Circadian Clock and Complement Immune System-Complementary Control of Physiology and Pathology?

abstract：:Escherichia coli O157:H7 and other pathogenic E. coli strains are enteric pathogens associated with food safety threats and which remain a significant cause of morbidity and mortality worldwide. In the current study, we investigated whether enterohemorrhagic E. coli (EHEC), Shiga toxin-producing E. coli (STEC), and en...

journal_title：Frontiers in cellular and infection microbiology

authors： Botkin DJ,Galli L,Sankarapani V,Soler M,Rivas M,Torres AG

更新日期：2012-02-14 00:00:00

abstract：:Iron is the most abundant transition metal in the human body and its bioavailability is stringently controlled. In particular, iron is tightly bound to host proteins such as transferrin to maintain homeostasis, to limit potential damage caused by iron toxicity under physiological conditions and to restrict access by p...

journal_title：Frontiers in cellular and infection microbiology

authors： Caza M,Kronstad JW

更新日期：2013-11-19 00:00:00

abstract：:Caprine parainfluenza virus type 3 (CPIV3) is a newly emerging pathogenic respiratory agent infecting both young and adult goats, and it was identified in eastern China in 2013. Cellular microRNAs (miRNAs) have been reported to be important modulators of the intricate virus-host interactions. In order to elucidate the...

journal_title：Frontiers in cellular and infection microbiology

authors： Li J,Mao L,Li W,Hao F,Zhong C,Zhu X,Ji X,Yang L,Zhang W,Liu M,Jiang J

更新日期：2018-03-29 00:00:00

abstract：:During chronic human immunodeficiency virus type 1 (HIV-1) infection, upregulation of inhibitory molecules contributes to effector cell dysfunction and exhaustion. This, in combination with the ability of HIV-1 to reside dormant in cellular reservoirs and escape immune recognition, makes the pathway to HIV-1 cure part...

journal_title：Frontiers in cellular and infection microbiology

authors： Holder KA,Grant MD

更新日期：2020-05-05 00:00:00

abstract：:Shiga toxin (Stx)-producing Escherichia coli (STEC) O157:H7 is an enteric pathogen that causes life-threatening disease in humans, with cattle being major natural reservoirs. A group of STEC O157:H7 with a dramatic combination of high virulence potentials and super-shedder bovine origin have been isolated. Here, an ST...

journal_title：Frontiers in cellular and infection microbiology

authors： Teng L,Lee S,Park D,Jeong KC

更新日期：2020-06-05 00:00:00

abstract：:In this study, a next-generation sequencing strategy on 16S ribosomal RNA (16S rRNA) gene was employed to analyze 70 oral samples from 32 patients with throat cancer, nine patients with vocal cord polyp, and 29 healthy individuals (normal controls). Using this strategy, we demonstrated, for the first time, that the sa...

journal_title：Frontiers in cellular and infection microbiology

authors： Wang L,Yin G,Guo Y,Zhao Y,Zhao M,Lai Y,Sui P,Shi T,Guo W,Huang Z

更新日期：2019-07-03 00:00:00

abstract：:Probiotics have been used to treat a variety of diseases for decades; however, what is the rationale for their application? Such a treatment was first proposed in the early nineteenth century based on observations of decreased bifidobacterial populations in children suffering from diarrhea, suggesting that oral intake...

journal_title：Frontiers in cellular and infection microbiology

authors： Wieërs G,Belkhir L,Enaud R,Leclercq S,Philippart de Foy JM,Dequenne I,de Timary P,Cani PD

更新日期：2020-01-15 00:00:00

abstract：:Cytolethal distending toxin (CDT) produced by Campylobacter jejuni contains three subunits: CdtA, CdtB, and CdtC. Among these three toxin subunits, CdtB is the toxic moiety of CDT with DNase I activity, resulting in DNA double-strand breaks (DSB) and, consequently, cell cycle arrest at the G2/M stage and apoptosis. Ra...

