Sperm miR-26a-5p and its target PTEN transcripts content in men with unexplained infertility.

abstract：:Erectile dysfunction (ED) is increasingly recognized as a public health problem. Several studies have reported the influence of the insertion/deletion (I/D) polymorphism in the Angiotensin-converting enzyme (ACE) gene on ED susceptibility, but the results remain controversial. To derive a more precise estimation of th...

journal_title：Andrology

authors： Zhang T,Li WL,He XF,Wu ZY,Liu LH,He SH,Wei AY

更新日期：2013-03-01 00:00:00

abstract：BACKGROUND:Severe peripheral angiopathy in patients with diabetes is a major contributing factor for low response rate to phosphodiesterase-5 inhibitors. OBJECTIVES:To examine whether and how Dickkopf3 (DKK3), a secreted modulator of the Wnt pathway that known to be involved in endothelial cell repair and vascular pro...

journal_title：Andrology

authors： Song KM,Kim WJ,Choi MJ,Limanjaya A,Ghatak K,Minh NN,Ock J,Yin GN,Hong SS,Suh JK,Ryu JK

更新日期：2020-09-01 00:00:00

abstract：:The use of intra-cytoplasmic sperm injection (ICSI) has increased significantly worldwide, often chosen instead of in vitro fertilization (IVF), yet long-term health outcomes are unknown and health differences between ICSI and IVF conceptions have not been comprehensively assessed. A systematic review of health outcom...

journal_title：Andrology

authors： Catford SR,McLachlan RI,O'Bryan MK,Halliday JL

更新日期：2017-07-01 00:00:00

abstract：BACKGROUND:Resistin is known as a potential mediator of obesity-associated insulin resistance. The high resistin level disrupts nitric oxide (NO)-mediated relaxation which is also important in erectile function. An antioxidant alkaloid, Boldine, is known as anti-diabetic and protects endothelial functions. OBJECTIVES:...

journal_title：Andrology

authors： Kara E,Kahraman E,Dayar E,Yetik Anacak G,Demir O,Gidener S,Atabey N,Durmus N

更新日期：2020-11-01 00:00:00

abstract：:Semen analysis is commonly used as a tool to assess the fertility potential of a male, despite its relatively low predictive power. In this study, we have assessed associations between semen analysis findings (low count, low motility, low viability, poor sperm penetration assay results, poor morphology, and increased ...

journal_title：Andrology

authors： Jenkins TG,Aston KI,Hotaling JM,Shamsi MB,Simon L,Carrell DT

更新日期：2016-09-01 00:00:00

abstract：:The second messenger cyclic adenosine monophosphate (cAMP) has a central role in sperm physiology. Extracellular cAMP can be sequentially degraded into 5'AMP and adenosine by ecto-phosphodiesterases (ecto-PDE) and ecto-nucleotidases, a phenomenon called extracellular cAMP-adenosine pathway. As cAMP-adenosine pathway i...

journal_title：Andrology

authors： Bergeron A,Aragon JP,Guillemette C,Hébert A,Sullivan R,Blondin P,Richard FJ

更新日期：2016-11-01 00:00:00

abstract：:Defects in bone regulatory pathways have been linked to chronic diseases including cardiovascular disease and cancer. In men, a link between bone metabolism and gonadal hormones has been suggested. However, to date, there is lack of evidence on the association between serum inorganic phosphate (Pi) and sex steroid hor...

journal_title：Andrology

authors： Wulaningsih W,Van Hemelrijck M,Michaelsson K,Kanarek N,Nelson WG,Ix JH,Platz EA,Rohrmann S

更新日期：2014-11-01 00:00:00

abstract：BACKGROUND:We aimed to examine the effects of pre-operative blood values on varicocelectomy success. MATERIALS AND METHODS:A total of 130 patients who underwent varicocelectomy in our clinic were retrospectively analyzed. Operation success was defined as the return of all semen parameters (concentration, progressive m...

journal_title：Andrology

authors： Erdogan O,Ok F,Carkci S

更新日期：2021-01-21 00:00:00

abstract：:Tributyltin (TBT), a pesticide used in antifouling paints, is toxic for aquatic invertebrates. In vertebrates, TBT may act in obesogen- inducing adipogenetic gene transcription for adipocyte differentiation. In a previous study, we demonstrated that acute administration of TBT induces c-fos expression in the arcuate n...

journal_title：Andrology

authors： Bo E,Farinetti A,Marraudino M,Sterchele D,Eva C,Gotti S,Panzica G

更新日期：2016-07-01 00:00:00

abstract：:The published incidence of bilateral varicocoeles in adults is much higher than among adolescents. We investigated our adolescent varicocoele database to determine (i) the presence of subclinical and palpable right varicocoele s in boys with a left varicocoele, (ii) the effect, if any, of right varicocoele on asymmetr...

