An investigation of the potential effect of sperm nuclear vacuoles in human spermatozoa on DNA fragmentation using a neutral and alkaline Comet assay.

abstract：:Semen quality is suggested to be a universal biomarker for future health. Previous studies have mostly been registry based excluding the possibility to address the importance of lifestyle, fertility status, health and socio-economic status. We aimed to investigate whether the association between semen quality and subs...

journal_title：Andrology

authors： Latif T,Lindahl-Jacobsen R,Mehlsen J,Eisenberg ML,Holmboe SA,Pors K,Brinth L,Skouby SO,Jørgensen N,Jensen TK

更新日期：2018-05-01 00:00:00

abstract：BACKGROUND:We previously demonstrated how mouse spermatozoa can be efficiently stored for two years in a -80°C freezer, maintaining their ability to fertilize mouse eggs. OBJECTIVES:The main objective here was to evaluate the effects of five years at -80°C compared to liquid nitrogen storage (LN2 , control condition) ...

journal_title：Andrology

authors： Raspa M,Putti S,Paoletti R,Barboni B,Ramal-Sanchez M,Lanuti P,Marchisio M,D'Atri M,Ortolani C,Papa S,Valbonetti L,Bernabo N,Scavizzi F

更新日期：2021-01-11 00:00:00

abstract：BACKGROUND:Recent evidence suggests that routine semen analysis has limited power to predict male fertility. Several efforts have been made to best discriminate between fertile and subfertile men using several sperm features. So, there is a need to more reliable assays for providing molecular data to evaluate sperm qua...

journal_title：Andrology

authors： Dorostghoal M,Galehdari H,Moramezi F,Danyari R

更新日期：2020-09-01 00:00:00

abstract：:To analyze the pathogenesis of persistent and refractory haematospermia and to evaluate the aetiological diagnostic value of magnetic resonance imaging (MRI) for this type of haematospermia. Clinical data from 102 patients with persistent and refractory haematospermia was retrospectively analysed. Data collected inclu...

journal_title：Andrology

authors： Li BJ,Zhang C,Li K,Zhang J,Zhang Y,Sun ZY,Kang HY,Zhou B,Jin FS,Zhang KQ,Li YF

更新日期：2013-11-01 00:00:00

abstract：:Cell-free seminal RNA (cfs-RNA) is mixed transcripts derived from male reproductive organs, and is potential biomarker for the research and diagnosis of male reproductive-related diseases. However, some clinical factors, including age, asymptomatic Ureaplasma urealyticum (UU) infection, scrotal heat stress, abstinence...

journal_title：Andrology

authors： Dong TT,Yu Q,Qing XR,Ma XL,Dong WW,Shi J,Li HG

更新日期：2016-11-01 00:00:00

abstract：:Tributyltin (TBT), a pesticide used in antifouling paints, is toxic for aquatic invertebrates. In vertebrates, TBT may act in obesogen- inducing adipogenetic gene transcription for adipocyte differentiation. In a previous study, we demonstrated that acute administration of TBT induces c-fos expression in the arcuate n...

journal_title：Andrology

authors： Bo E,Farinetti A,Marraudino M,Sterchele D,Eva C,Gotti S,Panzica G

更新日期：2016-07-01 00:00:00

abstract：BACKGROUND:The existing classifications of varicocoeles have poor predictive value regarding the effects of surgery on sperm count. OBJECTIVE:To develop a new grading system for varicocoeles, useful as an indication for surgery. MATERIALS AND METHODS:This is a three-center prospective study which examined 173 men hav...

journal_title：Andrology

authors： Cavallini G,Scroppo FI,Colpi GM

更新日期：2019-01-01 00:00:00

abstract：:Defects in bone regulatory pathways have been linked to chronic diseases including cardiovascular disease and cancer. In men, a link between bone metabolism and gonadal hormones has been suggested. However, to date, there is lack of evidence on the association between serum inorganic phosphate (Pi) and sex steroid hor...

journal_title：Andrology

authors： Wulaningsih W,Van Hemelrijck M,Michaelsson K,Kanarek N,Nelson WG,Ix JH,Platz EA,Rohrmann S

更新日期：2014-11-01 00:00:00

abstract：:Interactions between infertility and sexuality are numerous and complex. Infertile men may suffer from sexual dysfunction (SD) when undergoing an assisted reproductive technology programme. We undertook a review both in French and English of the available data on male SD when being diagnosed with a fertility problem w...

journal_title：Andrology

authors： Bechoua S,Hamamah S,Scalici E

更新日期：2016-05-01 00:00:00

abstract：BACKGROUND:At the beginning of the 20th century, the Viennese physiologist Eugen Steinach proposed to treat the effects of physiological ageing by vasectomy. After experimenting his theory with animal, he published his results, and convinced scientists to apply this method to humans (ie men). The scientific community h...

