Toxicological profile of lipid-based nanostructures: are they considered as completely safe nanocarriers?


:Nanoparticles are ubiquitous in the environment and are widely used in medical science (e.g. bioimaging, diagnosis, and drug therapy delivery). Due to unique physicochemical properties, they are able to cross many barriers, which is not possible for traditional drugs. Nevertheless, exposure to NPs and their following interactions with organelles and macromolecules can result in negative effects on cells, especially, they can induce cytotoxicity, epigenicity, genotoxicity, and cell death. Lipid-based nanomaterials (LNPs) are one of the most important achievements in drug delivery mainly due to their superior physicochemical and biological characteristics, particularly its safety. Although they are considered as the completely safe nanocarriers in biomedicine, the lipid composition, the surfactant, emulsifier, and stabilizer used in the LNP preparation, and surface electrical charge are important factors that might influence the toxicity of LNPs. According to the author's opinion, their toxicity profile should be evaluated case-by-case regarding the intended applications. Since there is a lack of all-inclusive review on the various aspects of LNPs with an emphasis on toxicological profiles including cyto-genotoxiciy, this comprehensive and critical review is outlined.


Crit Rev Toxicol


Azarnezhad A,Samadian H,Jaymand M,Sobhani M,Ahmadi A




Has Abstract


2020-02-01 00:00:00












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    authors: Haber LT,Dourson ML,Allen BC,Hertzberg RC,Parker A,Vincent MJ,Maier A,Boobis AR

    更新日期:2018-05-01 00:00:00

  • Ozone exposure and systemic biomarkers: Evaluation of evidence for adverse cardiovascular health impacts.

    abstract::The US Environmental Protection Agency (EPA) recently concluded that there is likely to be a causal relationship between short-term (< 30 days) ozone exposure and cardiovascular (CV) effects; however, biological mechanisms to link transient effects with chronic cardiovascular disease (CVD) have not been established. S...

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    pub_type: 杂志文章,评审


    authors: Goodman JE,Prueitt RL,Sax SN,Pizzurro DM,Lynch HN,Zu K,Venditti FJ

    更新日期:2015-05-01 00:00:00

  • Validity of biomarkers in environmental health studies: the case of PAHs and benzene.

    abstract::Exposure biomarkers, which have long been restricted to the framework of occupational hygiene, currently arouse increasing interest in the field of environmental pollution. To assess their validity, we propose here a conceptual framework that is based on their intrinsic characteristics and on properties related to the...

    journal_title:Critical reviews in toxicology

    pub_type: 杂志文章,评审


    authors: Dor F,Dab W,Empereur-Bissonnet P,Zmirou D

    更新日期:1999-03-01 00:00:00

  • Pharmacokinetics and toxicity testing.

    abstract::The pharmacokinetic basis for the design of toxicity tests is discussed with reference to the absorption and clearance of drugs. The absorption and clearance of a wide range of drugs by laboratory animals and man has been examined and reviewed to provide a firm basis against which new drugs can be compared. Some pitfa...

    journal_title:Critical reviews in toxicology

    pub_type: 杂志文章,评审


    authors: Clark B,Smith DA

    更新日期:1984-01-01 00:00:00

  • Aquatic insects and trace metals: bioavailability, bioaccumulation, and toxicity.

    abstract::The uptake of metals from food and water sources by insects is thought to be additive. For a given metal, the proportions taken up from water and food will depend both on the bioavailable concentration of the metal associated with each source and the mechanism and rate by which the metal enters the insect. Attempts to...

