Abstract:
:The use of intra-cytoplasmic sperm injection (ICSI) has increased significantly worldwide, often chosen instead of in vitro fertilization (IVF), yet long-term health outcomes are unknown and health differences between ICSI and IVF conceptions have not been comprehensively assessed. A systematic review of health outcomes of ICSI-conceived offspring beyond the neonatal period compared to IVF-conceived offspring was carried out. PubMed, OVID Medline/Embase, Informit, Web of Science and Proquest databases were searched on 9 November 2016 for studies reporting on health outcomes in ICSI-conceived offspring beyond 28 days after birth. Physical and psychosocial health were the main outcome measures. The search strategy yielded 2781 articles; 2539 were not relevant or did not meet inclusion criteria and 137 were duplicates. One hundred and five full-text papers were evaluated further and 34 satisfied the inclusion criteria. Studies comparing ICSI- and IVF-conceived children suggest their neurodevelopment is comparable. Growth and aspects of physical health are also similar; however, studies are few and limited to childhood. ICSI-conceived children may be at increased risk of autism and intellectual impairment. No difference in risk of childhood cancer was reported in one study. Whilst the neurodevelopment of ICSI-conceived children appears comparable to those of IVF conception, data relating to neurodevelopmental disorders, growth, physical health and childhood cancer are inconclusive. Further research into health outcomes in adolescence and adulthood is required before conclusions can be drawn about the long-term safety of ICSI compared to IVF. Until then, ICSI might be better reserved for its original intended use, male-factor infertility.
journal_name
Andrologyjournal_title
Andrologyauthors
Catford SR,McLachlan RI,O'Bryan MK,Halliday JLdoi
10.1111/andr.12369subject
Has Abstractpub_date
2017-07-01 00:00:00pages
610-621issue
4eissn
2047-2919issn
2047-2927journal_volume
5pub_type
杂志文章,评审相关文献
Andrology文献大全abstract::Erectile dysfunction (ED) is increasingly recognized as a public health problem. Several studies have reported the influence of the insertion/deletion (I/D) polymorphism in the Angiotensin-converting enzyme (ACE) gene on ED susceptibility, but the results remain controversial. To derive a more precise estimation of th...
journal_title:Andrology
pub_type: 杂志文章,meta分析
doi:10.1111/j.2047-2927.2012.00029.x
更新日期:2013-03-01 00:00:00
abstract::Maternal overweight and obesity in pregnancy has been associated with earlier age of menarche in daughters as well as reduced semen quality in sons. We aimed at investigating pubertal development in sons born by mothers with a high body mass index (BMI). The study included 2522 sons of mothers that during pregnancy in...
journal_title:Andrology
pub_type: 杂志文章
doi:10.1111/j.2047-2927.2013.00171.x
更新日期:2014-03-01 00:00:00
abstract::Tributyltin (TBT), a pesticide used in antifouling paints, is toxic for aquatic invertebrates. In vertebrates, TBT may act in obesogen- inducing adipogenetic gene transcription for adipocyte differentiation. In a previous study, we demonstrated that acute administration of TBT induces c-fos expression in the arcuate n...
journal_title:Andrology
pub_type: 杂志文章
doi:10.1111/andr.12222
更新日期:2016-07-01 00:00:00
abstract::Nitric oxide is a physiologic signal essential to penile erection. l-citrulline (l-Cit) is converted into l-arginine (l-Arg), the precursor from which nitric oxide is generated. The level of l-Arg and l-Cit in the field of male sexual function remains relatively underexplored. The aim of the study was to evaluate the ...
journal_title:Andrology
pub_type: 杂志文章
doi:10.1111/andr.12293
更新日期:2017-03-01 00:00:00
abstract::Highly active antiretroviral therapy has evolved over the years, leading to a boost in the quality of life in people living with HIV and AIDS. However, growing evidence has shown that highly active antiretroviral therapy has deleterious effects on the testes and the overall reproductive capacity. Therefore, this study...
journal_title:Andrology
pub_type: 杂志文章
doi:10.1111/andr.12439
更新日期:2018-01-01 00:00:00
abstract::Male factor etiology may be a contributing factor in up to 60% of infertility cases. Dietary intake of phytoestrogens has been related to abnormal semen quality and hormone levels. However, its effect on couple fecundity is still unclear. Intake of soy products was assessed in 184 men from couples undergoing infertili...
journal_title:Andrology
pub_type: 杂志文章
doi:10.1111/andr.12046
更新日期:2015-07-01 00:00:00
abstract:BACKGROUND:Men with congenital unilateral absence of vas deferens were reported to be mainly azoospermic, with both unilateral renal absence and mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) but some have neither. OBJECTIVES:To assess whether in infertile couples the male partners with co...
journal_title:Andrology
pub_type: 杂志文章
doi:10.1111/andr.12749
更新日期:2020-05-01 00:00:00
abstract::The published incidence of bilateral varicocoeles in adults is much higher than among adolescents. We investigated our adolescent varicocoele database to determine (i) the presence of subclinical and palpable right varicocoele s in boys with a left varicocoele, (ii) the effect, if any, of right varicocoele on asymmetr...
