期：2019-08-28 00:00:00
abstract：:We present an automated droplet microfluidic system (DMF) to generate monitored nanoliter aqueous droplets in oil and their deposition on a commercial stainless steel plate for MALDI-TOF analysis of peptides or protein digests. We demonstrate that DMF-MALDI combination focuses the analyte on the MALDI plate, increasin...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-06660-8
更新日期：2017-07-28 00:00:00
abstract：:Cancer chemotherapies have improved prognosis in cancer patients, resulting in a large and rapidly increasing number of cancer survivors. "Onco-cardiology" or "cardio-oncology" is a new discipline for addressing the unanticipated cardiac side effects of newly developed cancer drugs. Lapatinib, a tyrosine kinase inhibi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-57601-x
更新日期：2020-01-20 00:00:00
abstract：:Siwei Jianghuang Decoction Powder (SWJH) documented originally in the Four Medical Tantras-Blue Glaze exhibited beneficial effects on diabetic nephropathy (DN) via combined synergistically action of multiple formula components including Curcumae longae Rhizoma, Berberidis dictyophyllae Cortex, Phyllanthi Fructus and T...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-35148-2
更新日期：2018-11-12 00:00:00
abstract：:Phosphoinositides play important roles in numerous intracellular membrane pathways. Little is known about the regulation or function of these lipids in rod photoreceptor cells, which have highly active membrane dynamics. Using new assays with femtomole sensitivity, we determined that whereas levels of phosphatidylinos...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep26978
更新日期：2016-06-01 00:00:00
abstract：:Olfactory receptors are believed to play a central role in insects host-seeking, mating, and ovipositing. On the basis of male and female antennal transcriptome of adult Apolygus lucorum, a total of 110 candidate A. lucorum odorant receptors (AlucOR) were identified in this study including five previously annotated Al...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep37870
更新日期：2016-11-28 00:00:00
abstract：:Recent genome-wide association studies (GWAS) of Parkinson's disease (PD) revealed at least 26 risk loci, with associated single nucleotide polymorphisms (SNPs) located in non-coding DNA having unknown functions in risk. In order to explore in which cell types these SNPs (and their correlated surrogates at r(2) ≥ 0.8)...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep30509
更新日期：2016-07-27 00:00:00
abstract：:Quality assessment of protein models using no other information than the structure of the model itself has been shown to be useful for structure prediction. Here, we introduce two novel methods, ProQRosFA and ProQRosCen, inspired by the state-of-art method ProQ2, but using a completely different description of a prote...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep33509
更新日期：2016-10-04 00:00:00
abstract：:The design, fabrication, and characterization of ultra-high responsivity photodetectors based on mesoscopic multilayer MoS2 is presented, which is a less explored system compared to direct band gap monolayer MoS2 that has received increasing attention in recent years. The device architecture is comprised of a metal-se...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-19367-1
更新日期：2018-01-19 00:00:00
abstract：:Autophagy is the major intracellular degradation system by which cytoplasmic materials are delivered to and degraded in the vacuole/lysosome in eukaryotic cells. MoAtg14 in M. oryzae, a hitherto uncharacterized protein, is the highly divergent homolog of the yeast Atg14 and the mammal BARKOR. The MoATG14 deletion muta...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep40018
更新日期：2017-01-09 00:00:00
abstract：:Multi-atlas-based segmentation (MAS) methods have demonstrated superior performance in the field of automatic image segmentation, and label fusion is an important part of MAS methods. In this paper, we propose a label fusion method that incorporates pixel greyscale probability information. The proposed method combines...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-54527-x
更新日期：2019-11-29 00:00:00
abstract：:Herein, water-oxidation reaction by cobalt(II) phthalocyanine, N,N'-bis (salicylidene) ethylenediamino cobalt(II), nickel(II) Schiff base (N,N'-bis (salicylidene)ethylenediamino nickel(II), nickel(II)) phthalocyanine-tetrasulfonate tetrasodium, manganese(II) phthalocyanine, 5,10,15,20-Tetraphenyl-21H,23H-porphine mang...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-43953-6
更新日期：2019-05-16 00:00:00
abstract：:The extensive reliance on insecticides to control Aedes aegypti mosquitoes and disrupt transmission of dengue, chikungunya and Zika has fueled the emergence of widespread resistance to insecticides. Mismatch between the frequency of pyrethroid resistance in mosquitoes and the occurrence of pyrethroid-based insecticide...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-30968-8
更新日期：2018-08-22 00:00:00
abstract：:Agricultural soil is often subjected to waterlogging after heavy rainfalls, resulting in sharp and explosive increases in the emission of nitrous oxide (N2O), an important greenhouse gas primarily released from agricultural soil ecosystems. Previous studies on waterlogged soil examined the abundance of denitrifiers bu...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-00953-8
更新日期：2017-04-11 00:00:00
abstract：:Endocannabinoids are small signaling lipids, with 2-arachidonoylglycerol (2-AG) implicated in modulating axonal growth and synaptic plasticity. The concept of short-range extracellular signaling by endocannabinoids is supported by the lack of trans-synaptic 2-AG signaling in mice lacking sn-1-diacylglycerol lipases (D...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep02093
更新日期：2013-01-01 00:00:00
abstract：:Graphene quantum dots (GQDs) have received much attention due to their novel phenomena of charge transport and light absorption/emission. The optical transitions are known to be available up to ~6 eV in GQDs, especially useful for ultraviolet (UV) photodetectors (PDs). Thus, the demonstration of photodetection gain wi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep05603
更新日期：2014-07-07 00:00:00
abstract：:Growing evidence indicates that nomogram combined with the biomarkers of systemic inflammation response could provide more accurate prediction than conventional staging systems in tumors. This study aimed to establish an effective prognostic nomogram for resectable thoracic esophageal squamous cell carcinoma (ESCC) ba...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep18811
更新日期：2015-12-22 00:00:00
