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Weak interactions in higher-order chromatin organization.

Abstract：

:The detailed principles of the hierarchical folding of eukaryotic chromosomes have been revealed during the last two decades. Along with structures composing three-dimensional (3D) genome organization (chromatin compartments, topologically associating domains, chromatin loops, etc.), the molecular mechanisms that are involved in their establishment and maintenance have been characterized. Generally, protein-protein and protein-DNA interactions underlie the spatial genome organization in eukaryotes. However, it is becoming increasingly evident that weak interactions, which exist in biological systems, also contribute to the 3D genome. Here, we provide a snapshot of our current understanding of the role of the weak interactions in the establishment and maintenance of the 3D genome organization. We discuss how weak biological forces, such as entropic forces operating in crowded solutions, electrostatic interactions of the biomolecules, liquid-liquid phase separation, DNA supercoiling, and RNA environment participate in chromosome segregation into structural and functional units and drive intranuclear functional compartmentalization.

journal_name

Nucleic Acids Res

journal_title

Nucleic acids research

authors

Kantidze OL,Razin SV

doi

10.1093/nar/gkaa261

subject

Has Abstract

pub_date

2020-05-21 00:00:00

pages

4614-4626

issue

9

eissn

0305-1048

issn

1362-4962

pii

5822964

journal_volume

48

pub_type

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