Abstract:
:Erectile dysfunction (ED) is increasingly recognized as a public health problem. Several studies have reported the influence of the insertion/deletion (I/D) polymorphism in the Angiotensin-converting enzyme (ACE) gene on ED susceptibility, but the results remain controversial. To derive a more precise estimation of the relationship, a meta-analysis was conducted using data published previously by other groups. A total of six case-control studies, including 1039 cases and 927 controls, were selected. The pooled odds ratios (ORs) and respective 95% confidence intervals (CIs) were calculated by comparing the carriers of D-allele with the wild homozygotes (ID + DD vs. II). Comparisons of other genetic models were also performed (ID + II vs. DD, DD vs. II, DI vs. II and D vs. I). In the overall analysis, no significant association between the polymorphism and ED risk was observed (OR=1.07, 95% CI = 0.84 - 1.37, p = 0.575 for ID + DD vs. II). In the subgroup analysis by ethnic, no significant association was detected among Asian, Latino and European for the comparison of ID + DD vs. II (Asian: OR=1.27, 95% CI = 0.89 - 1.81; Latino: OR=0.76, 95% CI = 0.46 - 1.27; European: OR=1.06, 95% CI = 0.67 - 1.66). Results from other comparative genetic models also indicated the lack of associations between this polymorphism and ED risk. In conclusion, this meta-analysis indicates that the ACE I/D polymorphism might not contribute to the risk of ED.
journal_name
Andrologyjournal_title
Andrologyauthors
Zhang T,Li WL,He XF,Wu ZY,Liu LH,He SH,Wei AYdoi
10.1111/j.2047-2927.2012.00029.xsubject
Has Abstractpub_date
2013-03-01 00:00:00pages
274-80issue
2eissn
2047-2919issn
2047-2927journal_volume
1pub_type
杂志文章,meta分析相关文献
Andrology文献大全abstract::Smoking is strongly associated with abnormalities in histone-to-protamine transition and with alteration of protamine expression in human spermatozoa. A proper protamine to histone ratio is, however, essential for sperm chromatin maturity and DNA integrity. Alterations in these sperm nuclear proteins were observed in ...
journal_title:Andrology
pub_type: 杂志文章
doi:10.1111/j.2047-2927.2014.00245.x
更新日期:2014-09-01 00:00:00
abstract::Scarce data are available on epidemiology of varicocoele, the most common surgically correctable cause of male infertility. The objectives of this study were to evaluate the association between body mass index (BMI) and varicocoele and to assess trends in prevalence over time. We conducted a nationwide population-base...
journal_title:Andrology
pub_type: 杂志文章
doi:10.1111/j.2047-2927.2013.00113.x
更新日期:2013-09-01 00:00:00
abstract::To add new arguments concerning the origin of the sperm-head vacuoles observed under high magnification with interference contrast microscopy, we carried out in two patients with total globozoospermia confirmed using transmission electron microscopy (TEM), a detailed sperm morphometric analysis with high magnification...
journal_title:Andrology
pub_type: 杂志文章
doi:10.1111/j.2047-2927.2012.00011.x
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND:Germ cell tumours are uniquely associated with the gametogenic tissues of males and females. A feature of these cancers is that they can express genes that are normally tightly restricted to meiotic cells. This aberrant gene expression has been used as an indicator that these cancer cells are attempting a pr...
journal_title:Andrology
pub_type: 杂志文章,评审
doi:10.1111/andr.12628
更新日期:2019-07-01 00:00:00
abstract::Prevalence and risk factors of concomitant primary low sexual desire/interest (LSD/I) and subsequent new-onset erectile dysfunction (ED) in men have been only partially investigated. We looked at the sociodemographic and clinical predictors of the concomitant condition of primary LSD/I - defined as the reduction in th...
journal_title:Andrology
pub_type: 杂志文章
doi:10.1111/j.2047-2927.2014.00236.x
更新日期:2014-09-01 00:00:00
abstract:OBJECTIVE:To evaluate the association between cannabis use and testicular function (as assessed through semen quality and serum hormone levels) in different populations. EVIDENCE REVIEW:Systematic review and meta-analysis of population-based retrospective cohort studies. PRISMA guidelines were used for abstracting dat...
journal_title:Andrology
pub_type: 杂志文章
doi:10.1111/andr.12953
更新日期:2020-11-29 00:00:00
abstract::The main aim of this work was to evaluate how supplementing freezing media with reduced glutathione (GSH) affected the 'in vivo' fertilizing ability of boar semen subjected to cryopreservation procedures. With this purpose, 12 ejaculates coming from 12 boars were cryopreserved in the presence or absence of 2 mm GSH, w...
journal_title:Andrology
pub_type: 杂志文章
doi:10.1111/j.2047-2927.2013.00144.x
更新日期:2014-01-01 00:00:00
abstract:STUDY QUESTION:Are de novo mutations in the human genome associated with male infertility? SUMMARY ANSWER:We identified de novo mutations in five candidate genes: SEMA5A, NEURL4, BRD2, CD1D, and CD63. WHAT IS KNOWN ALREADY:Epidemiological and genetic studies have consistently indicated contribution of genetic factors...
