A unified simulation model for understanding the diversity of cancer evolution.

abstract：:A new species of freshwater crab, Fredius ibiapaba, is described and illustrated from a mid-altitude forested patch in Ipú (Ibiapaba plateau, Ceará, northeastern Brazil), between 635 to 782 m. The new species can be separated from its congeners by the morphology of its first gonopod: proximal half remarkably swollen, ...

journal_title：PeerJ

authors： Santos LC,Tavares M,Silva JRF,Cervini M,Pinheiro AP,Santana W

更新日期：2020-06-29 00:00:00

abstract：:Supertree methods enable the reconstruction of large phylogenies. The supertree problem can be formalized in different ways in order to cope with contradictory information in the input. Some supertree methods are based on encoding the input trees in a matrix; other methods try to find minimum cuts in some graph. Recen...

journal_title：PeerJ

authors： Fleischauer M,Böcker S

更新日期：2018-06-08 00:00:00

abstract：INTRODUCTION:The aim of this study was to determine the incidence rates of endometrial hyperplasia (EH) and endometrial cancer (EC) in the Republic of Korea using national insurance claim data generated from 2009 to 2012. MATERIALS AND METHODS:Data that were generated from 2009 to 2012 were sourced from the Korean Hea...

journal_title：PeerJ

authors： Yuk JS

更新日期：2016-08-24 00:00:00

abstract：:As the most widely distributed snake in Eurasia, the adder (Vipera berus) has been extensively investigated in Europe but poorly understood in Asia. The Southern Altay Mountains represent the adder's southern distribution limit in Central Asia, whereas its population status has never been assessed. We conducted, for t...

journal_title：PeerJ

authors： Cui S,Luo X,Chen D,Sun J,Chu H,Li C,Jiang Z

更新日期：2016-08-16 00:00:00

abstract：:Here we describe an efficient and effective technique for rearing sexually-derived coral propagules from spawning through larval settlement and symbiont uptake with minimal impact on natural coral populations. We sought to maximize larval survival while minimizing expense and daily husbandry maintenance by experimenta...

journal_title：PeerJ

authors： Pollock FJ,Katz SM,van de Water JAJM,Davies SW,Hein M,Torda G,Matz MV,Beltran VH,Buerger P,Puill-Stephan E,Abrego D,Bourne DG,Willis BL

更新日期：2017-09-06 00:00:00

abstract：Background:Epidemiological surveillance of HIV infection in Japan involves two technical problems for directly applying a classical backcalculation method, i.e., (i) all AIDS cases are not counted over time and (ii) people diagnosed with HIV have received antiretroviral therapy, extending the incubation period. The pre...

journal_title：PeerJ

authors： Nishiura H

更新日期：2019-01-15 00:00:00

abstract：Background:Lumbar spinal stenosis (LSS) is a common cause of low back pain with degenerative spinal change in older adults. Telomeres are repetitive nucleoprotein DNA sequences of TTAGGG at the ends of chromosomes. Oxidative stress originates from an imbalance in pro-oxidant and antioxidant homeostasis that results in ...

journal_title：PeerJ

authors： Dechsupa S,Yingsakmongkol W,Limthongkul W,Singhatanadgige W,Honsawek S

更新日期：2018-08-09 00:00:00

abstract：:Crop landraces are fundamental resources to increase the eroded genepool of modern crops in order to adapt agriculture to future challenges; plus, they are of immeasurable heritage and cultural value. Between the 1940s and the 1960s open-pollinated varieties (OPVs) of flint and semi-flint maize in Europe were almost c...

journal_title：PeerJ

authors： Ardenghi NMG,Rossi G,Guzzon F

更新日期：2018-07-04 00:00:00

abstract：Background:A virus-like particle (VLP) is an excellent tool for a compound delivery system due to its simple composition, symmetrical structure and self-assembly. Its surface modification both chemically and genetically is established, leading to the target-specific delivery and improved encapsulation efficiency. Howev...

journal_title：PeerJ

authors： Kiatmetha P,Chotwiwatthanakun C,Jariyapong P,Santimanawong W,Ounjai P,Weerachatyanukul W

更新日期：2018-12-18 00:00:00

abstract：:Sugarcane-soybean intercropping has been widely used to control disease and improve nutrition in the field. However, the response of the soil microbial community diversity and structure to intercropping is not well understood. Since microbial diversity corresponds to soil quality and plant health, a pot experiment was...

journal_title：PeerJ

authors： Lian T,Mu Y,Jin J,Ma Q,Cheng Y,Cai Z,Nian H

更新日期：2019-02-08 00:00:00

abstract：Background:The increasing production of sewage sludge (SS) engenders the problem of its responsible utilization and disposal. Likewise, urban sediments (SED) are deposited at the bottom of urban reservoirs and sedimentation ponds, and these require periodical dredging and utilization. However, while the SS and SED depo...

