Metabolomic analysis identifies inflammatory and noninflammatory metabolic effects of genetic modification in a mouse model of Crohn's disease.

abstract：:Schistosomes are blood-dwelling helminth parasites that cause schistosomiasis, a debilitating disease resulting in inflammation and, in extreme cases, multiple organ damage. Major challenges to control the transmission persist, and the discovery of protective antigens remains of critical importance for vaccine develop...

journal_title：Journal of proteome research

authors： Neves LX,Wilson RA,Brownridge P,Harman VM,Holman SW,Beynon RJ,Eyers CE,DeMarco R,Castro-Borges W

更新日期：2020-01-03 00:00:00

abstract：:Skeletal muscle has emerged as an important secretory organ that produces so-called myokines, regulating energy metabolism via autocrine, paracrine, and endocrine actions; however, the nature and extent of the muscle secretome has not been fully elucidated. Mass spectrometry (MS)-based proteomics, in principle, allows...

journal_title：Journal of proteome research

authors： Deshmukh AS,Cox J,Jensen LJ,Meissner F,Mann M

更新日期：2015-11-06 00:00:00

abstract：:As a model carcinogen in studying the mutagenicity and carcinogenicity of N-nitroso alkylating agent, N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) can induce DNA damages and many cellular defensive events, such as DNA repair, G2/M-phase arrest and apoptosis. Noticeably, diverse cellular responses were observed to occur...

journal_title：Journal of proteome research

authors： Shen J,Zhu H,Xiang X,Yu Y

更新日期：2009-06-01 00:00:00

abstract：:Although some outer membrane (OM) proteins involved in antibiotic resistance have been previously reported, the OM proteins regulating chlortetracycline (CTC) resistance are largely unknown. In this study, we employed a subproteomics approach to identify altered OM proteins of Escherichia coli in response to CTC expos...

journal_title：Journal of proteome research

authors： Lin XM,Yang JN,Peng XX,Li H

更新日期：2010-11-05 00:00:00

abstract：:Somatic embryo development (SED) in upland cotton shows low frequencies of embryo maturation and plantlet regeneration. Progress in increasing the regeneration rate has been limited. Here a global analysis of proteome dynamics between globular and cotyledonary embryos was performed using isobaric tags for relative and...

journal_title：Journal of proteome research

authors： Ge X,Zhang C,Wang Q,Yang Z,Wang Y,Zhang X,Wu Z,Hou Y,Wu J,Li F

更新日期：2015-01-02 00:00:00

abstract：:Using an integrated transcriptomic and proteomic approach, we characterized the venom peptidome of the European red ant, Manica rubida. We identified 13 "myrmicitoxins" that share sequence similarities with previously identified ant venom peptides, one of them being identified as an EGF-like toxin likely resulting fro...

journal_title：Journal of proteome research

authors： Touchard A,Aili SR,Téné N,Barassé V,Klopp C,Dejean A,Kini RM,Mrinalini,Coquet L,Jouenne T,Lefranc B,Leprince J,Escoubas P,Nicholson GM,Treilhou M,Bonnafé E

更新日期：2020-04-03 00:00:00

abstract：:The Chromosome-Centric Human Proteome Project (C-HPP) aims to identify "missing" proteins in the neXtProt knowledgebase. We present an in-depth proteomics analysis of the human sperm proteome to identify testis-enriched missing proteins. Using protein extraction procedures and LC-MS/MS analysis, we detected 235 protei...

journal_title：Journal of proteome research

authors： Vandenbrouck Y,Lane L,Carapito C,Duek P,Rondel K,Bruley C,Macron C,Gonzalez de Peredo A,Couté Y,Chaoui K,Com E,Gateau A,Hesse AM,Marcellin M,Méar L,Mouton-Barbosa E,Robin T,Burlet-Schiltz O,Cianferani S,Ferro M,Fr

更新日期：2016-11-04 00:00:00

abstract：:The CB1 and CB2 cannabinoid receptors belong to the GPCR superfamily and are associated with a variety of physiological and pathophysiological processes. Both receptors, with several lead compounds at different phases of development, are potentially useful targets for drug discovery. For this reason, fully elucidating...

journal_title：Journal of proteome research

authors： Zvonok N,Yaddanapudi S,Williams J,Dai S,Dong K,Rejtar T,Karger BL,Makriyannis A

更新日期：2007-06-01 00:00:00

abstract：:Birch pollen allergy is diagnosed and treated with aqueous extracts from birch pollen, which contain a mixture of allergens and nonallergenic proteins, including large numbers of closely related sequence variants, so-called iso-allergens of the major allergen, Bet v 1. The quality of therapeutic and diagnostic allerge...

journal_title：Journal of proteome research

authors： Spiric J,Schulenborg T,Schwaben L,Engin AM,Karas M,Reuter A

更新日期：2017-10-06 00:00:00

abstract：:The last two decades have seen a broad diversity of methods used to identify and/or characterize proteins in the archeological and paleontological record. Of these, mass spectrometry has opened an unprecedented window into the proteomes of the past, providing protein sequence data from long extinct animals as well as ...