journal_title:Andrology
pub_type: 杂志文章
doi:10.1111/andr.12897
更新日期:2021-01-01 00:00:00
abstract::Peyronie's disease (PD) is an under-diagnosed condition with prevalence in the male population as high as 9%. It is a localized connective tissue disorder of the penis characterized by scarring of the tunica albuginea. Its pathophysiology, however, remains incompletely elucidated. For the management of the acute phase...
journal_title:Andrology
pub_type: 杂志文章,评审
doi:10.1111/andr.12058
更新日期:2015-07-01 00:00:00
abstract::The molecular basis of spermatogenic failure (SpF) is still largely unknown. Accumulating evidence suggests that a series of specific events such as meiosis, are determined at the early stage of spermatogenesis. This study aims to assess the expression profile of pre-meiotic genes of infertile testicular biopsies that...
journal_title:Andrology
pub_type: 杂志文章
doi:10.1111/j.2047-2927.2014.00217.x
更新日期:2014-07-01 00:00:00
abstract::Semen quality is suggested to be a universal biomarker for future health. Previous studies have mostly been registry based excluding the possibility to address the importance of lifestyle, fertility status, health and socio-economic status. We aimed to investigate whether the association between semen quality and subs...
journal_title:Andrology
pub_type: 杂志文章
doi:10.1111/andr.12477
更新日期:2018-05-01 00:00:00
abstract::Tributyltin (TBT), a pesticide used in antifouling paints, is toxic for aquatic invertebrates. In vertebrates, TBT may act in obesogen- inducing adipogenetic gene transcription for adipocyte differentiation. In a previous study, we demonstrated that acute administration of TBT induces c-fos expression in the arcuate n...
journal_title:Andrology
pub_type: 杂志文章
doi:10.1111/andr.12222
更新日期:2016-07-01 00:00:00
abstract::The second messenger cyclic adenosine monophosphate (cAMP) has a central role in sperm physiology. Extracellular cAMP can be sequentially degraded into 5'AMP and adenosine by ecto-phosphodiesterases (ecto-PDE) and ecto-nucleotidases, a phenomenon called extracellular cAMP-adenosine pathway. As cAMP-adenosine pathway i...
journal_title:Andrology
pub_type: 杂志文章
doi:10.1111/andr.12267
更新日期:2016-11-01 00:00:00
abstract:BACKGROUND:Testicular germ cell tumour is the most common cancer to be diagnosed among young men. In New Zealand, we have observed some puzzling trends in the epidemiology of this disease. METHODS:We have conducted a narrative review of available evidence regarding the puzzling epidemiology of testicular germ cell tum...
journal_title:Andrology
pub_type: 杂志文章,评审
doi:10.1111/andr.12584
更新日期:2019-07-01 00:00:00
abstract:BACKGROUND:Severe peripheral angiopathy in patients with diabetes is a major contributing factor for low response rate to phosphodiesterase-5 inhibitors. OBJECTIVES:To examine whether and how Dickkopf3 (DKK3), a secreted modulator of the Wnt pathway that known to be involved in endothelial cell repair and vascular pro...
journal_title:Andrology
pub_type: 杂志文章
doi:10.1111/andr.12784
更新日期:2020-09-01 00:00:00
abstract::Germ cell and Sertoli cell proliferation and maturation in human testes occur in three main waves, during the late fetal and early neonatal period and at early puberty. They are triggered by periods of increased activity of the hypothalamic-pituitary-gonadal (HPG) axis. In hypogonadotropic hypogonadism (HH), these pro...
journal_title:Andrology
pub_type: 杂志文章
doi:10.1111/andr.12128
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:Knowledge about Klinefelter syndrome (KS) has increased substantially since its first description almost 80 years ago. A variety of treatment options concerning the spectrum of symptoms associated with KS exists, also regarding aspects beyond testicular dysfunction. Nevertheless, the diagnostic rate is still...
journal_title:Andrology
pub_type: 杂志文章,评审
doi:10.1111/andr.12909
更新日期:2021-01-01 00:00:00
abstract:BACKGROUND:The existing classifications of varicocoeles have poor predictive value regarding the effects of surgery on sperm count. OBJECTIVE:To develop a new grading system for varicocoeles, useful as an indication for surgery. MATERIALS AND METHODS:This is a three-center prospective study which examined 173 men hav...
journal_title:Andrology
pub_type: 杂志文章,多中心研究
doi:10.1111/andr.12556
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:Gene expression patterns along the epididymis are established by specific transcription factor networks that coordinate region-specific functions. In rodents, the epididymis can be divided in up to 19 segments. Based on gross anatomy, the human epididymis is divided into caput, corpus, and cauda segments tog...
