The puzzling incidence of testicular cancer in New Zealand: what can we learn?

abstract：:Testicular germ cell tumours (TGCT) typically contain high numbers of infiltrating immune cells, yet the functional nature and consequences of interactions between GCNIS (germ cell neoplasia in situ) or seminoma cells and immune cells remain unknown. A co-culture model using the seminoma-derived TCam-2 cell line and p...

journal_title：Andrology

authors： Klein B,Schuppe HC,Bergmann M,Hedger MP,Loveland BE,Loveland KL

更新日期：2017-07-01 00:00:00

abstract：:The aim of this study was to investigate the effects of castration and testosterone supplementation on nitroso-redox status, cardiac metabolism markers, and S100 proteins expression in the heart of male rats. 50 male Wistar rats were randomized into five groups with ten animals each: group 1: control intact (CON); gro...

journal_title：Andrology

authors： Regouat N,Cheboub A,Benahmed M,Belarbi A,Hadj-Bekkouche F

更新日期：2018-01-01 00:00:00

abstract：:Cell-free seminal RNA (cfs-RNA) is mixed transcripts derived from male reproductive organs, and is potential biomarker for the research and diagnosis of male reproductive-related diseases. However, some clinical factors, including age, asymptomatic Ureaplasma urealyticum (UU) infection, scrotal heat stress, abstinence...

journal_title：Andrology

authors： Dong TT,Yu Q,Qing XR,Ma XL,Dong WW,Shi J,Li HG

更新日期：2016-11-01 00:00:00

abstract：BACKGROUND:The transcription factor DMRTB1 plays a pivotal role in coordinating the transition between mitosis and meiosis in murine germ cells. No reliable data are available for human testis. OBJECTIVES:The present study aims to examine the testicular expression pattern of DMRTB1 in men showing normal and impaired s...

journal_title：Andrology

authors： Hilbold E,Bergmann M,Fietz D,Kliesch S,Weidner W,Langeheine M,Rode K,Brehm R

更新日期：2019-07-01 00:00:00

abstract：:In cryptorchid boys, failures in germ cell development have been clearly established. Some studies reported some abnormalities in Sertoli cells morphology but the results regarding their endocrine secretion remain controversial. To compare testicular hormone levels in young boys with and without cryptorchidism, we per...

journal_title：Andrology

authors： Hamdi SM,Almont T,Galinier P,Mieusset R,Thonneau P

更新日期：2017-07-01 00:00:00

abstract：:Interactions between infertility and sexuality are numerous and complex. Infertile men may suffer from sexual dysfunction (SD) when undergoing an assisted reproductive technology programme. We undertook a review both in French and English of the available data on male SD when being diagnosed with a fertility problem w...

journal_title：Andrology

authors： Bechoua S,Hamamah S,Scalici E

更新日期：2016-05-01 00:00:00

abstract：:Tributyltin (TBT), a pesticide used in antifouling paints, is toxic for aquatic invertebrates. In vertebrates, TBT may act in obesogen- inducing adipogenetic gene transcription for adipocyte differentiation. In a previous study, we demonstrated that acute administration of TBT induces c-fos expression in the arcuate n...

journal_title：Andrology

authors： Bo E,Farinetti A,Marraudino M,Sterchele D,Eva C,Gotti S,Panzica G

更新日期：2016-07-01 00:00:00

abstract：BACKGROUND:Concerns exist about the effect of delaying treatment for prostate cancer (PCa) regarding both oncological and functional outcomes after radical prostatectomy (RP). OBJECTIVE:To assess the impact of time from diagnosis to RP on post-operative erectile function (EF) outcomes. MATERIALS AND METHODS:We analyz...

journal_title：Andrology

authors： Schifano N,Capogrosso P,Pozzi E,Ventimiglia E,Cazzaniga W,Matloob R,Gandaglia G,Dehò F,Briganti A,Montorsi F,Salonia A

更新日期：2020-03-01 00:00:00

abstract：:Spermiogenesis is the final phase of spermatogenesis. During this process, haploid round spermatids differentiate into spermatozoa, with dramatic morphological changes, including elongation and condensation of the nuclei, and formation of the flagella. Meig1 is one of many genes involved in the regulation of this proc...

journal_title：Andrology

authors： Shi Y,Zhang L,Song S,Teves ME,Li H,Wang Z,Hess RA,Jiang G,Zhang Z

更新日期：2013-05-01 00:00:00

abstract：:Sperm count, morphology, and motility have been reported to be predictive of pregnancy, although with equivocal basis prompting some authors to question the prognostic value of semen analysis. To assess the utility of including semen quality data in predicting conception delay or requiring >6 cycles to become pregnant...

