Abstract:
:Curative treatments for very early-stage hepatocellular carcinoma (HCC), defined as single HCC with a maximum diameter of <2 cm in patients with well-preserved liver function, consist of surgical resection or radiofrequency ablation (RFA). In this retrospective study, we compared the efficacy of both treatments in 154 patients with very early-stage HCCs who underwent resection or RFA as initial therapy and were followed up for a median of 56.8 months. Propensity score matching analysis was also conducted. Overall survival was comparable between treatment groups (median survival time of 143 vs 97 months for resection and RFA, respectively; P = .132). Resection group; however, demonstrated a significantly lower recurrence rate after initial therapy than RFA group (42.3% vs 65.7%; P = .006) with a longer median recurrence-free survival time (66.7 vs 33.8 months; P = .002), which was confirmed even after matching (P = .04). In contrast, the recurrence pattern in advanced-stage (9.6% vs 1.0%; P = .01) or incurable recurrences (19% vs 13%; P = .04) was more frequent following resection than RFA. Recurrent lesions were comparatively more curable in RFA group than in resection group (80% vs 54.5%; P = .02). The recurrence of HCC was independently associated with lower serum albumin level (P = .027), the presence of comorbid diabetes mellitus (P = .010), and RFA (P = .034). In conclusion, in patients with very early-stage HCC, surgical resection has achieved significantly better recurrence-free survival than RFA. A closer follow-up is required after resection.
journal_name
Medicine (Baltimore)journal_title
Medicineauthors
Kim TH,Chang JM,Um SH,Jee H,Lee YR,Lee HA,Yim SY,Han NY,Lee JM,Choi HS,Kim ES,Yu YD,Keum B,Kim MJ,An H,Park BJ,Seo YS,Kim DS,Yim HJ,Cho SB,Jeen YT,Lee HS,Chun HJ,Kim YH,Kim CDdoi
10.1097/MD.0000000000016279subject
Has Abstractpub_date
2019-06-01 00:00:00pages
e16279issue
26eissn
0025-7974issn
1536-5964pii
00005792-201906280-00111journal_volume
98pub_type
杂志文章相关文献
MEDICINE文献大全abstract:RATIONALE:Acute cerebral infarction after snake bites is rare. The underlying mechanism causing the thrombotic process remains complex and unknown. PATIENT CONCERNS:We herein describe a 49-year-old female who was bitten by a Trimeresurus stejnegeri. After 4 days of biting, she developed acute ischemic infarct. DIAGNO...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000015684
更新日期:2019-06-01 00:00:00
abstract::Intra-abdominal infection (IAI) after hepatectomy is an important morbidity. Identification of risk factors that could be avoided in the perioperative period may reduce the prevalence of IAI after hepatectomy for hepatocelluar carcinoma (HCC).Between January 1995 and December 2009, all patients with HCC who underwent ...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000006795
更新日期:2017-04-01 00:00:00
abstract:RATIONALE:All the enteric ganglion cells are fully mature by 2 to 5 years of age in human. No one had reported the presentation of immature enteric ganglion cells in elder ones. Colorectal carcinoma is also rare in the adolescent population. The coincidence of these 2 rare events in a 13-year-old boy has never been rep...
