Combined effects of arsenic exposure and diabetes on male reproductive functions.

Abstract:

BACKGROUND:It is known that exposure to either arsenic or hyperglycemia can induce male reproductive damages. However, their combined effects on male reproductive organs are still unclear. Therefore, the present study investigated morphological and functional parameters of the testis, epididymis, and spermatozoa in diabetic rats exposed to arsenate. MATERIALS AND METHODS:Diabetes was induced in male rats by intraperitoneal streptozotocin injection. While a set of healthy and diabetic animals received saline solution (negative control and diabetes control, respectively), the other set received 10 mg/L sodium arsenate (arsenic control and diabetes + arsenic groups, respectively) for 40 days in drinking water. Testosterone concentration, daily sperm production, sperm counts in the testis and epididymis, and sperm parameters were evaluated in the groups. Moreover, testis and epididymis were subjected to antioxidant enzymes analysis, micromineral determination, and histopathological evaluation. RESULTS:Arsenate exposure reduced serum testosterone concentration in healthy animals and worsened this reduction in diabetic rats. In addition, the number of spermatozoa in testis and epididymis tissues, as well as the daily sperm production, was decreased in these groups. Sperm parameters such as motility, morphology, and integrity of acrosomal and plasma membranes were impaired in health animals exposed to arsenate. The combination of diabetes and arsenate, in turn, increased only the percentage of spermatozoa with abnormal morphology. Moreover, the proportion of arsenic increased in the testis and epididymis of both groups receiving arsenate. Its bioaccumulation in these organs caused an imbalance in antioxidant enzymes activities and mineral content in healthy animals, enhancing these changes in diabetic rats. Testicular pathologies occurred mainly in animals co-exposed to diabetes and arsenate. CONCLUSION:Our results indicate that arsenate exposure enhances several damages to male reproductive functions in diabetic rats, mainly by impairing testosterone levels and inducing nitrosative stress in testis and epididymis.

journal_name

Andrology

journal_title

Andrology

authors

Souza ACF,Bastos DSS,Sertorio MN,Santos FC,Ervilha LOG,de Oliveira LL,Machado-Neves M

doi

10.1111/andr.12613

subject

Has Abstract

pub_date

2019-09-01 00:00:00

pages

730-740

issue

5

eissn

2047-2919

issn

2047-2927

journal_volume

7

pub_type

杂志文章
  • Meiotic gene activation in somatic and germ cell tumours.

    abstract:BACKGROUND:Germ cell tumours are uniquely associated with the gametogenic tissues of males and females. A feature of these cancers is that they can express genes that are normally tightly restricted to meiotic cells. This aberrant gene expression has been used as an indicator that these cancer cells are attempting a pr...

    journal_title:Andrology

    pub_type: 杂志文章,评审

    doi:10.1111/andr.12628

    authors: Feichtinger J,McFarlane RJ

    更新日期:2019-07-01 00:00:00

  • p53 and MDM2 expression in primary and metastatic testicular germ cell tumors: Association with clinical outcome.

    abstract:BACKGROUND:Testicular germ cell tumors (TGCTs) are highly sensitive to platinum-based chemotherapy, and wild-type p53 seems to play a pivotal role in this susceptibility. On the other hand, overexpression of MDM2 seems to entail treatment resistance and unfavorable prognosis. OBJECTIVES:We aimed to describe p53 and MD...

    journal_title:Andrology

    pub_type: 杂志文章

    doi:10.1111/andr.12814

    authors: Lobo J,Alzamora MA,Guimarães R,Cantante M,Lopes P,Braga I,Maurício J,Jerónimo C,Henrique R

    更新日期:2020-09-01 00:00:00

  • Conditional survival after surgery for patients with penile cancer.

    abstract:BACKGROUND:Penile cancer represents a rare pathology whose natural history of treatment is poorly understood. OBJECTIVE:To illustrate the dynamic survival profiles in surgically treated patients with squamous cell carcinoma of the penis (SCCP) using the conditional survival (CS) estimates. MATERIALS AND METHODS:Patie...

    journal_title:Andrology

    pub_type: 杂志文章

    doi:10.1111/andr.12856

    authors: Liu W,Luo Y,Wang G,Li N,Wang Z,Lei J,Wang X

    更新日期:2020-11-01 00:00:00

  • Therapeutic advances in the treatment of Peyronie's disease.

    abstract::Peyronie's disease (PD) is an under-diagnosed condition with prevalence in the male population as high as 9%. It is a localized connective tissue disorder of the penis characterized by scarring of the tunica albuginea. Its pathophysiology, however, remains incompletely elucidated. For the management of the acute phase...

