Abstract:
OBJECTIVES:Clinicians agree that children with isolated cleft lip have fewer cleft-associated problems than children with cleft lip and palate. Unfortunately, for isolated cleft lip children, the risk of cleft-associated problems is unknown and maybe underestimated. Often, these children do not get the required follow-up by a multidisciplinary team and thereby not the known benefits in supporting their development. This study examines the incidence of cleft-related speech problems and ear problems in children with isolated cleft lip. MATERIALS AND METHODS:A prospective study was performed on all children born with an isolated cleft lip and treated at the Wilhelmina Children's Hospital in Utrecht between January 2007 and April 2014. Data were collected for sex, date of birth, genetics, cleft lip type, date of cleft lip repair, type of repair, speech/language problems, and ear problems. RESULTS:This study included 75 patients (59% male). The mean age of the children at the moment of speech examination was 32.5 months (SD 6.1). Eighteen of the 75 children (24%) needed speech and language therapy; however, only one child (1.3%) had a cleft-related speech problem. Sixteen of the 75 patients (21%) reported a history of one or more episodes of acute otitis media (AOM)/otitis media with effusion (OME) during the first 6 years. CONCLUSION/CLINICAL RELEVANCE:This is the first prospective study analyzing the incidence of cleft-related speech problems in children with an isolated cleft lip. These children do not have a higher risk of cleft-related speech problems or AOM/OME when compared to the general population. However, children with an isolated cleft do have a higher incidence of speech therapy.
journal_name
Clin Oral Investigjournal_title
Clinical oral investigationsauthors
Smarius BJA,Haverkamp S,de Wilde H,van Wijck-Warnaar A,Mink van der Molen AB,Breugem CCdoi
10.1007/s00784-020-03367-5subject
Has Abstractpub_date
2020-06-04 00:00:00eissn
1432-6981issn
1436-3771pii
10.1007/s00784-020-03367-5pub_type
杂志文章abstract:OBJECTIVES:Geranylgeraniol (GGOH) has been reported as a potential treatment option for bisphosphonate-associated osteonecrosis of the jaws (BP-ONJ). The aim of this study was to analyze the effects of GGOH on endothelial progenitor cells (EPC) after bisphosphonate treatment in vitro. MATERIALS AND METHODS:EPC were in...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-014-1394-z
更新日期:2015-09-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to investigate if a minimally invasive oral health package with the use of atraumatic restorative treatment (ART) or a conventional restorative technique (CT) would result in any perceived benefit from the patients' perspective and if there would be any difference between the two tr...
journal_title:Clinical oral investigations
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00784-014-1290-6
更新日期:2015-04-01 00:00:00
abstract:OBJECTIVES:The purpose of this study was to evaluate the effect of early functional loading to plateaued implants on bone formation and implant stability in a dog model. MATERIALS AND METHODS:Early loading (EL), nonloading control, and delayed loading (DL) groups were compared using six beagle dogs under functional lo...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-013-0929-z
更新日期:2014-01-01 00:00:00
abstract:OBJECTIVES:BioAggregate™ is a novel material introduced for use as a root-end filling material. It is tricalcium silicate-based, free of aluminium and uses tantalum oxide as radiopacifier. BioAggregate contains additives to enhance the material performance. The purpose of this research was to characterize the un-hydrat...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-014-1292-4
更新日期:2015-04-01 00:00:00
abstract:OBJECTIVES:The purpose of this experimental in vivo investigation was to evaluate the influence of modifying the implant surface by adding a monolayer of multi-phosphonate molecules on the development of experimental peri-implantitis. MATERIAL AND METHODS:Eight beagle dogs received 5 tests and 5 control implants each ...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-020-03708-4
更新日期:2021-01-06 00:00:00
abstract::The purpose of this 4-day plaque regrowth study was to assess the effect of N-chlorotaurine (NCT) mouth rinses on plaque inhibition and plaque vitality. Eighty volunteers participated in this investigator-blind, randomized, clinical controlled study in parallel groups. No oral hygiene was permitted except rinsing with...
journal_title:Clinical oral investigations
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00784-008-0207-7
更新日期:2009-03-01 00:00:00
abstract::To evaluate the efficacy of metronidazole on cyclosporine-induced gingival overgrowth (GO), a prospective intra-subject double-blind longitudinal study was performed on six heart transplant patients with GO. All patients underwent scaling and root planing before any treatment. Metronidazole gel (Elyzol, Cabon) was the...