journal_title：Andrology

authors： Benmoussa N,Charlier P,Rebibo JD

更新日期：2020-05-01 00:00:00

abstract：BACKGROUND:Despite existing evidence regarding the role of testosterone as a protective factor for the kidney function in male adults, there are conflicting and inconclusive results on the influence of testosterone deficiency on developing chronic kidney disease (CKD). OBJECTIVE:This study aimed to investigate the inc...

journal_title：Andrology

authors： Amiri M,Ramezani Tehrani F,Rahmati M,Amanollahi Soudmand S,Behboudi-Gandevani S,Sabet Z,Azizi F

更新日期：2020-05-01 00:00:00

abstract：BACKGROUND:Penile cancer represents a rare pathology whose natural history of treatment is poorly understood. OBJECTIVE:To illustrate the dynamic survival profiles in surgically treated patients with squamous cell carcinoma of the penis (SCCP) using the conditional survival (CS) estimates. MATERIALS AND METHODS:Patie...

journal_title：Andrology

authors： Liu W,Luo Y,Wang G,Li N,Wang Z,Lei J,Wang X

更新日期：2020-11-01 00:00:00

abstract：:Increasing evidence disclosed the existence of a novel multi-organ endocrine pathway, involving bone, pancreas and testis, of high penetrance in energy metabolism and male fertility. The main mediator of this axis is undercarboxylated osteocalcin (ucOC), a bone-derived protein-exerting systemic effects on tissues expr...

journal_title：Andrology

authors： De Toni L,Di Nisio A,Rocca MS,De Rocco Ponce M,Ferlin A,Foresta C

更新日期：2017-07-01 00:00:00

abstract：:Nitric oxide is a physiologic signal essential to penile erection. l-citrulline (l-Cit) is converted into l-arginine (l-Arg), the precursor from which nitric oxide is generated. The level of l-Arg and l-Cit in the field of male sexual function remains relatively underexplored. The aim of the study was to evaluate the ...

journal_title：Andrology

authors： Barassi A,Corsi Romanelli MM,Pezzilli R,Damele CA,Vaccalluzzo L,Goi G,Papini N,Colpi GM,Massaccesi L,Melzi d'Eril GV

更新日期：2017-03-01 00:00:00

abstract：:Tamoxifen is an off-label option to treat men for breast cancer, infertility, and idiopathic gynecomastia. Lately, tamoxifen has been proposed as a treatment to prevent gynecomastia in prostate cancer patients receiving antiandrogen therapy. We reviewed the adverse events (AEs) reported in studies of men prescribed ta...

journal_title：Andrology

authors： Wibowo E,Pollock PA,Hollis N,Wassersug RJ

更新日期：2016-09-01 00:00:00

abstract：:Estrogens are involved in growth, differentiation and pathogenesis of human prostate through the mediation of the classical estrogen receptors ERα and ERβ. The G protein-coupled estrogen receptor (GPER) is a 'novel' mediator of estrogen signaling which has been recently recognized in some human reproductive tissues, b...

journal_title：Andrology

authors： Rago V,Romeo F,Giordano F,Ferraro A,Carpino A

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Diabetes mellitus is one of the risk factors for male subfertility/infertility. Malaysian propolis is reported to decrease hyperglycaemia in diabetic state. OBJECTIVES:The present study investigated the protective effect of Malaysian propolis on diabetes-induced subfertility/infertility. Additionally, its c...

journal_title：Andrology

authors： Nna VU,Bakar ABA,Ahmad A,Umar UZ,Suleiman JB,Zakaria Z,Othman ZA,Mohamed M

更新日期：2020-05-01 00:00:00

abstract：BACKGROUND:A significant increase in the use of intracytoplasmic sperm injection (ICSI) since its introduction in 1992 has been observed worldwide, including beyond its original intended use for severe male factor infertility. Concerns regarding ICSI include the effects of poor quality spermatozoa on offspring health a...

journal_title：Andrology

authors： Catford SR,McLachlan RI,O'Bryan MK,Halliday JL

更新日期：2018-09-01 00:00:00

abstract：:Erectile dysfunction (ED) is very prevalent in the older population, although the ageing-related mechanisms involved in the development of ED are poorly understood. We propose that age-induced differences in nerve- and endothelium-mediated smooth muscle contractility in the corpus cavernosum (CC) could be found betwee...

journal_title：Andrology

authors： Lafuente-Sanchis A,Triguero D,Garcia-Pascual A

更新日期：2014-07-01 00:00:00

abstract：STUDY QUESTION:Are de novo mutations in the human genome associated with male infertility? SUMMARY ANSWER:We identified de novo mutations in five candidate genes: SEMA5A, NEURL4, BRD2, CD1D, and CD63. WHAT IS KNOWN ALREADY:Epidemiological and genetic studies have consistently indicated contribution of genetic factors...

