Abstract：
:Understanding how chromatin is regulated is essential to fully grasp genome biology, and establishing the locus-specific protein composition is a major step toward this goal. Here we explain why the isolation and analysis of a specific chromatin segment are technically challenging, independently of the method. We then describe the published strategies and discuss their advantages and limitations. We conclude by discussing why significant technology developments are required to unambiguously describe the composition of small single loci.
journal_name
Nat Methodsjournal_title
Nature methodsauthors
Gauchier M,van Mierlo G,Vermeulen M,Déjardin Jdoi
10.1038/s41592-020-0765-4subject
Has Abstractpub_date
2020-04-01 00:00:00pages
380-389issue
4eissn
1548-7091issn
1548-7105pii
10.1038/s41592-020-0765-4journal_volume
17pub_type
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