In vitro synergistic potentials of novel antibacterial combination therapies against Salmonella enterica serovar Typhimurium.

abstract：BACKGROUND:The human gastrointestinal (GI) tract microbiota is characterised by an abundance of uncultured bacteria most often assigned in phyla Firmicutes and Bacteroidetes. Diversity of this microbiota, even though approached with culture independent techniques in several studies, still requires more elucidation. The...

journal_title：BMC microbiology

authors： Krogius-Kurikka L,Kassinen A,Paulin L,Corander J,Mäkivuokko H,Tuimala J,Palva A

更新日期：2009-04-08 00:00:00

abstract：BACKGROUND:For a good probiotic candidate, the abilities to adhere to intestinal epithelium and to fortify barrier function are considered to be crucial for colonization and functionality of the strain. The strain Lactobacillus acidophilus LAB20 was isolated from the jejunum of a healthy dog, where it was found to be t...

journal_title：BMC microbiology

authors： Kainulainen V,Tang Y,Spillmann T,Kilpinen S,Reunanen J,Saris PE,Satokari R

更新日期：2015-01-16 00:00:00

abstract：BACKGROUND:Fungi are the second most abundant type of human pathogens. Invasive fungal pathogens are leading causes of life-threatening infections in clinical settings. Toxicity to the host and drug-resistance are two major deleterious issues associated with existing antifungal agents. Increasing a host's tolerance and...

journal_title：BMC microbiology

authors： Kidane YH,Lawrence C,Murali TM

更新日期：2013-10-07 00:00:00

abstract：BACKGROUND:Poorly understood but highly diverse microbial communities exist within anoxic and oxygen-depleted marine sediments. These communities often harbour single-celled eukaryotes that form symbiotic associations with different prokaryotes. During low tides in South-western British Columbia, Canada, vast areas of ...

journal_title：BMC microbiology

authors： Breglia SA,Yubuki N,Hoppenrath M,Leander BS

更新日期：2010-05-19 00:00:00

abstract：BACKGROUND:The ATP-Binding Cassette (ABC) functional superfamily includes integral transmembrane exporters that have evolved three times independently, forming three families termed ABC1, ABC2 and ABC3, upon which monophyletic ATPases have been superimposed for energy-coupling purposes [e.g., J Membr Biol 231(1):1-10, ...

journal_title：BMC microbiology

authors： Zheng WH,Västermark Å,Shlykov MA,Reddy V,Sun EI,Saier MH Jr

更新日期：2013-05-06 00:00:00

abstract：BACKGROUND:Bacillus spp. have prominent ability to suppress plant pathogens and corresponding diseases. Previous analyses of Bacillus spp. revealed numerous gene clusters involved in nonribosomal synthesis of cyclic lipopeptides with distinct antimicrobial action. The 4'-phosphopantetheinyl transferase (PPTase) encoded...

journal_title：BMC microbiology

authors： Jin P,Wang H,Liu W,Miao W

更新日期：2017-12-04 00:00:00

abstract：BACKGROUND:Suppression subtractive hybridization (SSH) strategy was used with extraintestinal pathogenic Escherichia coli (EXPEC) that cause avian colibacillosis (avian pathogenic E. coli or APEC) and human urinary tract infections (uropathogenic E. coli or UPEC) to determine if they possessed genes that were host and/...

journal_title：BMC microbiology

authors： Kariyawasam S,Scaccianoce JA,Nolan LK

更新日期：2007-08-30 00:00:00

abstract：BACKGROUND:Many plants have been used in traditional medicine for their antibacterial, antifungal, antiprotozoal, antiviral, antidiarrhoeal, analgesic, antimalarial, antioxidant, anti-inflammatory and anticancer activities. In order to find novel antimicrobial and antiviral agents, the aim of the present study was the ...

journal_title：BMC microbiology

authors： Di Petrillo A,Fais A,Pintus F,Santos-Buelga C,González-Paramás AM,Piras V,Orrù G,Mameli A,Tramontano E,Frau A

更新日期：2017-07-14 00:00:00

abstract：BACKGROUND:The complete genome sequences of 44 Bacillus cereus group isolates collected from diverse sources in Japan were analyzed to determine their genetic backgrounds and diversity levels in Japan. Multilocus sequence typing (MLST) and core-genome single-nucleotide polymorphism (SNP) typing data from whole-genome s...

journal_title：BMC microbiology

authors： Okutani A,Inoue S,Noguchi A,Kaku Y,Morikawa S

更新日期：2019-12-16 00:00:00

abstract：BACKGROUND:Papua New Guinea (PNG) is a high tuberculosis (TB) burden country of the WHO Western Pacific Region, but so far research on drug resistance (DR) and genotypes of Mycobacterium tuberculosis (M. tuberculosis) was only conducted in few provinces in the country. The aim of the present study was to obtain baselin...

journal_title：BMC microbiology

authors： Ley SD,Harino P,Vanuga K,Kamus R,Carter R,Coulter C,Pandey S,Feldmann J,Ballif M,Siba PM,Phuanukoonnon S,Gagneux S,Beck HP

