Abstract:
:To evaluate the efficacy of metronidazole on cyclosporine-induced gingival overgrowth (GO), a prospective intra-subject double-blind longitudinal study was performed on six heart transplant patients with GO. All patients underwent scaling and root planing before any treatment. Metronidazole gel (Elyzol, Cabon) was then applied in two of the four anterior hemi-sextants of each subject, following a balanced random pre-programmed list, with a placebo gel being applied to the remaining two hemi-sextants. Plaque index (PI), bleeding on probing (BP) and probing depth (PD) were recorded for all teeth of the four anterior hemi-sextants before and at 1, 2, 3, and 4 months after gel application. A general linear model was fitted and ANOVA for repeated measurements with split-plot design and Chi-square analysis were used for statistical analysis. PD significantly decreased after 1 month following both treatments. Analogous results were obtained as regards PI and BP. No statistically significant difference was detected between results obtained with metronidazole and placebo. However, PD in the group of teeth treated with placebo significantly increased after 4 months, while PD values obtained from teeth treated with metronidazole remained statistically unchanged with respect to the 1st month. In conclusion, short-term results suggest that metronidazole and placebo are equally effective in reducing periodontal parameters and GO when associated with scaling and root planing. Long-term results, however, showed greater efficacy of metronidazole with respect to placebo in controlling cyclosporine-induced GO.
journal_name
Clin Oral Investigjournal_title
Clinical oral investigationsauthors
Montebugnoli L,Servidio D,Prati Cdoi
10.1007/s00784-001-0142-3keywords:
subject
Has Abstractpub_date
2002-03-01 00:00:00pages
24-7issue
1eissn
1432-6981issn
1436-3771journal_volume
6pub_type
临床试验,杂志文章,随机对照试验abstract::The objective of this study is to determine if there is an association between HIV infection in children and alterations in the chronological development of permanent dentition detectable by radiographic examination. The sample comprised two groups of children: (1) 50 children infected with HIV by vertical transmissio...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-007-0124-1
更新日期:2007-12-01 00:00:00
abstract:OBJECTIVES:This study evaluated the danger zone (DZ) in mesial roots of mandibular molars and the correlation between anatomical references of the DZ and some anatomical landmarks including tooth/root length, depth of mesial and distal grooves, and inter-canal orifices distance. MATERIAL AND METHODS:Twenty-eight mesia...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-020-03686-7
更新日期:2020-11-24 00:00:00
abstract:OBJECTIVES:The purpose of this laboratory study was to evaluate the influence of the attachment design and material on the retention of resin-bonded attachments (RBAs) before and after dynamic loading. MATERIALS AND METHODS:Forty-eight caries-free human premolars were prepared for RBAs fabricated either from a CoCr al...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-018-2544-5
更新日期:2019-03-01 00:00:00
abstract:PURPOSE:Root migration occurs after most third molar coronectomy and a portion may be exposed in the oral cavity. This study compared the root migration rate, surgical morbidities after third molar coronectomy with or without adjunctive guided bone regeneration (GBR). METHODS:A split-mouth randomized clinical trial wa...
journal_title:Clinical oral investigations
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00784-018-2594-8
更新日期:2019-04-01 00:00:00
abstract:OBJECTIVE:The purpose of this study was to assess whether and how the information obtained by means of cone beam computed tomography (CBCT) on maxillary posterior teeth differs from that obtained by panoramic radiography. MATERIALS AND METHOD:From 157 subjects (mean age 48 years, range 19-84 years; 89 females) referre...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-013-0963-x
更新日期:2014-01-01 00:00:00
abstract:OBJECTIVES:This study evaluated the effect of the administration of pre-operative dexamethasone on tooth sensitivity stemming from in-office bleaching. MATERIALS AND METHODS:A triple-blind, parallel-design, randomized clinical trial was conducted on 70 volunteers who received dexamethasone or placebo capsules. The dru...
