Abstract:
:Erectile Dysfunction is considered a multifactorial disease, where organic and psychological aspects are often interconnected. In a randomized controlled pilot study, we compared the efficacy of combined vardenafil orodispersible tablet (VARD) and cognitive-behavioral sex therapy (CBST) vs. VARD alone in improving sexual symptoms in both male and female partners. Thirty male patients with erectile dysfunction, and their partners were randomly assigned with a 2 : 1 ratio, to two different arms and treated for 10 weeks with VARD (Group A; n = 19) or VARD+CBST (Group B; n = 11). International Index of Erectile Dysfunction (IIEF-15), Female Sexual Function Index (FSFI) and Index of Sexual Satisfaction (ISS) were, respectively, administered to male, female, and both partners at times (T) 0, 1 (+5 weeks of therapy) and 2 (+10 weeks of therapy). Groups A and B were similar in their sociodemographic and clinical characteristics. Pre-treatment (T0) test scores did not significantly differ among the groups. In both group A and B, the IIEF-Erectile Function domain showed a significant improvement from T0 to T1 (p = 0.005 and p < 0.0001 vs. T0, respectively) and from T0 to T2 only in group B (p = 0.013). In group A, FSFI and both male and female ISS did not show any significant change at T1 and T2 vs. T0. In group B, a significant improvement at final time-point in FSFI and male and female ISS scores was reported (p < 0.05, T2 vs. T0 in all scores). The results of our study suggest that both VARD alone and VARD+CBST improved erectile function, however, only VARD+CBST improved couple sexual satisfaction and female sexual function.
journal_name
Andrologyjournal_title
Andrologyauthors
Boddi V,Castellini G,Casale H,Rastrelli G,Boni L,Corona G,Maggi Mdoi
10.1111/andr.12079subject
Has Abstractpub_date
2015-09-01 00:00:00pages
909-18issue
5eissn
2047-2919issn
2047-2927journal_volume
3pub_type
杂志文章,随机对照试验相关文献
Andrology文献大全abstract::Scarce data are available on epidemiology of varicocoele, the most common surgically correctable cause of male infertility. The objectives of this study were to evaluate the association between body mass index (BMI) and varicocoele and to assess trends in prevalence over time. We conducted a nationwide population-base...
journal_title:Andrology
pub_type: 杂志文章
doi:10.1111/j.2047-2927.2013.00113.x
更新日期:2013-09-01 00:00:00
abstract:BACKGROUND:Diabetes mellitus is one of the risk factors for male subfertility/infertility. Malaysian propolis is reported to decrease hyperglycaemia in diabetic state. OBJECTIVES:The present study investigated the protective effect of Malaysian propolis on diabetes-induced subfertility/infertility. Additionally, its c...
journal_title:Andrology
pub_type: 杂志文章
doi:10.1111/andr.12739
更新日期:2020-05-01 00:00:00
abstract::Escherichia coli (E. coli) is a common pathogen in epididymitis, which represents a prevalent entity in male reproductive tract infections (RTI). Although current treatment regimens using antibiotics are satisfactory, development of antimicrobial resistance by the pathogen represents a challenge in the management of R...
journal_title:Andrology
pub_type: 杂志文章
doi:10.1111/andr.12012
更新日期:2015-03-01 00:00:00
abstract::The molecular basis of spermatogenic failure (SpF) is still largely unknown. Accumulating evidence suggests that a series of specific events such as meiosis, are determined at the early stage of spermatogenesis. This study aims to assess the expression profile of pre-meiotic genes of infertile testicular biopsies that...
journal_title:Andrology
pub_type: 杂志文章
doi:10.1111/j.2047-2927.2014.00217.x
更新日期:2014-07-01 00:00:00
abstract:OBJECTIVE:To investigate the possible role of serum norepinephrine (NE), leptin, and 5-hydroxytryptamine (5-HT) and their correlations with sympathetic skin response located in the penis (PSSR) in primary premature ejaculation (PPE). METHODS:We compared the serum level of NE, leptin, and 5-HT, intravaginal ejaculatory...
journal_title:Andrology
pub_type: 杂志文章
doi:10.1111/andr.12773
更新日期:2020-09-01 00:00:00
abstract:OBJECTIVE:To evaluate the association between cannabis use and testicular function (as assessed through semen quality and serum hormone levels) in different populations. EVIDENCE REVIEW:Systematic review and meta-analysis of population-based retrospective cohort studies. PRISMA guidelines were used for abstracting dat...
journal_title:Andrology
pub_type: 杂志文章
doi:10.1111/andr.12953
更新日期:2020-11-29 00:00:00
abstract:BACKGROUND:Knowledge about Klinefelter syndrome (KS) has increased substantially since its first description almost 80 years ago. A variety of treatment options concerning the spectrum of symptoms associated with KS exists, also regarding aspects beyond testicular dysfunction. Nevertheless, the diagnostic rate is still...