journal_title:Clinical oral investigations
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/s00784-001-0142-3
更新日期:2002-03-01 00:00:00
abstract:OBJECTIVES:To assess the potential influence of systemic antibiotic administration on the healing of periodontal intrabony defects treated with deproteinized bovine bone mineral (DBBM) and collagen membrane. MATERIALS AND METHODS:Forty-one intrabony defects were treated by means of DBBM and collagen membrane (GTR). Po...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-020-03616-7
更新日期:2020-10-13 00:00:00
abstract:OBJECTIVES:Previous research revealed that autogenous tooth roots may be biologically equivalent to conventional bone grafts for lateral ridge augmentation. However, these analyses were limited to two dimensions, whereas healing is a volumetric process. The present study aimed at volumetrically assessing the microstruc...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-018-2723-4
更新日期:2019-07-01 00:00:00
abstract:OBJECTIVES:Candida albicans is the most common fungal pathogen in humans, but other Candida species cause candidosis. Candida species display significant differences in their susceptibility to antimycotic drugs. Patients with symptomatic or erythematous oral lichen planus (OLP) commonly have Candida infection requiring...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-012-0757-6
更新日期:2013-04-01 00:00:00
abstract:OBJECTIVES:Different studies suggest that inflammation as well as hypoxia leads to an increase of p53 protein levels. However, the implication of p53 during oral inflammatory processes is still unknown. The aim of this study was therefore to investigate the effect of hypoxia and inflammation on p53 regulation in human ...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-015-1679-x
更新日期:2016-09-01 00:00:00
abstract::To present the safety profile, the early healing phase and the clinical outcomes at 24 weeks following treatment of human intrabony defects with open flap debridement (OFD) alone or with OFD and rhGDF-5 adsorbed onto a particulate β-tricalcium phosphate (β-TCP) carrier. Twenty chronic periodontitis patients, each with...
journal_title:Clinical oral investigations
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00784-011-0610-3
更新日期:2012-08-01 00:00:00
abstract:OBJECTIVES:The current study aimed to evaluate different CBCT exposure protocols and influencing factors affecting the subjective image quality of scans taken for endodontic indications. MATERIALS AND METHODS:Twelve extracted teeth, comprising of two sets of maxillary molars, premolars, canines and incisors, mandibula...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-020-03524-w
更新日期:2020-08-25 00:00:00
abstract:OBJECTIVE:Intrapapillary injection (IPI) has been suggested to improve pulpal anesthesia of mandibular teeth and to avoid complications from inferior alveolar nerve block (IANB). This study aimed to determine and compare clinical efficacies and prostaglandin E2 (PGE2) levels between IPI and IANB. MATERIALS AND METHODS...
journal_title:Clinical oral investigations
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00784-019-02954-5
更新日期:2020-02-01 00:00:00
abstract:OBJECTIVES:Cell-free DNA (cfDNA) harboring mutations has been found in patients with diseases. Experimental studies have shown that cfDNA can be transmitted, leading to transformations in the host. In the present study, we evaluated whether bone allograft material contains cfDNA and whether this foreign cfDNA can be re...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-019-02867-3
更新日期:2019-12-01 00:00:00
abstract:: ...
journal_title:Clinical oral investigations
pub_type: 信件
doi:10.1007/s00784-018-2619-3
更新日期:2018-11-01 00:00:00
abstract::The purpose of the present study was to examine the effects of a newly developed water-soluble reduced chitosan on Streptococcus mutans, plaque regrowth, and biofilm vitality. A 1.0%, water-soluble reduced chitosan, with pH ranging from 6.0 to 6.5, molecular weights between 3,000 and 5,000 Da, and 70% degree of deacet...