journal_title：Andrology

authors： Patel CJ,Sundaram R,Buck Louis GM

更新日期：2017-01-01 00:00:00

abstract：:Research in the last decade has revealed that bone is not only a target tissue for numerous circulating hormones but functions as an endocrine organ itself. As a recent study demonstrated a stimulatory effect of the osteoblast-derived hormone osteocalcin (OCN) on testosterone production in mice, we investigated whethe...

journal_title：Andrology

authors： Hannemann A,Breer S,Wallaschofski H,Nauck M,Baumeister SE,Barvencik F,Amling M,Schinke T,Haring R,Keller J

更新日期：2013-05-01 00:00:00

abstract：:In recent reports, an association between altered TRPC channel function and the development of various diabetic complications has drawn the attention of many investigators. The aim of this study was to investigate the expression of TRPC4 channels of corpus smooth muscle (CSM) cells in diabetes, and to evaluate the ass...

journal_title：Andrology

authors： Sung HH,Choo SH,Ko M,Kang SJ,Chae MR,Kam SC,Han DH,So I,Lee SW

更新日期：2014-07-01 00:00:00

abstract：:Sickle cell disease (SCD)-associated priapism is characterized by decreased nitric oxide (NO) signaling and downregulated phosphodiesterase (PDE)5 protein expression and activity in the penis. Priapism is also associated with testosterone deficiency, but molecular mechanisms underlying testosterone effects in the peni...

journal_title：Andrology

authors： Musicki B,Karakus S,Akakpo W,Silva FH,Liu J,Chen H,Zirkin BR,Burnett AL

更新日期：2018-01-01 00:00:00

abstract：:Germ cell and Sertoli cell proliferation and maturation in human testes occur in three main waves, during the late fetal and early neonatal period and at early puberty. They are triggered by periods of increased activity of the hypothalamic-pituitary-gonadal (HPG) axis. In hypogonadotropic hypogonadism (HH), these pro...

journal_title：Andrology

authors： Rohayem J,Sinthofen N,Nieschlag E,Kliesch S,Zitzmann M

更新日期：2016-01-01 00:00:00

abstract：:Male factor etiology may be a contributing factor in up to 60% of infertility cases. Dietary intake of phytoestrogens has been related to abnormal semen quality and hormone levels. However, its effect on couple fecundity is still unclear. Intake of soy products was assessed in 184 men from couples undergoing infertili...

journal_title：Andrology

authors： Mínguez-Alarcón L,Afeiche MC,Chiu YH,Vanegas JC,Williams PL,Tanrikut C,Toth TL,Hauser R,Chavarro JE

更新日期：2015-07-01 00:00:00

abstract：BACKGROUND:We aimed to examine the effects of pre-operative blood values on varicocelectomy success. MATERIALS AND METHODS:A total of 130 patients who underwent varicocelectomy in our clinic were retrospectively analyzed. Operation success was defined as the return of all semen parameters (concentration, progressive m...

journal_title：Andrology

authors： Erdogan O,Ok F,Carkci S

更新日期：2021-01-21 00:00:00

abstract：BACKGROUND:The existing classifications of varicocoeles have poor predictive value regarding the effects of surgery on sperm count. OBJECTIVE:To develop a new grading system for varicocoeles, useful as an indication for surgery. MATERIALS AND METHODS:This is a three-center prospective study which examined 173 men hav...

journal_title：Andrology

authors： Cavallini G,Scroppo FI,Colpi GM

更新日期：2019-01-01 00:00:00

abstract：:Tamoxifen is an off-label option to treat men for breast cancer, infertility, and idiopathic gynecomastia. Lately, tamoxifen has been proposed as a treatment to prevent gynecomastia in prostate cancer patients receiving antiandrogen therapy. We reviewed the adverse events (AEs) reported in studies of men prescribed ta...

journal_title：Andrology

authors： Wibowo E,Pollock PA,Hollis N,Wassersug RJ

更新日期：2016-09-01 00:00:00

abstract：:To analyze the pathogenesis of persistent and refractory haematospermia and to evaluate the aetiological diagnostic value of magnetic resonance imaging (MRI) for this type of haematospermia. Clinical data from 102 patients with persistent and refractory haematospermia was retrospectively analysed. Data collected inclu...

journal_title：Andrology

authors： Li BJ,Zhang C,Li K,Zhang J,Zhang Y,Sun ZY,Kang HY,Zhou B,Jin FS,Zhang KQ,Li YF

更新日期：2013-11-01 00:00:00

abstract：OBJECTIVE:To evaluate the association between cannabis use and testicular function (as assessed through semen quality and serum hormone levels) in different populations. EVIDENCE REVIEW:Systematic review and meta-analysis of population-based retrospective cohort studies. PRISMA guidelines were used for abstracting dat...

journal_title：Andrology

authors： Belladelli F,Del Giudice F,Kasman A,Kold Jensen T,Jørgensen N,Salonia A,Eisenberg ML

