Abstract:
BACKGROUND:Diabetes mellitus is one of the risk factors for male subfertility/infertility. Malaysian propolis is reported to decrease hyperglycaemia in diabetic state. OBJECTIVES:The present study investigated the protective effect of Malaysian propolis on diabetes-induced subfertility/infertility. Additionally, its combined beneficial effects with metformin were investigated. MATERIALS AND METHODS:Forty adult male Sprague Dawley rats were randomly assigned into five groups, namely normal control, diabetic control, diabetic + Malaysian propolis (300 mg/k.g. b.w.), diabetic + metformin (300 mg/kg b.w.) and diabetic + Malaysian propolis + metformin. Diabetes was induced using a single intraperitoneal injection of streptozotocin (60 mg/kg b.w.) and treatment lasted for 4 weeks. During the 4th week, mating behavioural experiments were performed using sexually receptive female rats. Thereafter, fertility parameters were assessed in the female rats. RESULTS:Malaysian propolis increased serum and intratesticular free testosterone levels, up-regulated the mRNA levels of AR and luteinizing hormone receptor, up-regulated the mRNA and protein levels of StAR, CYP11A1, CYP17A1, 3β-HSD and 17β-HSD in the testes of diabetic rats. Furthermore, Malaysian propolis up-regulated testicular MCT2, MCT4 and lactate dehydrogenase type C mRNA levels, in addition to improving sperm parameters (count, motility, viability and normal morphology) and decreasing sperm nDNA fragmentation in diabetic rats. Malaysian propolis improved mating behaviour by increasing penile guanosine monophosphate levels. Malaysian propolis also improved fertility outcome as seen with decreases in pre- and post-implantation losses, increases in gravid uterine weight, litter size per dam and foetal weight. Malaysian propolis's effects were comparable to metformin. However, their combination yielded better results relative to the monotherapeutic interventions. CONCLUSION:Malaysian propolis improves fertility potential in diabetic state by targeting steroidogenesis, testicular lactate metabolism, spermatogenesis and mating behaviour, with better effects when co-administered with metformin. Therefore, Malaysian propolis shows a promising complementary effect with metformin in mitigating Diabetes mellitus-induced subfertility/infertility.
journal_name
Andrologyjournal_title
Andrologyauthors
Nna VU,Bakar ABA,Ahmad A,Umar UZ,Suleiman JB,Zakaria Z,Othman ZA,Mohamed Mdoi
10.1111/andr.12739subject
Has Abstractpub_date
2020-05-01 00:00:00pages
731-746issue
3eissn
2047-2919issn
2047-2927journal_volume
8pub_type
杂志文章相关文献
Andrology文献大全abstract::Maternal overweight and obesity in pregnancy has been associated with earlier age of menarche in daughters as well as reduced semen quality in sons. We aimed at investigating pubertal development in sons born by mothers with a high body mass index (BMI). The study included 2522 sons of mothers that during pregnancy in...
journal_title:Andrology
pub_type: 杂志文章
doi:10.1111/j.2047-2927.2013.00171.x
更新日期:2014-03-01 00:00:00
abstract::In cryptorchid boys, failures in germ cell development have been clearly established. Some studies reported some abnormalities in Sertoli cells morphology but the results regarding their endocrine secretion remain controversial. To compare testicular hormone levels in young boys with and without cryptorchidism, we per...
journal_title:Andrology
pub_type: 杂志文章
doi:10.1111/andr.12373
更新日期:2017-07-01 00:00:00
abstract::The double sex and mab-3-related transcription factor 1 (DMRT1) gene has long been linked to sex-determining pathways across vertebrates and is known to play an essential role in gonadal development and maintenance of spermatogenesis in mice. In humans, the genomic region harboring the DMRT gene cluster has been impli...
