Changes in nerve- and endothelium-mediated contractile tone of the corpus cavernosum in a mouse model of pre-mature ageing.

abstract：:Approximately 40% of middle-aged men exhibit symptoms of late-onset hypogonadism (LOH). However, the mechanism of androgen deficiency is still currently unclear. As shown in our previous studies, the SET protein is expressed in testicular Leydig cells and ovarian granule cells. This study was designed to investigate t...

journal_title：Andrology

authors： Zhang B,Ma W,Zhu Q,Xu W,Gao L,Xu B,Xu S,Gao C,Gao L,Liu J,Cui Y

更新日期：2018-05-01 00:00:00

abstract：:Tributyltin (TBT), a pesticide used in antifouling paints, is toxic for aquatic invertebrates. In vertebrates, TBT may act in obesogen- inducing adipogenetic gene transcription for adipocyte differentiation. In a previous study, we demonstrated that acute administration of TBT induces c-fos expression in the arcuate n...

journal_title：Andrology

authors： Bo E,Farinetti A,Marraudino M,Sterchele D,Eva C,Gotti S,Panzica G

更新日期：2016-07-01 00:00:00

abstract：:Treatment of testicular cancer includes the coadministration of bleomycin, etoposide and cis-platinum (BEP); however, along with its therapeutic benefit, BEP exposure results in extensive reproductive chemotoxic effects, including alterations to sperm chromatin integrity. As an intact paternal genome is essential for ...

journal_title：Andrology

authors： Maselli J,Hales BF,Robaire B

更新日期：2014-03-01 00:00:00

abstract：:In this study a Bayesian network (BN) has been built for the study of the objective motility of Tinca tinca spermatozoa (spz). Semen from eight 2-year-old sexually mature male tenchs was obtained and motility analyses were performed at 6-17, 23-34 and 40-51 s after activation, using computer-assisted sperm analysis (C...

journal_title：Andrology

authors： Gil Anaya MC,Calle F,Pérez CJ,Martín-Hidalgo D,Fallola C,Bragado MJ,García-Marín LJ,Oropesa AL

更新日期：2015-09-01 00:00:00

abstract：BACKGROUND:Men with congenital unilateral absence of vas deferens were reported to be mainly azoospermic, with both unilateral renal absence and mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) but some have neither. OBJECTIVES:To assess whether in infertile couples the male partners with co...

journal_title：Andrology

authors： Mieusset R,Bieth E,Daudin M,Isus F,Delaunay B,Bujan L,Monteil L,Fauquet I,Huyghe E,Hamdi SM

更新日期：2020-05-01 00:00:00

abstract：:Spermiogenesis is the final phase of spermatogenesis. During this process, haploid round spermatids differentiate into spermatozoa, with dramatic morphological changes, including elongation and condensation of the nuclei, and formation of the flagella. Meig1 is one of many genes involved in the regulation of this proc...

journal_title：Andrology

authors： Shi Y,Zhang L,Song S,Teves ME,Li H,Wang Z,Hess RA,Jiang G,Zhang Z

更新日期：2013-05-01 00:00:00

abstract：:To analyze the pathogenesis of persistent and refractory haematospermia and to evaluate the aetiological diagnostic value of magnetic resonance imaging (MRI) for this type of haematospermia. Clinical data from 102 patients with persistent and refractory haematospermia was retrospectively analysed. Data collected inclu...

journal_title：Andrology

authors： Li BJ,Zhang C,Li K,Zhang J,Zhang Y,Sun ZY,Kang HY,Zhou B,Jin FS,Zhang KQ,Li YF

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND:The transcription factor DMRTB1 plays a pivotal role in coordinating the transition between mitosis and meiosis in murine germ cells. No reliable data are available for human testis. OBJECTIVES:The present study aims to examine the testicular expression pattern of DMRTB1 in men showing normal and impaired s...

journal_title：Andrology

authors： Hilbold E,Bergmann M,Fietz D,Kliesch S,Weidner W,Langeheine M,Rode K,Brehm R

更新日期：2019-07-01 00:00:00

abstract：BACKGROUND:Oocyte activation is driven by intracellular calcium (Ca2+ ) oscillations induced by sperm-specific PLCζ, abrogation of which causes oocyte activation deficiency in humans. Clinical PLCζ investigations have been limited to severe male infertility conditions, while PLCζ levels and localisation patterns have y...

journal_title：Andrology

authors： Kashir J,Mistry BV,BuSaleh L,Abu-Dawas R,Nomikos M,Ajlan A,Abu-Dawud R,AlYacoub N,AlHassan S,Lai FA,Assiri AM,Coskun S

更新日期：2020-09-01 00:00:00

abstract：:In cryptorchid boys, failures in germ cell development have been clearly established. Some studies reported some abnormalities in Sertoli cells morphology but the results regarding their endocrine secretion remain controversial. To compare testicular hormone levels in young boys with and without cryptorchidism, we per...

