Estimation of the relationship between body mass index and EQ-5D health utilities in individuals with type 2 diabetes: evidence from the population-based KORA studies.

Abstract:

OBJECTIVES:Obesity is known to be an important risk factor for type 2 diabetes and its related comorbid conditions; however, its specific impact on generic health-related quality of life (HRQL) is less clear. The objective of this study was to estimate the association between body mass index (BMI) and HRQL in individuals with type 2 diabetes. METHODS:The EQ-5D quality of life questionnaire was administered in a follow-up of 10,385 participants aged 33-94 of the population-based German MONICA/KORA surveys. 1033 participants with type 2 diabetes were identified by self-report combined with validated physician diagnoses. Semiparametric additive regression models were used to estimate the effect of BMI on EQ-5D health utilities adjusted for age, sex, education and comorbidities. RESULTS:BMI was significantly associated with EQ-5D health utilities even after adjustment for macro- and microvascular complications. The functional relationship between BMI and utilities was nonlinear, reflecting optimal health around 26 kg/m² and significantly decreasing health utilities with increasing levels of overweight and obesity (-0.09 points between BMI values 26 and 40). Among the diabetic complications, the history of a stroke (-0.13) and neuropathy (-0.10) were the strongest predictors of reduced health utility scores. CONCLUSIONS:BMI is strongly associated with health utilities in persons with type 2 diabetes. This suggests that lifestyle measures to reduce obesity can markedly improve patients' health-related quality of life and that the negative effect of potential weight gain should be taken into account when determining patient preferences for different type 2 diabetes treatment options.

authors

Hunger M,Schunk M,Meisinger C,Peters A,Holle R

doi

10.1016/j.jdiacomp.2012.05.008

subject

Has Abstract

pub_date

2012-09-01 00:00:00

pages

413-8

issue

5

eissn

1056-8727

issn

1873-460X

pii

S1056-8727(12)00162-6

journal_volume

26

pub_type

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