    journal_title:Andrology

    pub_type: 杂志文章,评审

    doi:10.1111/andr.12058

    authors: Yafi FA,Pinsky MR,Sangkum P,Hellstrom WJ

    更新日期:2015-07-01 00:00:00

  • Semen quality associated with subsequent hospitalizations - Can the effect be explained by socio-economic status and lifestyle factors?

    abstract::Semen quality is suggested to be a universal biomarker for future health. Previous studies have mostly been registry based excluding the possibility to address the importance of lifestyle, fertility status, health and socio-economic status. We aimed to investigate whether the association between semen quality and subs...

    journal_title:Andrology

    pub_type: 杂志文章

    doi:10.1111/andr.12477

    authors: Latif T,Lindahl-Jacobsen R,Mehlsen J,Eisenberg ML,Holmboe SA,Pors K,Brinth L,Skouby SO,Jørgensen N,Jensen TK

    更新日期:2018-05-01 00:00:00

  • Changes in nerve- and endothelium-mediated contractile tone of the corpus cavernosum in a mouse model of pre-mature ageing.

    abstract::Erectile dysfunction (ED) is very prevalent in the older population, although the ageing-related mechanisms involved in the development of ED are poorly understood. We propose that age-induced differences in nerve- and endothelium-mediated smooth muscle contractility in the corpus cavernosum (CC) could be found betwee...

    journal_title:Andrology

    pub_type: 杂志文章

    doi:10.1111/j.2047-2927.2014.00213.x

    authors: Lafuente-Sanchis A,Triguero D,Garcia-Pascual A

    更新日期:2014-07-01 00:00:00

  • Tamoxifen in men: a review of adverse events.

    abstract::Tamoxifen is an off-label option to treat men for breast cancer, infertility, and idiopathic gynecomastia. Lately, tamoxifen has been proposed as a treatment to prevent gynecomastia in prostate cancer patients receiving antiandrogen therapy. We reviewed the adverse events (AEs) reported in studies of men prescribed ta...

    journal_title:Andrology

    pub_type: 杂志文章,评审

    doi:10.1111/andr.12197

    authors: Wibowo E,Pollock PA,Hollis N,Wassersug RJ

    更新日期:2016-09-01 00:00:00

  • The association between cannabis use and testicular function in men: A systematic review and meta-analysis.

    abstract:OBJECTIVE:To evaluate the association between cannabis use and testicular function (as assessed through semen quality and serum hormone levels) in different populations. EVIDENCE REVIEW:Systematic review and meta-analysis of population-based retrospective cohort studies. PRISMA guidelines were used for abstracting dat...

    journal_title:Andrology

    pub_type: 杂志文章

    doi:10.1111/andr.12953

    authors: Belladelli F,Del Giudice F,Kasman A,Kold Jensen T,Jørgensen N,Salonia A,Eisenberg ML

    更新日期:2020-11-29 00:00:00

  • Association of NE, leptin, and 5-HT with electrophysiological parameters in patients with primary premature ejaculation.

    abstract:OBJECTIVE:To investigate the possible role of serum norepinephrine (NE), leptin, and 5-hydroxytryptamine (5-HT) and their correlations with sympathetic skin response located in the penis (PSSR) in primary premature ejaculation (PPE). METHODS:We compared the serum level of NE, leptin, and 5-HT, intravaginal ejaculatory...

    journal_title:Andrology

    pub_type: 杂志文章

    doi:10.1111/andr.12773

    authors: Xia J,Zhang Q,Wang Y,Luan J,Yang J,Cong R,Wang Z,Song N

    更新日期:2020-09-01 00:00:00

  • Altered secretion of Sertoli cells hormones in 2-year-old prepubertal cryptorchid boys: a cross-sectional study.

    abstract::In cryptorchid boys, failures in germ cell development have been clearly established. Some studies reported some abnormalities in Sertoli cells morphology but the results regarding their endocrine secretion remain controversial. To compare testicular hormone levels in young boys with and without cryptorchidism, we per...

    journal_title:Andrology

    pub_type: 杂志文章

    doi:10.1111/andr.12373

    authors: Hamdi SM,Almont T,Galinier P,Mieusset R,Thonneau P

    更新日期:2017-07-01 00:00:00

  • Male soy food intake was not associated with in vitro fertilization outcomes among couples attending a fertility center.

