Abstract:
OBJECTIVE:To investigate the possible role of serum norepinephrine (NE), leptin, and 5-hydroxytryptamine (5-HT) and their correlations with sympathetic skin response located in the penis (PSSR) in primary premature ejaculation (PPE). METHODS:We compared the serum level of NE, leptin, and 5-HT, intravaginal ejaculatory latency time (IELT) and the premature ejaculation diagnostic tool (PEDT) scores between 57 PPE patients and 42 healthy control men as controls, who were recruited between September 2016 and January 2019. Additionally, the amplitude and latency of PSSR were measured and compared between the two groups. RESULTS:Compared with healthy men, both leptin and NE increased significantly in PPE patients (P = .003, P = .005), while serum 5-HT remarkably decreased (P = .002). Serum leptin, NE, and 5-HT were significantly correlated with the diagnosis of PPE, PSSR amplitude, and latency. Moreover, compared with single serum indicator, NE/5-HT and leptin/5-HT had a stronger correlation with both PSSR amplitude (r = .8377, P < .001; r = .9323, P < .001, respectively) and latency (r = -.8058, P < .001; r = -.8901, P < .001, respectively). CONCLUSION:Significant differences in leptin, NE, and 5-HT are observed between PPE patients and the controls, which supports the hypothesis of hyperactive sympathetic nerve system (SNS) in PPE. Additionally, leptin/5-HT ratio may serve as an ideal indicator for reflecting SNS activity and predicting treatment response in PPE patients in the future.
journal_name
Andrologyjournal_title
Andrologyauthors
Xia J,Zhang Q,Wang Y,Luan J,Yang J,Cong R,Wang Z,Song Ndoi
10.1111/andr.12773subject
Has Abstractpub_date
2020-09-01 00:00:00pages
1070-1075issue
5eissn
2047-2919issn
2047-2927journal_volume
8pub_type
杂志文章相关文献
Andrology文献大全abstract::Spermatogenesis involves the aggregated action of up to 2300 genes, any of which, could, potentially, provide targets for diagnostic tests of male factor infertility. Contrary to the previously proposed common variant hypothesis for common diseases such as male infertility, genome-wide association studies and targeted...
journal_title:Andrology
pub_type: 杂志文章,评审
doi:10.1111/j.2047-2927.2014.00200.x
更新日期:2014-05-01 00:00:00
abstract::Escherichia coli (E. coli) is a common pathogen in epididymitis, which represents a prevalent entity in male reproductive tract infections (RTI). Although current treatment regimens using antibiotics are satisfactory, development of antimicrobial resistance by the pathogen represents a challenge in the management of R...
journal_title:Andrology
pub_type: 杂志文章
doi:10.1111/andr.12012
更新日期:2015-03-01 00:00:00
abstract::The use of intra-cytoplasmic sperm injection (ICSI) has increased significantly worldwide, often chosen instead of in vitro fertilization (IVF), yet long-term health outcomes are unknown and health differences between ICSI and IVF conceptions have not been comprehensively assessed. A systematic review of health outcom...
journal_title:Andrology
pub_type: 杂志文章,评审
doi:10.1111/andr.12369
更新日期:2017-07-01 00:00:00
abstract::Presence of vacuoles and degree of sperm DNA damage are considered to be the basic factors used for the assessment of sperm fertilization capacity. We aimed to investigate the link between these two parameters. According to our knowledge, this is the first study where the Comet assay was used to assess the degree of D...
journal_title:Andrology
pub_type: 杂志文章
doi:10.1111/andr.12324
更新日期:2017-03-01 00:00:00
abstract::The second messenger cyclic adenosine monophosphate (cAMP) has a central role in sperm physiology. Extracellular cAMP can be sequentially degraded into 5'AMP and adenosine by ecto-phosphodiesterases (ecto-PDE) and ecto-nucleotidases, a phenomenon called extracellular cAMP-adenosine pathway. As cAMP-adenosine pathway i...
journal_title:Andrology
pub_type: 杂志文章
doi:10.1111/andr.12267
更新日期:2016-11-01 00:00:00
abstract::The discontinuation rate with phosphodiesterase type 5 inhibitors (PDE5i) remains very high. The aim of this study was to review and meta-analyze currently available data regarding dropout of the first-generation of PDE5i including sildenafil, vardenafil, and tadalafil. An extensive Medline Embase and Cochrane search ...
journal_title:Andrology
pub_type: 杂志文章,meta分析,评审
doi:10.1111/andr.12255
更新日期:2016-11-01 00:00:00
abstract::Scrotal skin is thin and has high steroid permeability, but the pharmacokinetics of testosterone via the scrotal skin route has not been studied in detail. The aim of this study was to define the pharmacokinetics of testosterone delivered via the scrotal skin route. The study was a single-center, three-phase cross-ove...
