Toxicological profile of lipid-based nanostructures: are they considered as completely safe nanocarriers?


:Nanoparticles are ubiquitous in the environment and are widely used in medical science (e.g. bioimaging, diagnosis, and drug therapy delivery). Due to unique physicochemical properties, they are able to cross many barriers, which is not possible for traditional drugs. Nevertheless, exposure to NPs and their following interactions with organelles and macromolecules can result in negative effects on cells, especially, they can induce cytotoxicity, epigenicity, genotoxicity, and cell death. Lipid-based nanomaterials (LNPs) are one of the most important achievements in drug delivery mainly due to their superior physicochemical and biological characteristics, particularly its safety. Although they are considered as the completely safe nanocarriers in biomedicine, the lipid composition, the surfactant, emulsifier, and stabilizer used in the LNP preparation, and surface electrical charge are important factors that might influence the toxicity of LNPs. According to the author's opinion, their toxicity profile should be evaluated case-by-case regarding the intended applications. Since there is a lack of all-inclusive review on the various aspects of LNPs with an emphasis on toxicological profiles including cyto-genotoxiciy, this comprehensive and critical review is outlined.


Crit Rev Toxicol


Azarnezhad A,Samadian H,Jaymand M,Sobhani M,Ahmadi A




Has Abstract


2020-02-01 00:00:00












  • An improved model to predict physiologically based model parameters and their inter-individual variability from anthropometry.

    abstract::We developed a population physiology model, physB, which provides a statistical description of the physiological characteristics in the human population, in terms of the physiological parameters that are needed in physiologically based pharmacokinetic modelling. The model predicts individual organ weights, blood flows...

    journal_title:Critical reviews in toxicology

    pub_type: 杂志文章,评审


    authors: Bosgra S,van Eijkeren J,Bos P,Zeilmaker M,Slob W

    更新日期:2012-10-01 00:00:00

  • A perspective on benzene leukemogenesis.

    abstract::Although benzene is best known as a compound that causes bone marrow depression leading to aplastic anemia in animals and humans, it also induces acute myelogenous leukemia in humans. The epidemiological evidence for leukemogenesis in humans is contrasted with the results of animal bioassays. This review focuses on se...

    journal_title:Critical reviews in toxicology

    pub_type: 杂志文章,评审


    authors: Snyder R,Kalf GF

    更新日期:1994-01-01 00:00:00

  • Effects of atrazine on fish, amphibians, and reptiles: update of the analysis based on quantitative weight of evidence.

    abstract::Quantitative weight of evidence (QWoE) provides a framework and process for evaluating different toxicological studies based on quality and relevance of the results. This framework allows for data from these studies to be combined in separate lines of evidence to address causality, and relevance to environmental risks...

    journal_title:Critical reviews in toxicology

    pub_type: 杂志文章,评审


    authors: Hanson ML,Solomon KR,Van Der Kraak GJ,Brian RA

    更新日期:2019-09-01 00:00:00

  • Genetic polymorphisms of human N-acetyltransferase, cytochrome P450, glutathione-S-transferase, and epoxide hydrolase enzymes: relevance to xenobiotic metabolism and toxicity.

    abstract::In this review, an overview is presented of the current knowledge of genetic polymorphisms of four of the most important enzyme families involved in the metabolism of xenobiotics, that is, the N-acetyltransferase (NAT), cytochrome P450 (P450), glutathione-S-transferase (GST), and microsomal epoxide hydrolase (mEH) enz...

    journal_title:Critical reviews in toxicology

    pub_type: 杂志文章,评审


    authors: Wormhoudt LW,Commandeur JN,Vermeulen NP

    更新日期:1999-01-01 00:00:00

  • Interspecies comparisons of lung responses to inhaled particles and gases.

    abstract::Two important challenges for inhalation toxicologists involve the elucidation of mechanisms of lung toxicity caused by inhalation of chemicals or particulate materials, as well as the extrapolation of animal data to humans. Because risk estimates of toxicity generally are dependent upon experimental data for which a v...

    journal_title:Critical reviews in toxicology

    pub_type: 杂志文章,评审


    authors: Warheit DB

    更新日期:1989-01-01 00:00:00

  • Toxicity of the antimalarial artemisinin and its dervatives.

    abstract::As long as no effective malaria vaccine is available, chemotherapy belongs to the most important weapons fighting malaria. One of the most promising new drug developments is the sesquiterpene artemisinin (ARS) and its derivatives, e.g., artemether, arteether, and sodium artesunate. Large clinical studies and meta-anal...