journal_title:Andrology
pub_type: 杂志文章,评审
doi:10.1111/andr.12909
更新日期:2021-01-01 00:00:00
abstract:BACKGROUND:Men with congenital unilateral absence of vas deferens were reported to be mainly azoospermic, with both unilateral renal absence and mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) but some have neither. OBJECTIVES:To assess whether in infertile couples the male partners with co...
journal_title:Andrology
pub_type: 杂志文章
doi:10.1111/andr.12749
更新日期:2020-05-01 00:00:00
abstract::Exosomes are membranous nanovesicles of endocytic origin that carry and transfer regulatory bioactive molecules and mediate intercellular communication between cells and tissues. Although seminal exosomes have been identified in human seminal plasma, their exact composition and possible physiologic function remain unk...
journal_title:Andrology
pub_type: 杂志文章
doi:10.1111/andr.12412
更新日期:2017-09-01 00:00:00
abstract::Cryoinjury is a consequence of cryopreservation and may have a negative impact on sperm quality regarding motility, morphology, and viability. This study was designed to identify potential proteomic changes in human sperm cells throughout the cryopreservation process. Comparisons made within this study included the de...
journal_title:Andrology
pub_type: 杂志文章
doi:10.1111/andr.12279
更新日期:2017-01-01 00:00:00
abstract::Research in the last decade has revealed that bone is not only a target tissue for numerous circulating hormones but functions as an endocrine organ itself. As a recent study demonstrated a stimulatory effect of the osteoblast-derived hormone osteocalcin (OCN) on testosterone production in mice, we investigated whethe...
journal_title:Andrology
pub_type: 杂志文章
doi:10.1111/j.2047-2927.2012.00044.x
更新日期:2013-05-01 00:00:00
abstract:BACKGROUND:The current results of in vitro reproduction techniques in pigs, such as in vitro fertilization (IVF) and embryo development, show high performance with both epididymal and ejaculated spermatozoa. However, the results using ejaculated spermatozoa are even better. Ejaculated spermatozoa are exposed to the sec...
journal_title:Andrology
pub_type: 杂志文章
doi:10.1111/andr.12902
更新日期:2021-01-01 00:00:00
abstract::Cell-free seminal RNA (cfs-RNA) is mixed transcripts derived from male reproductive organs, and is potential biomarker for the research and diagnosis of male reproductive-related diseases. However, some clinical factors, including age, asymptomatic Ureaplasma urealyticum (UU) infection, scrotal heat stress, abstinence...
journal_title:Andrology
pub_type: 杂志文章
doi:10.1111/andr.12238
更新日期:2016-11-01 00:00:00
abstract:BACKGROUND:We previously demonstrated how mouse spermatozoa can be efficiently stored for two years in a -80°C freezer, maintaining their ability to fertilize mouse eggs. OBJECTIVES:The main objective here was to evaluate the effects of five years at -80°C compared to liquid nitrogen storage (LN2 , control condition) ...
journal_title:Andrology
pub_type: 杂志文章
doi:10.1111/andr.12971
更新日期:2021-01-11 00:00:00
abstract::The main aim of this work was to evaluate how supplementing freezing media with reduced glutathione (GSH) affected the 'in vivo' fertilizing ability of boar semen subjected to cryopreservation procedures. With this purpose, 12 ejaculates coming from 12 boars were cryopreserved in the presence or absence of 2 mm GSH, w...
journal_title:Andrology
pub_type: 杂志文章
doi:10.1111/j.2047-2927.2013.00144.x
更新日期:2014-01-01 00:00:00
abstract:STUDY QUESTION:Are de novo mutations in the human genome associated with male infertility? SUMMARY ANSWER:We identified de novo mutations in five candidate genes: SEMA5A, NEURL4, BRD2, CD1D, and CD63. WHAT IS KNOWN ALREADY:Epidemiological and genetic studies have consistently indicated contribution of genetic factors...
journal_title:Andrology
pub_type: 杂志文章
doi:10.1111/andr.12897
更新日期:2021-01-01 00:00:00
abstract:BACKGROUND:Oocyte activation is driven by intracellular calcium (Ca2+ ) oscillations induced by sperm-specific PLCζ, abrogation of which causes oocyte activation deficiency in humans. Clinical PLCζ investigations have been limited to severe male infertility conditions, while PLCζ levels and localisation patterns have y...
journal_title:Andrology
pub_type: 杂志文章
doi:10.1111/andr.12796
更新日期:2020-09-01 00:00:00
abstract::Humanin (HN) has cytoprotective action on male germ cells after testicular stress induced by heat and hormonal deprivation. To examine whether HN has protective effects on chemotherapy-induced male germ cell apoptosis, we treated four groups of adult rats with (i) vehicle (control), (ii) HN, (iii) cyclophosphamide (CP...
journal_title:Andrology
pub_type: 杂志文章
doi:10.1111/andr.12036
更新日期:2015-05-01 00:00:00
abstract::In males, age-related decline in free testosterone (T) and dehydroepiandrosterone (DHEA) by 2-3% per year has been reported. Estradiol (E2) and progesterone (P) seem to decrease as well, but to a lesser extent. Lower sex steroid levels in men have been related to physical and mental symptoms. Low birthweight and left-...
