Abstract：
AIMS:Albuminuria and reduced glomerular filtration rate (GFR) are manifestations of diabetic kidney disease and are both shown to be associated with cardiovascular outcomes. However, the differential association of albuminuria and reduced GFR with endothelial dysfunction, an early feature of atherosclerotic vascular damage, remains unclear. In this study, we investigated the association between albuminuria or estimated GFR (eGFR) and flow-mediated dilatation (FMD), a marker of endothelial function, in patients with type 2 diabetes. METHODS:This study included 633 patients with type 2 diabetes. The FMD of the brachial artery was measured by ultrasonography. Albuminuria was evaluated by urinary albumin-to-creatinine ratio (ACR). RESULTS:The mean FMD and eGFR, and the median value of ACR were 6.7%, 66.5 mL/min/1.73m2 and 12.5 mg/g creatinine, respectively. Impaired FMD was found in patients with advanced stages of chronic kidney disease based on both GFR and albuminuria categories. Multivariate analysis after adjusting for potential confounders revealed that ACR, but not eGFR, was significantly and inversely associated with FMD. CONCLUSIONS:Albuminuria is associated with FMD, independently of traditional cardiovascular risk factors in patients with type 2 diabetes. This study suggests a close relationship between albuminuria, rather than reduced GFR, and endothelial dysfunction in type 2 diabetes.
journal_name
J Diabetes Complicationsjournal_title
Journal of diabetes and its complicationsauthors
Kakutani Y,Morioka T,Mori K,Yamazaki Y,Ochi A,Kurajoh M,Fukumoto S,Shioi A,Shoji T,Inaba M,Emoto Mdoi
10.1016/j.jdiacomp.2020.107702subject
Has Abstractpub_date
2020-12-01 00:00:00pages
107702issue
12eissn
1056-8727issn
1873-460Xpii
S1056-8727(20)30470-0journal_volume
34pub_type
杂志文章abstract：:A few reports have suggested that angiotensin-converting enzyme inhibitors (ACE-I) have a beneficial effect on mild diabetic retinopathy (DR). This pilot study was carried out to determine if a small dose of an ACE-I would retard the progression of moderate to severe DR in normotensive Type 2 diabetic patients. Normot...
journal_title：Journal of diabetes and its complications
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1016/s1056-8727(02)00188-5
更新日期：2002-11-01 00:00:00
abstract：AIM:The present study evaluates autonomic and somatic nerve function in different stages of glucose tolerance and its correlation with different cardio-metabolic parameters. MATERIAL AND METHODS:Four hundred seventy-eight subjects, mean age 49.3±13.7years and mean BMI 31.0±6.2kg/m2, divided according to glucose tolera...
journal_title：Journal of diabetes and its complications
pub_type： 杂志文章
doi：10.1016/j.jdiacomp.2016.11.002
更新日期：2017-03-01 00:00:00
abstract：AIMS:Metformin treatment is associated with a decrease of serum vitamin B12, but whether this reflects tissue B12 deficiency is controversial. We studied the effects of metformin on serum levels of methylmalonic acid (MMA), a biomarker for tissue B12 deficiency, and on onset or progression of neuropathy. METHODS:In th...
journal_title：Journal of diabetes and its complications
pub_type： 杂志文章
doi：10.1016/j.jdiacomp.2017.11.001
更新日期：2018-02-01 00:00:00
abstract：AIMS:Young-onset T2D (YT2D) is associated with a more fulminant course and greater propensity for diabetic complications. The association of PAX4 R192H (rs2233580) variation with YT2D was inconsistent partly because of its Asian-specificity and under-representation of Asians in international consortiums. Interestingly,...
journal_title：Journal of diabetes and its complications
pub_type： 杂志文章
doi：10.1016/j.jdiacomp.2018.10.002
更新日期：2019-01-01 00:00:00
abstract：:The mechanism(s) resulting in the premature atherosclerosis of diabetes is unknown. Increased phagocyte release of reactive oxygen species such as superoxide anion (O2.-), resulting in low-density lipoprotein (LDL) oxidation, could be one possible cause. The purpose of the present study was to compare the abilities of...
