Abstract:
OBJECTIVES:To assess the potential influence of systemic antibiotic administration on the healing of periodontal intrabony defects treated with deproteinized bovine bone mineral (DBBM) and collagen membrane. MATERIALS AND METHODS:Forty-one intrabony defects were treated by means of DBBM and collagen membrane (GTR). Postoperatively, the patients received either systemic antibiotics (i.e., 1 g of amoxicillin, twice daily for 7 days) (test) or no antibiotics (control). Clinical attachment level (CAL), probing depth (PD), and gingival recession (GR) were measured at baseline and at 1 year following regenerative surgery. The depth of the intrabony component (INTRA DD) and its width (INTRA DW) were measured during surgery and after 1 year at reentry. The depth (RxD) and width (RxW) of the intrabony defects were evaluated radiographically at baseline and at 1 year. RESULTS:No adverse events were observed in any of the two groups throughout the entire study period. In the test group, mean CAL changed from 8.7 ± 1.4 mm at baseline to 5.0 ± 1.7 mm at 1 year (p < 0.0001), while PD decreased from 7.8 ± 1.5 mm at baseline to 4.0 ± 0.9 mm at 1 year (p < 0.0001). In the control group, mean CAL changed from 8.6 ± 1.9 mm to 5.9 ± 1.6 mm (p < 0.001) and mean PD improved from 7.4 ± 1.3 mm to 4.1 ± 1.3 mm (p < 0.001). Mean CAL gain measured 3.6 ± 1.6 mm in the test and 2.7 ± 1.6 mm in the control group, respectively. Defect fill (i.e., INTRA DD gain) at re-entry measured 3.7 ± 1.8 mm in the test and 2.7 ± 2.1 mm in the control group. A CAL gain of ≥ 3 mm was measured in 76% of the defects in the test group and in 40% of the defects in the control group, respectively. In both groups, all evaluated clinical and radiographic parameters improved statistically significantly compared with baseline, but no statistically significant differences were found between the two groups. CONCLUSIONS:Within their limits, the present study has failed to show any substantial added clinical benefits following the postoperative administration of amoxicillin in conjunction with regenerative periodontal surgery using DBBM and GTR. CLINICAL RELEVANCE:The post-surgically administration of systemic antibiotics does not seem to be necessary following regenerative periodontal surgery.
journal_name
Clin Oral Investigjournal_title
Clinical oral investigationsauthors
Pietruska M,Dolińska E,Milewski R,Sculean Adoi
10.1007/s00784-020-03616-7subject
Has Abstractpub_date
2020-10-13 00:00:00eissn
1432-6981issn
1436-3771pii
10.1007/s00784-020-03616-7pub_type
杂志文章abstract::Dear Professor Dr. Matthias Hannig. Editor-in-Chief Clinical Oral Investigations. Following the publication of our paper by Calvo Guirado et al, 2015 [1] in Clinical Oral Investigations, it came to light that a certain part of the text at the materials and methods and results sections were similar. ...
journal_title:Clinical oral investigations
pub_type: 杂志文章,已发布勘误
doi:10.1007/s00784-018-2763-9
更新日期:2019-01-01 00:00:00
abstract::The aim of the present study was to evaluate the efficacy of autogenous bone graft (ABG) with and without autogenous periodontal ligament graft (PDLG) in the management of human two-wall intrabony periodontal defects. Twenty-six similar two-wall intrabony periodontal defects with >or=5 mm probing depths and >or=3 mm d...
journal_title:Clinical oral investigations
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00784-008-0235-3
更新日期:2009-09-01 00:00:00
abstract::To present the safety profile, the early healing phase and the clinical outcomes at 24 weeks following treatment of human intrabony defects with open flap debridement (OFD) alone or with OFD and rhGDF-5 adsorbed onto a particulate β-tricalcium phosphate (β-TCP) carrier. Twenty chronic periodontitis patients, each with...
journal_title:Clinical oral investigations
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00784-011-0610-3
更新日期:2012-08-01 00:00:00
abstract::The aim of this study was to investigate the possible association of a distinct combination of polymorphisms in the interleukin (IL)-1 gene cluster on gingival bleeding tendency in young adult Arabs with plaque-induced gingivitis. Fifty otherwise healthy, nonsmoking volunteers, 19-28 years of age, participated. Clinic...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-007-0120-5
更新日期:2007-09-01 00:00:00
abstract:OBJECTIVES:To evaluate the diagnostic efficacy of CBCT-MRI fused images for articular disc calcification of temporomandibular joint (TMJ). MATERIALS AND METHODS:Twenty patients (24 TMJs) whose image examinations showed dense bodies in the TMJ space were included in the study. The locations of dense bodies evaluated by...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-020-03497-w
更新日期:2020-08-12 00:00:00
abstract:OBJECTIVES:The purpose of this prospective clinical trial was to examine the clinical and patient outcomes following esthetic reconstruction of interdental papilla loss in anterior teeth, using an injectable, non-animal-based, hyaluronic acid gel. MATERIALS AND METHODS:Ten systemically healthy adults, with at least on...
