Abstract:
:Congenital osteopetrosis in the mutant rat "op" is accompanied by early atrophy of the thymus gland. The response of thymocytes to concanavalin A and phytohemagglutinin P was greatly diminished at age 28 days, even before pronounced thymic atrophy could be detected. The response of spleen cells to mitogens that stimulate thymus-derived (T) and bone-marrow-derived (B) cells was diminished as early as 35 days of age. A single injection of a suspension of normal bone marrow, which cures osteopetrosis, increased thymus weight and restored the normal responses of both thymus and spleen to various mitogens. These results add further support to the hypothesis that the thymus is involved in the pathogenesis of osteopetrosis.
journal_name
Proc Natl Acad Sci U S Aauthors
Milhaud G,Labat ML,Parant M,Damais C,Chedid Ldoi
10.1073/pnas.74.1.339subject
Has Abstractpub_date
1977-01-01 00:00:00pages
339-42issue
1eissn
0027-8424issn
1091-6490journal_volume
74pub_type
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