更新日期：2020-11-29 00:00:00

abstract：:The main aim of this work was to evaluate how supplementing freezing media with reduced glutathione (GSH) affected the 'in vivo' fertilizing ability of boar semen subjected to cryopreservation procedures. With this purpose, 12 ejaculates coming from 12 boars were cryopreserved in the presence or absence of 2 mm GSH, w...

journal_title：Andrology

authors： Estrada E,Rodríguez-Gil JE,Rocha LG,Balasch S,Bonet S,Yeste M

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:A significant increase in the use of intracytoplasmic sperm injection (ICSI) since its introduction in 1992 has been observed worldwide, including beyond its original intended use for severe male factor infertility. Concerns regarding ICSI include the effects of poor quality spermatozoa on offspring health a...

journal_title：Andrology

authors： Catford SR,McLachlan RI,O'Bryan MK,Halliday JL

更新日期：2018-09-01 00:00:00

abstract：BACKGROUND:Maximum urinary flow rate (Qmax) is usually increased after holmium laser enucleation of the prostate (HoLEP). However, improvements vary between patients and results regarding potential predictors of Qmax after HoLEP are inconsistent. Thus, we investigated pre-operative variables including second to fourth ...

journal_title：Andrology

authors： Park IN,Kim TB

更新日期：2019-03-01 00:00:00

abstract：:Deletions on the long arm of the Y chromosome are a well-known cause of male infertility and it is generally accepted that deletions involving the AZFb region are not compatible with sperm production. Here, we report on two patients for whom basic diagnostic tests showed a deletion of the AZFb region. Unexpectedly, bo...

journal_title：Andrology

authors： Stouffs K,Vloeberghs V,Gheldof A,Tournaye H,Seneca S

更新日期：2017-07-01 00:00:00

abstract：STUDY QUESTION:Are de novo mutations in the human genome associated with male infertility? SUMMARY ANSWER:We identified de novo mutations in five candidate genes: SEMA5A, NEURL4, BRD2, CD1D, and CD63. WHAT IS KNOWN ALREADY:Epidemiological and genetic studies have consistently indicated contribution of genetic factors...

journal_title：Andrology

authors： Hodžić A,Maver A,Plaseska-Karanfilska D,Ristanović M,Noveski P,Zorn B,Terzic M,Kunej T,Peterlin B

更新日期：2021-01-01 00:00:00

abstract：:Growth hormone (GH) and insulin-like growth factor I (IGF-I) receptors are present on pituitary gonadotrophs and on testicular Leydig and Sertoli cells. Thus, the GH/IGF-I system may modulate the pituitary-gonadal axis in males. This is a randomized cross-over study. Eight healthy male volunteers (mean age 35, range 2...

journal_title：Andrology

authors： Andreassen M,Frystyk J,Faber J,Kristensen LØ,Juul A

更新日期：2013-07-01 00:00:00

abstract：:Sperm DNA fragmentation varies between individuals and is more pronounced with increased patient age and time after sperm donation. The intensification of DNA fragmentation depends on the balance of the oxidoreductive system, which is regulated mainly by two enzymes - superoxide dismutase (SOD) and catalase. The objec...

journal_title：Andrology

authors： Wdowiak A,Bakalczuk S,Bakalczuk G

更新日期：2015-07-01 00:00:00

abstract：BACKGROUND:Germ cells have a unique and critical role as the conduit for hereditary information and therefore employ multiple strategies to protect genomic integrity and avoid mutations. Unlike somatic cells, which often respond to DNA damage by arresting the cell cycle and conducting DNA repair, germ cells as well as ...

journal_title：Andrology

authors： Bloom JC,Loehr AR,Schimenti JC,Weiss RS

更新日期：2019-07-01 00:00:00

abstract：:The medical treatment is indicated in the development stage of Peyronie's disease (PD) for at least 1 year after diagnosis and whenever in case of penile pain. This research was conducted to demonstrate the possible effectiveness of vitamin E in PD treatment, whereas in the scientific literature this topic is much dis...

journal_title：Andrology

authors： Paulis G,Brancato T,D'Ascenzo R,De Giorgio G,Nupieri P,Orsolini G,Alvaro R

更新日期：2013-01-01 00:00:00

abstract：:The discontinuation rate with phosphodiesterase type 5 inhibitors (PDE5i) remains very high. The aim of this study was to review and meta-analyze currently available data regarding dropout of the first-generation of PDE5i including sildenafil, vardenafil, and tadalafil. An extensive Medline Embase and Cochrane search ...

journal_title：Andrology

authors： Corona G,Rastrelli G,Burri A,Serra E,Gianfrilli D,Mannucci E,Jannini EA,Maggi M

更新日期：2016-11-01 00:00:00