Phosphoproteomic analysis of human mesenchymal stromal cells during osteogenic differentiation.

abstract：:Bacterial small RNAs (sRNAs) and two-component systems (TCSs) were two vital regulatory mechanisms employed by microorganisms to respond to environmental changes and stresses. As a promising "autotrophic cell factory", photosynthetic cyanobacteria have attracted a lot of attention these years. Although most studies fo...

journal_title：Journal of proteome research

authors： Sun T,Chen L,Zhang W

更新日期：2017-08-04 00:00:00

abstract：:Oligomeric amyloid-β is currently of interest in amyloid-β mediated toxicity and the pathogenesis of Alzheimer's disease. Mapping the amyloid-β interaction partners could help to discover novel pathways in disease pathogenesis. To discover the amyloid-β interaction partners, we applied a protein array with more than 8...

journal_title：Journal of proteome research

authors： Virok DP,Simon D,Bozsó Z,Rajkó R,Datki Z,Bálint É,Szegedi V,Janáky T,Penke B,Fülöp L

更新日期：2011-04-01 00:00:00

abstract：:Membrane proteins play a critical role in the process of neural stem cell self-renewal and differentiation. Here, we apply the SILAC (stable isotope labeling by amino acids in cell culture) approach to quantitatively compare the membrane proteome of the self-renewing and the astroglial differentiating cells. High-reso...

journal_title：Journal of proteome research

authors： Cao R,Chen K,Song Q,Zang Y,Li J,Wang X,Chen P,Liang S

更新日期：2012-02-03 00:00:00

abstract：:High plant lignan intake is associated with a number of health benefits, possibly induced by the lignan metabolite enterolactone (ENL). The gut microbiota plays a crucial role in converting dietary lignans into ENL, and epidemiological studies have shown that use of antibiotics is associated with lower levels of ENL. ...

journal_title：Journal of proteome research

authors： Bolvig AK,Nørskov NP,Hedemann MS,Foldager L,McCarthy-Sinclair B,Marco ML,Lærke HN,Bach Knudsen KE

更新日期：2017-06-02 00:00:00

abstract：:Lipolysis involves a number of components including signaling pathways, droplet-associated proteins, and lipases such as hormone-sensitive lipase (HSL). We used surface enhanced laser desorption/ionization time-of-flight mass spectroscopy to identify cellular proteins that might interact with HSL and potentially influ...

journal_title：Journal of proteome research

authors： Shen WJ,Patel S,Eriksson JE,Kraemer FB

更新日期：2010-04-05 00:00:00

abstract：:Ribosomal proteins of the model gram-positive bacterium B. subtilis 168 were extensively characterized in a proteomic study. Mass spectra of the 52 proteins expected to be constitutive components of the 70S ribosome were recorded. Peptide MS/MS analysis with an average sequence coverage of 85% supported the identifica...

journal_title：Journal of proteome research

authors： Lauber MA,Running WE,Reilly JP

更新日期：2009-09-01 00:00:00

abstract：:Salt stress is a major abiotic factor limiting maize yield. To characterize the mechanism underlying maize salt tolerance, we compared the seedling root proteomes of salt-tolerant Jing724 and salt-sensitive D9H. The germination rate and growth parameter values (weight and length) were higher for Jing724 than for D9H u...

journal_title：Journal of proteome research

authors： Luo M,Zhao Y,Wang Y,Shi Z,Zhang P,Zhang Y,Song W,Zhao J

更新日期：2018-01-05 00:00:00

abstract：:Using an integrated transcriptomic and proteomic approach, we characterized the venom peptidome of the European red ant, Manica rubida. We identified 13 "myrmicitoxins" that share sequence similarities with previously identified ant venom peptides, one of them being identified as an EGF-like toxin likely resulting fro...

journal_title：Journal of proteome research

authors： Touchard A,Aili SR,Téné N,Barassé V,Klopp C,Dejean A,Kini RM,Mrinalini,Coquet L,Jouenne T,Lefranc B,Leprince J,Escoubas P,Nicholson GM,Treilhou M,Bonnafé E

更新日期：2020-04-03 00:00:00

abstract：:Peptide amidination labeling using S-methyl thioacetimidate (SMTA) is investigated in an attempt to increase the number and types of peptides that can be detected in a bottom-up proteomics experiment. This derivatization method affects the basicity of lysine residues and is shown here to significantly impact the idios...

journal_title：Journal of proteome research

authors： Li S,Dabir A,Misal SA,Tang H,Radivojac P,Reilly JP

更新日期：2016-10-07 00:00:00

abstract：:Interleukin-10 is an immunosuppressive cytokine involved in the regulation of gastrointestinal mucosal immunity toward intestinal microbiota. Interleukin-10-deficient (IL10(-/-)) mice develop Crohn's disease-like colitis unless raised in germ-free conditions. Previous gas chromatography-mass spectrometry (GC-MS) metab...

journal_title：Journal of proteome research

authors： Lin HM,Barnett MP,Roy NC,Joyce NI,Zhu S,Armstrong K,Helsby NA,Ferguson LR,Rowan DD

