Abstract:
BACKGROUND:The association between alcohol intake and male reproductive function is still controversial. In the frame of a prospective cohort study, designed to investigate the relation between life style and fertility, we performed a cross-sectional analysis of semen quality. METHODS:Men of subfertile couples, referring to an Italian Infertility Unit and eligible for assisted reproductive techniques (ARTs), were asked about their lifestyle: BMI, smoking, caffeine intake, occupational and leisure physical activity (PA) and alcohol intake in the last year before ART procedure. Semen volume, sperm concentration, total sperm count and sperm motility were determined. Age, risk factors for impaired male fertility, caffeine, smoking, leisure PA, days of abstinence and daily calories intake were accounted for in the analyses. RESULTS:Between September 2014 and December 2016, we enrolled 323 male patients, mean age 39.3 years. Thirty-one (9.6%) were abstainers, 97 (30.0%) drank <1-3, 98 (30.3%) 4-7 and 97 (30.0%) ≥8 alcohol units per week. As compared to men drinking <1-3 units per week, median semen volume was higher in the 4-7 units/week group (3.0 mL, interquartile range, IQR, 2.0-4.0 vs. 2.4 mL, IQR 1.7-3.5), as well as total sperm count (87.9 mil/mL, IQR 20.2-182.1 vs. 51.5 mil/mL, IQR 15.2-114.7). Association with sperm concentration was also significant, with a U-shaped trend in groups of alcohol intake. After adjusting for potential confounders, these relations were confirmed. Similar patterns were observed in subgroups of leisure PA and risk factors for impaired male fertility, although these estimates often lacked statistical significance, presumably because of low sample size. CONCLUSIONS:Moderate alcohol intake appears positively associated to semen quality in male partners of infertile couples undergoing ARTs.
journal_name
Andrologyjournal_title
Andrologyauthors
Ricci E,Noli S,Ferrari S,La Vecchia I,Cipriani S,De Cosmi V,Somigliana E,Parazzini Fdoi
10.1111/andr.12521subject
Has Abstractpub_date
2018-09-01 00:00:00pages
690-696issue
5eissn
2047-2919issn
2047-2927journal_volume
6pub_type
杂志文章相关文献
Andrology文献大全abstract::Cell-free seminal RNA (cfs-RNA) is mixed transcripts derived from male reproductive organs, and is potential biomarker for the research and diagnosis of male reproductive-related diseases. However, some clinical factors, including age, asymptomatic Ureaplasma urealyticum (UU) infection, scrotal heat stress, abstinence...
journal_title:Andrology
pub_type: 杂志文章
doi:10.1111/andr.12238
更新日期:2016-11-01 00:00:00
abstract::The second messenger cyclic adenosine monophosphate (cAMP) has a central role in sperm physiology. Extracellular cAMP can be sequentially degraded into 5'AMP and adenosine by ecto-phosphodiesterases (ecto-PDE) and ecto-nucleotidases, a phenomenon called extracellular cAMP-adenosine pathway. As cAMP-adenosine pathway i...
journal_title:Andrology
pub_type: 杂志文章
doi:10.1111/andr.12267
更新日期:2016-11-01 00:00:00
abstract::Scarce data are available on epidemiology of varicocoele, the most common surgically correctable cause of male infertility. The objectives of this study were to evaluate the association between body mass index (BMI) and varicocoele and to assess trends in prevalence over time. We conducted a nationwide population-base...
journal_title:Andrology
pub_type: 杂志文章
doi:10.1111/j.2047-2927.2013.00113.x
更新日期:2013-09-01 00:00:00
abstract:BACKGROUND:Germ cells have a unique and critical role as the conduit for hereditary information and therefore employ multiple strategies to protect genomic integrity and avoid mutations. Unlike somatic cells, which often respond to DNA damage by arresting the cell cycle and conducting DNA repair, germ cells as well as ...
journal_title:Andrology
pub_type: 杂志文章,评审
doi:10.1111/andr.12651
更新日期:2019-07-01 00:00:00
abstract::Increasing evidence disclosed the existence of a novel multi-organ endocrine pathway, involving bone, pancreas and testis, of high penetrance in energy metabolism and male fertility. The main mediator of this axis is undercarboxylated osteocalcin (ucOC), a bone-derived protein-exerting systemic effects on tissues expr...
journal_title:Andrology
pub_type: 杂志文章,评审
doi:10.1111/andr.12359
更新日期:2017-07-01 00:00:00
abstract::In recent reports, an association between altered TRPC channel function and the development of various diabetic complications has drawn the attention of many investigators. The aim of this study was to investigate the expression of TRPC4 channels of corpus smooth muscle (CSM) cells in diabetes, and to evaluate the ass...
journal_title:Andrology
pub_type: 杂志文章
doi:10.1111/j.2047-2927.2014.00214.x
更新日期:2014-07-01 00:00:00
abstract:BACKGROUND:Regulatory bodies recommend inconsistent ejaculatory abstinence lengths before semen analysis. The literature exploring the effect of ejaculatory abstinence length on the outcomes of intracytoplasmic sperm injection is scarce. OBJECTIVE:To study the influence of ejaculatory abstinence length on semen qualit...