journal_title:Andrology
pub_type: 杂志文章
doi:10.1111/j.2047-2927.2013.00130.x
更新日期:2013-11-01 00:00:00
abstract:BACKGROUND:Knowledge about Klinefelter syndrome (KS) has increased substantially since its first description almost 80 years ago. A variety of treatment options concerning the spectrum of symptoms associated with KS exists, also regarding aspects beyond testicular dysfunction. Nevertheless, the diagnostic rate is still...
journal_title:Andrology
pub_type: 杂志文章,评审
doi:10.1111/andr.12909
更新日期:2021-01-01 00:00:00
abstract::Bisphenol A (BPA) is widely used in food contact materials, toys, and other products. Several studies have indicated that effects observed at doses near human exposure levels may not be observed at higher doses. Many studies have shown effects on mammary glands at low doses of BPA, however, because of small number of ...
journal_title:Andrology
pub_type: 杂志文章
doi:10.1111/andr.12193
更新日期:2016-07-01 00:00:00
abstract:BACKGROUND:Penile cancer represents a rare pathology whose natural history of treatment is poorly understood. OBJECTIVE:To illustrate the dynamic survival profiles in surgically treated patients with squamous cell carcinoma of the penis (SCCP) using the conditional survival (CS) estimates. MATERIALS AND METHODS:Patie...
journal_title:Andrology
pub_type: 杂志文章
doi:10.1111/andr.12856
更新日期:2020-11-01 00:00:00
abstract::In recent reports, an association between altered TRPC channel function and the development of various diabetic complications has drawn the attention of many investigators. The aim of this study was to investigate the expression of TRPC4 channels of corpus smooth muscle (CSM) cells in diabetes, and to evaluate the ass...
journal_title:Andrology
pub_type: 杂志文章
doi:10.1111/j.2047-2927.2014.00214.x
更新日期:2014-07-01 00:00:00
abstract::A recent study has demonstrated that porcine spermatozoa recognize with high affinity carbohydrate structures containing Lewis X motifs. Sperm adhesion to Lewis X is proposed to mediate sperm binding to the oviduct epithelium to form a reservoir. The objective of this study was to identify Lewis X-binding proteins fro...
journal_title:Andrology
pub_type: 杂志文章
doi:10.1111/andr.12340
更新日期:2017-05-01 00:00:00
abstract::In males, age-related decline in free testosterone (T) and dehydroepiandrosterone (DHEA) by 2-3% per year has been reported. Estradiol (E2) and progesterone (P) seem to decrease as well, but to a lesser extent. Lower sex steroid levels in men have been related to physical and mental symptoms. Low birthweight and left-...
journal_title:Andrology
pub_type: 杂志文章
doi:10.1111/andr.12516
更新日期:2018-11-01 00:00:00
abstract:BACKGROUND:The presence of miRNAs in human reproductive tissue is intriguing and suggests the possibility that these important regulatory molecules play a role in reproductive function. However, the regulatory role of miRNAs in reproductive tissue remains poorly understood with a significant amount of controversial and...
journal_title:Andrology
pub_type: 杂志文章
doi:10.1111/andr.12714
更新日期:2020-01-01 00:00:00
abstract::The medical treatment is indicated in the development stage of Peyronie's disease (PD) for at least 1 year after diagnosis and whenever in case of penile pain. This research was conducted to demonstrate the possible effectiveness of vitamin E in PD treatment, whereas in the scientific literature this topic is much dis...
journal_title:Andrology
pub_type: 杂志文章
doi:10.1111/j.2047-2927.2012.00007.x
更新日期:2013-01-01 00:00:00
abstract::Sperm count, morphology, and motility have been reported to be predictive of pregnancy, although with equivocal basis prompting some authors to question the prognostic value of semen analysis. To assess the utility of including semen quality data in predicting conception delay or requiring >6 cycles to become pregnant...
journal_title:Andrology
pub_type: 杂志文章
doi:10.1111/andr.12288
更新日期:2017-01-01 00:00:00
abstract::The molecular basis of spermatogenic failure (SpF) is still largely unknown. Accumulating evidence suggests that a series of specific events such as meiosis, are determined at the early stage of spermatogenesis. This study aims to assess the expression profile of pre-meiotic genes of infertile testicular biopsies that...
journal_title:Andrology
pub_type: 杂志文章
doi:10.1111/j.2047-2927.2014.00217.x
更新日期:2014-07-01 00:00:00
abstract::Fibroblast growth factors (FGFs) and their receptors (FGFRs) regulate several functions of somatic cells. In a previous work, we reported FGFR expression in human spermatozoa and their involvement in motility. This study aimed to evaluate the presence and localization of fibroblast growth factor 2 (FGF2) in human sper...