journal_title:Andrology
pub_type: 杂志文章
doi:10.1111/andr.12063
更新日期:2015-09-01 00:00:00
abstract:BACKGROUND:Knowledge about Klinefelter syndrome (KS) has increased substantially since its first description almost 80 years ago. A variety of treatment options concerning the spectrum of symptoms associated with KS exists, also regarding aspects beyond testicular dysfunction. Nevertheless, the diagnostic rate is still...
journal_title:Andrology
pub_type: 杂志文章,评审
doi:10.1111/andr.12909
更新日期:2021-01-01 00:00:00
abstract::Treatment of testicular cancer includes the coadministration of bleomycin, etoposide and cis-platinum (BEP); however, along with its therapeutic benefit, BEP exposure results in extensive reproductive chemotoxic effects, including alterations to sperm chromatin integrity. As an intact paternal genome is essential for ...
journal_title:Andrology
pub_type: 杂志文章
doi:10.1111/j.2047-2927.2014.00185.x
更新日期:2014-03-01 00:00:00
abstract::Spermiogenesis is the final phase of spermatogenesis. During this process, haploid round spermatids differentiate into spermatozoa, with dramatic morphological changes, including elongation and condensation of the nuclei, and formation of the flagella. Meig1 is one of many genes involved in the regulation of this proc...
journal_title:Andrology
pub_type: 杂志文章
doi:10.1111/j.2047-2927.2013.00069.x
更新日期:2013-05-01 00:00:00
abstract::Nitric oxide is a physiologic signal essential to penile erection. l-citrulline (l-Cit) is converted into l-arginine (l-Arg), the precursor from which nitric oxide is generated. The level of l-Arg and l-Cit in the field of male sexual function remains relatively underexplored. The aim of the study was to evaluate the ...
journal_title:Andrology
pub_type: 杂志文章
doi:10.1111/andr.12293
更新日期:2017-03-01 00:00:00
abstract:OBJECTIVE:To evaluate the association between cannabis use and testicular function (as assessed through semen quality and serum hormone levels) in different populations. EVIDENCE REVIEW:Systematic review and meta-analysis of population-based retrospective cohort studies. PRISMA guidelines were used for abstracting dat...
journal_title:Andrology
pub_type: 杂志文章
doi:10.1111/andr.12953
更新日期:2020-11-29 00:00:00
abstract::Increasing evidence disclosed the existence of a novel multi-organ endocrine pathway, involving bone, pancreas and testis, of high penetrance in energy metabolism and male fertility. The main mediator of this axis is undercarboxylated osteocalcin (ucOC), a bone-derived protein-exerting systemic effects on tissues expr...
journal_title:Andrology
pub_type: 杂志文章,评审
doi:10.1111/andr.12359
更新日期:2017-07-01 00:00:00
abstract::Testosterone (T) deficiency, sexual dysfunction, obesity and obstructive sleep apnea (OSA) are common and often coexist. T prescriptions have increased worldwide during the last decade, including to those with undiagnosed or untreated OSA. The effect of T administration on sexual function, neurocognitive performance a...
journal_title:Andrology
pub_type: 杂志文章,随机对照试验
doi:10.1111/andr.12132
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:Oocyte activation is driven by intracellular calcium (Ca2+ ) oscillations induced by sperm-specific PLCζ, abrogation of which causes oocyte activation deficiency in humans. Clinical PLCζ investigations have been limited to severe male infertility conditions, while PLCζ levels and localisation patterns have y...
journal_title:Andrology
pub_type: 杂志文章
doi:10.1111/andr.12796
更新日期:2020-09-01 00:00:00
abstract:BACKGROUND:Concerns exist about the effect of delaying treatment for prostate cancer (PCa) regarding both oncological and functional outcomes after radical prostatectomy (RP). OBJECTIVE:To assess the impact of time from diagnosis to RP on post-operative erectile function (EF) outcomes. MATERIALS AND METHODS:We analyz...