journal_title:Andrology
pub_type: 杂志文章
doi:10.1111/andr.12516
更新日期:2018-11-01 00:00:00
abstract::A recent study has demonstrated that porcine spermatozoa recognize with high affinity carbohydrate structures containing Lewis X motifs. Sperm adhesion to Lewis X is proposed to mediate sperm binding to the oviduct epithelium to form a reservoir. The objective of this study was to identify Lewis X-binding proteins fro...
journal_title:Andrology
pub_type: 杂志文章
doi:10.1111/andr.12340
更新日期:2017-05-01 00:00:00
abstract::Low testosterone levels in aging men are associated with insulin resistance. Mitochondrial dysfunction, changes in glycogen metabolism, and lipid accumulation are linked to insulin resistance in skeletal muscle. In this randomized, double-blinded, placebo-controlled study, we investigated the effects of six-month test...
journal_title:Andrology
pub_type: 杂志文章,随机对照试验
doi:10.1111/andr.12492
更新日期:2018-07-01 00:00:00
abstract:BACKGROUND:Concerns exist about the effect of delaying treatment for prostate cancer (PCa) regarding both oncological and functional outcomes after radical prostatectomy (RP). OBJECTIVE:To assess the impact of time from diagnosis to RP on post-operative erectile function (EF) outcomes. MATERIALS AND METHODS:We analyz...
journal_title:Andrology
pub_type: 杂志文章
doi:10.1111/andr.12699
更新日期:2020-03-01 00:00:00
abstract::Testicular germ cell tumours (TGCT) typically contain high numbers of infiltrating immune cells, yet the functional nature and consequences of interactions between GCNIS (germ cell neoplasia in situ) or seminoma cells and immune cells remain unknown. A co-culture model using the seminoma-derived TCam-2 cell line and p...
journal_title:Andrology
pub_type: 杂志文章
doi:10.1111/andr.12365
更新日期:2017-07-01 00:00:00
abstract::Approximately 40% of middle-aged men exhibit symptoms of late-onset hypogonadism (LOH). However, the mechanism of androgen deficiency is still currently unclear. As shown in our previous studies, the SET protein is expressed in testicular Leydig cells and ovarian granule cells. This study was designed to investigate t...
journal_title:Andrology
pub_type: 杂志文章
doi:10.1111/andr.12476
更新日期:2018-05-01 00:00:00
abstract:BACKGROUND:Recent evidence suggests that routine semen analysis has limited power to predict male fertility. Several efforts have been made to best discriminate between fertile and subfertile men using several sperm features. So, there is a need to more reliable assays for providing molecular data to evaluate sperm qua...
journal_title:Andrology
pub_type: 杂志文章
doi:10.1111/andr.12801
更新日期:2020-09-01 00:00:00
abstract:BACKGROUND:The presence of miRNAs in human reproductive tissue is intriguing and suggests the possibility that these important regulatory molecules play a role in reproductive function. However, the regulatory role of miRNAs in reproductive tissue remains poorly understood with a significant amount of controversial and...
journal_title:Andrology
pub_type: 杂志文章
doi:10.1111/andr.12714
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:Testicular architecture and sperm production are supported by a complex network of communication between various cell types. These signals ensure fertility by: regulating spermatogonial stem/progenitor cells; promoting steroidogenesis; and driving male-specific differentiation of the gonad. Sertoli cells hav...
journal_title:Andrology
pub_type: 杂志文章,评审
doi:10.1111/andr.12703
更新日期:2020-07-01 00:00:00
abstract::Scrotal skin is thin and has high steroid permeability, but the pharmacokinetics of testosterone via the scrotal skin route has not been studied in detail. The aim of this study was to define the pharmacokinetics of testosterone delivered via the scrotal skin route. The study was a single-center, three-phase cross-ove...
journal_title:Andrology
pub_type: 杂志文章,随机对照试验
doi:10.1111/andr.12357
更新日期:2017-07-01 00:00:00
abstract::To analyze the pathogenesis of persistent and refractory haematospermia and to evaluate the aetiological diagnostic value of magnetic resonance imaging (MRI) for this type of haematospermia. Clinical data from 102 patients with persistent and refractory haematospermia was retrospectively analysed. Data collected inclu...
journal_title:Andrology
pub_type: 杂志文章
doi:10.1111/j.2047-2927.2013.00132.x
更新日期:2013-11-01 00:00:00
abstract:BACKGROUND:The association between alcohol intake and male reproductive function is still controversial. In the frame of a prospective cohort study, designed to investigate the relation between life style and fertility, we performed a cross-sectional analysis of semen quality. METHODS:Men of subfertile couples, referr...
journal_title:Andrology
pub_type: 杂志文章
doi:10.1111/andr.12521
更新日期:2018-09-01 00:00:00