journal_title:Andrology
pub_type: 杂志文章
doi:10.1111/andr.12398
更新日期:2017-09-01 00:00:00
abstract:BACKGROUND:The association between alcohol intake and male reproductive function is still controversial. In the frame of a prospective cohort study, designed to investigate the relation between life style and fertility, we performed a cross-sectional analysis of semen quality. METHODS:Men of subfertile couples, referr...
journal_title:Andrology
pub_type: 杂志文章
doi:10.1111/andr.12521
更新日期:2018-09-01 00:00:00
abstract::Existing literature suggests evidence that protamine deficiency is related to DNA damage and male fertility. In this meta-analysis, we analyzed the relationship between the ratio of protamine-1 and protamine-2 with male fertility and the association of protamine deficiency with sperm DNA damage. Quality of available c...
journal_title:Andrology
pub_type: 杂志文章,meta分析,评审
doi:10.1111/andr.12216
更新日期:2016-09-01 00:00:00
abstract:BACKGROUND:Resistin is known as a potential mediator of obesity-associated insulin resistance. The high resistin level disrupts nitric oxide (NO)-mediated relaxation which is also important in erectile function. An antioxidant alkaloid, Boldine, is known as anti-diabetic and protects endothelial functions. OBJECTIVES:...
journal_title:Andrology
pub_type: 杂志文章
doi:10.1111/andr.12853
更新日期:2020-11-01 00:00:00
abstract::The aim of this study was to investigate the effects of castration and testosterone supplementation on nitroso-redox status, cardiac metabolism markers, and S100 proteins expression in the heart of male rats. 50 male Wistar rats were randomized into five groups with ten animals each: group 1: control intact (CON); gro...
journal_title:Andrology
pub_type: 杂志文章
doi:10.1111/andr.12449
更新日期:2018-01-01 00:00:00
abstract::Scarce data are available on epidemiology of varicocoele, the most common surgically correctable cause of male infertility. The objectives of this study were to evaluate the association between body mass index (BMI) and varicocoele and to assess trends in prevalence over time. We conducted a nationwide population-base...
journal_title:Andrology
pub_type: 杂志文章
doi:10.1111/j.2047-2927.2013.00113.x
更新日期:2013-09-01 00:00:00
abstract:BACKGROUND:Testicular germ cell tumour is the most common cancer to be diagnosed among young men. In New Zealand, we have observed some puzzling trends in the epidemiology of this disease. METHODS:We have conducted a narrative review of available evidence regarding the puzzling epidemiology of testicular germ cell tum...
journal_title:Andrology
pub_type: 杂志文章,评审
doi:10.1111/andr.12584
更新日期:2019-07-01 00:00:00
abstract:BACKGROUND:We aimed to examine the effects of pre-operative blood values on varicocelectomy success. MATERIALS AND METHODS:A total of 130 patients who underwent varicocelectomy in our clinic were retrospectively analyzed. Operation success was defined as the return of all semen parameters (concentration, progressive m...
journal_title:Andrology
pub_type: 杂志文章
doi:10.1111/andr.12976
更新日期:2021-01-21 00:00:00
abstract::The aetiology of severe asthenozoospermia in men with spinal cord injury includes an adverse impact of seminal plasma (SP) on sperm motility. In this study we investigated the effect exerted by SP from men with SCI on donor sperm mitochondrial activity and its reflection on motility. Donor spermatozoa were exposed (1 ...
journal_title:Andrology
pub_type: 杂志文章
doi:10.1111/j.2047-2927.2013.00077.x
更新日期:2013-05-01 00:00:00
abstract::Interactions between infertility and sexuality are numerous and complex. Infertile men may suffer from sexual dysfunction (SD) when undergoing an assisted reproductive technology programme. We undertook a review both in French and English of the available data on male SD when being diagnosed with a fertility problem w...
journal_title:Andrology
pub_type: 杂志文章,评审
doi:10.1111/andr.12160
更新日期:2016-05-01 00:00:00
abstract:OBJECTIVE:To evaluate the association between cannabis use and testicular function (as assessed through semen quality and serum hormone levels) in different populations. EVIDENCE REVIEW:Systematic review and meta-analysis of population-based retrospective cohort studies. PRISMA guidelines were used for abstracting dat...
journal_title:Andrology
pub_type: 杂志文章
doi:10.1111/andr.12953
更新日期:2020-11-29 00:00:00
abstract::The effects of equilibration times (E1, 2 h; E2, 4 h; E3, 6 h), freezing rates (FR1, manual, 5 cm above liquid nitrogen (LN2 ) for 10 min, plunging in LN2 ; FR2, programmable ultra-fast, holding at +4 °C for 2 min, from 4 to -10 °C at -10 °C/min, from -10 to -20 °C at -15 °C/min, from -20 to -120 °C at -60 °C/min, hol...
journal_title:Andrology
pub_type: 杂志文章
doi:10.1111/andr.12214
更新日期:2016-09-01 00:00:00