    abstract::Male factor etiology may be a contributing factor in up to 60% of infertility cases. Dietary intake of phytoestrogens has been related to abnormal semen quality and hormone levels. However, its effect on couple fecundity is still unclear. Intake of soy products was assessed in 184 men from couples undergoing infertili...

    journal_title:Andrology

    pub_type: 杂志文章

    doi:10.1111/andr.12046

    authors: Mínguez-Alarcón L,Afeiche MC,Chiu YH,Vanegas JC,Williams PL,Tanrikut C,Toth TL,Hauser R,Chavarro JE

    更新日期:2015-07-01 00:00:00

  • An integrated approach with vardenafil orodispersible tablet and cognitive behavioral sex therapy for treatment of erectile dysfunction: a randomized controlled pilot study.

    abstract::Erectile Dysfunction is considered a multifactorial disease, where organic and psychological aspects are often interconnected. In a randomized controlled pilot study, we compared the efficacy of combined vardenafil orodispersible tablet (VARD) and cognitive-behavioral sex therapy (CBST) vs. VARD alone in improving sex...

    journal_title:Andrology

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/andr.12079

    authors: Boddi V,Castellini G,Casale H,Rastrelli G,Boni L,Corona G,Maggi M

    更新日期:2015-09-01 00:00:00

  • Disruption of bovine sperm functions in the presence of aplastic midpiece defect.

    abstract:BACKGROUND:Bulls are of great importance in the productive chain and for this reason they should have a good semen quality. There is no doubt that sperm morphology is very important to bull fertility, although little is known about how exactly the abnormal morphologies may affect sperm functions. OBJECTIVES:To detail ...

    journal_title:Andrology

    pub_type: 杂志文章

    doi:10.1111/andr.12618

    authors: Díaz-Miranda EA,Maitan PP,Machado TP,Camilo BS,Lima DA,Okano DS,Penitente-Filho JM,Machado-Neves M,de Oliveira LL,Guimarães SEF,da Costa EP,Guimarães JD

    更新日期:2020-01-01 00:00:00

  • Identification of the G protein-coupled estrogen receptor (GPER) in human prostate: expression site of the estrogen receptor in the benign and neoplastic gland.

    abstract::Estrogens are involved in growth, differentiation and pathogenesis of human prostate through the mediation of the classical estrogen receptors ERα and ERβ. The G protein-coupled estrogen receptor (GPER) is a 'novel' mediator of estrogen signaling which has been recently recognized in some human reproductive tissues, b...

    journal_title:Andrology

    pub_type: 杂志文章

    doi:10.1111/andr.12131

    authors: Rago V,Romeo F,Giordano F,Ferraro A,Carpino A

    更新日期:2016-01-01 00:00:00

  • The insertion/deletion (I/D) polymorphism in the angiotensin-converting enzyme gene and erectile dysfunction risk: a meta-analysis.

    abstract::Erectile dysfunction (ED) is increasingly recognized as a public health problem. Several studies have reported the influence of the insertion/deletion (I/D) polymorphism in the Angiotensin-converting enzyme (ACE) gene on ED susceptibility, but the results remain controversial. To derive a more precise estimation of th...

    journal_title:Andrology

    pub_type: 杂志文章,meta分析

    doi:10.1111/j.2047-2927.2012.00029.x

    authors: Zhang T,Li WL,He XF,Wu ZY,Liu LH,He SH,Wei AY

    更新日期:2013-03-01 00:00:00

  • Varicocoele among 1 300 000 Israeli adolescent males: time trends and association with body mass index.

    abstract::Scarce data are available on epidemiology of varicocoele, the most common surgically correctable cause of male infertility. The objectives of this study were to evaluate the association between body mass index (BMI) and varicocoele and to assess trends in prevalence over time. We conducted a nationwide population-base...

    journal_title:Andrology

    pub_type: 杂志文章

    doi:10.1111/j.2047-2927.2013.00113.x

    authors: Rais A,Zarka S,Derazne E,Tzur D,Calderon-Margalit R,Davidovitch N,Afek A,Carel R,Levine H

    更新日期:2013-09-01 00:00:00

  • Low-dose effects of bisphenol A on mammary gland development in rats.

    abstract::Bisphenol A (BPA) is widely used in food contact materials, toys, and other products. Several studies have indicated that effects observed at doses near human exposure levels may not be observed at higher doses. Many studies have shown effects on mammary glands at low doses of BPA, however, because of small number of ...