journal_title:Andrology
pub_type: 杂志文章,随机对照试验
doi:10.1111/andr.12357
更新日期:2017-07-01 00:00:00
abstract::Male factor etiology may be a contributing factor in up to 60% of infertility cases. Dietary intake of phytoestrogens has been related to abnormal semen quality and hormone levels. However, its effect on couple fecundity is still unclear. Intake of soy products was assessed in 184 men from couples undergoing infertili...
journal_title:Andrology
pub_type: 杂志文章
doi:10.1111/andr.12046
更新日期:2015-07-01 00:00:00
abstract:BACKGROUND:The existing classifications of varicocoeles have poor predictive value regarding the effects of surgery on sperm count. OBJECTIVE:To develop a new grading system for varicocoeles, useful as an indication for surgery. MATERIALS AND METHODS:This is a three-center prospective study which examined 173 men hav...
journal_title:Andrology
pub_type: 杂志文章,多中心研究
doi:10.1111/andr.12556
更新日期:2019-01-01 00:00:00
abstract::Pubertal gynecomastia is a common condition observed in up to 65% of adolescent males. It is usually idiopathic and tends to regress within 1-2 years. In this descriptive cross-sectional study, we investigated 25 adolescent males with prominent (>B3) and/or persistent (>2 years) pubertal gynecomastia (P/PPG) to determ...
journal_title:Andrology
pub_type: 杂志文章
doi:10.1111/andr.12145
更新日期:2016-03-01 00:00:00
abstract::Sperm count, morphology, and motility have been reported to be predictive of pregnancy, although with equivocal basis prompting some authors to question the prognostic value of semen analysis. To assess the utility of including semen quality data in predicting conception delay or requiring >6 cycles to become pregnant...
journal_title:Andrology
pub_type: 杂志文章
doi:10.1111/andr.12288
更新日期:2017-01-01 00:00:00
abstract::Brain dysfunction in erectile dysfunction (ED) has been identified by multiple neuroimaging studies. A recent MRI study indicated grey matter alterations in ED patients. This study aims to investigate the microstructural changes of cerebral white matter (WM) in psychological ED patients and their possible correlations...
journal_title:Andrology
pub_type: 杂志文章
doi:10.1111/j.2047-2927.2014.00191.x
更新日期:2014-05-01 00:00:00
abstract:BACKGROUND:Oocyte activation is driven by intracellular calcium (Ca2+ ) oscillations induced by sperm-specific PLCζ, abrogation of which causes oocyte activation deficiency in humans. Clinical PLCζ investigations have been limited to severe male infertility conditions, while PLCζ levels and localisation patterns have y...
journal_title:Andrology
pub_type: 杂志文章
doi:10.1111/andr.12796
更新日期:2020-09-01 00:00:00
abstract::Maternal overweight and obesity in pregnancy has been associated with earlier age of menarche in daughters as well as reduced semen quality in sons. We aimed at investigating pubertal development in sons born by mothers with a high body mass index (BMI). The study included 2522 sons of mothers that during pregnancy in...
journal_title:Andrology
pub_type: 杂志文章
doi:10.1111/j.2047-2927.2013.00171.x
更新日期:2014-03-01 00:00:00
abstract:BACKGROUND:We previously demonstrated how mouse spermatozoa can be efficiently stored for two years in a -80°C freezer, maintaining their ability to fertilize mouse eggs. OBJECTIVES:The main objective here was to evaluate the effects of five years at -80°C compared to liquid nitrogen storage (LN2 , control condition) ...
journal_title:Andrology
pub_type: 杂志文章
doi:10.1111/andr.12971
更新日期:2021-01-11 00:00:00
abstract::Peyronie's disease (PD) is an under-diagnosed condition with prevalence in the male population as high as 9%. It is a localized connective tissue disorder of the penis characterized by scarring of the tunica albuginea. Its pathophysiology, however, remains incompletely elucidated. For the management of the acute phase...
journal_title:Andrology
pub_type: 杂志文章,评审
doi:10.1111/andr.12058
更新日期:2015-07-01 00:00:00
abstract::Deletions on the long arm of the Y chromosome are a well-known cause of male infertility and it is generally accepted that deletions involving the AZFb region are not compatible with sperm production. Here, we report on two patients for whom basic diagnostic tests showed a deletion of the AZFb region. Unexpectedly, bo...
journal_title:Andrology
pub_type: 杂志文章
doi:10.1111/andr.12350
更新日期:2017-07-01 00:00:00
abstract::In cryptorchid boys, failures in germ cell development have been clearly established. Some studies reported some abnormalities in Sertoli cells morphology but the results regarding their endocrine secretion remain controversial. To compare testicular hormone levels in young boys with and without cryptorchidism, we per...
journal_title:Andrology
pub_type: 杂志文章
doi:10.1111/andr.12373
更新日期:2017-07-01 00:00:00
abstract::To analyze the pathogenesis of persistent and refractory haematospermia and to evaluate the aetiological diagnostic value of magnetic resonance imaging (MRI) for this type of haematospermia. Clinical data from 102 patients with persistent and refractory haematospermia was retrospectively analysed. Data collected inclu...
