Impact of cigarette smoking on histone (H2B) to protamine ratio in human spermatozoa and its relation to sperm parameters.

abstract：:Oxidation-reduction potential describes the balance between the oxidants and antioxidants in fluids including semen. Various artificial culture media are used in andrology and IVF laboratories for sperm preparation and to support the development of fertilized oocytes under in vitro conditions. The composition and cond...

journal_title：Andrology

authors： Panner Selvam MK,Henkel R,Sharma R,Agarwal A

更新日期：2018-03-01 00:00:00

abstract：STUDY QUESTION:Are de novo mutations in the human genome associated with male infertility? SUMMARY ANSWER:We identified de novo mutations in five candidate genes: SEMA5A, NEURL4, BRD2, CD1D, and CD63. WHAT IS KNOWN ALREADY:Epidemiological and genetic studies have consistently indicated contribution of genetic factors...

journal_title：Andrology

authors： Hodžić A,Maver A,Plaseska-Karanfilska D,Ristanović M,Noveski P,Zorn B,Terzic M,Kunej T,Peterlin B

更新日期：2021-01-01 00:00:00

abstract：:Growth hormone (GH) and insulin-like growth factor I (IGF-I) receptors are present on pituitary gonadotrophs and on testicular Leydig and Sertoli cells. Thus, the GH/IGF-I system may modulate the pituitary-gonadal axis in males. This is a randomized cross-over study. Eight healthy male volunteers (mean age 35, range 2...

journal_title：Andrology

authors： Andreassen M,Frystyk J,Faber J,Kristensen LØ,Juul A

更新日期：2013-07-01 00:00:00

abstract：BACKGROUND:A significant increase in the use of intracytoplasmic sperm injection (ICSI) since its introduction in 1992 has been observed worldwide, including beyond its original intended use for severe male factor infertility. Concerns regarding ICSI include the effects of poor quality spermatozoa on offspring health a...

journal_title：Andrology

authors： Catford SR,McLachlan RI,O'Bryan MK,Halliday JL

更新日期：2018-09-01 00:00:00

abstract：:Prevalence and risk factors of concomitant primary low sexual desire/interest (LSD/I) and subsequent new-onset erectile dysfunction (ED) in men have been only partially investigated. We looked at the sociodemographic and clinical predictors of the concomitant condition of primary LSD/I - defined as the reduction in th...

journal_title：Andrology

authors： Salonia A,Clementi MC,Ventimiglia E,Colicchia M,Capogrosso P,Castiglione F,Castagna G,Boeri L,Suardi N,Cantiello F,Damiano R,Montorsi F

更新日期：2014-09-01 00:00:00

abstract：:Sperm count, morphology, and motility have been reported to be predictive of pregnancy, although with equivocal basis prompting some authors to question the prognostic value of semen analysis. To assess the utility of including semen quality data in predicting conception delay or requiring >6 cycles to become pregnant...

journal_title：Andrology

authors： Patel CJ,Sundaram R,Buck Louis GM

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Penile cancer represents a rare pathology whose natural history of treatment is poorly understood. OBJECTIVE:To illustrate the dynamic survival profiles in surgically treated patients with squamous cell carcinoma of the penis (SCCP) using the conditional survival (CS) estimates. MATERIALS AND METHODS:Patie...

journal_title：Andrology

authors： Liu W,Luo Y,Wang G,Li N,Wang Z,Lei J,Wang X

更新日期：2020-11-01 00:00:00

abstract：BACKGROUND:Recent evidence suggests that routine semen analysis has limited power to predict male fertility. Several efforts have been made to best discriminate between fertile and subfertile men using several sperm features. So, there is a need to more reliable assays for providing molecular data to evaluate sperm qua...

journal_title：Andrology

authors： Dorostghoal M,Galehdari H,Moramezi F,Danyari R

更新日期：2020-09-01 00:00:00

abstract：:Semen quality is suggested to be a universal biomarker for future health. Previous studies have mostly been registry based excluding the possibility to address the importance of lifestyle, fertility status, health and socio-economic status. We aimed to investigate whether the association between semen quality and subs...

journal_title：Andrology

authors： Latif T,Lindahl-Jacobsen R,Mehlsen J,Eisenberg ML,Holmboe SA,Pors K,Brinth L,Skouby SO,Jørgensen N,Jensen TK

更新日期：2018-05-01 00:00:00

abstract：:Increasing evidence disclosed the existence of a novel multi-organ endocrine pathway, involving bone, pancreas and testis, of high penetrance in energy metabolism and male fertility. The main mediator of this axis is undercarboxylated osteocalcin (ucOC), a bone-derived protein-exerting systemic effects on tissues expr...