    journal_title:Andrology

    pub_type: 杂志文章

    doi:10.1111/andr.12193

    authors: Mandrup K,Boberg J,Isling LK,Christiansen S,Hass U

    更新日期:2016-07-01 00:00:00

  • Historical Vignette: Attempted treatment of Sigmund Freud's oral squamous cell carcinoma by vasectomy (Steinach Operation) in 1923.

    abstract:BACKGROUND:At the beginning of the 20th century, the Viennese physiologist Eugen Steinach proposed to treat the effects of physiological ageing by vasectomy. After experimenting his theory with animal, he published his results, and convinced scientists to apply this method to humans (ie men). The scientific community h...

    journal_title:Andrology

    pub_type: 杂志文章

    doi:10.1111/andr.12729

    authors: Benmoussa N,Charlier P,Rebibo JD

    更新日期:2020-05-01 00:00:00

  • Impact of cigarette smoking on histone (H2B) to protamine ratio in human spermatozoa and its relation to sperm parameters.

    abstract::Smoking is strongly associated with abnormalities in histone-to-protamine transition and with alteration of protamine expression in human spermatozoa. A proper protamine to histone ratio is, however, essential for sperm chromatin maturity and DNA integrity. Alterations in these sperm nuclear proteins were observed in ...

    journal_title:Andrology

    pub_type: 杂志文章

    doi:10.1111/j.2047-2927.2014.00245.x

    authors: Hamad MF,Shelko N,Kartarius S,Montenarh M,Hammadeh ME

    更新日期:2014-09-01 00:00:00

  • The mouse transcription factor-like 5 gene encodes a protein localized in the manchette and centriole of the elongating spermatid.

    abstract::Spermiogenesis is the final phase of spermatogenesis. During this process, haploid round spermatids differentiate into spermatozoa, with dramatic morphological changes, including elongation and condensation of the nuclei, and formation of the flagella. Meig1 is one of many genes involved in the regulation of this proc...

    journal_title:Andrology

    pub_type: 杂志文章

    doi:10.1111/j.2047-2927.2013.00069.x

    authors: Shi Y,Zhang L,Song S,Teves ME,Li H,Wang Z,Hess RA,Jiang G,Zhang Z

    更新日期:2013-05-01 00:00:00

  • Osteocalcin is associated with testosterone in the general population and selected patients with bone disorders.

    abstract::Research in the last decade has revealed that bone is not only a target tissue for numerous circulating hormones but functions as an endocrine organ itself. As a recent study demonstrated a stimulatory effect of the osteoblast-derived hormone osteocalcin (OCN) on testosterone production in mice, we investigated whethe...

    journal_title:Andrology

    pub_type: 杂志文章

    doi:10.1111/j.2047-2927.2012.00044.x

    authors: Hannemann A,Breer S,Wallaschofski H,Nauck M,Baumeister SE,Barvencik F,Amling M,Schinke T,Haring R,Keller J

    更新日期:2013-05-01 00:00:00

  • Immunolocalization of DMRTB1 in human testis with normal and impaired spermatogenesis.

    abstract:BACKGROUND:The transcription factor DMRTB1 plays a pivotal role in coordinating the transition between mitosis and meiosis in murine germ cells. No reliable data are available for human testis. OBJECTIVES:The present study aims to examine the testicular expression pattern of DMRTB1 in men showing normal and impaired s...

    journal_title:Andrology

    pub_type: 杂志文章

    doi:10.1111/andr.12617

    authors: Hilbold E,Bergmann M,Fietz D,Kliesch S,Weidner W,Langeheine M,Rode K,Brehm R

    更新日期:2019-07-01 00:00:00

  • Association of serum inorganic phosphate with sex steroid hormones and vitamin D in a nationally representative sample of men.

    abstract::Defects in bone regulatory pathways have been linked to chronic diseases including cardiovascular disease and cancer. In men, a link between bone metabolism and gonadal hormones has been suggested. However, to date, there is lack of evidence on the association between serum inorganic phosphate (Pi) and sex steroid hor...

    journal_title:Andrology

    pub_type: 杂志文章

    doi:10.1111/andr.285

    authors: Wulaningsih W,Van Hemelrijck M,Michaelsson K,Kanarek N,Nelson WG,Ix JH,Platz EA,Rohrmann S

    更新日期:2014-11-01 00:00:00

  • Effect of testosterone supplementation on nitroso-redox imbalance, cardiac metabolism markers, and S100 proteins expression in the heart of castrated male rats.

    abstract::The aim of this study was to investigate the effects of castration and testosterone supplementation on nitroso-redox status, cardiac metabolism markers, and S100 proteins expression in the heart of male rats. 50 male Wistar rats were randomized into five groups with ten animals each: group 1: control intact (CON); gro...