journal_title:Clinical oral investigations
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00784-018-2452-8
更新日期:2019-01-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to evaluate long-term (≥5 years) tooth survival after resective therapy of multi-rooted, periodontally treated teeth and investigate the influence of patient-, tooth-, and dentist-related risk factors on tooth loss. MATERIALS AND METHODS:A total of 128 patients with root-resected m...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-019-03091-9
更新日期:2020-07-01 00:00:00
abstract:OBJECTIVES:The purpose of this randomized controlled trial was to compare the 24-month success rates of indirect pulp treatment (IPT) and iRoot BP Plus pulpotomy of primary molars with extremely deep caries. MATERIALS AND METHODS:Generally healthy children aged 3-7 years requiring general anesthesia for treating prima...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-020-03627-4
更新日期:2020-10-15 00:00:00
abstract:OBJECTIVE:Noninvasive optical methods such as photoplethysmography, established for blood pulse detection in organs, have been proposed for vitality testing of human dental pulp. However, no information is available on the mechanism of action in a closed pulp chamber and on the impairing influence of other than pulpal ...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-013-1115-z
更新日期:2014-01-01 00:00:00
abstract:OBJECTIVES:This systematic review (SR) aimed to summarise and critically appraise available evidence about the association between the synergistic consumption of alcohol and tobacco and the occurrence of oral squamous cell carcinoma (OSCC). MATERIALS AND METHODS:Observational studies investigating the association betw...
journal_title:Clinical oral investigations
pub_type: 杂志文章,meta分析
doi:10.1007/s00784-019-02958-1
更新日期:2019-07-01 00:00:00
abstract:OBJECTIVE:This aimed to assess the potential role of chronic stress in saliva secretion, xerostomia, and oral health in a population attending a saliva clinic. MATERIALS AND METHODS:Data of 114 patients who met the inclusion criteria and completed all questionnaires were analyzed in this study. Participants completed ...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-018-2393-2
更新日期:2018-12-01 00:00:00
abstract:OBJECTIVES:To evaluate, longitudinally, the impacts of orthognathic surgery in patients with skeletal class II malocclusion on oral health-related quality of life (OHRQoL), temporomandibular disorders (TMD) and psychological symptoms. MATERIALS AND METHODS:Forty-three patients with skeletal class II malocclusion who w...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-020-03709-3
更新日期:2021-01-07 00:00:00
abstract:OBJECTIVE:Dental materials and oral hygiene products may be responsible for oral contact allergic reactions. We aimed to determine the occurrence of allergies in patients with symptomatic oral lichen planus (OLP), oral lichenoid lesions (OLLs) and stomatitis and investigate if patch testing could identify contact aller...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-017-2053-y
更新日期:2017-11-01 00:00:00
abstract:OBJECTIVES:Intermittent parathyroid hormone (PTH) exerts anabolic effects on bone and has been approved for osteoporosis therapy. The dual actions of PTH are mediated primarily through the parathyroid hormone 1 receptor (PTH1R). Upon ligand binding, PTH1R activates diverse signaling pathways, including cAMP/protein kin...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-013-0985-4
更新日期:2014-01-01 00:00:00
abstract:OBJECTIVES:This study evaluated the influence of different rehydration media and time periods on biomechanical and structural properties of different acellular collagen matrices (ACMs). MATERIALS AND METHODS:Specimens of three ACMs (mucoderm®, Mucograft®, Dynamatrix®) were rehydrated in saline solution (SS) or human b...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-015-1614-1
更新日期:2016-07-01 00:00:00
abstract:BACKGROUND:Interleukin 8 (IL-8) is a pro-angiogenic, pro-inflammatory mediator that belongs to the family of chemokines. Due to its pro-angiogenic characteristic, it may play a vital role in tumour angiogenesis and progression. OBJECTIVES:This study was designed to estimate the levels of salivary IL-8 in oral precance...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-012-0723-3
更新日期:2013-03-01 00:00:00
abstract:OBJECTIVES:To evaluate and compare the obturation quality of mineral trioxide aggregate (MTA) and Biodentine placed with hand condensation or indirect ultrasonic activation technique in teeth models simulating perforating internal root resorption (IRR) using micro-computed tomographic (micro-CT) imaging. MATERIALS AND...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-018-2502-2
更新日期:2019-02-01 00:00:00
abstract::The use of oral implants opened a wide range of prosthetic treatment possibilities in edentulous patients. Although the reported success rates of oral implants are high, failures do occur. This paper reviews the current knowledge about the aetiology, the signs and symptoms and the possible influencing factors of impla...
journal_title:Clinical oral investigations
pub_type: 杂志文章,评审
doi:10.1007/s007840050054
更新日期:1998-09-01 00:00:00
abstract::The objective of this prospective clinical follow-up was to evaluate the 2-year clinical performance of a nanofilled resin composite in class II restorations. The restorations were made with and without intermediary layer of a nanofilled flowable resin composite studied in an intraindividual comparison. Each participa...
