Peptide Capping Agent Design for Gold (111) Facet by Molecular Simulation and Experimental Approaches.

abstract：:Target-guided synthesis is an approach to drug discovery that allows the target to self-assemble its own binding agents. So far, target-guided synthesis and especially in situ click chemistry have attracted extensive attention and have led to the identification of highly potent inhibitors for proteins. In this study, ...

journal_title：Scientific reports

authors： Hu MH,Chen X,Chen SB,Ou TM,Yao M,Gu LQ,Huang ZS,Tan JH

更新日期：2015-11-25 00:00:00

abstract：:We characterised changes in reproductive hormones-LH, FSH, SHBG and AMH-by chronological age and time around the menopause (reproductive age) in mid-life women and explored their associations with lifestyle and reproductive factors. We used data from 1608 women from a UK cohort who had repeat hormone measures and expe...

journal_title：Scientific reports

authors： Soares AG,Kilpi F,Fraser A,Nelson SM,Sattar N,Welsh PI,Tilling K,Lawlor DA

更新日期：2020-12-04 00:00:00

abstract：:The poor control of the adhesion of TiO2 nanotubes (TNTs) layers to a non-anodized titanium (Ti) substrate has limited their widespread application, because the stripping mechanism has not yet been revealed. Here, we report a novel method to control the detachment of TNTs by post-treatment of the as-fabricated samples...

journal_title：Scientific reports

authors： Zhao M,Li J,Li Y,Wang J,Zuo Y,Jiang J,Wang H

更新日期：2014-11-24 00:00:00

abstract：:In order to investigate the role of lateral angle ratio (LA ratio) and daughter artery ratio (DA ratio) for predicting aneurysmal presence in main cerebral arterial bifurcations, three-dimensional cerebral angiographic data of major cerebral artery bifurcations were used for measurement of artery diameters and bifurca...

journal_title：Scientific reports

authors： Zhang XJ,Hao WL,Zhang DH,Gao BL

更新日期：2019-11-20 00:00:00

abstract：:Lonicera japonica Thunb, rich in chlorogenic acid (CHA), is used for viral upper respiratory tract infection treatment caused by influenza virus, parainfluenza virus, and respiratory syncytial virus, ect in China. It was reported that CHA reduced serum hepatitis B virus level and death rate of influenza virus-infected...

journal_title：Scientific reports

authors： Ding Y,Cao Z,Cao L,Ding G,Wang Z,Xiao W

更新日期：2017-04-10 00:00:00

abstract：:We performed two phase I trials of the histone deacetylase inhibitor vorinostat combined with either the vascular endothelial growth factor inhibitor pazopanib (NCT01339871) or the proteasome inhibitor ixazomib (NCT02042989) in patients with metastatic TP53 mutant solid tumors. Both trials followed a 3 + 3 dose-escala...

journal_title：Scientific reports

authors： Wang Y,Janku F,Piha-Paul S,Hess K,Broaddus R,Liu L,Shi N,Overman M,Kopetz S,Subbiah V,Naing A,Hong D,Tsimberidou AM,Karp D,Yao J,Fu S

更新日期：2020-02-20 00:00:00

abstract：:Based on a hybrid pumping method consisting of a 1150 nm continuous-wave pump source and a 1950 nm pulsed pump source, we demonstrate a power controllable gain-switched fiber laser in dual wavebands at ~ 3 μm and ~ 2.1 μm. Different pumping schemes for pumping a Ho3+-doped ZBLAN fiber are studied. Using only the 1950 ...

journal_title：Scientific reports

authors： Shi Y,Li J,Lai C,Peng H,Zhu C,Liu Y

更新日期：2021-01-13 00:00:00

abstract：:Holography--originally developed for correcting spherical aberration in transmission electron microscopes--is now used in a wide range of disciplines that involve the propagation of waves, including light optics, electron microscopy, acoustics and seismology. In electron microscopy, the two primary modes of holography...

journal_title：Scientific reports

authors： Ozsoy-Keskinbora C,Boothroyd CB,Dunin-Borkowski RE,van Aken PA,Koch CT

更新日期：2014-11-12 00:00:00

abstract：:Multiple sclerosis (MS) is a neurodegenerative autoimmune disease, where chronic inflammation plays an essential role in its pathology. A feature of MS is the production of autoantibodies stimulated by an altered-peptide-ligand response and epitope spreading, resulting in loss of tolerance for self-proteins. The invol...

journal_title：Scientific reports

authors： Mørkholt AS,Kastaniegaard K,Trabjerg MS,Gopalasingam G,Niganze W,Larsen A,Stensballe A,Nielsen S,Nieland JD