journal_title:Andrology
pub_type: 杂志文章
doi:10.1111/andr.12699
更新日期:2020-03-01 00:00:00
abstract::The morphology, ultrastructure, and functions of mature avian spermatozoa have been of immense commercial and scientific interest for several reasons. This is mainly important in case of birds in poultry production, conservation, and in the use of sperm morphometry as phylogenetic evidence. Avian spermatozoa share com...
journal_title:Andrology
pub_type: 杂志文章
doi:10.1111/andr.12130
更新日期:2016-03-01 00:00:00
abstract:BACKGROUND:The association between alcohol intake and male reproductive function is still controversial. In the frame of a prospective cohort study, designed to investigate the relation between life style and fertility, we performed a cross-sectional analysis of semen quality. METHODS:Men of subfertile couples, referr...
journal_title:Andrology
pub_type: 杂志文章
doi:10.1111/andr.12521
更新日期:2018-09-01 00:00:00
abstract::The published incidence of bilateral varicocoeles in adults is much higher than among adolescents. We investigated our adolescent varicocoele database to determine (i) the presence of subclinical and palpable right varicocoele s in boys with a left varicocoele, (ii) the effect, if any, of right varicocoele on asymmetr...
journal_title:Andrology
pub_type: 杂志文章
doi:10.1111/j.2047-2927.2013.00130.x
更新日期:2013-11-01 00:00:00
abstract::Bisphenol A (BPA) is widely used in food contact materials, toys, and other products. Several studies have indicated that effects observed at doses near human exposure levels may not be observed at higher doses. Many studies have shown effects on mammary glands at low doses of BPA, however, because of small number of ...
journal_title:Andrology
pub_type: 杂志文章
doi:10.1111/andr.12193
更新日期:2016-07-01 00:00:00
abstract::Genomic and protein-coding transcriptomic data have suggested that germ cell tumours (GCTs) of childhood are biologically distinct from those of adulthood. Global messenger RNA profiles segregate malignant GCTs primarily by histology, but then also by age, with numerous transcripts showing age-related differential exp...
journal_title:Andrology
pub_type: 杂志文章,评审
doi:10.1111/andr.277
更新日期:2015-01-01 00:00:00
abstract::The main aim of this work was to evaluate how supplementing freezing media with reduced glutathione (GSH) affected the 'in vivo' fertilizing ability of boar semen subjected to cryopreservation procedures. With this purpose, 12 ejaculates coming from 12 boars were cryopreserved in the presence or absence of 2 mm GSH, w...
journal_title:Andrology
pub_type: 杂志文章
doi:10.1111/j.2047-2927.2013.00144.x
更新日期:2014-01-01 00:00:00
abstract:STUDY QUESTION:Are de novo mutations in the human genome associated with male infertility? SUMMARY ANSWER:We identified de novo mutations in five candidate genes: SEMA5A, NEURL4, BRD2, CD1D, and CD63. WHAT IS KNOWN ALREADY:Epidemiological and genetic studies have consistently indicated contribution of genetic factors...
journal_title:Andrology
pub_type: 杂志文章
doi:10.1111/andr.12897
更新日期:2021-01-01 00:00:00
abstract:BACKGROUND:The existing classifications of varicocoeles have poor predictive value regarding the effects of surgery on sperm count. OBJECTIVE:To develop a new grading system for varicocoeles, useful as an indication for surgery. MATERIALS AND METHODS:This is a three-center prospective study which examined 173 men hav...
journal_title:Andrology
pub_type: 杂志文章,多中心研究
doi:10.1111/andr.12556
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:Germ cells have a unique and critical role as the conduit for hereditary information and therefore employ multiple strategies to protect genomic integrity and avoid mutations. Unlike somatic cells, which often respond to DNA damage by arresting the cell cycle and conducting DNA repair, germ cells as well as ...