journal_title:Clinical oral investigations
pub_type: 临床试验,杂志文章
doi:10.1007/s00784-015-1677-z
更新日期:2016-09-01 00:00:00
abstract:OBJECTIVES:The main objective of this study was to evaluate clinical and radiographic outcomes of implant-supported fixed partial prostheses, comparing platform switching and standard platform concepts. MATERIALS AND METHODS:Patients with single or multiple partial edentulism were included in this prospective multicen...
journal_title:Clinical oral investigations
pub_type: 杂志文章,多中心研究
doi:10.1007/s00784-015-1462-z
更新日期:2015-12-01 00:00:00
abstract:OBJECTIVES:Most patients with bisphosphonate-associated osteonecrosis of the jaws (BP-ONJ) report a previous tooth extraction at the necrosis site before the diagnosis was made. At older ages, most teeth are extracted due to periodontal disease, which is per se another BP-ONJ trigger factor. The aim of this study was t...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-013-0974-7
更新日期:2014-01-01 00:00:00
abstract:OBJECTIVE:Edible oils are an empiric approach for the prevention of oral diseases. The present in situ study investigated the effect of edible oils on initial bacterial colonization of enamel surfaces. METHODS AND MATERIALS:Initial biofilm formation was performed on enamel specimens mounted on maxillary splints and ca...
journal_title:Clinical oral investigations
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00784-012-0734-0
更新日期:2013-03-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to evaluate the 12-year clinical performance of sintered (Duceram, Dentsply-Degussa, Dentsply International Inc., PA, USA)-D and pressable (IPS Empress, Ivoclar-Vivadent, Schaan, Leichtenstein)-IPS ceramic inlay and onlay restorations. METHODS:Eighty-six restorations were placed in...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-015-1669-z
更新日期:2016-09-01 00:00:00
abstract::The objective of this prospective clinical follow-up was to evaluate the 2-year clinical performance of a nanofilled resin composite in class II restorations. The restorations were made with and without intermediary layer of a nanofilled flowable resin composite studied in an intraindividual comparison. Each participa...
journal_title:Clinical oral investigations
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00784-010-0485-8
更新日期:2012-02-01 00:00:00
abstract:OBJECTIVE:Aggregatibacter actinomycetemcomitans, specially its highly leucotoxic strain (JP2 clone), represents an etiological factor for the onset and progression of aggressive types of periodontitis. The aims of this investigation were to investigate the most relevant periodontal pathogens in the subgingival microbio...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-015-1653-7
更新日期:2016-09-01 00:00:00
abstract:OBJECTIVES:Cell-free DNA (cfDNA) harboring mutations has been found in patients with diseases. Experimental studies have shown that cfDNA can be transmitted, leading to transformations in the host. In the present study, we evaluated whether bone allograft material contains cfDNA and whether this foreign cfDNA can be re...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-019-02867-3
更新日期:2019-12-01 00:00:00
abstract::The present study compared the recovery of six periodontal pathogens by paper point samples from two different aspects of periodontal lesions by quantitative real-time polymerase chain reaction (PCR). Twenty patients with untreated chronic periodontitis were randomized into two groups. Before subgingival instrumentati...
journal_title:Clinical oral investigations
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00784-009-0333-x
更新日期:2010-10-01 00:00:00
abstract:AIM:The primary objective of this study was (1) to evaluate the 5-year clinical outcome of regenerative periodontal therapy (RPT) using minimally invasive surgery and a collagen-enriched bovine-derived xenograft and (2) to identify predictors for clinical attachment level (CAL) gain and vertical radiographic bone (RB) ...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-017-2208-x
更新日期:2018-04-01 00:00:00
abstract:OBJECTIVE:Information about the spectrum of microorganisms in the intraimplant cavities of two-piece dental implants is scarce. The purpose of this study was to assess the intraimplant microflora of two-piece dental implants by conventional biochemical testing, matrix-assisted laser desorption/ionization time-of-flight...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-012-0805-2
更新日期:2013-05-01 00:00:00
abstract:OBJECTIVES:To assess the status of health services provision of public tertiary dental hospitals during the COVID-19 epidemic in China and to evaluate the regional difference of telehealth. MATERIALS AND METHODS:The health services provision of public tertiary dental hospitals in China mainland during the COVID-19 epi...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-020-03267-8
更新日期:2020-05-01 00:00:00
abstract::Acidogenicity and the levels of mutans streptococci (MS) in dental plaque after the use of Lactobacillus rhamnosus GG (LGG) and Lactobacillus reuteri were determined. The study had a randomised, double-blind, crossover design. Thirteen volunteers used tablets containing LGG or a combination of L. reuteri SD2112 and PT...