journal_title：Andrology

authors： Hamdi SM,Almont T,Galinier P,Mieusset R,Thonneau P

更新日期：2017-07-01 00:00:00

abstract：:Scrotal skin is thin and has high steroid permeability, but the pharmacokinetics of testosterone via the scrotal skin route has not been studied in detail. The aim of this study was to define the pharmacokinetics of testosterone delivered via the scrotal skin route. The study was a single-center, three-phase cross-ove...

journal_title：Andrology

authors： Iyer R,Mok SF,Savkovic S,Turner L,Fraser G,Desai R,Jayadev V,Conway AJ,Handelsman DJ

更新日期：2017-07-01 00:00:00

abstract：:The medical treatment is indicated in the development stage of Peyronie's disease (PD) for at least 1 year after diagnosis and whenever in case of penile pain. This research was conducted to demonstrate the possible effectiveness of vitamin E in PD treatment, whereas in the scientific literature this topic is much dis...

journal_title：Andrology

authors： Paulis G,Brancato T,D'Ascenzo R,De Giorgio G,Nupieri P,Orsolini G,Alvaro R

更新日期：2013-01-01 00:00:00

abstract：:Semen analysis is commonly used as a tool to assess the fertility potential of a male, despite its relatively low predictive power. In this study, we have assessed associations between semen analysis findings (low count, low motility, low viability, poor sperm penetration assay results, poor morphology, and increased ...

journal_title：Andrology

authors： Jenkins TG,Aston KI,Hotaling JM,Shamsi MB,Simon L,Carrell DT

更新日期：2016-09-01 00:00:00

abstract：:Existing literature suggests evidence that protamine deficiency is related to DNA damage and male fertility. In this meta-analysis, we analyzed the relationship between the ratio of protamine-1 and protamine-2 with male fertility and the association of protamine deficiency with sperm DNA damage. Quality of available c...

journal_title：Andrology

authors： Ni K,Spiess AN,Schuppe HC,Steger K

更新日期：2016-09-01 00:00:00

abstract：BACKGROUND:Germ cells have a unique and critical role as the conduit for hereditary information and therefore employ multiple strategies to protect genomic integrity and avoid mutations. Unlike somatic cells, which often respond to DNA damage by arresting the cell cycle and conducting DNA repair, germ cells as well as ...

journal_title：Andrology

authors： Bloom JC,Loehr AR,Schimenti JC,Weiss RS

更新日期：2019-07-01 00:00:00

abstract：OBJECTIVE:Testicular germ cell tumour (TGCT) is a malignancy with a high heritable component. The inherited risk is polygenic, and around 50 susceptibility genes are identified. The functional role of the gene products for TGCT development is not well understood. The focus of this review is functional studies of geneti...

journal_title：Andrology

authors： Das MK,Kleppa L,Haugen TB

更新日期：2019-07-01 00:00:00

abstract：:Oxidation-reduction potential describes the balance between the oxidants and antioxidants in fluids including semen. Various artificial culture media are used in andrology and IVF laboratories for sperm preparation and to support the development of fertilized oocytes under in vitro conditions. The composition and cond...

journal_title：Andrology

authors： Panner Selvam MK,Henkel R,Sharma R,Agarwal A

更新日期：2018-03-01 00:00:00

abstract：BACKGROUND:Maximum urinary flow rate (Qmax) is usually increased after holmium laser enucleation of the prostate (HoLEP). However, improvements vary between patients and results regarding potential predictors of Qmax after HoLEP are inconsistent. Thus, we investigated pre-operative variables including second to fourth ...

journal_title：Andrology

authors： Park IN,Kim TB

更新日期：2019-03-01 00:00:00

abstract：:Highly active antiretroviral therapy has evolved over the years, leading to a boost in the quality of life in people living with HIV and AIDS. However, growing evidence has shown that highly active antiretroviral therapy has deleterious effects on the testes and the overall reproductive capacity. Therefore, this study...

journal_title：Andrology

authors： Adana MY,Akang EN,Peter AI,Jegede AI,Naidu ECS,Tiloke C,Chuturgoon AA,Azu OO

更新日期：2018-01-01 00:00:00

abstract：:In recent reports, an association between altered TRPC channel function and the development of various diabetic complications has drawn the attention of many investigators. The aim of this study was to investigate the expression of TRPC4 channels of corpus smooth muscle (CSM) cells in diabetes, and to evaluate the ass...

journal_title：Andrology

authors： Sung HH,Choo SH,Ko M,Kang SJ,Chae MR,Kam SC,Han DH,So I,Lee SW

更新日期：2014-07-01 00:00:00

abstract：:Escherichia coli (E. coli) is a common pathogen in epididymitis, which represents a prevalent entity in male reproductive tract infections (RTI). Although current treatment regimens using antibiotics are satisfactory, development of antimicrobial resistance by the pathogen represents a challenge in the management of R...