journal_title：Journal of diabetes and its complications
pub_type： 杂志文章
doi：10.1016/1056-8727(95)00002-x
更新日期：1996-07-01 00:00:00
abstract：AIMS:The objective of this study was to evaluate diabetes-related healthcare resource use and associated costs in patients with type 2 diabetes (T2DM) treated with a sulfonylurea (SU), with and without hypoglycemia. METHODS:In this retrospective cohort study, patients 18years or older receiving SU monotherapy or as ad...
journal_title：Journal of diabetes and its complications
pub_type： 杂志文章
doi：10.1016/j.jdiacomp.2017.07.012
更新日期：2017-11-01 00:00:00
abstract：AIM:Changes in glycoconjugate metabolism during the development of diabetic complications and their modulation by feeding bitter gourd and spent turmeric as fiber-rich source. METHOD:This was studied by measuring the contents of total sugar, uronic acid, amino sugar, and sulfate in the streptozotocin-induced diabetic ...
journal_title：Journal of diabetes and its complications
pub_type： 杂志文章
doi：10.1016/j.jdiacomp.2007.09.005
更新日期：2009-01-01 00:00:00
abstract：BACKGROUND:Data on psychological distress (DIS), behavioral impact (BI) and health-related quality of life (HRQoL) are important yet lacking among Asian patients with Type 2 diabetes mellitus (T2DM). We aim to identify factors associated with DIS, BI and HRQoL among T2DM to better understand patient needs. METHODS:DIS...
journal_title：Journal of diabetes and its complications
pub_type： 杂志文章
doi：10.1016/j.jdiacomp.2015.01.009
更新日期：2015-04-01 00:00:00
abstract：BACKGROUND:To determine if serum pigment epithelium-derived factor (PEDF) levels predict cardiovascular events, renal dysfunction and mortality in the Veterans Affairs Diabetes Study (VADT). METHODS:PEDF was evaluated in relation to subsequent cardiovascular outcomes, mortality, and renal dysfunction (defined as urina...
journal_title：Journal of diabetes and its complications
pub_type： 杂志文章
doi：10.1016/j.jdiacomp.2019.107410
更新日期：2019-10-01 00:00:00
abstract：AIMS:Using psychological and quality of life assessment tools, we prospectively studied changes in health-related quality of life and emotional well-being in patients who had commenced GLP-1 analogue therapy (exenatide) and compared them with new insulin starters. METHODS:Two matched groups of patients with type 2 dia...
journal_title：Journal of diabetes and its complications
pub_type： 杂志文章
doi：10.1016/j.jdiacomp.2011.03.002
更新日期：2011-07-01 00:00:00
abstract：:The long-term effects of angiotensin-converting enzyme inhibitors (captopril and enalapril), calcium-entry blockers (diltiazem and nicardipine), and good glycemic control on plasma lipids and lipoproteins were studied in streptozotocin diabetic rats. Diabetic rats had increased plasma cholesterol, tryiglycerides, very...
journal_title：Journal of diabetes and its complications
pub_type： 杂志文章
doi：10.1016/1056-8727(94)00045-p
更新日期：1995-07-01 00:00:00
abstract：:This work presents a systematic review of long-term risk assessment models for evaluating the probability of developing complications in diabetes patients. Diabetes mellitus can cause many complications if not adequately controlled; risk assessment models can help physicians and patients in identifying the complicatio...
journal_title：Journal of diabetes and its complications
pub_type： 杂志文章,评审
doi：10.1016/j.jdiacomp.2012.11.003
更新日期：2013-07-01 00:00:00
abstract：AIMS:The aim of this study is to explore whether administration timing affects glycaemic control by lixisenatide once-daily in type 2 diabetes mellitus (T2DM). METHODS:A phase IIIb, open-label, 1:1 randomized, active-controlled, 24-week multicentre study of T2DM patients inadequately controlled on metformin was conduc...
journal_title：Journal of diabetes and its complications
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1016/j.jdiacomp.2014.05.012
更新日期：2014-09-01 00:00:00
abstract：BACKGROUND:A quantifiable assessment of socioeconomic status and its bearing on clinical outcome in patients with diabetes is lacking. The social adaptability index (SAI) has previously been validated in the general population and in patients with chronic kidney disease, including those on dialysis and with kidney tran...