journal_title:Andrology
pub_type: 杂志文章
doi:10.1111/andr.12572
更新日期:2019-03-01 00:00:00
abstract::Interactions between infertility and sexuality are numerous and complex. Infertile men may suffer from sexual dysfunction (SD) when undergoing an assisted reproductive technology programme. We undertook a review both in French and English of the available data on male SD when being diagnosed with a fertility problem w...
journal_title:Andrology
pub_type: 杂志文章,评审
doi:10.1111/andr.12160
更新日期:2016-05-01 00:00:00
abstract::Research in the last decade has revealed that bone is not only a target tissue for numerous circulating hormones but functions as an endocrine organ itself. As a recent study demonstrated a stimulatory effect of the osteoblast-derived hormone osteocalcin (OCN) on testosterone production in mice, we investigated whethe...
journal_title:Andrology
pub_type: 杂志文章
doi:10.1111/j.2047-2927.2012.00044.x
更新日期:2013-05-01 00:00:00
abstract::Highly active antiretroviral therapy has evolved over the years, leading to a boost in the quality of life in people living with HIV and AIDS. However, growing evidence has shown that highly active antiretroviral therapy has deleterious effects on the testes and the overall reproductive capacity. Therefore, this study...
journal_title:Andrology
pub_type: 杂志文章
doi:10.1111/andr.12439
更新日期:2018-01-01 00:00:00
abstract::Our objective was to study the birth defect rates in intracytoplasmic morphologically selected sperm injection (IMSI) pregnancies. A cohort of couples presenting male factor infertility between January 2006 and January 2014 was retrospectively analyzed. Discharge letters and a telephone interview were performed for as...
journal_title:Andrology
pub_type: 杂志文章
doi:10.1111/andr.12221
更新日期:2016-09-01 00:00:00
abstract:BACKGROUND:Testicular germ cell tumors (TGCTs) are highly sensitive to platinum-based chemotherapy, and wild-type p53 seems to play a pivotal role in this susceptibility. On the other hand, overexpression of MDM2 seems to entail treatment resistance and unfavorable prognosis. OBJECTIVES:We aimed to describe p53 and MD...
journal_title:Andrology
pub_type: 杂志文章
doi:10.1111/andr.12814
更新日期:2020-09-01 00:00:00
abstract:BACKGROUND:Maximum urinary flow rate (Qmax) is usually increased after holmium laser enucleation of the prostate (HoLEP). However, improvements vary between patients and results regarding potential predictors of Qmax after HoLEP are inconsistent. Thus, we investigated pre-operative variables including second to fourth ...
journal_title:Andrology
pub_type: 杂志文章
doi:10.1111/andr.12564
更新日期:2019-03-01 00:00:00
abstract::Defects in bone regulatory pathways have been linked to chronic diseases including cardiovascular disease and cancer. In men, a link between bone metabolism and gonadal hormones has been suggested. However, to date, there is lack of evidence on the association between serum inorganic phosphate (Pi) and sex steroid hor...
journal_title:Andrology
pub_type: 杂志文章
doi:10.1111/andr.285
更新日期:2014-11-01 00:00:00
abstract:OBJECTIVE:To evaluate the association between cannabis use and testicular function (as assessed through semen quality and serum hormone levels) in different populations. EVIDENCE REVIEW:Systematic review and meta-analysis of population-based retrospective cohort studies. PRISMA guidelines were used for abstracting dat...
journal_title:Andrology
pub_type: 杂志文章
doi:10.1111/andr.12953
更新日期:2020-11-29 00:00:00
abstract::Deletions on the long arm of the Y chromosome are a well-known cause of male infertility and it is generally accepted that deletions involving the AZFb region are not compatible with sperm production. Here, we report on two patients for whom basic diagnostic tests showed a deletion of the AZFb region. Unexpectedly, bo...
journal_title:Andrology
pub_type: 杂志文章
doi:10.1111/andr.12350
更新日期:2017-07-01 00:00:00
abstract::In cryptorchid boys, failures in germ cell development have been clearly established. Some studies reported some abnormalities in Sertoli cells morphology but the results regarding their endocrine secretion remain controversial. To compare testicular hormone levels in young boys with and without cryptorchidism, we per...
journal_title:Andrology
pub_type: 杂志文章
doi:10.1111/andr.12373
更新日期:2017-07-01 00:00:00
abstract:OBJECTIVE:Testicular germ cell tumour (TGCT) is a malignancy with a high heritable component. The inherited risk is polygenic, and around 50 susceptibility genes are identified. The functional role of the gene products for TGCT development is not well understood. The focus of this review is functional studies of geneti...
journal_title:Andrology
pub_type: 杂志文章,评审
doi:10.1111/andr.12663
更新日期:2019-07-01 00:00:00
abstract:BACKGROUND:Testicular architecture and sperm production are supported by a complex network of communication between various cell types. These signals ensure fertility by: regulating spermatogonial stem/progenitor cells; promoting steroidogenesis; and driving male-specific differentiation of the gonad. Sertoli cells hav...
