Abstract:
:Toxicogenomics focuses on assessing the safety of compounds using gene expression profiles. Gene expression signatures from large toxicogenomics databases are expected to perform better than small databases in identifying biomarkers for the prediction and evaluation of drug safety based on a compound's toxicological mechanisms in animal target organs. Over the past 10 years, the Japanese Toxicogenomics Project consortium (TGP) has been developing a large-scale toxicogenomics database consisting of data from 170 compounds (mostly drugs) with the aim of improving and enhancing drug safety assessment. Most of the data generated by the project (e.g. gene expression, pathology, lot number) are freely available to the public via Open TG-GATEs (Toxicogenomics Project-Genomics Assisted Toxicity Evaluation System). Here, we provide a comprehensive overview of the database, including both gene expression data and metadata, with a description of experimental conditions and procedures used to generate the database. Open TG-GATEs is available from http://toxico.nibio.go.jp/english/index.html.
journal_name
Nucleic Acids Resjournal_title
Nucleic acids researchauthors
Igarashi Y,Nakatsu N,Yamashita T,Ono A,Ohno Y,Urushidani T,Yamada Hdoi
10.1093/nar/gku955subject
Has Abstractpub_date
2015-01-01 00:00:00pages
D921-7issue
Database issueeissn
0305-1048issn
1362-4962pii
gku955journal_volume
43pub_type
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