journal_title：Journal of diabetes and its complications
pub_type： 杂志文章
doi：10.1016/j.jdiacomp.2011.12.002
更新日期：2012-01-01 00:00:00
abstract：AIMS:To estimate short-term mortality rates for individuals with type 1 or type 2 diabetes diagnosed before age 20 years from the SEARCH for Diabetes in Youth study. METHODS:We included 8358 individuals newly-diagnosed with type 1 (n = 6840) or type 2 (n = 1518) diabetes from 1/1/2002-12/31/2008. We searched the Natio...
journal_title：Journal of diabetes and its complications
pub_type： 杂志文章,多中心研究
doi：10.1016/j.jdiacomp.2018.03.015
更新日期：2018-06-01 00:00:00
abstract：:Recommended low-density lipoprotein cholesterol (LDL-C) levels for patients with documented cardiovascular disease (CVD) are <100mg/dL (2.6mmol/l) with further reduction to <70mg/dL (1.8mmol/l) for higher-risk patients. High-intensity statin treatment may halt the progression as well as stabilize and induce regression...
journal_title：Journal of diabetes and its complications
pub_type： 杂志文章,评审
doi：10.1016/j.jdiacomp.2014.10.004
更新日期：2015-01-01 00:00:00
abstract：OBJECTIVES:Obesity is known to be an important risk factor for type 2 diabetes and its related comorbid conditions; however, its specific impact on generic health-related quality of life (HRQL) is less clear. The objective of this study was to estimate the association between body mass index (BMI) and HRQL in individua...
journal_title：Journal of diabetes and its complications
pub_type： 杂志文章
doi：10.1016/j.jdiacomp.2012.05.008
更新日期：2012-09-01 00:00:00
abstract：:Diabetes mellitus (DM) is a metabolic disorder of glucose homeostasis caused by insufficient secretion or inadequate action of insulin. Nowadays, the increased morbidity of DM is a worldwide issue. Pancreatic beta cell death plays a key role in the progress of DM, especially Type 1 diabetes (T1D). Traditional biomarke...
journal_title：Journal of diabetes and its complications
pub_type： 杂志文章,评审
doi：10.1016/j.jdiacomp.2017.08.012
更新日期：2018-03-01 00:00:00
abstract：AIM:Posttransplantation diabetes mellitus (PTDM) is a common complication after renal transplantation leading to increased cardiovascular morbidity and mortality. In subjects with type 2 diabetes (T2DM) increased glycemic variability and poor glycemic control have been associated with cardiovascular complications. We t...
journal_title：Journal of diabetes and its complications
pub_type： 杂志文章
doi：10.1016/j.jdiacomp.2015.07.014
更新日期：2015-11-01 00:00:00
abstract：BACKGROUND:Digital toe amputation is a relatively minor surgical procedure but there is a historical view that it is the "first stage in a predictable clinical course" leading to eventual limb loss. There is a paucity of contemporaneous data on the long-term outcomes of patients undergoing toe amputation. We aim to stu...
journal_title：Journal of diabetes and its complications
pub_type： 杂志文章
doi：10.1016/j.jdiacomp.2012.03.003
更新日期：2012-05-01 00:00:00
abstract：:Vasomotion, the spontaneous rhythmic contraction exhibited by small arteries and arterioles is dysregulated in patients with diabetic neuropathy. We examined the relationship between Charcot arthropathy and vasomotion at the dorsum of the foot. We studied nine diabetic patients with clinically diagnosed neuropathy and...
journal_title：Journal of diabetes and its complications
pub_type： 杂志文章
doi：10.1016/s1056-8727(97)00080-9
更新日期：1998-05-01 00:00:00
abstract：:We have previously reported that high glucose stimulates osteopontin (OPN) expression through protein kinase C-dependent pathway, as well as the hexosamine pathway, in cultured rat aortic smooth muscle cells (SMC). The finding prompted us to study in vivo expression of OPN in diabetes mellitus. In the present study, w...