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    authors: Hare L

    更新日期:1992-01-01 00:00:00

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    abstract::A high intake of fruits and vegetables is associated with a lower risk of cancer. In this context, considerable attention is paid to Asian populations who consume high amounts of soy and soy-derived isoflavones, and have a lower risk for several cancer types such as breast and prostate cancers than populations in West...

    journal_title:Critical reviews in toxicology

    pub_type: 杂志文章,评审


    authors: Andres S,Abraham K,Appel KE,Lampen A

    更新日期:2011-07-01 00:00:00

  • Extraperoxisomal targets of peroxisome proliferators: mitochondrial, microsomal, and cytosolic effects. Implications for health and disease.

    abstract::Peroxisome proliferators are a structurally diverse group of compounds that include the fibrate hypolipidemic drugs, the phthalate ester industrial plasticizers, the phenoxy acid herbicides, and the anti-wetting corrosion inhibitors perfluorinated straight-chain monocarboxylic fatty acids. Administration of these chem...

    journal_title:Critical reviews in toxicology

    pub_type: 杂志文章,评审


    authors: Youssef J,Badr M

    更新日期:1998-01-01 00:00:00

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    abstract::Exposure to combustion-derived particles, quartz and asbestos is associated with increased levels of oxidized and mutagenic DNA lesions. The aim of this survey was to critically assess the measurements of oxidatively damaged DNA as marker of particle-induced genotoxicity in animal tissues. Publications based on non-op...

    journal_title:Critical reviews in toxicology

    pub_type: 杂志文章,评审


    authors: Møller P,Danielsen PH,Jantzen K,Roursgaard M,Loft S

    更新日期:2013-02-01 00:00:00

  • Environmental concentrations and aquatic toxicity data on diflubenzuron (dimilin).

    abstract::The insecticide diflubenzuron (DFB) is commonly used in various mid-Atlantic states for suppression of gypsy moths in hardwood forests. DFB is potentially toxic to nontarget biota because it can enter aquatic systems through aerial application or runoff after precipitation events. Based on this concern, the objectives...

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    authors: Fischer SA,Hall LW Jr

    更新日期:1992-01-01 00:00:00

  • Intragenomic heterogeneity of DNA damage formation and repair: a review of cellular responses to covalent drug DNA interaction.

    abstract::Chemical DNA interaction and its processing can now be studied at the level of specific genomic regions. Such investigations have revealed important new information about the molecular biology of the cellular responses to genomic insult and especially of the repair processes. They also have demonstrated that both the ...

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    pub_type: 杂志文章,评审


    authors: Wassermann K

    更新日期:1994-01-01 00:00:00

  • Improving the risk assessment of lipophilic persistent environmental chemicals in breast milk.

    abstract::Lipophilic persistent environmental chemicals (LPECs) have the potential to accumulate within a woman's body lipids over the course of many years prior to pregnancy, to partition into human milk, and to transfer to infants upon breastfeeding. As a result of this accumulation and partitioning, a breastfeeding infant's ...

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    authors: Lehmann GM,Verner MA,Luukinen B,Henning C,Assimon SA,LaKind JS,McLanahan ED,Phillips LJ,Davis MH,Powers CM,Hines EP,Haddad S,Longnecker MP,Poulsen MT,Farrer DG,Marchitti SA,Tan YM,Swartout JC,Sagiv SK,Welsh C,Camp

    更新日期:2014-08-01 00:00:00

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    abstract::The toxicological profiles of monopropylene glycol (MPG), dipropylene glycol (DPG), tripropylene glycol (TPG) and polypropylene glycols (PPG; including tetra-rich oligomers) are collectively reviewed, and assessed considering regulatory toxicology endpoints. The review confirms a rich data set for these compounds, cov...

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    authors: Fowles JR,Banton MI,Pottenger LH

    更新日期:2013-04-01 00:00:00

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    abstract::Quantitative weight of evidence (QWoE) provides a framework and process for evaluating different toxicological studies based on quality and relevance of the results. This framework allows for data from these studies to be combined in separate lines of evidence to address causality, and relevance to environmental risks...

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    authors: Hanson ML,Solomon KR,Van Der Kraak GJ,Brian RA

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    authors: Greim H,Saltmiras D,Mostert V,Strupp C

    更新日期:2015-03-01 00:00:00

  • Beryllium and lung cancer: a weight of evidence evaluation of the toxicological and epidemiological literature.

    abstract::The potential carcinogenicity of beryllium has been a topic of study since the mid-1940s. Since then, numerous scientific and regulatory bodies have assigned beryllium to various categories with respect to its carcinogenicity. Past epidemiologic and animal studies, however, have been marked with notable methodological...