journal_title:Andrology
pub_type: 杂志文章,评审
doi:10.1111/andr.12703
更新日期:2020-07-01 00:00:00
abstract::Escherichia coli (E. coli) is a common pathogen in epididymitis, which represents a prevalent entity in male reproductive tract infections (RTI). Although current treatment regimens using antibiotics are satisfactory, development of antimicrobial resistance by the pathogen represents a challenge in the management of R...
journal_title:Andrology
pub_type: 杂志文章
doi:10.1111/andr.12012
更新日期:2015-03-01 00:00:00
abstract::Growth hormone (GH) and insulin-like growth factor I (IGF-I) receptors are present on pituitary gonadotrophs and on testicular Leydig and Sertoli cells. Thus, the GH/IGF-I system may modulate the pituitary-gonadal axis in males. This is a randomized cross-over study. Eight healthy male volunteers (mean age 35, range 2...
journal_title:Andrology
pub_type: 杂志文章,随机对照试验
doi:10.1111/j.2047-2927.2013.00096.x
更新日期:2013-07-01 00:00:00
abstract:BACKGROUND:It is known that exposure to either arsenic or hyperglycemia can induce male reproductive damages. However, their combined effects on male reproductive organs are still unclear. Therefore, the present study investigated morphological and functional parameters of the testis, epididymis, and spermatozoa in dia...
journal_title:Andrology
pub_type: 杂志文章
doi:10.1111/andr.12613
更新日期:2019-09-01 00:00:00
abstract::Male factor etiology may be a contributing factor in up to 60% of infertility cases. Dietary intake of phytoestrogens has been related to abnormal semen quality and hormone levels. However, its effect on couple fecundity is still unclear. Intake of soy products was assessed in 184 men from couples undergoing infertili...
journal_title:Andrology
pub_type: 杂志文章
doi:10.1111/andr.12046
更新日期:2015-07-01 00:00:00
abstract::Nitric oxide is a physiologic signal essential to penile erection. l-citrulline (l-Cit) is converted into l-arginine (l-Arg), the precursor from which nitric oxide is generated. The level of l-Arg and l-Cit in the field of male sexual function remains relatively underexplored. The aim of the study was to evaluate the ...
journal_title:Andrology
pub_type: 杂志文章
doi:10.1111/andr.12293
更新日期:2017-03-01 00:00:00
abstract::Scrotal skin is thin and has high steroid permeability, but the pharmacokinetics of testosterone via the scrotal skin route has not been studied in detail. The aim of this study was to define the pharmacokinetics of testosterone delivered via the scrotal skin route. The study was a single-center, three-phase cross-ove...
journal_title:Andrology
pub_type: 杂志文章,随机对照试验
doi:10.1111/andr.12357
更新日期:2017-07-01 00:00:00
abstract::Smoking is strongly associated with abnormalities in histone-to-protamine transition and with alteration of protamine expression in human spermatozoa. A proper protamine to histone ratio is, however, essential for sperm chromatin maturity and DNA integrity. Alterations in these sperm nuclear proteins were observed in ...
journal_title:Andrology
pub_type: 杂志文章
doi:10.1111/j.2047-2927.2014.00245.x
更新日期:2014-09-01 00:00:00
abstract:BACKGROUND:Recent evidence suggests that routine semen analysis has limited power to predict male fertility. Several efforts have been made to best discriminate between fertile and subfertile men using several sperm features. So, there is a need to more reliable assays for providing molecular data to evaluate sperm qua...
journal_title:Andrology
pub_type: 杂志文章
doi:10.1111/andr.12801
更新日期:2020-09-01 00:00:00
abstract::Tamoxifen is an off-label option to treat men for breast cancer, infertility, and idiopathic gynecomastia. Lately, tamoxifen has been proposed as a treatment to prevent gynecomastia in prostate cancer patients receiving antiandrogen therapy. We reviewed the adverse events (AEs) reported in studies of men prescribed ta...
journal_title:Andrology
pub_type: 杂志文章,评审
doi:10.1111/andr.12197
更新日期:2016-09-01 00:00:00
abstract::Sperm count, morphology, and motility have been reported to be predictive of pregnancy, although with equivocal basis prompting some authors to question the prognostic value of semen analysis. To assess the utility of including semen quality data in predicting conception delay or requiring >6 cycles to become pregnant...
journal_title:Andrology
pub_type: 杂志文章
doi:10.1111/andr.12288
更新日期:2017-01-01 00:00:00
abstract::Fibroblast growth factors (FGFs) and their receptors (FGFRs) regulate several functions of somatic cells. In a previous work, we reported FGFR expression in human spermatozoa and their involvement in motility. This study aimed to evaluate the presence and localization of fibroblast growth factor 2 (FGF2) in human sper...
journal_title:Andrology
pub_type: 杂志文章
doi:10.1111/andr.12398
更新日期:2017-09-01 00:00:00