更新日期：2010-04-05 00:00:00

abstract：:The solventogenic bacterium Clostridium acetobutylicum is an important species of the Clostridium community. To develop a fundamental tool that is useful for biological studies of C. acetobutylicum, we established a high resolution proteome reference map for this species. We identified 1206 spots representing 564 diff...

journal_title：Journal of proteome research

authors： Mao S,Luo Y,Zhang T,Li J,Bao G,Zhu Y,Chen Z,Zhang Y,Li Y,Ma Y

更新日期：2010-06-04 00:00:00

abstract：:The gut microbiota plays a critical role in the pathogenesis of nonalcoholic fatty liver disease (NAFLD). Increased fructose consumption and inadequate copper intake are two critical risk factors in the development of NAFLD. To gain insight into the role of gut microbiota, fecal metabolites, obtained from rats exposed...

journal_title：Journal of proteome research

authors： Wei X,Song M,Yin X,Schuschke DA,Koo I,McClain CJ,Zhang X

更新日期：2015-09-04 00:00:00

abstract：:Almond, as a part of the nut family, is an important source of biological compounds, and specifically, almond skins have been considered an important source of polyphenols, including flavan-3-ols and flavonols. Polyphenol metabolism may produce several classes of metabolites that could often be more biologically activ...

journal_title：Journal of proteome research

authors： Llorach R,Garrido I,Monagas M,Urpi-Sarda M,Tulipani S,Bartolome B,Andres-Lacueva C

更新日期：2010-11-05 00:00:00

abstract：:The chromatophore membrane of the photosynthetic diazotroph Rhodospirillum rubrum is of vital importance for a number of central processes, including nitrogen fixation. Using a novel amphiphile, we have identified protein complexes present under different nitrogen availability conditions by the use of two-dimensional ...

journal_title：Journal of proteome research

authors： Selao TT,Branca R,Chae PS,Lehtiö J,Gellman SH,Rasmussen SG,Nordlund S,Norén A

更新日期：2011-06-03 00:00:00

abstract：:Tandem mass spectrometry (MS/MS) combined with bioinformatics tools have enabled fast and systematic protein identification based on peptide-to-spectrum matches. However, it remains challenging to obtain accurate identification of endogenous peptides, such as neuropeptides, peptide hormones, peptide pheromones, venom ...

journal_title：Journal of proteome research

authors： Hayakawa E,Menschaert G,De Bock PJ,Luyten W,Gevaert K,Baggerman G,Schoofs L

更新日期：2013-12-06 00:00:00

abstract：:Hepatocellular carcinoma (HCC) remains as the fifth most common cancer in the world and accounts for more than 700,000 deaths annually. Changes in serum glycosylation have long been associated with this cancer but the source of that material is unknown and direct glycan analysis of HCC tissues has been limited. Our la...

journal_title：Journal of proteome research

authors： West CA,Wang M,Herrera H,Liang H,Black A,Angel PM,Drake RR,Mehta AS

更新日期：2018-10-05 00:00:00

abstract：:The development of computational strategies for the quantitative characterization of the functional mechanisms of SARS-CoV-2 spike proteins is of paramount importance in efforts to accelerate the discovery of novel therapeutic agents and vaccines combating the COVID-19 pandemic. Structural and biophysical studies have...

journal_title：Journal of proteome research

authors： Verkhivker GM

更新日期：2020-11-06 00:00:00

abstract：:The gene transfer agent of Rhodobacter capsulatus (GTA) is a unique phage-like particle that exchanges genetic information between members of this same species of bacterium. Besides being an excellent tool for genetic mapping, the GTA has a number of advantages for biotechnological and nanoengineering purposes. To fac...

journal_title：Journal of proteome research

authors： Chen F,Spano A,Goodman BE,Blasier KR,Sabat A,Jeffery E,Norris A,Shabanowitz J,Hunt DF,Lebedev N

更新日期：2009-02-01 00:00:00

abstract：:To comprehensively study autoantibodies in patients with hepatocellular carcinoma (HCC), we used an approach-based serology and proteomics technologies. Total proteins extracted from HepG2 cells and HepG2.2.15 cells were separated by two-dimensional gel electrophoresis (2DE) and then transferred onto polyvinylidene di...

journal_title：Journal of proteome research

authors： Li L,Chen SH,Yu CH,Li YM,Wang SQ

更新日期：2008-02-01 00:00:00

abstract：:Metabolic phenotyping of tissues uses metabolomics and lipidomics to measure the relative polar and nonpolar (lipid) metabolite levels in biological samples. This approach aims to understand disease biochemistry and identify biochemical markers of disease. Sample preparation methods must be reproducible, sensitive (hi...

journal_title：Journal of proteome research

authors： Southam AD,Pursell H,Frigerio G,Jankevics A,Weber RJM,Dunn WB

更新日期：2021-01-01 00:00:00

abstract：:Protein tyrosine nitration by oxidative and nitrate stress is important in the pathogenesis of many inflammatory or aging-related diseases. Mass spectrometry analysis of protein nitrotyrosine is very challenging because the non-nitrated peptides suppress the signals of the low-abundance nitrotyrosine (NT) peptides. No...