    journal_title:Critical reviews in toxicology

    pub_type: 杂志文章,评审


    authors: Efferth T,Kaina B

    更新日期:2010-05-01 00:00:00

  • Evidence for DNA and protein binding by styrene and styrene oxide.

    abstract::Styrene is metabolized to styrene oxide, a direct-acting mutagen and carcinogen. Styrene oxide reacts with DNA mainly at the N-7 position in guanine, but also at other sites and with other bases. Substitution occurs at both the alpha- and beta-positions of the styrene molecule. Experiments with radiolabeled styrene an...

    journal_title:Critical reviews in toxicology

    pub_type: 杂志文章,评审


    authors: Phillips DH,Farmer PB

    更新日期:1994-01-01 00:00:00

  • Histamine food poisoning: toxicology and clinical aspects.

    abstract::Histamine poisoning can result from the ingestion of food containing unusually high levels of histamine. Fish are most commonly involved in incidents of histamine poisoning, although cheese has also been implicated on occasion. The historic involvement of tuna and mackerel in histamine poisoning led to the longtime us...

    journal_title:Critical reviews in toxicology

    pub_type: 杂志文章,评审


    authors: Taylor SL

    更新日期:1986-01-01 00:00:00

  • The estrogenic activity of resveratrol: a comprehensive review of in vitro and in vivo evidence and the potential for endocrine disruption.

    abstract::trans-Resveratrol, a polyphenolic stilbene of plant origin is structurally similar to natural and synthetic estrogens and has been classified a phytoestrogen. Direct binding of resveratrol to the nuclear estrogen receptor (ER) and modulation of its genomic activity was among the first of its reported pharmacological a...

    journal_title:Critical reviews in toxicology

    pub_type: 杂志文章,评审


    authors: Qasem RJ

    更新日期:2020-05-01 00:00:00

  • Consequences of chemical impact of disinfectants: safe preventive measures against COVID-19.

    abstract::Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has created a significant threat to global health. It originated in Wuhan, China and caused a total of 83,483 confirmed cases and 4634 deaths until June 2020. This novel virus spread primarily through respiratory...

    journal_title:Critical reviews in toxicology

    pub_type: 杂志文章,评审


    authors: Rai NK,Ashok A,Akondi BR

    更新日期:2020-07-01 00:00:00

  • Adenosine: biphasic dose responses.

    abstract::This article characterizes the occurrence of biphasic dose responses by adenosine and its stable analogs in numerous systems, including the respiratory tract, kidney, cardiovascular system, and brain. Considerable mechanistic research on various systems explored and clarified the interactions of the A-1 and A-2 recept...

    journal_title:Critical reviews in toxicology

    pub_type: 杂志文章,评审


    authors: Calabrese EJ

    更新日期:2001-07-01 00:00:00

  • Extraperoxisomal targets of peroxisome proliferators: mitochondrial, microsomal, and cytosolic effects. Implications for health and disease.

    abstract::Peroxisome proliferators are a structurally diverse group of compounds that include the fibrate hypolipidemic drugs, the phthalate ester industrial plasticizers, the phenoxy acid herbicides, and the anti-wetting corrosion inhibitors perfluorinated straight-chain monocarboxylic fatty acids. Administration of these chem...

    journal_title:Critical reviews in toxicology

    pub_type: 杂志文章,评审


    authors: Youssef J,Badr M

    更新日期:1998-01-01 00:00:00

  • Hormetic responses in neural systems: consideration, contexts, and caveats.

    abstract::Dr. Edward Calabrese asserts that hormetic responses occur in neural systems, and provides ample review of evidence to support this claim. In this essay, we survey Dr. Calabrese's findings, illustrate the somewhat provocative premise of hormesis, and posit that while evidence suggests that amplification of low-dose ef...

    journal_title:Critical reviews in toxicology

    pub_type: 杂志文章


    authors: Giordano J,Ives JA,Jonas WB

    更新日期:2008-01-01 00:00:00

  • Assessing cancer hazards of bitumen emissions - a case study for complex petroleum substances.

    abstract::When assessing cancer hazard and risk associated with a complex petroleum substance, like bitumen emissions, there are often conflicting results related to human, animal and mechanistic studies. Validation of the complex composition to assure that it matches real-world exposures and control of confounders are pivotal ...

    journal_title:Critical reviews in toxicology

    pub_type: 杂志文章,评审


    authors: Kriech AJ,Schreiner CA,Osborn LV,Riley AJ

    更新日期:2018-02-01 00:00:00

  • Aquatic insects and trace metals: bioavailability, bioaccumulation, and toxicity.

