Abstract:
BACKGROUND:Acupuncture therapy is frequently used to treat Knee Osteoarthritis (KOA) in clinic, and usually used local acupoints near the diseased knees as therapeutic targets. Some local acupoints appeared sensitization phenomenon which was called sensitized acupoints, which were regarded as important therapeutic targets to get better therapeutic effect on clinic. Therefore, it is necessary to explore the biological basis of acupoint sensitization. Meanwhile, there is a lack of an analysis of the metabolism for sensitized acupoints in KOA patients. Considering that acupuncture effect could be multi-targeted, omics (such as metabolomics) may be a useful method to reveal the relationship between sensitized acupoints and clinical efficacy of acupuncture. METHODS AND ANALYSIS:This study is a parallel design trial. Thirty KOA patients and 30 healthy volunteers will be recruited in this study. Mechanical pain threshold will be measured by Electron Von frey in order to confirm the highest sensitized acupoints. Then collect tissue fluid from the highest sensitized acupoints by micro dialysis technical, then apply electro-acupuncture method on the highest sensitized acupoints to treat KOA patients, after 20 sessions treatments, measure and collect again. Liquid chromatography-tandem mass spectrometry method will be used to analyze the metabonomics of dialysate. RESULTS:This study will provide a high-quality evidence to reveal the local molecular mechanism of acupuncture sensitized acupoints for patient with KOA. CONCLUSION:This study will provide up-date evidence of whether acupuncture sensitized acupoints have local molecular mechanism for KOA. TRIAL REGISTRATION NUMBER:NCT03599180 (24 Jul. 2018).
journal_name
Medicine (Baltimore)journal_title
Medicineauthors
Li S,Chai XN,Zuo CY,Lv P,Tang Y,Tan HJ,Liu LZ,Yin HY,Yu SGdoi
10.1097/MD.0000000000017843subject
Has Abstractpub_date
2019-11-01 00:00:00pages
e17843issue
45eissn
0025-7974issn
1536-5964pii
00005792-201911080-00034journal_volume
98pub_type
临床试验,杂志文章相关文献
MEDICINE文献大全abstract:BACKGROUND:Renal cell carcinoma metastasizing to rectum is very rare, and the unusual metastatic sites should be paid attention to during the follow-up of renal cell carcinoma. CASE SUMMARY:We describe a case of a 65-year-old male who was diagnosed with metastatic renal cell carcinoma to rectum 10 years after the righ...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000005720
更新日期:2017-01-01 00:00:00
abstract::Congenital chloride losing diarrhea (CCLD) is a rare type of chronic watery diarrhea due to mutations in SLC26A3 gene leading to defective chloride-bicarbonate exchanges with the resultant loss of chloride and retention of bicarbonate.We aim to define pediatric Saudi CCLD patients' characteristics to achieve prompt di...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000015928
更新日期:2019-05-01 00:00:00
abstract::Curative treatments for very early-stage hepatocellular carcinoma (HCC), defined as single HCC with a maximum diameter of <2 cm in patients with well-preserved liver function, consist of surgical resection or radiofrequency ablation (RFA). In this retrospective study, we compared the efficacy of both treatments in 154...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000016279
更新日期:2019-06-01 00:00:00
abstract::To investigate relevant factors and patients with acute myocardial infarction (AMI) were admitted during between weekdays and weekends period.Retrospective population-based study setting: from the 2005 population-based national health insurance underwriting database of millions of people, random sampling (National Hea...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000013883
更新日期:2019-01-01 00:00:00
abstract::Enterovirus (EV) infection is common among children and adolescents. Few studies have investigated the relationship of depression after EV infection. This study explores an association between EV infection and subsequent depression in children and adolescents and assesses the risk of depression after EV infection with...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000005983
更新日期:2017-02-01 00:00:00
abstract::For early diagnosis and treatment of invasive candidiasis (IC), the well-known risk factors may not apply in the intensive care unit (ICU). This retrospective study identified the risk factors predicting IC and candidemia in cancer patients under intensive care after gastrointestinal surgery.Enrolled were 229 cancer p...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000017704
更新日期:2019-11-01 00:00:00
abstract::To explore the safety and efficacy of the selective 5-serotonin and norepinephrine reuptake inhibitor duloxetine hydrochloride and alpha-adrenergic receptor blocker (alpha-blocker) doxazosin mesylate-controlled tablets in the treatment of pain disorder in chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS).In a...
