Abstract：
AIM:To assess diseases outcomes and tolerability of real-life second-line nivolumab in a series of metastatic renal cell carcinoma (mRCC) patients. METHODS:This retrospective chart review involved prospectively monitored patients (named patient program) treated with second-line nivolumab for mRCC at the University Hospital Centre Zagreb from February 2016 to March 2018. RESULTS:The study enrolled 30 patients, 5 of whom (16.7%) had a complete response. The mean ± standard deviation therapeutic response time to nivolumab treatment was 14.07 ± 8.92 months, with a minimum treatment duration of 2 months and a maximum of 24 months. The median duration of therapy was 17 months (mean: 15.8 months; range: 3-24 months), and 50% (n=15/30) of patients remained alive at the end of follow up. The most common adverse events associated with nivolumab were fatigue (26.67%; n=8/30), anemia (10.0%; n=3/30), adrenal insufficiency (6.67%; n=2/30: G1=1, G2=1), grade 2 pneumonitis (6.67%; n=2/30), grade 2 neuropathy (6.67%; n=2/30), rash (6.67%; n = 2/30: G1=1, G2=1), and hepatitis (3.33%; n=1/30). CONCLUSION:The present study indicates acceptable patient responses and tolerability of nivolumab in mRCC.
journal_name
Croat Med Jjournal_title
Croatian medical journalauthors
Gamulin M,Nham E,Rkman D,Antunac Golubić Z,Likić Rsubject
Has Abstractpub_date
2020-08-31 00:00:00pages
326-332issue
4eissn
0353-9504issn
1332-8166journal_volume
61pub_type
杂志文章abstract：AIM:Several amplification and detection formats for the analysis of short tandem repeat loci are readily available to the forensic laboratory. Careful consideration must be given to the throughput, sensitivity, concordance, data interpretation, facility requirements, and costs of operation. The Pennsylvania State Polic...
journal_title：Croatian medical journal
pub_type： 杂志文章
doi：
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abstract：AIM:To determine the incidence of possible transfusion-related acute lung injury (TRALI) and related risk factors in cardiac surgery patients. METHODS:A single-center prospective cohort study was conducted from January 2009 to March 2010 at the Zagreb University Hospital Center, Croatia. Patient-, transfusion-, and su...
journal_title：Croatian medical journal
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abstract：AIM:To asses prevalence of essential arterial hypertension in family members of soldiers killed in 1992-1995 war in Bosnia and Herzegovina. METHODS:The study enrolled 1144 subjects who lost a family member in the war and 582 of their close neighbors who experienced no such loss. Data on their medical history and habit...
journal_title：Croatian medical journal
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doi：
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abstract：AIM:To investigate whether socioeconomic inequalities at a micro-scale, through their effect on major health risk factors and other health indicators, contribute to health status in an isolated island population with demonstrated reduced genetic and environmental variability. METHODS:This cross-sectional study was per...
journal_title：Croatian medical journal
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abstract：AIM:To examine relationships among combat exposure, posttraumatic stress disorder (PTSD) symptoms, depression, suicidality, nicotine dependence, and religiosity in Croatian veterans. METHODS:This cross-sectional study used Combat Exposure Scale (CES) to quantify the stressor severity, PTSD Checklist 5 (PCL) to quantif...
journal_title：Croatian medical journal
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journal_title：Croatian medical journal
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doi：
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journal_title：Croatian medical journal
pub_type： 杂志文章,评审
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doi：
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pub_type： 杂志文章
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journal_title：Croatian medical journal
pub_type： 杂志文章
doi：
更新日期：2002-08-01 00:00:00
abstract：:Hereditary factor XI (FXI) deficiency is a mild bleeding disorder, rare in the general population but relatively common among Ashkenazi Jews. The human F11 gene comprises 15 exons, spanning over 23 kb of the long arm of chromosome 4 (4q35). Homozygotes or compound heterozygotes typically show severe FXI deficiency, wh...
journal_title：Croatian medical journal
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doi：
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journal_title：Croatian medical journal
pub_type： 杂志文章
doi：
更新日期：2006-04-01 00:00:00
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journal_title：Croatian medical journal
pub_type： 杂志文章
doi：10.3325/cmj.2015.56.542
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journal_title：Croatian medical journal
pub_type： 杂志文章
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journal_title：Croatian medical journal
pub_type： 社论
doi：
更新日期：2002-06-01 00:00:00
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journal_title：Croatian medical journal
pub_type： 杂志文章
doi：10.3325/cmj.2014.55.3
更新日期：2014-02-01 00:00:00
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journal_title：Croatian medical journal
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journal_title：Croatian medical journal
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doi：
更新日期：2005-12-01 00:00:00
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journal_title：Croatian medical journal
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doi：
更新日期：2019-04-30 00:00:00
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journal_title：Croatian medical journal
pub_type： 杂志文章
doi：
更新日期：1998-06-01 00:00:00
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doi：
更新日期：2006-04-01 00:00:00
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doi：
更新日期：2004-10-01 00:00:00
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journal_title：Croatian medical journal
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doi：
更新日期：2004-08-01 00:00:00
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doi：
更新日期：2007-04-01 00:00:00
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pub_type： 杂志文章
doi：
更新日期：2001-10-01 00:00:00
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journal_title：Croatian medical journal
pub_type： 杂志文章
doi：
更新日期：2004-06-01 00:00:00
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journal_title：Croatian medical journal
pub_type： 杂志文章,多中心研究
doi：
更新日期：2005-10-01 00:00:00