更新日期：2018-05-04 00:00:00

abstract：:Directed transport of biological species across the surface of a substrate is essential for realizing lab-on-chip technologies. Approaches that utilize localized magnetic fields to manipulate magnetic particles carrying biological entities are attractive owing to their sensitivity, selectivity, and minimally disruptiv...

journal_title：Scientific reports

authors： Rapoport E,Beach GSD

更新日期：2017-08-31 00:00:00

abstract：:Stress-induced viscous flow is the characteristic of atomic movements during plastic deformation of metallic glasses in the absence of substantial temperature increase, which suggests that stress state plays an important role in mechanically induced crystallization in a metallic glass. However, it is poorly understood...

journal_title：Scientific reports

authors： Yan Z,Song K,Hu Y,Dai F,Chu Z,Eckert J

更新日期：2016-01-13 00:00:00

abstract：:Lipases are interfacially activated enzymes that catalyze the hydrolysis of ester bonds and constitute prime candidates for industrial and biotechnological applications ranging from detergent industry, to chiral organic synthesis. As a result, there is an incentive to understand the mechanisms underlying lipase activi...

journal_title：Scientific reports

authors： Bohr SS,Lund PM,Kallenbach AS,Pinholt H,Thomsen J,Iversen L,Svendsen A,Christensen SM,Hatzakis NS

更新日期：2019-11-07 00:00:00

abstract：:The threshold size for enlarged abdominal lymph nodes (E-ALNs), a common pediatric disorder, has yet to be standardized. According to the maximum short-axis diameter, this study divided ALNs into Grade A (≥ 10 mm), Grade B (8-10 mm), Grade C (5-8 mm), and Grade D (< 5 mm, normal). To identify the threshold size for E-...

journal_title：Scientific reports

authors： He L,Sun Y,Huang G

更新日期：2021-01-19 00:00:00

abstract：:Animals thriving in hot deserts rely on extraordinary adaptations and thermoregulatory capacities to cope with heat. Uncovering such adaptations, and how they may be favoured by selection, is essential for predicting climate change impacts. Recently, the arid-adapted zebra finch was discovered to program their offspri...

journal_title：Scientific reports

authors： Pessato A,McKechnie AE,Buchanan KL,Mariette MM

更新日期：2020-11-03 00:00:00

abstract：:Solute segregating to grain boundary can stabilize the microstructure of nanocrystalline materials, but a lot of solutes also cause embrittlement effect on interfacial strength. Therefore, uncovering the solute effect on grain boundary strength is very important for nanocrystalline alloys design. In this work, we have...

journal_title：Scientific reports

authors： Huang Z,Wang P,Chen F,Shen Q,Zhang L

更新日期：2020-10-08 00:00:00

abstract：:One of the key motivations in producing 3D structures has always been the realization of metamaterials with effective constituent properties that can be tuned in all propagation directions at various frequencies. Here, we report the investigation of spatially oriented "Nanograter" structures with orientation-dependent...

journal_title：Scientific reports

authors： Liu Z,Cui A,Gong Z,Li H,Xia X,Shen TH,Li J,Yang H,Li W,Gu C

更新日期：2016-06-30 00:00:00

abstract：:Exposure to an adverse early-life environment leads to long-term health problems, many of which are recapitulated in subsequent generations. The female reproductive tract is particularly sensitive to early-life influences, and plays a pivotal role in programming the conceptus. We examine the influence of suboptimal gr...

journal_title：Scientific reports

authors： Aiken CE,Tarry-Adkins JL,Ozanne SE

更新日期：2015-11-03 00:00:00

abstract：:Primordial germ cells (PGCs), the embryonic precursors of the sperm and egg, are used for the introduction of genetic modifications into avian genome. Introduction of small defined sequences using genome editing has not been demonstrated in bird species. Here, we compared oligonucleotide-mediated HDR using wild type S...

journal_title：Scientific reports

authors： Idoko-Akoh A,Taylor L,Sang HM,McGrew MJ

更新日期：2018-10-11 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Scientific reports

authors： Ashokkumar M,Sonawane A,Sperk M,Tripathy SP,Neogi U,Hanna LE

更新日期：2020-08-10 00:00:00

abstract：:Room-temperature ferromagnetism in Mn-doped chalcopyrites is a desire aspect when applying those materials to spin electronics. However, dominance of high Curie-temperatures due to cluster formation or inhomogeneities limited their consideration. Here we report how an external perturbation such as applied hydrostatic ...

journal_title：Scientific reports

authors： Arslanov TR,Mollaev AY,Kamilov IK,Arslanov RK,Kilanski L,Minikaev R,Reszka A,López-Moreno S,Romero AH,Ramzan M,Panigrahi P,Ahuja R,Trukhan VM,Chatterji T,Marenkin SF,Shoukavaya TV