journal_title:Medicine
pub_type: 杂志文章,随机对照试验
doi:10.1097/MD.0000000000006243
更新日期:2017-03-01 00:00:00
abstract::Recognition of the close relationship of nonalcoholic fatty liver disease (NAFLD) with diabetes mellitus 2, obesity, metabolic syndrome, and cardiovascular disease has stimulated growing interest in NAFLD as a public health problem. Serum alanine aminotransferase (ALT) has been proposed as a marker of NAFLD, but level...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000006770
更新日期:2017-04-01 00:00:00
abstract:INTRODUCTION:The clinical treatment is complicated for patients with placenta previa who must terminate pregnancy due to fetal malformation, death, or inevitable abortion in the second trimester. It is difficult to manage excessive bleeding during pregnancy termination; and those patients face risks of removing the ute...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000022499
更新日期:2020-09-25 00:00:00
abstract::Previous studies suggest that the future risk for type 2 diabetes is not similar among subjects in the same glucose tolerance category. In this study, we aimed to evaluate simple intuitive indices to identify subjects at high risk for future diabetes development by using 0, 30, 120 minute glucose levels obtained durin...
journal_title:Medicine
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1097/MD.0000000000003053
更新日期:2016-03-01 00:00:00
abstract:BACKGROUND:Pentraxin 3 is an acute inflammatory protein of the long pentraxin subfamily. A meta-analysis was performed to assess diagnostic accuracy of pentraxin 3 for respiratory tract infections. METHODS:We identify studies examining diagnostic value of pentraxin 3 for respiratory tract infections by searching Pubme...
journal_title:Medicine
pub_type: 杂志文章,meta分析
doi:10.1097/MD.0000000000019532
更新日期:2020-04-01 00:00:00
abstract:RATIONALE:Airway stabilization for severe, symptomatic tracheobronchomalacia (TBM) may be accomplished by silicone Y-stent placement. Common complications of the Y-stent include mucus plugging and granulation tissue formation. PATIENT CONCERNS:We describe a rare case of massive hemoptysis originating from a silicone Y...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000009980
更新日期:2018-02-01 00:00:00
abstract:INTRODUCTION:Stroke-like episodes (SLEs) are typical cerebral manifestations of certain mitochondrial disorders (MIDs). They are characterised by a vasogenic edema in a non-vascular distribution. PATIENTS CONCERNS:: none DIAGNOSIS:: SLEs show up on cerebral MRI as stroke-like lesions (SLLs), characterised by vasogenic ...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000019141
更新日期:2020-02-01 00:00:00
abstract::Primary Amyloid Light-chain (AL) amyloidosis is a rare form of plasma cell dyscrasia characterized by tissue deposition of monoclonal immunoglobulin light chain. Kidney involvement is the most frequent manifestation, and patients usually present with glomerular disease.We report an exceptional case of bilateral kidney...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000000777
更新日期:2015-05-01 00:00:00
abstract::Subcutaneous and submuscular anterior ulnar nerve transposition have been widely used in patients with cubital tunnel syndrome. However, the reliable evidence in favor of 1 of 2 surgical options on clinical improvement remains controversial. To maximize the value of the available literature, we performed a systematic ...