journal_title：PeerJ

authors： Wyrwicka A,Urbaniak M,Przybylski M

更新日期：2019-05-01 00:00:00

abstract：:This study aimed to characterize the antioxidant properties of Rama Forte persimmon, a tannin-rich fruit variety produced in Brazil. Extracts prepared with lyophilized pulps from fruits obtained in local markets were analyzed individually to evaluate the extent of antioxidant protection and investigate the antioxidant...

journal_title：PeerJ

authors： Dalvi LT,Moreira DC,Alonso A,de Avellar IGJ,Hermes-Lima M

更新日期：2018-07-25 00:00:00

abstract：:Human hands, when compared to that of apes, have a series of adaptations to facilitate manipulation. Numerous studies have shown that Australopithecus afarensis and Au. africanus display some of these adaptations, such as a longer thumb relative to the other fingers, asymmetric heads on the second and fifth metacarpal...

journal_title：PeerJ

authors： Drapeau MS

更新日期：2015-10-06 00:00:00

abstract：Background:Prognostic genes in the tumor microenvironment play an important role in immune biological processes and the response of cancer to immunotherapy. Thus, we aimed to assess new biomarkers that are associated with immune/stromal cells in lung adenocarcinomas (LUAD) using the ESTIMATE algorithm, which also signi...

journal_title：PeerJ

authors： Xu ZY,Zhao M,Chen W,Li K,Qin F,Xiang WW,Sun Y,Wei J,Yuan LQ,Li SK,Lin SH

更新日期：2020-07-23 00:00:00

abstract：:A period of starvation is regarded as a sound practice in aquaculture prior to handling, transportation and harvest, to minimise impacts on welfare and ensure proper hygiene after harvest. However, documentation of welfare issues such as stress following starvation and handling in adult Atlantic salmon are lacking. Th...

journal_title：PeerJ

authors： Waagbø R,Jørgensen SM,Timmerhaus G,Breck O,Olsvik PA

更新日期：2017-04-27 00:00:00

abstract：:Clostridium septicum produces a number of diseases in human and farm animals which, in most of the cases, are fatal without clinical intervention. Alpha toxin is an important agent and the unique lethal virulent factor produced by Clostridium septicum. This toxin is haemolytic, highly lethal and necrotizing activities...

journal_title：PeerJ

authors： Vázquez-Iglesias L,Estefanell-Ucha B,Barcia-Castro L,Páez de la Cadena M,Álvarez-Chaver P,Ayude-Vázquez D,Rodríguez-Berrocal FJ

更新日期：2017-06-22 00:00:00

abstract：:Seasonal upwelling at the northern Pacific coast of Costa Rica offers the opportunity to investigate the effects of pronounced changes in key water parameters on fine-scale dynamics of local coral reef communities. This study monitored benthic community composition at Matapalo reef (10.539°N, 85.766°W) by weekly obser...

journal_title：PeerJ

authors： Stuhldreier I,Sánchez-Noguera C,Roth F,Jiménez C,Rixen T,Cortés J,Wild C

更新日期：2015-11-24 00:00:00

abstract：:The consumption of raw fish has increased considerably in the West, since it is said to be potentially healthier than processed fish (for containing omega 3 and 6, essential amino acids and vitamins). However this potential benefit, as well as the taste, value and even the risk of extinction are not the same for all s...

journal_title：PeerJ

authors： Staffen CF,Staffen MD,Becker ML,Löfgren SE,Muniz YCN,de Freitas RHA,Marrero AR

更新日期：2017-11-29 00:00:00

abstract：:The family Pseudopimelodidae is widely distributed in South America and includes 51 described species organized in seven genera. Only two of four species of the genus Pseudopimelodus have been recorded for the trans-Andean basins of Colombia, Pseudopimelodus bufonius and P. schultzi, whose similarity in external morph...

journal_title：PeerJ

authors： Restrepo-Gómez AM,Rangel-Medrano JD,Márquez EJ,Ortega-Lara A

更新日期：2020-09-03 00:00:00

abstract：Background:This study evaluates the generalizability of an eight-station progress clinical skills examination and assesses the growth in performance for six clinical skills domains among first- and second-year medical students over four time points during the academic year. Methods:We conducted a generalizability stud...

journal_title：PeerJ

authors： Laird-Fick HS,Chang C,Wang L,Parker C,Malinowski R,Emery M,Solomon DJ

更新日期：2020-05-01 00:00:00

abstract：BACKGROUND:Antimicrobial peptides (AMPs) are of great potential as novel antibiotics for the treatment of broad spectrum of pathogenic microorganisms including resistant bacteria. In this study, the mechanisms of action and the therapeutic efficacy of the hybrid peptides were examined. METHODS:TEM, SEM and ATP efflux ...