journal_title：Andrology

authors： De Toni L,Di Nisio A,Rocca MS,De Rocco Ponce M,Ferlin A,Foresta C

更新日期：2017-07-01 00:00:00

abstract：BACKGROUND:Germ cells have a unique and critical role as the conduit for hereditary information and therefore employ multiple strategies to protect genomic integrity and avoid mutations. Unlike somatic cells, which often respond to DNA damage by arresting the cell cycle and conducting DNA repair, germ cells as well as ...

journal_title：Andrology

authors： Bloom JC,Loehr AR,Schimenti JC,Weiss RS

更新日期：2019-07-01 00:00:00

abstract：:Scarce data are available on epidemiology of varicocoele, the most common surgically correctable cause of male infertility. The objectives of this study were to evaluate the association between body mass index (BMI) and varicocoele and to assess trends in prevalence over time. We conducted a nationwide population-base...

journal_title：Andrology

authors： Rais A,Zarka S,Derazne E,Tzur D,Calderon-Margalit R,Davidovitch N,Afek A,Carel R,Levine H

更新日期：2013-09-01 00:00:00

abstract：:The molecular basis of spermatogenic failure (SpF) is still largely unknown. Accumulating evidence suggests that a series of specific events such as meiosis, are determined at the early stage of spermatogenesis. This study aims to assess the expression profile of pre-meiotic genes of infertile testicular biopsies that...

journal_title：Andrology

authors： Bonache S,Algaba F,Franco E,Bassas L,Larriba S

更新日期：2014-07-01 00:00:00

abstract：:Cell-free seminal RNA (cfs-RNA) is mixed transcripts derived from male reproductive organs, and is potential biomarker for the research and diagnosis of male reproductive-related diseases. However, some clinical factors, including age, asymptomatic Ureaplasma urealyticum (UU) infection, scrotal heat stress, abstinence...

journal_title：Andrology

authors： Dong TT,Yu Q,Qing XR,Ma XL,Dong WW,Shi J,Li HG

更新日期：2016-11-01 00:00:00

abstract：:The discontinuation rate with phosphodiesterase type 5 inhibitors (PDE5i) remains very high. The aim of this study was to review and meta-analyze currently available data regarding dropout of the first-generation of PDE5i including sildenafil, vardenafil, and tadalafil. An extensive Medline Embase and Cochrane search ...

journal_title：Andrology

authors： Corona G,Rastrelli G,Burri A,Serra E,Gianfrilli D,Mannucci E,Jannini EA,Maggi M

更新日期：2016-11-01 00:00:00

abstract：:Peyronie's disease (PD) is an under-diagnosed condition with prevalence in the male population as high as 9%. It is a localized connective tissue disorder of the penis characterized by scarring of the tunica albuginea. Its pathophysiology, however, remains incompletely elucidated. For the management of the acute phase...

journal_title：Andrology

authors： Yafi FA,Pinsky MR,Sangkum P,Hellstrom WJ

更新日期：2015-07-01 00:00:00

abstract：:Pubertal gynecomastia is a common condition observed in up to 65% of adolescent males. It is usually idiopathic and tends to regress within 1-2 years. In this descriptive cross-sectional study, we investigated 25 adolescent males with prominent (>B3) and/or persistent (>2 years) pubertal gynecomastia (P/PPG) to determ...

journal_title：Andrology

authors： Paris F,Gaspari L,Mbou F,Philibert P,Audran F,Morel Y,Biason-Lauber A,Sultan C

更新日期：2016-03-01 00:00:00

abstract：BACKGROUND:Despite existing evidence regarding the role of testosterone as a protective factor for the kidney function in male adults, there are conflicting and inconclusive results on the influence of testosterone deficiency on developing chronic kidney disease (CKD). OBJECTIVE:This study aimed to investigate the inc...

journal_title：Andrology

authors： Amiri M,Ramezani Tehrani F,Rahmati M,Amanollahi Soudmand S,Behboudi-Gandevani S,Sabet Z,Azizi F

更新日期：2020-05-01 00:00:00

abstract：BACKGROUND:Regulatory bodies recommend inconsistent ejaculatory abstinence lengths before semen analysis. The literature exploring the effect of ejaculatory abstinence length on the outcomes of intracytoplasmic sperm injection is scarce. OBJECTIVE:To study the influence of ejaculatory abstinence length on semen qualit...

journal_title：Andrology

authors： Borges E Jr,Braga DPAF,Zanetti BF,Iaconelli A Jr,Setti AS

更新日期：2019-03-01 00:00:00

abstract：:In cryptorchid boys, failures in germ cell development have been clearly established. Some studies reported some abnormalities in Sertoli cells morphology but the results regarding their endocrine secretion remain controversial. To compare testicular hormone levels in young boys with and without cryptorchidism, we per...

journal_title：Andrology

authors： Hamdi SM,Almont T,Galinier P,Mieusset R,Thonneau P

更新日期：2017-07-01 00:00:00

abstract：:Genomic and protein-coding transcriptomic data have suggested that germ cell tumours (GCTs) of childhood are biologically distinct from those of adulthood. Global messenger RNA profiles segregate malignant GCTs primarily by histology, but then also by age, with numerous transcripts showing age-related differential exp...

