Abstract：
:The world is currently facing the COVID-19 pandemic caused by the SARS-CoV-2 virus. The pandemic is causing the death of people around the world, and public and social health measures to slow or prevent the spread of COVID-19 are being implemented with the involvement of all members of society. Research institutions are accelerating the discovery of vaccines and therapies for COVID-19. In this work, molecular docking was used to study (in silico) the interaction of 24 ligands, divided into four groups, with four SARS-CoV-2 receptors, Nsp9 replicase, main protease (Mpro), NSP15 endoribonuclease, and spike protein (S-protein) interacting with human ACE2. The results showed that the antimalarial drug Metaquine and anti-HIV antiretroviral Saquinavir interacted with all the studied receptors, indicating that they are potential candidates for multitarget drugs for COVID-19.
journal_name
J Proteome Resjournal_title
Journal of proteome researchauthors
Barros RO,Junior FLCC,Pereira WS,Oliveira NMN,Ramos RMdoi
10.1021/acs.jproteome.0c00327subject
Has Abstractpub_date
2020-11-06 00:00:00pages
4567-4575issue
11eissn
1535-3893issn
1535-3907journal_volume
19pub_type
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