journal_title:Andrology
pub_type: 杂志文章,评审
doi:10.1111/andr.12651
更新日期:2019-07-01 00:00:00
abstract::Scrotal skin is thin and has high steroid permeability, but the pharmacokinetics of testosterone via the scrotal skin route has not been studied in detail. The aim of this study was to define the pharmacokinetics of testosterone delivered via the scrotal skin route. The study was a single-center, three-phase cross-ove...
journal_title:Andrology
pub_type: 杂志文章,随机对照试验
doi:10.1111/andr.12357
更新日期:2017-07-01 00:00:00
abstract::Defects in bone regulatory pathways have been linked to chronic diseases including cardiovascular disease and cancer. In men, a link between bone metabolism and gonadal hormones has been suggested. However, to date, there is lack of evidence on the association between serum inorganic phosphate (Pi) and sex steroid hor...
journal_title:Andrology
pub_type: 杂志文章
doi:10.1111/andr.285
更新日期:2014-11-01 00:00:00
abstract::Testicular germ cell tumours (TGCT) typically contain high numbers of infiltrating immune cells, yet the functional nature and consequences of interactions between GCNIS (germ cell neoplasia in situ) or seminoma cells and immune cells remain unknown. A co-culture model using the seminoma-derived TCam-2 cell line and p...
journal_title:Andrology
pub_type: 杂志文章
doi:10.1111/andr.12365
更新日期:2017-07-01 00:00:00
abstract::The use of intra-cytoplasmic sperm injection (ICSI) has increased significantly worldwide, often chosen instead of in vitro fertilization (IVF), yet long-term health outcomes are unknown and health differences between ICSI and IVF conceptions have not been comprehensively assessed. A systematic review of health outcom...
journal_title:Andrology
pub_type: 杂志文章,评审
doi:10.1111/andr.12369
更新日期:2017-07-01 00:00:00
abstract:BACKGROUND:The transcription factor DMRTB1 plays a pivotal role in coordinating the transition between mitosis and meiosis in murine germ cells. No reliable data are available for human testis. OBJECTIVES:The present study aims to examine the testicular expression pattern of DMRTB1 in men showing normal and impaired s...
journal_title:Andrology
pub_type: 杂志文章
doi:10.1111/andr.12617
更新日期:2019-07-01 00:00:00
abstract:OBJECTIVE:To investigate the possible role of serum norepinephrine (NE), leptin, and 5-hydroxytryptamine (5-HT) and their correlations with sympathetic skin response located in the penis (PSSR) in primary premature ejaculation (PPE). METHODS:We compared the serum level of NE, leptin, and 5-HT, intravaginal ejaculatory...
journal_title:Andrology
pub_type: 杂志文章
doi:10.1111/andr.12773
更新日期:2020-09-01 00:00:00
abstract::Zona pellucida-based induction of acrosome reaction (AR) is a popular and well-accepted hypothesis. However, this hypothesis is being challenged in recent years and it has been proposed that the cumulus cells might be the site of AR. In our previous study, we reported the presence of a synaptic protein Liprin α3 on sp...
journal_title:Andrology
pub_type: 杂志文章
doi:10.1111/j.2047-2927.2013.00167
更新日期:2014-03-01 00:00:00
abstract::Escherichia coli (E. coli) is a common pathogen in epididymitis, which represents a prevalent entity in male reproductive tract infections (RTI). Although current treatment regimens using antibiotics are satisfactory, development of antimicrobial resistance by the pathogen represents a challenge in the management of R...
journal_title:Andrology
pub_type: 杂志文章
doi:10.1111/andr.12012
更新日期:2015-03-01 00:00:00
abstract::Sperm DNA fragmentation varies between individuals and is more pronounced with increased patient age and time after sperm donation. The intensification of DNA fragmentation depends on the balance of the oxidoreductive system, which is regulated mainly by two enzymes - superoxide dismutase (SOD) and catalase. The objec...
journal_title:Andrology
pub_type: 杂志文章
doi:10.1111/andr.12061
更新日期:2015-07-01 00:00:00