journal_title:Clinical oral investigations
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00784-011-0584-1
更新日期:2012-06-01 00:00:00
abstract:OBJECTIVES:Mandibular reconstruction after segmental mandibulectomy can be challenging without virtual surgical planning and osteotomy guides. The purpose of this study was to analyze anatomic parameters to facilitate the evaluation of ideal fibula wedge osteotomies to reconstruct the neomandibula in a simple and cost-...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-019-03177-4
更新日期:2020-09-01 00:00:00
abstract:OBJECTIVES:This in situ study aims to evaluate the effects of chlorhexidine (CHX) mouth rinsing on biofilm formation and moreover on the disruption of existing mature dental biofilms. METHODS:Biofilms were formed in situ by five volunteers on bovine enamel specimens fixed to individual acrylic splints. For biofilm for...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-020-03250-3
更新日期:2020-11-01 00:00:00
abstract:OBJECTIVES:The corona disease (COVID-19) is developing into one of the greatest challenges for healthcare professionals around the world. In this article, we report the detailed actions taken in the Department of Conservative Dentistry and Periodontology, University Hospital, Ludwig-Maximilians-University (LMU), Munich...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-020-03440-z
更新日期:2020-08-01 00:00:00
abstract:BACKGROUND:The aim of this study was to evaluate through a systematic review the extraction of third molars as a risk factor for temporomandibular disorders (TMDs). TYPES OF STUDIES REVIEWED:Randomized and nonrandomized controlled clinical trials where patients underwent third molar extraction and with qualitative eva...
journal_title:Clinical oral investigations
pub_type: 杂志文章,评审
doi:10.1007/s00784-020-03277-6
更新日期:2020-10-01 00:00:00
abstract:OBJECTIVES:Postoperative pain management is of highest interest for patients undergoing maxillofacial surgery including microvascular reconstructive surgery. Currently, there is a lack of information regarding process and outcome of postoperative pain management after microvascular reconstruction. MATERIALS AND METHOD...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-016-1809-0
更新日期:2017-01-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to determine the frequency and quality of root canal fillings (RCF) and the prevalence of apical radiolucency (AR) in a German population. MATERIAL AND METHODS:Five hundred randomly selected full-size CBCT images (Planmeca ProMax 3D, FOV = 8 × 8 cm, voxel size 160 μm or 200 μm) wer...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-019-02985-y
更新日期:2020-03-01 00:00:00
abstract::The goal of the study was to develop a validated manual preparation process that conforms to the requirements of validation guidelines. Twelve dental transmission devices from various manufacturers (turbines, handpieces, and contra-angle handpieces) were artificially contaminated with bovine hemoglobin for the test. T...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-010-0425-7
更新日期:2011-10-01 00:00:00
abstract::Apical periodontitis (AP) are frequent findings in contemporary dental practice in association with dental pathology or dental care. They have also been studied from an anthropological background. The purpose of this study was to compare the prevalence of apical and dental lesions in an archeological Middle Ages sampl...
journal_title:Clinical oral investigations
pub_type: 历史文章,杂志文章
doi:10.1007/s00784-005-0318-3
更新日期:2005-09-01 00:00:00
abstract:OBJECTIVES:Numerous different attachments are used to retain overdentures on implants. The purpose of this study was to evaluate a new chairside attachment system based on polyvinylsiloxane (PVS). MATERIAL AND METHODS:A total of 250 specimens were fabricated (n = 10) to measure the retention force (RF) in dependence o...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-014-1307-1
更新日期:2015-05-01 00:00:00
abstract:OBJECTIVES:The main goal of the present study was to compare the biomechanical stability of locking plates and conventional miniplate combinations in human mandibles reconstructed with fibular grafts. MATERIALS AND METHODS:A specially developed and well-proven testing device reproduced the in vivo loading conditions o...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-013-1105-1
更新日期:2014-05-01 00:00:00
abstract:OBJECTIVES:The purpose of this study was to assess the efficacy of different cleansing agents in killing mixed species biofilms on silicone facial prostheses. MATERIALS AND METHODS:Two bacterial and three yeast strains, isolated from silicone facial prostheses, were selected for the mixed species biofilms. A variety o...
journal_title:Clinical oral investigations
pub_type: 杂志文章
doi:10.1007/s00784-015-1453-0
更新日期:2015-12-01 00:00:00
abstract:OBJECTIVES:This systematic review (SR) aimed to summarise and critically appraise available evidence about the association between the synergistic consumption of alcohol and tobacco and the occurrence of oral squamous cell carcinoma (OSCC). MATERIALS AND METHODS:Observational studies investigating the association betw...
journal_title:Clinical oral investigations
pub_type: 杂志文章,meta分析
doi:10.1007/s00784-019-02958-1
更新日期:2019-07-01 00:00:00