journal_title:Andrology
pub_type: 杂志文章
doi:10.1111/j.2047-2927.2013.00132.x
更新日期:2013-11-01 00:00:00
abstract::The morphology, ultrastructure, and functions of mature avian spermatozoa have been of immense commercial and scientific interest for several reasons. This is mainly important in case of birds in poultry production, conservation, and in the use of sperm morphometry as phylogenetic evidence. Avian spermatozoa share com...
journal_title:Andrology
pub_type: 杂志文章
doi:10.1111/andr.12130
更新日期:2016-03-01 00:00:00
abstract:BACKGROUND:The association between alcohol intake and male reproductive function is still controversial. In the frame of a prospective cohort study, designed to investigate the relation between life style and fertility, we performed a cross-sectional analysis of semen quality. METHODS:Men of subfertile couples, referr...
journal_title:Andrology
pub_type: 杂志文章
doi:10.1111/andr.12521
更新日期:2018-09-01 00:00:00
abstract::Approximately 40% of middle-aged men exhibit symptoms of late-onset hypogonadism (LOH). However, the mechanism of androgen deficiency is still currently unclear. As shown in our previous studies, the SET protein is expressed in testicular Leydig cells and ovarian granule cells. This study was designed to investigate t...
journal_title:Andrology
pub_type: 杂志文章
doi:10.1111/andr.12476
更新日期:2018-05-01 00:00:00
abstract::Most of the non-obstructive azoospermia (NOA)-patients have only focal spermatogenesis which results in insufficient numbers of spermatozoa to reach the ejaculate. In ≈50% of these NOA-patients testicular sperm extraction (TESE) is successful and intracytoplasmic sperm injection (ICSI) is pursued. We studied whether (...
journal_title:Andrology
pub_type: 杂志文章
doi:10.1111/andr.12023
更新日期:2015-05-01 00:00:00
abstract::The molecular basis of spermatogenic failure (SpF) is still largely unknown. Accumulating evidence suggests that a series of specific events such as meiosis, are determined at the early stage of spermatogenesis. This study aims to assess the expression profile of pre-meiotic genes of infertile testicular biopsies that...
journal_title:Andrology
pub_type: 杂志文章
doi:10.1111/j.2047-2927.2014.00217.x
更新日期:2014-07-01 00:00:00
abstract::Sickle cell disease (SCD)-associated priapism is characterized by decreased nitric oxide (NO) signaling and downregulated phosphodiesterase (PDE)5 protein expression and activity in the penis. Priapism is also associated with testosterone deficiency, but molecular mechanisms underlying testosterone effects in the peni...
journal_title:Andrology
pub_type: 杂志文章
doi:10.1111/andr.12442
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:Germ cell tumours are uniquely associated with the gametogenic tissues of males and females. A feature of these cancers is that they can express genes that are normally tightly restricted to meiotic cells. This aberrant gene expression has been used as an indicator that these cancer cells are attempting a pr...
journal_title:Andrology
pub_type: 杂志文章,评审
doi:10.1111/andr.12628
更新日期:2019-07-01 00:00:00
abstract:BACKGROUND:Testicular architecture and sperm production are supported by a complex network of communication between various cell types. These signals ensure fertility by: regulating spermatogonial stem/progenitor cells; promoting steroidogenesis; and driving male-specific differentiation of the gonad. Sertoli cells hav...
journal_title:Andrology
pub_type: 杂志文章,评审
doi:10.1111/andr.12703
更新日期:2020-07-01 00:00:00
abstract:BACKGROUND:Bulls are of great importance in the productive chain and for this reason they should have a good semen quality. There is no doubt that sperm morphology is very important to bull fertility, although little is known about how exactly the abnormal morphologies may affect sperm functions. OBJECTIVES:To detail ...
journal_title:Andrology
pub_type: 杂志文章
doi:10.1111/andr.12618
更新日期:2020-01-01 00:00:00
abstract::Testicular germ cell tumours (TGCT) typically contain high numbers of infiltrating immune cells, yet the functional nature and consequences of interactions between GCNIS (germ cell neoplasia in situ) or seminoma cells and immune cells remain unknown. A co-culture model using the seminoma-derived TCam-2 cell line and p...
journal_title:Andrology
pub_type: 杂志文章
doi:10.1111/andr.12365
更新日期:2017-07-01 00:00:00
abstract::The published incidence of bilateral varicocoeles in adults is much higher than among adolescents. We investigated our adolescent varicocoele database to determine (i) the presence of subclinical and palpable right varicocoele s in boys with a left varicocoele, (ii) the effect, if any, of right varicocoele on asymmetr...
journal_title:Andrology
pub_type: 杂志文章
doi:10.1111/j.2047-2927.2013.00130.x
更新日期:2013-11-01 00:00:00