journal_title：Journal of proteome research

authors： Cleland TP,Schroeter ER

更新日期：2018-03-02 00:00:00

abstract：:The processing of peptide tandem mass spectrometry data involves matching observed spectra against a sequence database. The ranking and calibration of these peptide-spectrum matches can be improved substantially using a machine learning postprocessor. Here, we describe our efforts to speed up one widely used postproce...

journal_title：Journal of proteome research

authors： Halloran JT,Zhang H,Kara K,Renggli C,The M,Zhang C,Rocke DM,Käll L,Noble WS

更新日期：2019-09-06 00:00:00

abstract：:We investigated the effect of homogenization strategy and protein precipitation on downstream protein quantitation using multiple reaction monitoring mass spectrometry (MRM-MS). Our objective was to develop a workflow capable of processing disparate tissue types with high throughput, minimal variability, and maximum p...

journal_title：Journal of proteome research

authors： Michaud SA,Pětrošová H,Jackson AM,McGuire JC,Sinclair NJ,Ganguly M,Flenniken AM,Nutter LMJ,McKerlie C,Schibli D,Smith D,Borchers CH

更新日期：2021-01-01 00:00:00

abstract：:Bacillus Amyloliquefaciens SQR9 is a well-investigated plant growth-promoting rhizobacteria with strong root colonization capability. To identify the key proteins involved in in situ root colonization and biofilm formation, the proteomic profiles of planktonic and root colonized SQR9 cells were compared. A total of 75...

journal_title：Journal of proteome research

authors： Qiu M,Xu Z,Li X,Li Q,Zhang N,Shen Q,Zhang R

更新日期：2014-12-05 00:00:00

abstract：:Reference materials are vital to benchmarking the reproducibility of clinical tests and essential for monitoring laboratory performance for clinical proteomics. The reference material utilized for mass spectrometric analysis of the human proteome would ideally contain enough proteins to be suitably representative of t...

journal_title：Journal of proteome research

authors： Clark DJ,Hu Y,Bocik W,Chen L,Schnaubelt M,Roberts R,Shah P,Whiteley G,Zhang H

更新日期：2018-06-01 00:00:00

abstract：:Adipose tissue is a major storage site for lipophilic environmental contaminants. The environmental metabolic disruptor hypothesis postulates that some pollutants can promote obesity or metabolic disorders by activating nuclear receptors involved in the control of energetic homeostasis. In this context, monoethylhexyl...

journal_title：Journal of proteome research

authors： Ellero-Simatos S,Claus SP,Benelli C,Forest C,Letourneur F,Cagnard N,Beaune PH,de Waziers I

更新日期：2011-12-02 00:00:00

abstract：:Tear proteome profiling may generate useful information for the understanding of the interaction between an eye and its contacting objects, such as a contact lens or a lens implant. This is important for designing improved eye-care devices and maintaining the health of an eye. Proteome profiles of tear fluids may also...

journal_title：Journal of proteome research

authors： Li N,Wang N,Zheng J,Liu XM,Lever OW,Erickson PM,Li L

更新日期：2005-11-01 00:00:00

abstract：:Protein phosphorylation is essential for numerous cellular processes. Large-scale profiling of phosphoproteins continues to enhance the depth and speed at which we understand these processes. The development of effective phosphoprotein and peptide enrichment techniques and improvements to mass spectrometric instrument...

journal_title：Journal of proteome research

authors： Li X,Gerber SA,Rudner AD,Beausoleil SA,Haas W,Villén J,Elias JE,Gygi SP

更新日期：2007-03-01 00:00:00

abstract：:Ricin is a type II ribosome-inactivating protein toxin consisting of A and B chains linked by one interchain disulfide bond. Because of its high toxicity depending on both chains together, confirming the presence of both A and B chains of intact ricin is required during the investigation of the illegal production and ...

journal_title：Journal of proteome research

authors： Liu CC,Liang LH,Yang Y,Yu HL,Yan L,Li XS,Chen B,Liu SL,Xi HL

更新日期：2021-01-01 00:00:00

abstract：:We analyzed the whole-cell protein content of gastrocnemius muscles from rats in different thyroid states. Twenty differentially expressed proteins were unambiguously identified. They were involved in substrates and energy metabolism, stress response, cell structure, and gene expression. This study represents the firs...

journal_title：Journal of proteome research

authors： Silvestri E,Burrone L,de Lange P,Lombardi A,Farina P,Chambery A,Parente A,Lanni A,Goglia F,Moreno M

更新日期：2007-08-01 00:00:00

abstract：:To assess the global effect of preterm birth on fetal metabolism and maternal-fetal nutrient transfer, we used a mass spectrometric-based chemical phenotyping approach on cord blood obtained at the time of birth. We sampled umbilical venous, umbilical arterial, and maternal blood from mothers delivering very-low birth...

journal_title：Journal of proteome research

authors： Alexandre-Gouabau MC,Courant F,Moyon T,Küster A,Le Gall G,Tea I,Antignac JP,Darmaun D