journal_title:Andrology
pub_type: 杂志文章
doi:10.1111/andr.12745
更新日期:2020-05-01 00:00:00
abstract:BACKGROUND:Testicular germ cell tumors (TGCTs) are highly sensitive to platinum-based chemotherapy, and wild-type p53 seems to play a pivotal role in this susceptibility. On the other hand, overexpression of MDM2 seems to entail treatment resistance and unfavorable prognosis. OBJECTIVES:We aimed to describe p53 and MD...
journal_title:Andrology
pub_type: 杂志文章
doi:10.1111/andr.12814
更新日期:2020-09-01 00:00:00
abstract::In recent reports, an association between altered TRPC channel function and the development of various diabetic complications has drawn the attention of many investigators. The aim of this study was to investigate the expression of TRPC4 channels of corpus smooth muscle (CSM) cells in diabetes, and to evaluate the ass...
journal_title:Andrology
pub_type: 杂志文章
doi:10.1111/j.2047-2927.2014.00214.x
更新日期:2014-07-01 00:00:00
abstract:BACKGROUND:Penile cancer represents a rare pathology whose natural history of treatment is poorly understood. OBJECTIVE:To illustrate the dynamic survival profiles in surgically treated patients with squamous cell carcinoma of the penis (SCCP) using the conditional survival (CS) estimates. MATERIALS AND METHODS:Patie...
journal_title:Andrology
pub_type: 杂志文章
doi:10.1111/andr.12856
更新日期:2020-11-01 00:00:00
abstract:BACKGROUND:The transcription factor DMRTB1 plays a pivotal role in coordinating the transition between mitosis and meiosis in murine germ cells. No reliable data are available for human testis. OBJECTIVES:The present study aims to examine the testicular expression pattern of DMRTB1 in men showing normal and impaired s...
journal_title:Andrology
pub_type: 杂志文章
doi:10.1111/andr.12617
更新日期:2019-07-01 00:00:00
abstract::Presence of vacuoles and degree of sperm DNA damage are considered to be the basic factors used for the assessment of sperm fertilization capacity. We aimed to investigate the link between these two parameters. According to our knowledge, this is the first study where the Comet assay was used to assess the degree of D...
journal_title:Andrology
pub_type: 杂志文章
doi:10.1111/andr.12324
更新日期:2017-03-01 00:00:00
abstract:BACKGROUND:It is known that exposure to either arsenic or hyperglycemia can induce male reproductive damages. However, their combined effects on male reproductive organs are still unclear. Therefore, the present study investigated morphological and functional parameters of the testis, epididymis, and spermatozoa in dia...
journal_title:Andrology
pub_type: 杂志文章
doi:10.1111/andr.12613
更新日期:2019-09-01 00:00:00
abstract::Approximately 40% of middle-aged men exhibit symptoms of late-onset hypogonadism (LOH). However, the mechanism of androgen deficiency is still currently unclear. As shown in our previous studies, the SET protein is expressed in testicular Leydig cells and ovarian granule cells. This study was designed to investigate t...
journal_title:Andrology
pub_type: 杂志文章
doi:10.1111/andr.12476
更新日期:2018-05-01 00:00:00
abstract::To analyze the pathogenesis of persistent and refractory haematospermia and to evaluate the aetiological diagnostic value of magnetic resonance imaging (MRI) for this type of haematospermia. Clinical data from 102 patients with persistent and refractory haematospermia was retrospectively analysed. Data collected inclu...
journal_title:Andrology
pub_type: 杂志文章
doi:10.1111/j.2047-2927.2013.00132.x
更新日期:2013-11-01 00:00:00
abstract::Bisphenol A (BPA) is widely used in food contact materials, toys, and other products. Several studies have indicated that effects observed at doses near human exposure levels may not be observed at higher doses. Many studies have shown effects on mammary glands at low doses of BPA, however, because of small number of ...
journal_title:Andrology
pub_type: 杂志文章
doi:10.1111/andr.12193
更新日期:2016-07-01 00:00:00
abstract::Tamoxifen is an off-label option to treat men for breast cancer, infertility, and idiopathic gynecomastia. Lately, tamoxifen has been proposed as a treatment to prevent gynecomastia in prostate cancer patients receiving antiandrogen therapy. We reviewed the adverse events (AEs) reported in studies of men prescribed ta...
journal_title:Andrology
pub_type: 杂志文章,评审
doi:10.1111/andr.12197
更新日期:2016-09-01 00:00:00
abstract::Spermatogenesis involves the aggregated action of up to 2300 genes, any of which, could, potentially, provide targets for diagnostic tests of male factor infertility. Contrary to the previously proposed common variant hypothesis for common diseases such as male infertility, genome-wide association studies and targeted...
journal_title:Andrology
pub_type: 杂志文章,评审
doi:10.1111/j.2047-2927.2014.00200.x
更新日期:2014-05-01 00:00:00