journal_title:Clinical oral investigations
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00784-010-0485-8
更新日期:2012-02-01 00:00:00
abstract:BACKGROUND:The use of the autogenous periosteal graft as biological barrier has been proposed for periodontal regeneration. The aim of this study was to evaluate the histometric findings of the subepithelial connective tissue graft as barrier in intrabony defects compared to a bioabsorbable membrane. METHODS:Three-wal...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-014-1323-1
更新日期:2015-06-01 00:00:00
abstract:OBJECTIVES:To describe changes in growth factor mediators in the gingival crevicular fluid (GCF) of patients with aggressive periodontitis (AgP) undergoing regenerative (GTR) and access flap (AF) surgery. MATERIALS AND METHODS:This was a 12-month, single-blind, split-mouth RCT involving 18 AgP patients with a bilatera...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-018-2752-z
更新日期:2019-08-01 00:00:00
abstract:OBJECTIVES:Milling is a crucial step in producing restorations using computer-aided design and computer-aided manufacturing (CAD/CAM) systems. In this study the trueness of currently available milling devices was evaluated. MATERIALS AND METHODS:Thirty clinical cases (ten inlays, ten crowns, ten onlays) were milled fr...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-016-1916-y
更新日期:2017-03-01 00:00:00
abstract:OBJECTIVES:To assess how to control, detect, and treat secondary caries. This review serves to inform a joint ORCA/EFCD consensus process. METHODS:Systematic and non-systematic reviews were performed or consulted and narratively synthesized. RESULTS:Secondary (or recurrent) caries is defined as a lesion associated wi...
journal_title:Clinical oral investigations
pub_type: 杂志文章,评审
doi:10.1007/s00784-020-03268-7
更新日期:2020-05-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to compare the effects of a hemostatic collagen sponge and a collagen sponge sealed with a bio-adhesive material on the palatal donor sites with the purpose of minimizing postoperative pain after epithelialized gingival graft (EGG) harvesting. MATERIAL AND METHODS:The present study...
journal_title:Clinical oral investigations
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00784-018-2455-5
更新日期:2019-01-01 00:00:00
abstract::Optimizing the quality of tooth-colored restorations is one of the main topics of current research. But there is only little information available about university education in this field. The aim of this study was to collect and evaluate data about the different aspects of dental education in Germany concerning tooth...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s007840050075
更新日期:1999-03-01 00:00:00
abstract:OBJECTIVES:The purpose of the present study was to evaluate the frequency, locations, and dimensions of mucous retention cysts of the maxillary sinus and analyze potential associated dental pathology. MATERIALS AND METHODS:A total of 156 cone beam computed tomography (CBCT) scans were included in the analysis, resulti...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-017-2206-z
更新日期:2018-04-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to investigate differences between the virtually planned and clinically achieved implant positions in completely template-guided implantations as a function of the type of edentulous space, the residual natural dentition, and the surgical implementation. MATERIALS AND METHODS:Fifty-...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-018-2339-8
更新日期:2018-07-01 00:00:00
abstract::The purpose of this 4-day plaque regrowth study was to assess the effect of N-chlorotaurine (NCT) mouth rinses on plaque inhibition and plaque vitality. Eighty volunteers participated in this investigator-blind, randomized, clinical controlled study in parallel groups. No oral hygiene was permitted except rinsing with...
journal_title:Clinical oral investigations
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00784-008-0207-7
更新日期:2009-03-01 00:00:00
abstract:OBJECTIVE:To describe and explore the association between proxy-reported sleep bruxism (SB) and quality of life (QoL) in a population of Colombian children belonging to different social layers. METHODS:The parents of 1556, 6-13-year-old school children, were administered the Pediatric Inventory of Quality of Life (Ped...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-016-1901-5
更新日期:2017-05-01 00:00:00
abstract:OBJECTIVES:Ventilator-associated pneumonia (VAP) is the most frequent hospital-acquired infections in intensive care units (ICU). In the bundle of care to prevent the VAP, the oral care is very important strategies, to decrease the oropharyngeal bacterial colonization and presence of causative bacteria of VAP. In view ...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-017-2289-6
更新日期:2018-06-01 00:00:00