journal_title：Frontiers in cellular and infection microbiology

authors： Lin HJ,Liu HH,Lin CD,Kao MC,Chen YA,Chiang-Ni C,Jiang ZP,Huang MZ,Lin CJ,Lo UG,Lin LC,Lai CK,Lin H,Hsieh JT,Chiu CH,Lai CH

更新日期：2017-06-08 00:00:00

abstract：:Pathogenic fungi have developed many strategies to evade the host immune system. Multiple escape mechanisms appear to function together to inhibit attack by the various stages of both the adaptive and the innate immune response. Thus, after entering the host, such pathogens fight to overcome the immune system to allow...

journal_title：Frontiers in cellular and infection microbiology

authors： Marcos CM,de Oliveira HC,de Melo WC,da Silva JF,Assato PA,Scorzoni L,Rossi SA,de Paula E Silva AC,Mendes-Giannini MJ,Fusco-Almeida AM

更新日期：2016-11-15 00:00:00

abstract：:Human coronaviruses, which can cause a range of infectious diseases, have been studied for nearly 60 years. The field has gained renewed interest from researchers around the world due to the COVID-19 outbreak in late 2019. Despite a large amount of research, little is known about the knowledge structure and developing...

journal_title：Frontiers in cellular and infection microbiology

authors： Deng Z,Chen J,Wang T

更新日期：2020-09-23 00:00:00

abstract：:The Mycobacterium fortuitum complex comprises several closely related species, causing pulmonary and extra-pulmonary infections. However, there is very limited knowledge about the disease pathogenesis involved in M. fortuitum infections, particularly due to the lack of suitable animal models. Using the zebrafish model...

journal_title：Frontiers in cellular and infection microbiology

authors： Johansen MD,Kremer L

更新日期：2020-07-17 00:00:00

abstract：:Antifolate resistance is significant in Kenya and presumed to result from extensive use and cross-resistance between antifolate antimalarials and antibiotics, including cotrimoxazole/Bactrim used for HIV-1 chemotherapy. However, little is known about antifolate-resistant malaria in the context of newly diagnosed HIV-1...

journal_title：Frontiers in cellular and infection microbiology

authors： Torrevillas BK,Garrison SM,McKeeken AJ,Patel D,Van Leuven JT,Dizon NI,Rivas KI,Hathaway NJ,Bailey JA,Waitumbi JN,Kifude CM,Oyieko J,Stewart VA,Luckhart S

更新日期：2020-11-26 00:00:00

abstract：:Genital tract infections with Chlamydia trachomatis (C. trachomatis) are the most frequent sexually transmitted disease worldwide. Severe clinical sequelae such as pelvic inflammatory disease (PID), tubal occlusion, and tubal infertility are linked to inflammatory processes of chronically infected tissues. The oxygen ...

journal_title：Frontiers in cellular and infection microbiology

authors： Jerchel S,Kaufhold I,Schuchardt L,Shima K,Rupp J

更新日期：2014-04-16 00:00:00

abstract：:Nocardia is one of the causing agents of bovine mastitis and increasing prevalence of nocardial mastitis in shape of serious outbreaks has been reported from many countries. However, the mechanisms by which this pathogen damages the bovine mammary epithelial cells (bMECs) is not yet studied. Therefore, this study was ...

journal_title：Frontiers in cellular and infection microbiology

authors： Chen W,Liu Y,Zhang L,Gu X,Liu G,Shahid M,Gao J,Ali T,Han B

更新日期：2017-05-18 00:00:00

abstract：:Flavobacterium psychrophilum is the etiological agent of bacterial coldwater disease and the rainbow trout fry syndrome in salmonid aquaculture worldwide. However, there have been few studies into the capacity of F. psychrophilum to form biofilms and how these cellular accretions differ from planktonic cells or how th...

journal_title：Frontiers in cellular and infection microbiology

authors： Levipan HA,Avendaño-Herrera R

更新日期：2017-03-15 00:00:00

abstract：:The intracellular parasite Toxoplasma gondii can cause chronic infections in most warm-blooded animals, including humans. In the USA, strains belonging to four different Toxoplasma clonal lineages (types 1, 2, 3, and 12) are commonly isolated, whereas strains not belonging to these lineages are predominant in other co...