    journal_title:Andrology

    pub_type: 杂志文章

    doi:10.1111/andr.12449

    authors: Regouat N,Cheboub A,Benahmed M,Belarbi A,Hadj-Bekkouche F

    更新日期:2018-01-01 00:00:00

  • Long-term follow-up of intra-cytoplasmic sperm injection-conceived offspring compared with in vitro fertilization-conceived offspring: a systematic review of health outcomes beyond the neonatal period.

    abstract::The use of intra-cytoplasmic sperm injection (ICSI) has increased significantly worldwide, often chosen instead of in vitro fertilization (IVF), yet long-term health outcomes are unknown and health differences between ICSI and IVF conceptions have not been comprehensively assessed. A systematic review of health outcom...

    journal_title:Andrology

    pub_type: 杂志文章,评审

    doi:10.1111/andr.12369

    authors: Catford SR,McLachlan RI,O'Bryan MK,Halliday JL

    更新日期:2017-07-01 00:00:00

  • Prevalence and predictors of concomitant low sexual desire/interest and new-onset erectile dysfunction - a picture from the everyday clinical practice.

    abstract::Prevalence and risk factors of concomitant primary low sexual desire/interest (LSD/I) and subsequent new-onset erectile dysfunction (ED) in men have been only partially investigated. We looked at the sociodemographic and clinical predictors of the concomitant condition of primary LSD/I - defined as the reduction in th...

    journal_title:Andrology

    pub_type: 杂志文章

    doi:10.1111/j.2047-2927.2014.00236.x

    authors: Salonia A,Clementi MC,Ventimiglia E,Colicchia M,Capogrosso P,Castiglione F,Castagna G,Boeri L,Suardi N,Cantiello F,Damiano R,Montorsi F

    更新日期:2014-09-01 00:00:00

  • Humanin protects against chemotherapy-induced stage-specific male germ cell apoptosis in rats.

    abstract::Humanin (HN) has cytoprotective action on male germ cells after testicular stress induced by heat and hormonal deprivation. To examine whether HN has protective effects on chemotherapy-induced male germ cell apoptosis, we treated four groups of adult rats with (i) vehicle (control), (ii) HN, (iii) cyclophosphamide (CP...

    journal_title:Andrology

    pub_type: 杂志文章

    doi:10.1111/andr.12036

    authors: Surampudi P,Chang I,Lue Y,Doumit T,Jia Y,Atienza V,Liu PY,Swerdloff RS,Wang C

    更新日期:2015-05-01 00:00:00

  • Maternal pre-pregnancy body mass index and pubertal development among sons.

    abstract::Maternal overweight and obesity in pregnancy has been associated with earlier age of menarche in daughters as well as reduced semen quality in sons. We aimed at investigating pubertal development in sons born by mothers with a high body mass index (BMI). The study included 2522 sons of mothers that during pregnancy in...

    journal_title:Andrology

    pub_type: 杂志文章

    doi:10.1111/j.2047-2927.2013.00171.x

    authors: Hounsgaard ML,Håkonsen LB,Vested A,Thulstrup AM,Olsen J,Bonde JP,Nohr EA,Ramlau-Hansen CH

    更新日期:2014-03-01 00:00:00

  • Potential confounding factors in measurement of specific cell-free seminal mRNAs and microRNAs derived from human reproductive organs.

    abstract::Cell-free seminal RNA (cfs-RNA) is mixed transcripts derived from male reproductive organs, and is potential biomarker for the research and diagnosis of male reproductive-related diseases. However, some clinical factors, including age, asymptomatic Ureaplasma urealyticum (UU) infection, scrotal heat stress, abstinence...

    journal_title:Andrology

    pub_type: 杂志文章

    doi:10.1111/andr.12238

    authors: Dong TT,Yu Q,Qing XR,Ma XL,Dong WW,Shi J,Li HG

    更新日期:2016-11-01 00:00:00

  • Male infertility: an obstacle to sexuality?

    abstract::Interactions between infertility and sexuality are numerous and complex. Infertile men may suffer from sexual dysfunction (SD) when undergoing an assisted reproductive technology programme. We undertook a review both in French and English of the available data on male SD when being diagnosed with a fertility problem w...

    journal_title:Andrology

    pub_type: 杂志文章,评审

    doi:10.1111/andr.12160

    authors: Bechoua S,Hamamah S,Scalici E

    更新日期:2016-05-01 00:00:00