journal_title:Medicine
pub_type: 杂志文章,meta分析,评审
doi:10.1097/MD.0000000000001207
更新日期:2015-07-01 00:00:00
abstract:BACKGROUND:To explore the correlation between recurrent risk and CYP2C19 gene polymorphisms in patients with ischemic stroke (IS) treated with clopidogrel for prevention. METHODS:A total of 289 patients with IS treated with clopidogrel regularly were enrolled in this study, and stroke recurrence of all patients were r...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000019143
更新日期:2020-03-01 00:00:00
abstract:RATIONALE:Neurofibromatosis type 1 (NF-1) is an autosomal dominant disorder characterized by cafe au lait macules and neurofibromatosis. Renal artery aneurysms are relatively uncommon. Endovascular techniques are effective in treating renal aneurysms but successful cases are rarely reported in NF-1 adults. PATIENT CON...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000008858
更新日期:2017-11-01 00:00:00
abstract::Serum adiponectin levels have been suggested to be predictors of type 2 diabetes mellitus in diverse populations. However, the relationship between circulating adiponectin levels and the risk of development of type 2 diabetes in postmenopausal women has not been investigated.A total of 382 healthy postmenopausal women...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000001347
更新日期:2015-08-01 00:00:00
abstract::The occurrence of anastomotic leakage (AL) remains a major concern in the early postoperative stage. Because of the relatively high morbidity and mortality of AL in patients with laparoscopic low rectal cancer who receive an anterior resection, a fecal diverting method is usually introduced. The Valtrac™-secured intra...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000000224
更新日期:2014-12-01 00:00:00
abstract::This article explores information relating to female adolescents knowledge, attitudes, and behaviors toward human immunodeficiency virus (HIV) and other sexually transmitted diseases (STDs) in Carriacou. The authors aimed at finding out whether adolescent females in Carriacou receive adequate information about HIV and...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000004800
更新日期:2016-09-01 00:00:00
abstract:RATIONALE:Small-cell lung cancer (SCLC) is a common pathological type of lung cancer, but appendiceal metastasis of SCLC was rare. At present, clinical studies on the maintenance therapy of SCLC have not reached a significant conclusion. PATIENT CONCERNS:We reported on a 52-year-old man who diagnosed as extensive stag...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000015333
更新日期:2019-04-01 00:00:00
abstract::The current study was to evaluate soluble ST-2 level and left ventricular ejection fraction (LVEF) in patients with breast cancer receiving doxorubicin or trastuzumab treatment for 6 months and determine whether soluble ST-2 level can be used to predictive left ventricular function impairment.Patients who were diagnos...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000012447
更新日期:2018-09-01 00:00:00
abstract::Primary squamous cell carcinoma (SCC) of liver is rare, and its prognosis is extremely poor. This study aims at reviewing the clinical data of all pathologically diagnosed liver cancer in our institute, and discussing the clinical presentation, diagnosis, treatment, and prognosis of our cases of SCC and the literature...
journal_title:Medicine
pub_type: 杂志文章,评审
doi:10.1097/MD.0000000000000868
更新日期:2015-07-01 00:00:00
abstract::Adenoid cystic carcinoma (ACC) is one of the most frequent malignancies of salivary glands. The objective of this study was to identify key genes and potential mechanisms during ACC samples.The gene expression profiles of GSE88804 data set were downloaded from Gene Expression Omnibus. The GSE88804 data set contained 2...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000018676
更新日期:2020-01-01 00:00:00
abstract::There have been few reports on 2 tumor necrosis factor alpha inhibitors, infliximab and adalimumab, with respect to patient preference and efficacy in ulcerative colitis (UC).We used questionnaires to evaluate the preference and reasons for drug choice between infliximab and adalimumab in UC patients naive to antitumo...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000007800
更新日期:2017-08-01 00:00:00
abstract::The aim of this study was to investigate the usefulness of titanium mesh cage as an interlaminar spacer combined with nitinol shape memory loop fixation in patients with atlantoaxial instability.From April 2009 to March 2017, among the patients with atlantoaxial instability, a total of 30 patients were treated by niti...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000008022
更新日期:2017-09-01 00:00:00
abstract::Buddhist priests lead a unique lifestyle, practicing asceticism, with a vegetarian diet. Such behavior may have an impact on clinical outcomes. Hence, we explored the mortality among Korean Buddhist priests as compared with the general population.This study is a single-center, retrospective study. Among the 3867 Buddh...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000013099
更新日期:2018-11-01 00:00:00
abstract::The purpose of the current study was to investigate the characteristics of patients with diabetic nephropathy (DN) without diabetic retinopathy (DR).One hundred four patients with biopsy-proven DN, and 52 patients with diabetes mellitus (DM) without DR who were diagnosed as membranous nephropathy by renal biopsy were ...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000006805
更新日期:2017-05-01 00:00:00
abstract:RATIONALE:Ptosis is a rare complication of periocular steroid use. Studies report that local injections of steroids produce ptosis. We describe the first 2 cases of ptosis because of long-term treatment with topical steroid eye drops. PATIENT CONCERNS:Two cases admitted to our hospital because of ptosis of their right...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000009288
更新日期:2017-12-01 00:00:00
abstract::This study is to investigate the methylation status of multiple tumor suppressor 1 (p16), secreted glycoprotein 2 (SLIT2), scavenger receptor class A, member 5 putative (SCARA5), and human runt-related transcription factor 3 (Runx3) genes in the peripheral blood of hepatocellular carcinoma (HCC).This is a case-control...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000008279
更新日期:2017-10-01 00:00:00