journal_title：PeerJ

authors： Jindal HM,Zandi K,Ong KC,Velayuthan RD,Rasid SM,Samudi Raju C,Sekaran SD

更新日期：2017-10-05 00:00:00

abstract：:Vitellogenin has been proposed to regulate division of labor and social organization in social insects. The red imported fire ant (Solenopsis invicta) harbors four distinct, adjacent vitellogenin genes (Vg1, Vg2, Vg3, and Vg4). Contrary to honey bees that have a single Vg ortholog as well as potentially fertile nurses...

journal_title：PeerJ

authors： Hawkings C,Tamborindeguy C

更新日期：2018-05-28 00:00:00

abstract：Background:Administration of anandamide (AEA) or 2-arachidonoylglycerol (2AG) induces CB1 coupling and activation of TRKB receptors, regulating the neuronal migration and maturation in the developing cortex. However, at higher concentrations AEA also engages vanilloid receptor TRPV1, usually with opposed consequences o...

journal_title：PeerJ

authors： Diniz CRAF,Biojone C,Joca SRL,Rantamäki T,Castrén E,Guimarães FS,Casarotto PC

更新日期：2019-02-21 00:00:00

abstract：:The Asian citrus psyllid (ACP), Diaphorina citri Kuwayama, is one of the most serious citrus pests worldwide due to its role as vector of huanglongbing or citrus greening disease. While some optimal plant species for ACP oviposition and development have been identified, little is known of the influence of host plants ...

journal_title：PeerJ

authors： Paris TM,Allan SA,Hall DG,Hentz MG,Hetesy G,Stansly PA

更新日期：2016-11-03 00:00:00

abstract：:Many of the major locomotor transitions during the evolution of Archosauria, the lineage including crocodiles and birds as well as extinct Dinosauria, were shifts from quadrupedalism to bipedalism (and vice versa). Those occurred within a continuum between more sprawling and erect modes of locomotion and involved dras...

journal_title：PeerJ

authors： Otero A,Allen V,Pol D,Hutchinson JR

更新日期：2017-11-24 00:00:00

abstract：:Sponges are efficient filter feeders, removing significant portions of particulate and dissolved organic matter (POM, DOM) from the water column. While the assimilation and respiration of POM and DOM by sponges and their abundant microbial symbiont communities have received much attention, there is virtually no inform...

journal_title：PeerJ

authors： Fiore CL,Freeman CJ,Kujawinski EB

更新日期：2017-01-11 00:00:00

abstract：Background:Alcohol-related hepatocellular carcinoma (HCC) was reported to be diagnosed at a later stage, but the mechanism was unknown. This study aimed to identify special key genes (SKGs) during alcohol-related HCC development and progression. Methods:The mRNA data of 369 HCC patients and the clinical information we...

journal_title：PeerJ

authors： Zhang X,Kang C,Li N,Liu X,Zhang J,Gao F,Dai L

更新日期：2019-02-06 00:00:00

abstract：:Carrot is an important root vegetable crop abundant in bioactive compounds including carotenoids, vitamins, and dietary fibers. Carrot intake and its products are gradually growing owing to its high antioxidant activity. Auxins are a class of plant hormones that control many processes of plant growth and development. ...

journal_title：PeerJ

authors： Khadr A,Wang GL,Wang YH,Zhang RR,Wang XR,Xu ZS,Tian YS,Xiong AS

更新日期：2020-12-08 00:00:00

abstract：Background:Acute infective gastroenteritis (AIG) is a leading cause of mortality in children worldwide. In Peru, more than 40% of cases of AIG occurring in children under 5 years old. The disruption of the gut microbiota can increase risk for several health complications especially in patients with gastric infections c...

journal_title：PeerJ

authors： Taco-Masias AA,Fernandez-Aristi AR,Cornejo-Tapia A,Aguilar-Luis MA,Del Valle LJ,Silva-Caso W,Zavaleta-Gavidia V,Weilg P,Cornejo-Pacherres H,Bazán-Mayra J,Puyen ZM,Del Valle-Mendoza J

更新日期：2020-11-03 00:00:00

abstract：BACKGROUND:Seed-applied neonicotinoids are widely used in agriculture, yet their effects on non-target species remain incompletely understood. One important group of non-target species is arthropod natural enemies (predators and parasitoids), which contribute considerably to suppression of crop pests. We hypothesized t...

journal_title：PeerJ

authors： Douglas MR,Tooker JF

更新日期：2016-12-07 00:00:00