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    authors: Hollins DM,McKinley MA,Williams C,Wiman A,Fillos D,Chapman PS,Madl AK

    更新日期:2009-01-01 00:00:00

  • Mode of action: inhibition of histone deacetylase, altering WNT-dependent gene expression, and regulation of beta-catenin--developmental effects of valproic acid.

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    authors: Wiltse J

    更新日期:2005-10-01 00:00:00

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    abstract::This article explores the occurrence of U-shaped dose responses induced by neuroprotective agents in animal stroke and traumatic brain injury (TBI) screening/preclinical studies. The assessment was stimulated by suggestions that U-shaped dose responses may be common for neuroprotective agents in stroke and TBI models,...

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    authors: Calabrese EJ

    更新日期:2008-01-01 00:00:00

  • Genotoxicity Expert Panel review: weight of evidence evaluation of the genotoxicity of glyphosate, glyphosate-based formulations, and aminomethylphosphonic acid.

    abstract::In 2015, the International Agency for Research on Cancer (IARC) published a monograph concluding there was strong evidence for genotoxicity of glyphosate and glyphosate formulations and moderate evidence for genotoxicity of the metabolite aminomethylphosphonic acid (AMPA). These conclusions contradicted earlier extens...

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    authors: Brusick D,Aardema M,Kier L,Kirkland D,Williams G

    更新日期:2016-09-01 00:00:00

  • Potential pulmonary effects of man-made organic fiber (MMOF) dusts.

    abstract::In the first half of the twentieth century epidemiologic evidence linked elevated incidences of pulmonary fibrosis and cancer with inhalation of chrysotile and crocidolite asbestos, a family of naturally occurring inorganic fibrous materials. As the serpentine and amphibole forms of asbestos were phased out, synthetic...

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    authors: Warheit DB,Hart GA,Hesterberg TW,Collins JJ,Dyer WM,Swaen GM,Castranova V,Soiefer AI,Kennedy GL Jr

    更新日期:2001-11-01 00:00:00

  • Perfluoroalkyl and polyfluoroalkyl substances and human fetal growth: a systematic review.

    abstract:BACKGROUND:Exposure to perfluoroalkyl and polyfluoroalkyl substances (PFASs) is ubiquitous in most regions of the world. The most commonly studied PFASs are perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA). Animal studies indicate that maternal PFAS exposure is associated with reduced fetal growth. Howeve...

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    authors: Bach CC,Bech BH,Brix N,Nohr EA,Bonde JP,Henriksen TB

    更新日期:2015-01-01 00:00:00

  • The toxicology of mycotoxins.

    abstract::Mycotoxin problems are one of great concern to health scientists. Toxic fungal metabolites such as aflatoxins, trichothecenes, zearalenone and others are contaminated in our environments and induce various diseases. In this manuscript, the author will summarize the recent advances on toxicology of mycotoxins in specia...

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    authors: Ueno Y

    更新日期:1985-01-01 00:00:00

  • Evidence for DNA and protein binding by styrene and styrene oxide.

    abstract::Styrene is metabolized to styrene oxide, a direct-acting mutagen and carcinogen. Styrene oxide reacts with DNA mainly at the N-7 position in guanine, but also at other sites and with other bases. Substitution occurs at both the alpha- and beta-positions of the styrene molecule. Experiments with radiolabeled styrene an...

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    authors: Phillips DH,Farmer PB

    更新日期:1994-01-01 00:00:00

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    authors: Käfferlein HU,Marczynski B,Mensing T,Brüning T

    更新日期:2010-01-01 00:00:00

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    authors: Møller P,Scholten RH,Roursgaard M,Krais AM

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    pub_type: 杂志文章,评审


    authors: Warheit DB

    更新日期:1989-01-01 00:00:00

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    pub_type: 杂志文章,评审


    authors: Idée JM,Fretellier N,Robic C,Corot C

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    pub_type: 杂志文章


    authors: Giordano J,Ives JA,Jonas WB

    更新日期:2008-01-01 00:00:00

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    pub_type: 杂志文章,评审


    authors: Bhat VS,Meek MEB,Valcke M,English C,Boobis A,Brown R

    更新日期:2017-10-01 00:00:00