journal_title：Andrology

authors： Woldu S,Nees S,Van Batavia J,Spencer B,Glassberg K

更新日期：2013-11-01 00:00:00

abstract：:Spermatogenesis involves the aggregated action of up to 2300 genes, any of which, could, potentially, provide targets for diagnostic tests of male factor infertility. Contrary to the previously proposed common variant hypothesis for common diseases such as male infertility, genome-wide association studies and targeted...

journal_title：Andrology

authors： Hotaling J,Carrell DT

更新日期：2014-05-01 00:00:00

abstract：BACKGROUND:Testicular germ cell tumors (TGCTs) are highly sensitive to platinum-based chemotherapy, and wild-type p53 seems to play a pivotal role in this susceptibility. On the other hand, overexpression of MDM2 seems to entail treatment resistance and unfavorable prognosis. OBJECTIVES:We aimed to describe p53 and MD...

journal_title：Andrology

authors： Lobo J,Alzamora MA,Guimarães R,Cantante M,Lopes P,Braga I,Maurício J,Jerónimo C,Henrique R

更新日期：2020-09-01 00:00:00

abstract：:Interactions between infertility and sexuality are numerous and complex. Infertile men may suffer from sexual dysfunction (SD) when undergoing an assisted reproductive technology programme. We undertook a review both in French and English of the available data on male SD when being diagnosed with a fertility problem w...

journal_title：Andrology

authors： Bechoua S,Hamamah S,Scalici E

更新日期：2016-05-01 00:00:00

abstract：:Erectile Dysfunction is considered a multifactorial disease, where organic and psychological aspects are often interconnected. In a randomized controlled pilot study, we compared the efficacy of combined vardenafil orodispersible tablet (VARD) and cognitive-behavioral sex therapy (CBST) vs. VARD alone in improving sex...

journal_title：Andrology

authors： Boddi V,Castellini G,Casale H,Rastrelli G,Boni L,Corona G,Maggi M

更新日期：2015-09-01 00:00:00

abstract：:The discontinuation rate with phosphodiesterase type 5 inhibitors (PDE5i) remains very high. The aim of this study was to review and meta-analyze currently available data regarding dropout of the first-generation of PDE5i including sildenafil, vardenafil, and tadalafil. An extensive Medline Embase and Cochrane search ...

journal_title：Andrology

authors： Corona G,Rastrelli G,Burri A,Serra E,Gianfrilli D,Mannucci E,Jannini EA,Maggi M

更新日期：2016-11-01 00:00:00

abstract：:Highly active antiretroviral therapy has evolved over the years, leading to a boost in the quality of life in people living with HIV and AIDS. However, growing evidence has shown that highly active antiretroviral therapy has deleterious effects on the testes and the overall reproductive capacity. Therefore, this study...

journal_title：Andrology

authors： Adana MY,Akang EN,Peter AI,Jegede AI,Naidu ECS,Tiloke C,Chuturgoon AA,Azu OO

更新日期：2018-01-01 00:00:00

abstract：STUDY QUESTION:Are de novo mutations in the human genome associated with male infertility? SUMMARY ANSWER:We identified de novo mutations in five candidate genes: SEMA5A, NEURL4, BRD2, CD1D, and CD63. WHAT IS KNOWN ALREADY:Epidemiological and genetic studies have consistently indicated contribution of genetic factors...

journal_title：Andrology

authors： Hodžić A,Maver A,Plaseska-Karanfilska D,Ristanović M,Noveski P,Zorn B,Terzic M,Kunej T,Peterlin B

更新日期：2021-01-01 00:00:00

abstract：:In this study a Bayesian network (BN) has been built for the study of the objective motility of Tinca tinca spermatozoa (spz). Semen from eight 2-year-old sexually mature male tenchs was obtained and motility analyses were performed at 6-17, 23-34 and 40-51 s after activation, using computer-assisted sperm analysis (C...

journal_title：Andrology

authors： Gil Anaya MC,Calle F,Pérez CJ,Martín-Hidalgo D,Fallola C,Bragado MJ,García-Marín LJ,Oropesa AL

更新日期：2015-09-01 00:00:00

abstract：BACKGROUND:The current results of in vitro reproduction techniques in pigs, such as in vitro fertilization (IVF) and embryo development, show high performance with both epididymal and ejaculated spermatozoa. However, the results using ejaculated spermatozoa are even better. Ejaculated spermatozoa are exposed to the sec...

journal_title：Andrology

authors： Soriano-Úbeda C,Avilés-López K,García-Vázquez FA,Romero-Aguirregomezcorta J,Matás C

更新日期：2021-01-01 00:00:00

abstract：:Genomic and protein-coding transcriptomic data have suggested that germ cell tumours (GCTs) of childhood are biologically distinct from those of adulthood. Global messenger RNA profiles segregate malignant GCTs primarily by histology, but then also by age, with numerous transcripts showing age-related differential exp...

