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Direct Homologous dsDNA-dsDNA Pairing: How, Where, and Why?

Abstract：

:The ability of homologous chromosomes (or selected chromosomal loci) to pair specifically in the apparent absence of DNA breakage and recombination represents a prominent feature of eukaryotic biology. The mechanism of homology recognition at the basis of such recombination-independent pairing has remained elusive. A number of studies have supported the idea that sequence homology can be sensed between intact DNA double helices in vivo. In particular, recent analyses of the two silencing phenomena in fungi, known as "repeat-induced point mutation" (RIP) and "meiotic silencing by unpaired DNA" (MSUD), have provided genetic evidence for the existence of the direct homologous dsDNA-dsDNA pairing. Both RIP and MSUD likely rely on the same search strategy, by which dsDNA segments are matched as arrays of interspersed base-pair triplets. This process is general and very efficient, yet it proceeds normally without the RecA/Rad51/Dmc1 proteins. Further studies of RIP and MSUD may yield surprising insights into the function of DNA in the cell.

journal_name

J Mol Biol

journal_title

Journal of molecular biology

authors

Mazur AK,Nguyen TS,Gladyshev E

doi

10.1016/j.jmb.2019.11.005

subject

Has Abstract

pub_date

2020-02-07 00:00:00

pages

737-744

issue

3

eissn

0022-2836

issn

1089-8638

pii

S0022-2836(19)30661-8

journal_volume

432

pub_type

杂志文章,评审

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