    abstract::The uptake of metals from food and water sources by insects is thought to be additive. For a given metal, the proportions taken up from water and food will depend both on the bioavailable concentration of the metal associated with each source and the mechanism and rate by which the metal enters the insect. Attempts to...

    journal_title:Critical reviews in toxicology

    pub_type: 杂志文章,评审


    authors: Hare L

    更新日期:1992-01-01 00:00:00

  • Longitudinal relationships between lung cancer mortality rates, smoking, and ambient air quality: a comprehensive review and analysis.

    abstract::Lung cancer mortality (LCM) has been associated with smoking and air pollution. This article draws on smoking relationships to clarify air pollution relationships. We analyzed cohort and population-based smoking studies and identified effects of latency and cumulative exposures. We found cogent relationships through l...

    journal_title:Critical reviews in toxicology

    pub_type: 杂志文章,评审


    authors: Lipfert FW,Wyzga RE

    更新日期:2019-10-01 00:00:00

  • Assessment of the carcinogenicity of the nonnutritive sweetener cyclamate.

    abstract::The weight of the evidence from metabolic studies, short-term tests, animal bioassays, and epidemiological studies indicates that cyclamate (CHS) is not carcinogenic by itself; however, there is evidence from in vitro and in vivo studies in animals that implies it may have cancer-promoting or cocarcinogenic activity. ...

    journal_title:Critical reviews in toxicology

    pub_type: 杂志文章,评审


    authors: Ahmed FE,Thomas DB

    更新日期:1992-01-01 00:00:00

  • Using Bayesian networks to clarify interpretation of exposure-response regression coefficients: blood lead-mortality association as an example.

    abstract::We examine how Bayesian network (BN) learning and analysis methods can help to meet several methodological challenges that arise in interpreting significant regression coefficients in exposure-response regression modeling. As a motivating example, we consider the challenge of interpreting positive regression coefficie...

    journal_title:Critical reviews in toxicology

    pub_type: 杂志文章,评审


    authors: Cox LA Jr

    更新日期:2020-08-01 00:00:00

  • Oxidatively damaged DNA in animals exposed to particles.

    abstract::Exposure to combustion-derived particles, quartz and asbestos is associated with increased levels of oxidized and mutagenic DNA lesions. The aim of this survey was to critically assess the measurements of oxidatively damaged DNA as marker of particle-induced genotoxicity in animal tissues. Publications based on non-op...

    journal_title:Critical reviews in toxicology

    pub_type: 杂志文章,评审


    authors: Møller P,Danielsen PH,Jantzen K,Roursgaard M,Loft S

    更新日期:2013-02-01 00:00:00

  • Spontaneous eye lesions in laboratory animals: incidence in relation to age.

    abstract::Examination of the eye in experiments designed to test the toxicity of drugs or chemicals is of considerable importance and the investigator must have a clear idea of the spontaneous eye changes he can expect in the test species. We have attempted to review the literature relating to commonly used laboratory animals--...

    journal_title:Critical reviews in toxicology

    pub_type: 杂志文章,评审


    authors: Taradach C,Greaves P

    更新日期:1984-01-01 00:00:00

  • The toxicology of hydroquinone--relevance to occupational and environmental exposure.

    abstract::Hydroquinone (HQ) is a high-volume commodity chemical used as a reducing agent, antioxidant, polymerization inhibitor, and chemical intermediate. It is also used in over-the-counter (OTC) drugs as an ingredient in skin lighteners and is a natural ingredient in many plant-derived products, including vegetables, fruits,...

    journal_title:Critical reviews in toxicology

    pub_type: 杂志文章,评审


    authors: DeCaprio AP

    更新日期:1999-05-01 00:00:00

  • Pharmacokinetics and toxicity testing.

    abstract::The pharmacokinetic basis for the design of toxicity tests is discussed with reference to the absorption and clearance of drugs. The absorption and clearance of a wide range of drugs by laboratory animals and man has been examined and reviewed to provide a firm basis against which new drugs can be compared. Some pitfa...

    journal_title:Critical reviews in toxicology

    pub_type: 杂志文章,评审


    authors: Clark B,Smith DA

    更新日期:1984-01-01 00:00:00

  • Quantitative in vitro to in vivo extrapolation of cell-based toxicity assay results.