journal_title：Andrology

authors： Murray MJ,Nicholson JC,Coleman N

更新日期：2015-01-01 00:00:00

abstract：:Presence of vacuoles and degree of sperm DNA damage are considered to be the basic factors used for the assessment of sperm fertilization capacity. We aimed to investigate the link between these two parameters. According to our knowledge, this is the first study where the Comet assay was used to assess the degree of D...

journal_title：Andrology

authors： Pastuszek E,Kiewisz J,Skowronska P,Liss J,Lukaszuk M,Bruszczynska A,Jakiel G,Lukaszuk K

更新日期：2017-03-01 00:00:00

abstract：:Testosterone (T) deficiency, sexual dysfunction, obesity and obstructive sleep apnea (OSA) are common and often coexist. T prescriptions have increased worldwide during the last decade, including to those with undiagnosed or untreated OSA. The effect of T administration on sexual function, neurocognitive performance a...

journal_title：Andrology

authors： Melehan KL,Hoyos CM,Yee BJ,Wong KK,Buchanan PR,Grunstein RR,Liu PY

更新日期：2016-01-01 00:00:00

abstract：OBJECTIVE:To evaluate the association between cannabis use and testicular function (as assessed through semen quality and serum hormone levels) in different populations. EVIDENCE REVIEW:Systematic review and meta-analysis of population-based retrospective cohort studies. PRISMA guidelines were used for abstracting dat...

journal_title：Andrology

authors： Belladelli F,Del Giudice F,Kasman A,Kold Jensen T,Jørgensen N,Salonia A,Eisenberg ML

更新日期：2020-11-29 00:00:00

abstract：:Exosomes are membranous nanovesicles of endocytic origin that carry and transfer regulatory bioactive molecules and mediate intercellular communication between cells and tissues. Although seminal exosomes have been identified in human seminal plasma, their exact composition and possible physiologic function remain unk...

journal_title：Andrology

authors： Yang C,Guo WB,Zhang WS,Bian J,Yang JK,Zhou QZ,Chen MK,Peng W,Qi T,Wang CY,Liu CD

更新日期：2017-09-01 00:00:00

abstract：BACKGROUND:Concerns exist about the effect of delaying treatment for prostate cancer (PCa) regarding both oncological and functional outcomes after radical prostatectomy (RP). OBJECTIVE:To assess the impact of time from diagnosis to RP on post-operative erectile function (EF) outcomes. MATERIALS AND METHODS:We analyz...

journal_title：Andrology

authors： Schifano N,Capogrosso P,Pozzi E,Ventimiglia E,Cazzaniga W,Matloob R,Gandaglia G,Dehò F,Briganti A,Montorsi F,Salonia A

更新日期：2020-03-01 00:00:00

abstract：:In males, age-related decline in free testosterone (T) and dehydroepiandrosterone (DHEA) by 2-3% per year has been reported. Estradiol (E2) and progesterone (P) seem to decrease as well, but to a lesser extent. Lower sex steroid levels in men have been related to physical and mental symptoms. Low birthweight and left-...

journal_title：Andrology

authors： Hoppler S,Walther A,La Marca-Ghaemmaghami P,Ehlert U

更新日期：2018-11-01 00:00:00

abstract：BACKGROUND:Men with congenital unilateral absence of vas deferens were reported to be mainly azoospermic, with both unilateral renal absence and mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) but some have neither. OBJECTIVES:To assess whether in infertile couples the male partners with co...

journal_title：Andrology

authors： Mieusset R,Bieth E,Daudin M,Isus F,Delaunay B,Bujan L,Monteil L,Fauquet I,Huyghe E,Hamdi SM

更新日期：2020-05-01 00:00:00

abstract：:Scarce data are available on epidemiology of varicocoele, the most common surgically correctable cause of male infertility. The objectives of this study were to evaluate the association between body mass index (BMI) and varicocoele and to assess trends in prevalence over time. We conducted a nationwide population-base...

journal_title：Andrology

authors： Rais A,Zarka S,Derazne E,Tzur D,Calderon-Margalit R,Davidovitch N,Afek A,Carel R,Levine H

更新日期：2013-09-01 00:00:00

abstract：BACKGROUND:The association between alcohol intake and male reproductive function is still controversial. In the frame of a prospective cohort study, designed to investigate the relation between life style and fertility, we performed a cross-sectional analysis of semen quality. METHODS:Men of subfertile couples, referr...

journal_title：Andrology

authors： Ricci E,Noli S,Ferrari S,La Vecchia I,Cipriani S,De Cosmi V,Somigliana E,Parazzini F

更新日期：2018-09-01 00:00:00

abstract：:Maternal overweight and obesity in pregnancy has been associated with earlier age of menarche in daughters as well as reduced semen quality in sons. We aimed at investigating pubertal development in sons born by mothers with a high body mass index (BMI). The study included 2522 sons of mothers that during pregnancy in...

journal_title：Andrology

authors： Hounsgaard ML,Håkonsen LB,Vested A,Thulstrup AM,Olsen J,Bonde JP,Nohr EA,Ramlau-Hansen CH

更新日期：2014-03-01 00:00:00