journal_title：Andrology

authors： Murray MJ,Nicholson JC,Coleman N

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:The presence of miRNAs in human reproductive tissue is intriguing and suggests the possibility that these important regulatory molecules play a role in reproductive function. However, the regulatory role of miRNAs in reproductive tissue remains poorly understood with a significant amount of controversial and...

journal_title：Andrology

authors： Salas-Huetos A,James ER,Aston KI,Carrell DT,Jenkins TG,Yeste M

更新日期：2020-01-01 00:00:00

abstract：:Male factor etiology may be a contributing factor in up to 60% of infertility cases. Dietary intake of phytoestrogens has been related to abnormal semen quality and hormone levels. However, its effect on couple fecundity is still unclear. Intake of soy products was assessed in 184 men from couples undergoing infertili...

journal_title：Andrology

authors： Mínguez-Alarcón L,Afeiche MC,Chiu YH,Vanegas JC,Williams PL,Tanrikut C,Toth TL,Hauser R,Chavarro JE

更新日期：2015-07-01 00:00:00

abstract：:Spermiogenesis is the final phase of spermatogenesis. During this process, haploid round spermatids differentiate into spermatozoa, with dramatic morphological changes, including elongation and condensation of the nuclei, and formation of the flagella. Meig1 is one of many genes involved in the regulation of this proc...

journal_title：Andrology

authors： Shi Y,Zhang L,Song S,Teves ME,Li H,Wang Z,Hess RA,Jiang G,Zhang Z

更新日期：2013-05-01 00:00:00

abstract：BACKGROUND:Oocyte activation is driven by intracellular calcium (Ca2+ ) oscillations induced by sperm-specific PLCζ, abrogation of which causes oocyte activation deficiency in humans. Clinical PLCζ investigations have been limited to severe male infertility conditions, while PLCζ levels and localisation patterns have y...

journal_title：Andrology

authors： Kashir J,Mistry BV,BuSaleh L,Abu-Dawas R,Nomikos M,Ajlan A,Abu-Dawud R,AlYacoub N,AlHassan S,Lai FA,Assiri AM,Coskun S

更新日期：2020-09-01 00:00:00

abstract：:In recent reports, an association between altered TRPC channel function and the development of various diabetic complications has drawn the attention of many investigators. The aim of this study was to investigate the expression of TRPC4 channels of corpus smooth muscle (CSM) cells in diabetes, and to evaluate the ass...

journal_title：Andrology

authors： Sung HH,Choo SH,Ko M,Kang SJ,Chae MR,Kam SC,Han DH,So I,Lee SW

更新日期：2014-07-01 00:00:00

abstract：:The second messenger cyclic adenosine monophosphate (cAMP) has a central role in sperm physiology. Extracellular cAMP can be sequentially degraded into 5'AMP and adenosine by ecto-phosphodiesterases (ecto-PDE) and ecto-nucleotidases, a phenomenon called extracellular cAMP-adenosine pathway. As cAMP-adenosine pathway i...

journal_title：Andrology

authors： Bergeron A,Aragon JP,Guillemette C,Hébert A,Sullivan R,Blondin P,Richard FJ

更新日期：2016-11-01 00:00:00

abstract：:The double sex and mab-3-related transcription factor 1 (DMRT1) gene has long been linked to sex-determining pathways across vertebrates and is known to play an essential role in gonadal development and maintenance of spermatogenesis in mice. In humans, the genomic region harboring the DMRT gene cluster has been impli...

journal_title：Andrology

authors： Lima AC,Carvalho F,Gonçalves J,Fernandes S,Marques PI,Sousa M,Barros A,Seixas S,Amorim A,Conrad DF,Lopes AM

更新日期：2015-09-01 00:00:00

abstract：:Exosomes are membranous nanovesicles of endocytic origin that carry and transfer regulatory bioactive molecules and mediate intercellular communication between cells and tissues. Although seminal exosomes have been identified in human seminal plasma, their exact composition and possible physiologic function remain unk...

journal_title：Andrology

authors： Yang C,Guo WB,Zhang WS,Bian J,Yang JK,Zhou QZ,Chen MK,Peng W,Qi T,Wang CY,Liu CD

更新日期：2017-09-01 00:00:00

abstract：:Brain dysfunction in erectile dysfunction (ED) has been identified by multiple neuroimaging studies. A recent MRI study indicated grey matter alterations in ED patients. This study aims to investigate the microstructural changes of cerebral white matter (WM) in psychological ED patients and their possible correlations...

journal_title：Andrology

authors： Zhang P,Liu J,Li G,Pan J,Li Z,Liu Q,Qin W,Dong M,Sun J,Huang X,Wu T,Chang D

更新日期：2014-05-01 00:00:00