    abstract::The field of toxicology is currently undergoing a global paradigm shift to use of in vitro approaches for assessing the risks of chemicals and drugs in a more mechanistic and high throughput manner than current approaches relying primarily on in vivo testing. However, reliance on in vitro data entails a number of new ...

    journal_title:Critical reviews in toxicology

    pub_type: 杂志文章,评审


    authors: Yoon M,Campbell JL,Andersen ME,Clewell HJ

    更新日期:2012-09-01 00:00:00

  • Application of a novel integrated toxicity testing strategy incorporating "3R" principles of animal research to evaluate the safety of a new agrochemical sulfoxaflor.

    abstract::Plant protection products (PPPs) and the active substance(s) contained within them are rigorously and comprehensively tested prior to registration to ensure that human health is not impacted by their use. In recent years, there has been a widespread drive to have more relevant testing strategies (e.g., ILSI/HESI-ACSA ...

    journal_title:Critical reviews in toxicology

    pub_type: 杂志文章,评审


    authors: Terry C,Rasoulpour RJ,Saghir S,Marty S,Gollapudi BB,Billington R

    更新日期:2014-05-01 00:00:00

  • Risk assessments for chronic exposure of children and prospective parents to ethylbenzene (CAS No. 100-41-4).

    abstract::Potential chronic health risks for children and prospective parents exposed to ethylbenzene were evaluated in response to the Voluntary Children's Chemical Evaluation Program. Ethylbenzene exposure was found to be predominately via inhalation with recent data demonstrating continuing decreases in releases and both out...

    journal_title:Critical reviews in toxicology

    pub_type: 杂志文章,评审


    authors: Sweeney LM,Kester JE,Kirman CR,Gentry PR,Banton MI,Bus JS,Gargas ML

    更新日期:2015-01-01 00:00:00

  • Environmental concentrations and aquatic toxicity data on diflubenzuron (dimilin).

    abstract::The insecticide diflubenzuron (DFB) is commonly used in various mid-Atlantic states for suppression of gypsy moths in hardwood forests. DFB is potentially toxic to nontarget biota because it can enter aquatic systems through aerial application or runoff after precipitation events. Based on this concern, the objectives...

    journal_title:Critical reviews in toxicology

    pub_type: 杂志文章,评审


    authors: Fischer SA,Hall LW Jr

    更新日期:1992-01-01 00:00:00

  • Neurotoxicological effects and the mode of action of pyrethroid insecticides.

    abstract::Neuroexcitatory symptoms of acute poisoning of vertebrates by pyrethroids are related to the ability of these insecticides to modify electrical activity in various parts of the nervous system. Repetitive nerve activity, particularly in the sensory nervous system, membrane depolarization, and enhanced neurotransmitter ...

    journal_title:Critical reviews in toxicology

    pub_type: 杂志文章,评审


    authors: Vijverberg HP,van den Bercken J

    更新日期:1990-01-01 00:00:00

  • Critical review of the human data on short-term nitrogen dioxide (NO2) exposures: evidence for NO2 no-effect levels.

    abstract::Nitrogen dioxide (NO2) is a ubiquitous atmospheric pollutant due to the widespread prevalence of both natural and anthropogenic sources, and it can be a respiratory irritant when inhaled at elevated concentrations. Evidence for health effects of ambient NO2 derives from three types of studies: observational epidemiolo...

    journal_title:Critical reviews in toxicology

    pub_type: 杂志文章,评审


    authors: Hesterberg TW,Bunn WB,McClellan RO,Hamade AK,Long CM,Valberg PA

    更新日期:2009-01-01 00:00:00

  • Occupational exposure to beryllium and cancer risk: a review of the epidemiologic evidence.

    abstract::There is controversy on whether occupational exposure to beryllium causes lung cancer. We conducted a systematic review of epidemiologic studies on cancer among workers exposed to beryllium, including a study of seven U.S. production plants which has been recently updated, a study of patients with beryllium disease (l...

    journal_title:Critical reviews in toxicology

    pub_type: 杂志文章,评审


    authors: Boffetta P,Fryzek JP,Mandel JS

    更新日期:2012-02-01 00:00:00

  • Modernizing the Bradford Hill criteria for assessing causal relationships in observational data.

    abstract::Perhaps no other topic in risk analysis is more difficult, more controversial, or more important to risk management policy analysts and decision-makers than how to draw valid, correctly qualified causal conclusions from observational data. Statistical methods can readily quantify associations between observed variable...

    journal_title:Critical reviews in toxicology

    pub_type: 杂志文章


    authors: Cox LA Jr

    更新日期:2018-09-01 00:00:00