journal_title：Journal of diabetes and its complications
pub_type： 杂志文章
doi：10.1016/s1056-8727(01)00189-1
更新日期：2002-01-01 00:00:00
abstract：:The primary aims of this study have been to explore the diagnostic and prognostic significance of Tissue Doppler parameters (TDI), global longitudinal strain (GLS), and blood pressure (BP) pattern in normotensive diabetic patients. METHODS:The study consisted of 121 diabetic patients and 41 healthy subjects. Conventi...
journal_title：Journal of diabetes and its complications
pub_type： 杂志文章
doi：10.1016/j.jdiacomp.2017.07.022
更新日期：2018-01-01 00:00:00
abstract：:Distal symmetric peripheral polyneuropathy (DSPN) is a highly prevalent complication of diabetes. However, underlying pathophysiological mechanisms are multiple and not well understood. The aim of our study was to analyze the oxidative stress levels in circulating mononuclear cells by measuring the glutathione system,...
journal_title：Journal of diabetes and its complications
pub_type： 杂志文章
doi：10.1016/j.jdiacomp.2015.05.023
更新日期：2015-09-01 00:00:00
abstract：AIM:We conducted a systematic review of the use of continuous glucose monitoring (CGM) in older patients, in order to consolidate the growing evidence base in this area. METHODS:Our protocol was registered on PROSPERO (CRD42017068523). We searched SCI Web of Science, Ovid SP MEDLINE and EMBASE from January 2010 to Jun...
journal_title：Journal of diabetes and its complications
pub_type： 杂志文章
doi：10.1016/j.jdiacomp.2018.05.005
更新日期：2018-08-01 00:00:00
abstract：AIM:To examine the trajectory of small artery elasticity (SAE) and pulse pressure (PP) in people with Type 1 diabetes and non-diabetic controls across the lifespan, and explore associations with microvascular complications (CX+). METHODS:This cross-sectional study included 477 Type 1 diabetes patients (188 with CX+, 2...
journal_title：Journal of diabetes and its complications
pub_type： 杂志文章,多中心研究
doi：10.1016/j.jdiacomp.2017.08.007
更新日期：2017-12-01 00:00:00
abstract：AIMS:Young adults with type 2 diabetes (T2D, 18-39years) face increased risk of vision loss from diabetic retinopathy (DR). Retinal screening is essential to detect DR, yet screening rates for this group are low and little is known about the underlying factors influencing this important behavior. Using the theoretical ...
journal_title：Journal of diabetes and its complications
pub_type： 杂志文章
doi：10.1016/j.jdiacomp.2017.02.020
更新日期：2017-06-01 00:00:00
abstract：AIMS:The GLP-1 receptor agonist liraglutide improves impaired pancreatic β-cell function, thereby exerting glucose-lowering effects. However, the association of remaining β-cell function with long-term therapeutic efficacy of liraglutide remains largely unknown. METHODS:Patients with type 2 diabetes who started liragl...
journal_title：Journal of diabetes and its complications
pub_type： 杂志文章
doi：10.1016/j.jdiacomp.2015.07.020
更新日期：2015-11-01 00:00:00
abstract：AIMS:The pathogenesis of diabetic kidney disease (DKD) is complex and multifactorial; increasing evidence suggests that tubular injury and inflammatory process are involved in disease progression. We investigated the potential association of renal expression of tubular injury markers, neutrophil gelatinase-associated l...
journal_title：Journal of diabetes and its complications
pub_type： 杂志文章
doi：10.1016/j.jdiacomp.2017.08.009
更新日期：2017-12-01 00:00:00
abstract：:Early diabetic kidney disease (DKD) occurs in adolescents with type 1 diabetes (T1D). Lower serum uromodulin (SUMOD) predicts DKD progression in adults with T1D. In this study, we demonstrate that lower SUMOD is associated with urinary albumin excretion in adolescents with T1D, suggesting a potential relationship betw...
journal_title：Journal of diabetes and its complications
pub_type： 杂志文章
doi：10.1016/j.jdiacomp.2019.05.023
更新日期：2019-09-01 00:00:00