journal_title：Frontiers in cellular and infection microbiology

authors： Arranz-Solís D,Cordeiro C,Young LH,Dardé ML,Commodaro AG,Grigg ME,Saeij JPJ

更新日期：2019-11-29 00:00:00

abstract：:Sepsis is a severe syndrome that arises when the host response to an insult is exacerbated, leading to organ failure and frequently to death. How a chronic infection that causes a prolonged Th1 expansion affects the course of sepsis is unknown. In this study, we showed that mice chronically infected with Toxoplasma go...

journal_title：Frontiers in cellular and infection microbiology

authors： Souza MC,Fonseca DM,Kanashiro A,Benevides L,Medina TS,Dias MS,Andrade WA,Bonfá G,Silva MAB,Gozzi A,Borges MC,Gazzinelli RT,Alves-Filho JC,Cunha FQ,Silva JS

更新日期：2017-04-07 00:00:00

abstract：:Programmed cell death plays crucial roles in organismal development and host defense. Recent studies have highlighted mechanistic overlaps and extensive, multifaceted crosstalk between pyroptosis, apoptosis, and necroptosis, three programmed cell death pathways traditionally considered autonomous. The growing body of ...

journal_title：Frontiers in cellular and infection microbiology

authors： Christgen S,Zheng M,Kesavardhana S,Karki R,Malireddi RKS,Banoth B,Place DE,Briard B,Sharma BR,Tuladhar S,Samir P,Burton A,Kanneganti TD

更新日期：2020-05-29 00:00:00

abstract：:Occurrence of non-Candida albicans Candida (NCAC) species that are associated with elevated MIC values and therapeutic failures are increasing. As a result, timely and accurate means of identification to the species level is becoming an essential part of diagnostic practices in clinical settings. In this study, 301 cl...

journal_title：Frontiers in cellular and infection microbiology

authors： Arastehfar A,Daneshnia F,Kord M,Roudbary M,Zarrinfar H,Fang W,Hashemi SJ,Najafzadeh MJ,Khodavaisy S,Pan W,Liao W,Badali H,Rezaie S,Zomorodian K,Hagen F,Boekhout T

更新日期：2019-02-15 00:00:00

abstract：:An attenuated vaccinia virus-MVTTEAB-was constructed by deletion of non-essential gene segments related to the immunomodulatory and virulence functions of the vaccinia virus Tiantan strain (VVTT). The shuttle plasmids pTC-EGFP, pTE-EGFP, pTA35-EGFP, pTB-EGFP, and pTA66-EGFP were constructed and combined with the early...

journal_title：Frontiers in cellular and infection microbiology

authors： Li Y,Zhu Y,Chen S,Li W,Yin X,Li S,Xiao P,Han J,Li X,Sun L,Jin N

更新日期：2017-10-31 00:00:00

abstract：:Most strains of Staphylococcus aureus and Staphylococcus epidermidis possess a strong restriction barrier that hinders exchange of DNA. Recently, major advances have been made in identifying and characterizing the restriction-modification (RM) systems involved. In particular a novel type IV restriction enzyme that rec...

journal_title：Frontiers in cellular and infection microbiology

authors： Monk IR,Foster TJ

更新日期：2012-04-12 00:00:00

abstract：:Influenza is a major public health problem that causes acute respiratory infection in humans. Identification of host factors influencing in disease outcome is critical for recognition of individuals with increased risk. Investigations on the role of rs34481144A and rs12252C IFITM3 polymorphisms in influenza A(H1N1)pdm...

journal_title：Frontiers in cellular and infection microbiology

authors： Martins JSC,Oliveira MLA,Garcia CC,Siqueira MM,Matos AR

更新日期：2020-07-10 00:00:00

abstract：:Shigella spp. are highly adapted human pathogens that cause bacillary dysentery (shigellosis). Via the type III secretion system (T3SS), Shigella deliver a subset of virulence proteins (effectors) that are responsible for pathogenesis, with functions including pyroptosis, invasion of the epithelial cells, intracellula...