更新日期：2014-12-05 00:00:00

abstract：BACKGROUND:The role of Aspergillus fumigatus mycotoxins in the colonization of the respiratory tract by conidia has not been studied extensively, even though patients at risk from invasive aspergillosis frequently exhibit respiratory epithelium damage. In a previous study, we found that filtrates of A. fumigatus cultur...

journal_title：BMC microbiology

authors： Khoufache K,Puel O,Loiseau N,Delaforge M,Rivollet D,Coste A,Cordonnier C,Escudier E,Botterel F,Bretagne S

更新日期：2007-01-23 00:00:00

abstract：BACKGROUND:In humans, the intestinal microbiota plays an important role in the maintenance of host health by providing energy, nutrients, and immunological protection. Applying current molecular methods is necessary to surmount the limitations of classical culturing techniques in order to obtain an accurate description...

journal_title：BMC microbiology

authors： Mariat D,Firmesse O,Levenez F,Guimarăes V,Sokol H,Doré J,Corthier G,Furet JP

更新日期：2009-06-09 00:00:00

abstract：BACKGROUND:Pseudomonas aeruginosa is the predominant pathogen associated with the decline of pulmonary function in cystic fibrosis (CF) patients. Both environment-to-host acquisition and patient-to-patient transmission have been described for P. aeruginosa infection. Epidemic clones and bacterial phenotypic adaptation ...

journal_title：BMC microbiology

authors： Cigana C,Melotti P,Baldan R,Pedretti E,Pintani E,Iansa P,De Fino I,Favari F,Bergamini G,Tridello G,Cirillo DM,Assael BM,Bragonzi A

更新日期：2016-07-11 00:00:00

abstract：BACKGROUND:Macrolide antibiotics are commonly administered for bacterial respiratory illnesses. Azithromycin (Az) is especially noted for extremely high intracellular concentrations achieved within macrophages which is far greater than the serum concentration. Clinical strains of Type B Francisella (F.) tularensis have...

journal_title：BMC microbiology

authors： Ahmad S,Hunter L,Qin A,Mann BJ,van Hoek ML

更新日期：2010-04-23 00:00:00

abstract：BACKGROUND:A major obstacle to industrial-scale astaxanthin production by the yeast Phaffia rhodozyma is the strong inhibitory effect of high glucose concentration on astaxanthin synthesis. We investigated, for the first time, the mechanism of the regulatory effect of high glucose (> 100 g/L) at the metabolite and tran...

journal_title：BMC microbiology

authors： Miao L,Chi S,Wu M,Liu Z,Li Y

更新日期：2019-06-15 00:00:00

abstract：BACKGROUND:Mob family proteins are conserved between animals, plants and fungi and are essential for the activation of NDR kinases that control crucial cellular processes like cytokinesis, proliferation and morphology. RESULTS:We identified a hypomorphic allele of ChMOB2 in a random insertional mutant (vir-88) of the ...

journal_title：BMC microbiology

authors： Schmidpeter J,Dahl M,Hofmann J,Koch C

更新日期：2017-01-19 00:00:00

abstract：BACKGROUND:Porphyromonas gingivalis is the foremost oral pathogen of adult periodontitis in humans. However, the mechanisms of bacterial invasion and the resultant destruction of the gingival tissue remain largely undefined. RESULTS:We report host-P. gingivalis interactions in primary human gingival fibroblast (HGF) c...

journal_title：BMC microbiology

authors： Urnowey S,Ansai T,Bitko V,Nakayama K,Takehara T,Barik S

更新日期：2006-03-08 00:00:00

abstract：BACKGROUND:Recent scientific developments have shed more light on the importance of the host-microbe interaction, particularly in the gut. However, the mechanistic study of the host-microbe interplay is complicated by the intrinsic limitations in reaching the different areas of the gastrointestinal tract (GIT) in vivo....

journal_title：BMC microbiology

authors： Marzorati M,Vanhoecke B,De Ryck T,Sadaghian Sadabad M,Pinheiro I,Possemiers S,Van den Abbeele P,Derycke L,Bracke M,Pieters J,Hennebel T,Harmsen HJ,Verstraete W,Van de Wiele T

更新日期：2014-05-22 00:00:00

abstract：BACKGROUND:Most lactic acid bacteria are non-motile but some of them are flagellated and exhibit motility. So far, motile lactobacilli have rarely been studied, and characteristics of their flagellins are poorly understood. In this study, a highly motile strain of Lactobacillus agilis was recruited for transcriptional ...

journal_title：BMC microbiology

authors： Kajikawa A,Midorikawa E,Masuda K,Kondo K,Irisawa T,Igimi S,Okada S

更新日期：2016-03-22 00:00:00

abstract：BACKGROUND:Accumulation of gyrase cleavage complex in Escherichia coli from the action of quinolone antibiotics induces an oxidative damage cell death pathway. The oxidative cell death pathway has also been shown to be involved in the lethality following accumulation of cleavage complex formed by bacterial topoisomeras...