journal_title：Journal of proteome research

authors： Zhao Y,Zhang Y,Sun H,Maroto R,Brasier AR

更新日期：2017-08-04 00:00:00

abstract：:Label-free quantification of shotgun proteomics data is a frequently used strategy, offering high dynamic range, sensitivity, and the ability to compare a high number of samples without additional labeling effort. Here, we present a bioinformatics approach that significantly improves label-free quantification results....

journal_title：Journal of proteome research

authors： Doblmann J,Dusberger F,Imre R,Hudecz O,Stanek F,Mechtler K,Dürnberger G

更新日期：2019-01-04 00:00:00

abstract：:New technologies have advanced the field of proteomics, and a number of companies have developed innovative platforms to drive this research. However, significant challenges are often encountered when trying to integrate complementary technologies from multiple manufacturers. We have developed a software and hardware ...

journal_title：Journal of proteome research

authors： Mahnke RC,Corzett TH,McCutchen-Maloney SL,Chromy BA

更新日期：2006-09-01 00:00:00

abstract：:Campylobacter jejuni is the most common cause of bacterial gastroenteritis in the developed world. Immunoproteomics highlighted a 42-45 kDa antigen that comigrated on two-dimensional (2-DE) gels with the C. jejuni major outer membrane protein (MOMP). Predictive analysis revealed two candidates for the identity of the ...

journal_title：Journal of proteome research

authors： Scott NE,Bogema DR,Connolly AM,Falconer L,Djordjevic SP,Cordwell SJ

更新日期：2009-10-01 00:00:00

abstract：:Biomarkers for colorectal cancer (CRC) early diagnosis are currently lacking. The purpose of this study was to interpret molecular events in the early stage of CRC that may bring about new biomarkers for early diagnosis. Methylation isotope labeling assistant gel-enhanced liquid chromatography-mass spectrometry (GeLC-...

journal_title：Journal of proteome research

authors： Xie LQ,Zhao C,Cai SJ,Xu Y,Huang LY,Bian JS,Shen CP,Lu HJ,Yang PY

更新日期：2010-09-03 00:00:00

abstract：:Numerous reports have predicted/hypothesized a role for probenazole-induced protein (PBZ1) as a molecular marker in rice self-defense mechanism. However, the precise function of PBZ1 remains unknown. In the present study, we examined PBZ1 as a putative cell death marker in rice. For this, we focused our attention on a...

journal_title：Journal of proteome research

authors： Kim ST,Kim SG,Kang YH,Wang Y,Kim JY,Yi N,Kim JK,Rakwal R,Koh HJ,Kang KY

更新日期：2008-04-01 00:00:00

abstract：:Antibiotic-induced microbial perturbations alter host metabolism and affect host physiology. In this study, we aimed to investigate the effects of vancomycin (Vanc) and ciprofloxacin/metronidazole (CiMe) exposures on the gut microbiome and metabolome in the colonic content and tissue samples from advanced-stage type 1...

journal_title：Journal of proteome research

authors： Zheng H,Fan K,Ji H,Jiang Q,Ning J,Xu P,Li C,Gao H

更新日期：2019-11-01 00:00:00

abstract：:Blood is an ideal window for viewing our health and disease status. Because blood circulates throughout the entire body and carries secreted, shed, and excreted signature proteins from every organ and tissue type, it is thus possible to use the blood proteome to achieve a comprehensive assessment of multiple-organ phy...

journal_title：Journal of proteome research

authors： Sun B,Utleg AG,Hu Z,Qin S,Keller A,Lorang C,Gray L,Brightman A,Lee D,Alexander VM,Ranish JA,Moritz RL,Hood L

更新日期：2013-05-03 00:00:00

abstract：:N-Glycans are an important source of milk oligosaccharides. In addition to free oligosaccharides found in milk, N-glycans can also be utilized by gut microbes. A potential for milk N-glycans to act as gut microbe regulators in suckling animals has attracted considerable attention; however, sow milk N-glycans and their...

journal_title：Journal of proteome research

authors： Mu C,Cai Z,Bian G,Du Y,Ma S,Su Y,Liu L,Voglmeir J,Huang R,Zhu W

更新日期：2019-03-01 00:00:00

abstract：:Frontotemporal lobar degeneration (FTLD) is an umbrella term for a heterogeneous group of young-onset dementias of uncertain prevalence and incidence worldwide. Atypical cases of FTLD with fused in sarcoma inclusions (aFTLD-U) have been described recently, but their molecular characterization is still due. Using shotg...

journal_title：Journal of proteome research

authors： Martins-de-Souza D,Guest PC,Mann DM,Roeber S,Rahmoune H,Bauder C,Kretzschmar H,Volk B,Baborie A,Bahn S

更新日期：2012-04-06 00:00:00