journal_title：Frontiers in cellular and infection microbiology

authors： Ashida H,Sasakawa C

更新日期：2016-01-06 00:00:00

abstract：:The cell surface mucin MUC1 is an important host factor limiting Helicobacter pylori (H. pylori) pathogenesis in both humans and mice by providing a protective barrier and modulating mucosal epithelial and leukocyte responses. The aim of this study was to establish the time-course of molecular events in MUC1-modulated...

journal_title：Frontiers in cellular and infection microbiology

authors： Sheng YH,Ng GZ,Summers KM,Every AL,Price G,Hasnain SZ,Sutton P,McGuckin MA

更新日期：2020-07-24 00:00:00

abstract：:In this original study, we retrospectively reviewed the cases of nocardiosis diagnosed through culture and next-generation sequencing (NGS) methods between 2014 and 2018 in Huashan Hospital and found out that the latter way can not only improve the detection rate of Nocardia spp. but also greatly reduce the turnaround...

journal_title：Frontiers in cellular and infection microbiology

authors： Weng SS,Zhang HY,Ai JW,Gao Y,Liu YY,Xu B,Zhang WH

更新日期：2020-02-18 00:00:00

abstract：:Syf1 is a tetratricopeptide repeat (TPR) protein implicated in transcription elongation, spliceosome conformation, mRNA nuclear-cytoplasmic export and transcription-coupled DNA repair. Recently, we identified the spliceosomal components of the human parasite Entamoeba histolytica, among them is EhSyf. Molecular predic...

journal_title：Frontiers in cellular and infection microbiology

authors： Torres-Cifuentes DM,Galindo-Rosales JM,Saucedo-Cárdenas O,Valdés J

更新日期：2018-07-09 00:00:00

abstract：:Thyroxine metabolism is an important topic of pathogenesis research and treatment schedule of subclinical hypothyroidism (SCH). L-Thyroxine replacement therapy (LRT) is usually recommended for severe SCH patients only. Our previous studies reported that disordered serum lipid of mild SCH people could also benefit from...

journal_title：Frontiers in cellular and infection microbiology

authors： Yao Z,Zhao M,Gong Y,Chen W,Wang Q,Fu Y,Guo T,Zhao J,Gao L,Bo T

更新日期：2020-09-18 00:00:00

abstract：:The SaeRS two-component system plays important roles in regulation of key virulence factors and pathogenicity. In this study, however, we found that the deletion mutation of saeRS enhanced bacterial survival in human blood, whereas complementation of the mutant with SaeRS returned survival to wild-type levels. Moreove...

journal_title：Frontiers in cellular and infection microbiology

authors： Guo H,Hall JW,Yang J,Ji Y

更新日期：2017-05-29 00:00:00

abstract：:Sepsis is a life-threatening health condition caused by infectious pathogens of the respiratory tract, and accounts for 28-50% of annual deaths in the US alone. Current treatment regimen advocates the use of corticosteroids as adjunct treatment with antibiotics, for their broad inhibitory effect on the activity and pr...

journal_title：Frontiers in cellular and infection microbiology

authors： Ngo Ndjom CG,Kantor LV,Jones HP

更新日期：2017-06-22 00:00:00

abstract：:Pathogenic species of Leptospira cause leptospirosis, a bacterial zoonotic disease with a global distribution affecting over one million people annually. Reservoir hosts of leptospirosis, including rodents, dogs, and cattle, exhibit little to no signs of disease but shed large numbers of organisms in their urine. Tran...

journal_title：Frontiers in cellular and infection microbiology

authors： Nally JE,Grassmann AA,Planchon S,Sergeant K,Renaut J,Seshu J,McBride AJ,Caimano MJ

更新日期：2017-08-09 00:00:00