journal_title：Andrology

authors： Biswas B,Bhushan S,Rajesh A,Suraj SK,Lu Y,Meinhardt A,Yenugu S

更新日期：2015-03-01 00:00:00

abstract：:The use of intra-cytoplasmic sperm injection (ICSI) has increased significantly worldwide, often chosen instead of in vitro fertilization (IVF), yet long-term health outcomes are unknown and health differences between ICSI and IVF conceptions have not been comprehensively assessed. A systematic review of health outcom...

journal_title：Andrology

authors： Catford SR,McLachlan RI,O'Bryan MK,Halliday JL

更新日期：2017-07-01 00:00:00

abstract：:Most of the non-obstructive azoospermia (NOA)-patients have only focal spermatogenesis which results in insufficient numbers of spermatozoa to reach the ejaculate. In ≈50% of these NOA-patients testicular sperm extraction (TESE) is successful and intracytoplasmic sperm injection (ICSI) is pursued. We studied whether (...

journal_title：Andrology

authors： Hessel M,de Vries M,D'Hauwers KW,Fleischer K,Hulsbergen-van de Kaa CA,Braat DD,Ramos L

更新日期：2015-05-01 00:00:00

abstract：:Pubertal gynecomastia is a common condition observed in up to 65% of adolescent males. It is usually idiopathic and tends to regress within 1-2 years. In this descriptive cross-sectional study, we investigated 25 adolescent males with prominent (>B3) and/or persistent (>2 years) pubertal gynecomastia (P/PPG) to determ...

journal_title：Andrology

authors： Paris F,Gaspari L,Mbou F,Philibert P,Audran F,Morel Y,Biason-Lauber A,Sultan C

更新日期：2016-03-01 00:00:00

abstract：:A recent study has demonstrated that porcine spermatozoa recognize with high affinity carbohydrate structures containing Lewis X motifs. Sperm adhesion to Lewis X is proposed to mediate sperm binding to the oviduct epithelium to form a reservoir. The objective of this study was to identify Lewis X-binding proteins fro...

journal_title：Andrology

authors： Silva E,Frost D,Li L,Bovin N,Miller DJ

更新日期：2017-05-01 00:00:00

abstract：:The second messenger cyclic adenosine monophosphate (cAMP) has a central role in sperm physiology. Extracellular cAMP can be sequentially degraded into 5'AMP and adenosine by ecto-phosphodiesterases (ecto-PDE) and ecto-nucleotidases, a phenomenon called extracellular cAMP-adenosine pathway. As cAMP-adenosine pathway i...

journal_title：Andrology

authors： Bergeron A,Aragon JP,Guillemette C,Hébert A,Sullivan R,Blondin P,Richard FJ

更新日期：2016-11-01 00:00:00

abstract：:Testosterone (T) deficiency, sexual dysfunction, obesity and obstructive sleep apnea (OSA) are common and often coexist. T prescriptions have increased worldwide during the last decade, including to those with undiagnosed or untreated OSA. The effect of T administration on sexual function, neurocognitive performance a...

journal_title：Andrology

authors： Melehan KL,Hoyos CM,Yee BJ,Wong KK,Buchanan PR,Grunstein RR,Liu PY

更新日期：2016-01-01 00:00:00

abstract：:Exosomes are membranous nanovesicles of endocytic origin that carry and transfer regulatory bioactive molecules and mediate intercellular communication between cells and tissues. Although seminal exosomes have been identified in human seminal plasma, their exact composition and possible physiologic function remain unk...

journal_title：Andrology

authors： Yang C,Guo WB,Zhang WS,Bian J,Yang JK,Zhou QZ,Chen MK,Peng W,Qi T,Wang CY,Liu CD

更新日期：2017-09-01 00:00:00

abstract：:Erectile Dysfunction is considered a multifactorial disease, where organic and psychological aspects are often interconnected. In a randomized controlled pilot study, we compared the efficacy of combined vardenafil orodispersible tablet (VARD) and cognitive-behavioral sex therapy (CBST) vs. VARD alone in improving sex...

journal_title：Andrology

authors： Boddi V,Castellini G,Casale H,Rastrelli G,Boni L,Corona G,Maggi M

更新日期：2015-09-01 00:00:00

abstract：:In males, age-related decline in free testosterone (T) and dehydroepiandrosterone (DHEA) by 2-3% per year has been reported. Estradiol (E2) and progesterone (P) seem to decrease as well, but to a lesser extent. Lower sex steroid levels in men have been related to physical and mental symptoms. Low birthweight and left-...

journal_title：Andrology

authors： Hoppler S,Walther A,La Marca-Ghaemmaghami P,Ehlert U

更新日期：2018-11-01 00:00:00