Abstract:
:In this issue of Cancer Discovery, Diab and colleagues demonstrate in a phase I trial enrolling 38 patients diagnosed with advanced solid tumors that combining the pegylated IL2 bempegaldesleukin with an anti-PD-1 mAb is safe, with an overall response rate of 59.5%. This compelling clinical activity is supported by the potent immune proliferation and activation of circulating T and natural killer cells with a >4-fold increase in the CD8/regulatory T-cell ratio in tumors, independent of baseline PD-L1 expression.See related article by Diab et al., p. 1158.
journal_name
Cancer Discovjournal_title
Cancer discoveryauthors
Rouanne M,Zitvogel L,Marabelle Adoi
10.1158/2159-8290.CD-20-0786subject
Has Abstractpub_date
2020-08-01 00:00:00pages
1097-1099issue
8eissn
2159-8274issn
2159-8290pii
10/8/1097journal_volume
10pub_type
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