更新日期：2013-06-07 00:00:00

abstract：:Due to the increasing prevalence of nosocomial and community-acquired antibiotic resistant Staphylococcus aureus (SA), understanding the determinants of SA nasal carriage has become a major imperative. Previous research has revealed many host and bacterial factors that contribute to SA nasal carriage. To assess bacter...

journal_title：Journal of proteome research

authors： Muthukrishnan G,Quinn GA,Lamers RP,Diaz C,Cole AL,Chen S,Cole AM

更新日期：2011-04-01 00:00:00

abstract：:Starting in 2007, we have grown soybean (Glycine max [L.] Merr. variety Soniachna) and flax (Linum usitatissimum, L. variety Kyivskyi) in the radio-contaminated Chernobyl area and analyzed the seed proteomes. In the second-generation flax seeds, we detected a 12% increase in oil content. To characterize the bases for ...

journal_title：Journal of proteome research

authors： Klubicová K,Danchenko M,Skultety L,Berezhna VV,Rashydov NM,Hajduch M

更新日期：2013-11-01 00:00:00

abstract：:Protein lysine acylation, including acetylation and succinylation, has been found to be a major post-translational modification (PTM) and is associated with the regulation of cellular processes that are widespread in bacteria. Vibrio parahemolyticus is a model marine bacterium that causes seafood-borne illness in huma...

journal_title：Journal of proteome research

authors： Pan J,Chen R,Li C,Li W,Ye Z

更新日期：2015-10-02 00:00:00

abstract：:The coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has impacted a large portion of the world population. From a virus genetic perspective, a recent study described what genomic data revealed about the origin and emergence of SARS-CoV-2, proposing stronger a...

journal_title：Journal of proteome research

authors： Zhang YM,Wang L,Liu XZ,Zhang H

更新日期：2020-11-06 00:00:00

abstract：:Metabolic profiling technology, a massive information provider, has promoted the understanding of the metabolism of multicomponent medicines and its interactions with endogenous metabolites, which was previously a challenge in clarification. In this study, an untargeted GC/MS-based approach was employed to investigate...

journal_title：Journal of proteome research

authors： Zhang Z,Wang X,Wang J,Jia Z,Liu Y,Xie X,Wang C,Jia W

更新日期：2016-06-03 00:00:00

abstract：:Dehydroeffusol (DHE) is a phenanthrene isolated from the Chinese medicinal plant Juncus effusus. Biological evaluation of DHE reveals in vitro and in vivo anticancer effects. We performed a shotgun proteomic analysis using liquid chromatography-tandem mass spectrometry to investigate the changes in the protein profile...

journal_title：Journal of proteome research

authors： Chang IS,Sy LK,Cao B,Lum CT,Kwong WL,Fung YE,Lok CN,Che CM

更新日期：2018-07-06 00:00:00

abstract：:Porphyromonas gingivalis is a keystone periodontal pathogen that has been associated with autoimmune disorders. The cell surface proteases Lys-gingipain (Kgp) and Arg-gingipains (RgpA and RgpB) are major virulence factors, and their proteolytic activity is enhanced by small peptides such as glycylglycine (GlyGly). The...

journal_title：Journal of proteome research

authors： Zhang L,Veith PD,Huq NL,Chen YY,Seers CA,Cross KJ,Gorasia DG,Reynolds EC

更新日期：2018-08-03 00:00:00

abstract：:We aimed to evaluate neuroendocrine pulmonary tumors (NEPT) by a novel method involving map tree construction by comparing all of the protein spots. We performed a proteomics analysis to assess the similarities in protein expression between neuroendocrine pulmonary tumors (NEPT), including typical carcinoids (TC), aty...

journal_title：Journal of proteome research

authors： Cho NH,Koh ES,Lee DW,Kim H,Choi YP,Cho SH,Kim DS

更新日期：2006-03-01 00:00:00

abstract：:Fucosylated alpha-fetoprotein (AFP) is a specific tumor marker for hepatocellular carcinomas (HCC). However, the mechanisms underlying the increase in fucosylated AFP in serum of patients with HCC are largely unknown. Recently, we reported that fucosylation is a possible signal for the secretion of glycoproteins into ...

journal_title：Journal of proteome research

authors： Nakagawa T,Takeishi S,Kameyama A,Yagi H,Yoshioka T,Moriwaki K,Masuda T,Matsumoto H,Kato K,Narimatsu H,Taniguchi N,Miyoshi E

更新日期：2010-10-01 00:00:00

abstract：:Secondary to the increased survival following chemotherapy, brain metastases have recently become a significant clinical problem for breast cancer patients. The aim of this study was to characterize those functional phenotypes that might enhance brain metastasis in breast cancer cells. We first analyzed by two-dimensi...

journal_title：Journal of proteome research

authors： Martín B,Aragüés R,Sanz R,Oliva B,Boluda S,Martínez A,Sierra A

更新日期：2008-03-01 00:00:00