journal_title：BMC microbiology

authors： Liu IF,Aedo S,Tse-Dinh YC

更新日期：2011-12-12 00:00:00

abstract：BACKGROUND:Recent studies have identified in Mycobacterium avium subsp. paratuberculosis (MAP), already known as a pathogen in ruminants, a potential zoonotic agent of some autoimmune diseases in humans. Therefore, considering the possible risk for public health, it is necessary a thorough understanding of MAP's gene e...

journal_title：BMC microbiology

authors： Cossu A,Sechi LA,Zanetti S,Rosu V

更新日期：2012-05-30 00:00:00

abstract：BACKGROUND:The human gastrointestinal (GI) tract microbiota has been a subject of intense research throughout the 3rd Millennium. Now that a general picture about microbiota composition in health and disease is emerging, questions about factors determining development of microbiotas with specific community structures w...

journal_title：BMC microbiology

authors： Peñate-Medina O,Tower RJ,Peñate-Medina T,Will O,Saris PEJ,Suojanen J,Sorsa T,Huuskonen L,Hiippala K,Satokari R,Glüer CC,de Vos WM,Reunanen J

更新日期：2019-07-18 00:00:00

abstract：BACKGROUND:Lactobacillus species are used as probiotics and play an important role in fermented food production. However, use of 16S rRNA gene sequences as standard markers for the differentiation of Lactobacillus species offers a very limited scope, as several species of Lactobacillus share similar 16S rRNA gene seque...

journal_title：BMC microbiology

authors： Kim E,Yang SM,Lim B,Park SH,Rackerby B,Kim HY

更新日期：2020-04-15 00:00:00

abstract：BACKGROUND:Atherosclerosis is still the leading cause of death in the western world. Besides known risk factors studies demonstrating Chlamydophila pneumoniae (C. pneumoniae) to be implicated in the progression of the disease, little is known about C. pneumoniae infection dynamics. We investigated whether C. pneumoniae...

journal_title：BMC microbiology

authors： Marino J,Stoeckli I,Walch M,Latinovic-Golic S,Sundstroem H,Groscurth P,Ziegler U,Dumrese C

更新日期：2008-02-19 00:00:00

abstract：BACKGROUND:In the present work, we describe a group of anomalous dose-response (DR) profiles and develop a dynamic model that is able to explain them. Responses were obtained from conventional assays of three antimicrobial agents (nisin, pediocin and phenol) against two microorganisms (Carnobacterium piscicola and Leuc...

journal_title：BMC microbiology

authors： Murado MA,Vázquez JA

更新日期：2010-08-19 00:00:00

abstract：BACKGROUND:Legionella pneumophila, the causative agent of Legionnaire's disease, may enter a viable but non-culturable (VBNC) state triggered by environmental stress conditions. Specific outer-membrane epitopes of L. pneumophila are used in many diagnostic applications and some of them are linked to important virulence...

journal_title：BMC microbiology

authors： Schrammel B,Petzold M,Cervero-Aragó S,Sommer R,Lück C,Kirschner A

更新日期：2018-07-17 00:00:00

abstract：BACKGROUND:The increase in resistance to antibiotics among disease-causing bacteria necessitates the development of alternative antimicrobial approaches such as the use of light-activated antimicrobial agents (LAAAs). Light of an appropriate wavelength activates the LAAA to produce cytotoxic species which can then caus...

journal_title：BMC microbiology

authors： Omar GS,Wilson M,Nair SP

更新日期：2008-07-01 00:00:00

abstract：BACKGROUND:Tsetse flies (Diptera: Glossinidae) are solely responsible for the transmission of African trypanosomes, causative agents of sleeping sickness in humans and nagana in livestock. Due to the lack of efficient vaccines and the emergence of drug resistance, vector control approaches such as the sterile insect te...

journal_title：BMC microbiology

authors： Augustinos AA,Meki IK,Demirbas-Uzel G,Ouédraogo GMS,Saridaki A,Tsiamis G,Parker AG,Abd-Alla AMM,Bourtzis K

更新日期：2018-11-23 00:00:00

abstract：BACKGROUND:Bloodstream infections represent serious conditions carrying a high mortality and morbidity rate. Rapid identification of microorganisms and prompt institution of adequate antimicrobial therapy is of utmost importance for a successful outcome. Aiming at the development of a rapid, simplified and efficient pr...

journal_title：BMC microbiology

authors： Jakovljev A,Bergh K

更新日期：2015-11-06 00:00:00

abstract：BACKGROUND:Infection with Brucella melitensis (B. melitensis) is one of the most important causes of abortion in goats and sheep, and also causes severe systemic disease in exposed humans. In Ethiopia, based on seroepidemiological studies, brucellosis is known to be endemic. However, there is little information on the ...

journal_title：BMC microbiology

authors： Tekle M,Legesse M,Edao BM,Ameni G,Mamo G

更新日期：2019-05-24 00:00:00