更新日期：2015-01-12 00:00:00

abstract：:In the fifty years since the postulation of Moore's Law, the increasing energy consumption in silicon electronics has motivated research into emerging devices. An attractive research direction is processing information via the phase of spin waves within magnonic-logic circuits, which function without charge transport ...

journal_title：Scientific reports

authors： Kanazawa N,Goto T,Sekiguchi K,Granovsky AB,Ross CA,Takagi H,Nakamura Y,Uchida H,Inoue M

更新日期：2017-08-11 00:00:00

abstract：:Chloroquine (CQ) and hydroxychloroquine, are promising anti-inflammatory drugs for the treatment of Diabetes mellitus (DM) to prevent associated complications. Therefore, this study evaluated the anti-inflammatory effects of CQ-free and CQ-incorporated polylactic acid nanoparticles (NPs) in the peripheral blood mononu...

journal_title：Scientific reports

authors： de Almeida Júnior RF,de Souza KSC,Galdino OA,da Silva Junior AA,Arrais RF,Machado PRL,Farias KJS,de Rezende AA

更新日期：2020-07-21 00:00:00

abstract：:Selective filtration of gas, water, and liquid or gaseous oil is essential to prevent possible environmental pollution and machine/facility malfunction in oil-based industries. Novel materials and structures able to selectively and efficiently filter liquid and vapor in various types of solutions are therefore in cont...

journal_title：Scientific reports

authors： Bong J,Lim T,Seo K,Kwon CA,Park JH,Kwak SK,Ju S

更新日期：2015-09-23 00:00:00

abstract：:Causal Structure Discovery (CSD) is the problem of identifying causal relationships from large quantities of data through computational methods. With the limited ability of traditional association-based computational methods to discover causal relationships, CSD methodologies are gaining popularity. The goal of the st...

journal_title：Scientific reports

authors： Shen X,Ma S,Vemuri P,Simon G,Alzheimer’s Disease Neuroimaging Initiative.

更新日期：2020-02-19 00:00:00

abstract：:Theoretical and experimental work has demonstrated that excitatory (E) and inhibitory (I) currents within cortical circuits stabilize to a balanced state. This E/I balance, observed from single neuron to network levels, has a fundamental role in proper brain function and its impairment has been linked to numerous brai...

journal_title：Scientific reports

authors： Shen K,Zeppillo T,Limon A

更新日期：2020-07-09 00:00:00

abstract：:Local mRNA translation occurs in growing axons enabling precise control of the proteome in response to signals. To measure quantitatively the spatiotemporal dynamics of protein synthesis in growth cones, we further developed a technique for single molecule translation imaging (SMTI). We report that Netrin-1 triggers a...

journal_title：Scientific reports

authors： Ströhl F,Lin JQ,Laine RF,Wong HH,Urbančič V,Cagnetta R,Holt CE,Kaminski CF

更新日期：2017-04-06 00:00:00

abstract：:The accident at the Fukushima Daiichi nuclear power plant caused serious radiocesium ((137)Cs) contamination of forest ecosystems located in mountainous and hilly regions with steep terrain. To understand topographic effects on the redistribution and accumulation of (137)Cs on forest floor, we investigated the distrib...

journal_title：Scientific reports

authors： Koarashi J,Atarashi-Andoh M,Takeuchi E,Nishimura S

更新日期：2014-10-31 00:00:00

abstract：:A bound state in the continuum (BIC) is an unusual localized state that is embedded in a continuum of extended states. Here, we present the general condition for BICs to arise from wave equation separability. Then we show that by exploiting perturbations of certain symmetry such BICs can be turned into resonances that...

journal_title：Scientific reports

authors： Rivera N,Hsu CW,Zhen B,Buljan H,Joannopoulos JD,Soljačić M

更新日期：2016-09-19 00:00:00

abstract：:Balancing the amounts of enzymes is one of the important factors to achieve optimum performance of a designed metabolic pathway. However, the random mutagenesis approach is impractical since it requires searching an unnecessarily large number of variants and often results in searching a narrow range of expression leve...

journal_title：Scientific reports

authors： Seo SW,Yang JS,Cho HS,Yang J,Kim SC,Park JM,Kim S,Jung GY

更新日期：2014-03-31 00:00:00

abstract：:The non-invasive high-resolution spatial mapping of cell metabolism within tissues could provide substantial advancements in assessing the efficacy of stem cell therapy and understanding tissue development. Here, using two-photon excited fluorescence microscopy, we elucidate the relationships among endogenous cell flu...

journal_title：Scientific reports

authors： Quinn KP,Sridharan GV,Hayden RS,Kaplan DL,Lee K,Georgakoudi I

更新日期：2013-12-05 00:00:00