journal_title:Clinical oral investigations
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00784-006-0038-3
更新日期:2006-06-01 00:00:00
abstract:OBJECTIVES:This study aimed to estimate the dental age (DA) using the London Atlas, Willems, and Nolla methods and to compare their accuracies. METHODS:The DA was estimated using the aforementioned methods on panoramic radiograms of a total of 919 Eastern Turkish patients aged 6-14 years, of whom 459 were female and 4...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-021-03788-w
更新日期:2021-01-18 00:00:00
abstract:OBJECTIVES:The present study aims to investigate the relevance of immunohistochemical p53 expression in carcinomas of the oral cavity and of the head and neck region. Long-term clinical and histopathological follow-up findings as well as HPV status are correlated with the results of this examination. MATERIALS AND MET...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-013-0939-x
更新日期:2014-01-01 00:00:00
abstract:: ...
journal_title:Clinical oral investigations
pub_type: 评论,信件
doi:10.1007/s00784-018-2636-2
更新日期:2018-11-01 00:00:00
abstract:OBJECTIVES:The present dental bleaching case report describes a new method that precisely quantifies the daily wearing-times of the bleaching product by inserting a microsensor in the acetate custom tray. The bleaching efficacy was also discussed since the patient was previously submitted to enamel microabrasion. METH...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-018-2439-5
更新日期:2019-01-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to evaluate the influence of [2-(methacryloyloxy)ethyl] trimethylammonium chloride (METAC) in the physico-chemical properties, antibacterial activity and cytotoxicity of an experimental resin-based sealant. MATERIALS AND METHODS:An experimental resin-based sealant was formulated wi...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-019-02971-4
更新日期:2020-02-01 00:00:00
abstract:OBJECTIVES:Recent scientific evidences suggest a relevant role of the oral cavity in the transmission and pathogenicity of SARS-CoV-2. METHODS:A literature search was performed in PubMed, up to April 30, 2020, focusing on SARS-CoV-2, COVID-19, oral cavity, and antimicrobial agents. RESULTS:Oral viral load of SARS-CoV...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-020-03413-2
更新日期:2020-08-01 00:00:00
abstract:OBJECTIVES:The aim of the study was to introduce a novel three-dimensional (3D) method to quantify the relative amount of different tissue components in bone substitute-treated defects by means of integration of confocal laser imaging into micro-computed tomography (μCT) analysis. MATERIALS AND METHODS:One standardize...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-013-1081-5
更新日期:2014-05-01 00:00:00
abstract:OBJECTIVE:Ex-vivo evaluation of the detectability of vertical root fractures (VRFs) using digital subtraction radiography (DSR) and conventional digital periapical radiography (CDPR); investigation of the effect of root canal filling, x-ray angulation, and thickness of the VRF in the diagnostic accuracy. MATERIALS AND...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-020-03245-0
更新日期:2020-10-01 00:00:00
abstract:OBJECTIVES:Sialolithiasis is the most common cause of chronic sialadenitis of the submandibular gland (SMG). Symptomatic superficial lobe stones are often treated by submandibulectomy. A gland preserving operation allows for transoral stone removal through endoscopically assisted sialolithotomy. Herein, we provide clin...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-019-02853-9
更新日期:2019-11-01 00:00:00
abstract:OBJECTIVES:To assess the quality of clinical practice guidelines (CPGs) on screening and diagnosis of oral cancer and to describe the characteristics of their recommendations. MATERIALS AND METHODS:We systematically searched EMBASE, MEDLINE, CPG' websites, and dentistry and oncology scientific societies to identify CP...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-018-2668-7
更新日期:2019-05-01 00:00:00
abstract::The main objective of this study was to identify the risk factors for the incidence of visible caries experience in a cohort of preschool children living in Flanders. Data were collected from 1,057 children; validated questionnaires on oral health-related behaviour were completed by parents at birth (2003-2004), at ag...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-011-0579-y
更新日期:2012-06-01 00:00:00
abstract::The aims of this study were to evaluate clinically and microbiologically the effects of two resin-modified glass-ionomer cements (RMGICs) used as liners after incomplete dentine caries removal and to identify Streptococcus mutans and Streptococcus sobrinus strains isolated from dentine samples, before and after indire...
journal_title:Clinical oral investigations
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00784-009-0304-2
更新日期:2009-12-01 00:00:00
abstract:OBJECTIVES:The aim of this study is to compare wound healing and patient pain perception of single-incision (single-incision, modified single-incision) and trap-door surgical techniques to harvest subepithelial connective tissue grafts from the palate. MATERIAL AND METHODS:Thirty-six patients were selected for root co...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-014-1204-7
更新日期:2014-12-01 00:00:00