journal_title：Andrology

authors： Hodžić A,Maver A,Plaseska-Karanfilska D,Ristanović M,Noveski P,Zorn B,Terzic M,Kunej T,Peterlin B

更新日期：2021-01-01 00:00:00

abstract：:The published incidence of bilateral varicocoeles in adults is much higher than among adolescents. We investigated our adolescent varicocoele database to determine (i) the presence of subclinical and palpable right varicocoele s in boys with a left varicocoele, (ii) the effect, if any, of right varicocoele on asymmetr...

journal_title：Andrology

authors： Woldu S,Nees S,Van Batavia J,Spencer B,Glassberg K

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND:Gene expression patterns along the epididymis are established by specific transcription factor networks that coordinate region-specific functions. In rodents, the epididymis can be divided in up to 19 segments. Based on gross anatomy, the human epididymis is divided into caput, corpus, and cauda segments tog...

journal_title：Andrology

authors： Légaré C,Sullivan R

更新日期：2020-05-01 00:00:00

abstract：BACKGROUND:Bulls are of great importance in the productive chain and for this reason they should have a good semen quality. There is no doubt that sperm morphology is very important to bull fertility, although little is known about how exactly the abnormal morphologies may affect sperm functions. OBJECTIVES:To detail ...

journal_title：Andrology

authors： Díaz-Miranda EA,Maitan PP,Machado TP,Camilo BS,Lima DA,Okano DS,Penitente-Filho JM,Machado-Neves M,de Oliveira LL,Guimarães SEF,da Costa EP,Guimarães JD

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:The association between alcohol intake and male reproductive function is still controversial. In the frame of a prospective cohort study, designed to investigate the relation between life style and fertility, we performed a cross-sectional analysis of semen quality. METHODS:Men of subfertile couples, referr...

journal_title：Andrology

authors： Ricci E,Noli S,Ferrari S,La Vecchia I,Cipriani S,De Cosmi V,Somigliana E,Parazzini F

更新日期：2018-09-01 00:00:00

abstract：:The medical treatment is indicated in the development stage of Peyronie's disease (PD) for at least 1 year after diagnosis and whenever in case of penile pain. This research was conducted to demonstrate the possible effectiveness of vitamin E in PD treatment, whereas in the scientific literature this topic is much dis...

journal_title：Andrology

authors： Paulis G,Brancato T,D'Ascenzo R,De Giorgio G,Nupieri P,Orsolini G,Alvaro R

更新日期：2013-01-01 00:00:00

abstract：:In recent reports, an association between altered TRPC channel function and the development of various diabetic complications has drawn the attention of many investigators. The aim of this study was to investigate the expression of TRPC4 channels of corpus smooth muscle (CSM) cells in diabetes, and to evaluate the ass...

journal_title：Andrology

authors： Sung HH,Choo SH,Ko M,Kang SJ,Chae MR,Kam SC,Han DH,So I,Lee SW

更新日期：2014-07-01 00:00:00

abstract：:Deletions on the long arm of the Y chromosome are a well-known cause of male infertility and it is generally accepted that deletions involving the AZFb region are not compatible with sperm production. Here, we report on two patients for whom basic diagnostic tests showed a deletion of the AZFb region. Unexpectedly, bo...

journal_title：Andrology

authors： Stouffs K,Vloeberghs V,Gheldof A,Tournaye H,Seneca S

更新日期：2017-07-01 00:00:00

abstract：:Bisphenol A (BPA) is widely used in food contact materials, toys, and other products. Several studies have indicated that effects observed at doses near human exposure levels may not be observed at higher doses. Many studies have shown effects on mammary glands at low doses of BPA, however, because of small number of ...

journal_title：Andrology

authors： Mandrup K,Boberg J,Isling LK,Christiansen S,Hass U

更新日期：2016-07-01 00:00:00

abstract：OBJECTIVE:Testicular germ cell tumour (TGCT) is a malignancy with a high heritable component. The inherited risk is polygenic, and around 50 susceptibility genes are identified. The functional role of the gene products for TGCT development is not well understood. The focus of this review is functional studies of geneti...

journal_title：Andrology

authors： Das MK,Kleppa L,Haugen TB

更新日期：2019-07-01 00:00:00

abstract：:The second messenger cyclic adenosine monophosphate (cAMP) has a central role in sperm physiology. Extracellular cAMP can be sequentially degraded into 5'AMP and adenosine by ecto-phosphodiesterases (ecto-PDE) and ecto-nucleotidases, a phenomenon called extracellular cAMP-adenosine pathway. As cAMP-adenosine pathway i...

journal_title：Andrology

authors： Bergeron A,Aragon JP,Guillemette C,Hébert A,Sullivan R,Blondin P,Richard FJ

更新日期：2016-11-01 00:00:00