journal_title:Medicine
pub_type: 杂志文章,评审
doi:10.1097/MD.0000000000007036
更新日期:2017-06-01 00:00:00
abstract::Cerebral edema is a frequent and serious complication in traumatic brain injury (TBI) patients. The objective is to study the effect of dexamethasone in patients with brain contusions, and to assess its effect on the vasogenic component of the pericontusional edema.Prospective-observational study to quantify, using ma...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000022879
更新日期:2020-10-23 00:00:00
abstract::The occurrence and characteristics of remissions in patients with systematic lupus erythematosus (SLE) have not been determined. We therefore studied this in a cohort of 667 patients and found that 156 patients had achieved at least 1 period of 1 year or more of treatment-free clinical remission. This represents an in...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/00005792-199603000-00005
更新日期:1996-03-01 00:00:00
abstract::Mental and physical stress is thought to play an important causative factor in apical ballooning syndrome (ABS) likely secondary to the vasomotor dysfunction. However, there are currently few data related to the impact of physical stress in this unique cardiomyopathy.A total 18 patients, including 8 females with histo...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000013841
更新日期:2019-01-01 00:00:00
abstract::Primary Amyloid Light-chain (AL) amyloidosis is a rare form of plasma cell dyscrasia characterized by tissue deposition of monoclonal immunoglobulin light chain. Kidney involvement is the most frequent manifestation, and patients usually present with glomerular disease.We report an exceptional case of bilateral kidney...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000000777
更新日期:2015-05-01 00:00:00
abstract::Tools for evaluation of disease activity in patients with anti-neutrophil cytoplasmic antibodies (ANCA)-associated vasculitis (AAV) include scoring clinical manifestations, determination of biochemical parameters of inflammation, and obtaining tissue biopsies. These tools, however, are sometimes inconclusive. 2-deoxy-...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000000747
更新日期:2015-05-01 00:00:00
abstract:RATIONALE:Invasive moles occur in the fertile period, with about 95% occurring after previous mole removal and the remaining 5% occurring after several other pregnancies. PATIENT CONCERNS:A 27-year-old patient developed a rare invasive mole two months after a missed abortion. DIAGNOSES:A transvaginal ultrasound scan ...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000017565
更新日期:2019-10-01 00:00:00
abstract::Unplanned reoperations have not been studied extensively in pediatric patients, especially concerning risk factors. We aim to estimate the rate of unplanned reoperations and to determine the associated factors in pediatric general surgical specialties.This analysis included a retrospective case-control study of unplan...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000019982
更新日期:2020-05-01 00:00:00
abstract::The incidence of nontuberculous mycobacterial pulmonary disease (NTMPD) is increasing worldwide. Secondary spontaneous pneumothorax occurs as a complication of underlying lung disease and is associated with higher morbidity, mortality, and recurrence than primary spontaneous pneumothorax. We here investigated the clin...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000004246
更新日期:2016-07-01 00:00:00
abstract::The present study provides a basic outline of the care and support that family caregivers offer to people affected by neuromuscular diseases.To determine the presence of burden in caregivers of people with neuromuscular diseases who use a wheelchair and to establish whether the presence of burden is influenced by cont...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000011039
更新日期:2018-06-01 00:00:00
abstract::Although studies have shown that chronic obstructive pulmonary disease (COPD) and hypertension are linked as comorbidities, it remains unclear whether COPD is independently associated with the risk of hypertension or is caused by common risk factors such as age and smoking. The objective of this study was to investiga...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000006826
更新日期:2017-05-01 00:00:00
abstract:BACKGROUND:Numerous reports have explored the prognostic value of pretransplant serum C-reactive protein (CRP) in patients receiving allogeneic stem cell transplant (ASCT), but the results remain conflicting. Therefore, we performed a meta-analysis to comprehensively assess the prognostic value of pretransplant serum C...
journal_title:Medicine
pub_type: 杂志文章,meta分析,评审
doi:10.1097/MD.0000000000014474
更新日期:2019-02-01 00:00:00
abstract::Patients with suspected non-ST-segment elevation acute coronary syndromes (NSTEACS) constitute a heterogeneous population with variable outcomes. Risk stratification in this population of patients is difficult due to the complexity in patient risk profile. We conducted this study to characterize the value of clinical ...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/00005792-200211000-00004
更新日期:2002-11-01 00:00:00
abstract::As the number of cardiac implantable electronic devices (CIEDs) is increasing annually, CIED-related complications are becoming increasingly important. The aim of the study was to assess the risks associated with CIEDs by a nationwide database. Patients were selected from the Taiwan National Health Insurance Database....
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000000213
更新日期:2014-12-01 00:00:00
abstract::To evaluate the value of lymph node status of primary tumors in predicting the prognosis of synchronous resectable metastatic colorectal cancer (mCRC).The characteristics of resectable mCRC are substantially different from other cancers, and the prognostic factors of resectable mCRC are still controversial.The data of...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000001215
更新日期:2015-07-01 00:00:00
abstract::Adjacent segmental degeneration (ASD) is a major issue after pedicular fixation. This study examined the degeneration of the adjacent levels due to the insertion of the Wallis interspinous stabilization system compared with discectomy, using magnetic resonance imaging (MRI).Thirty-eight patients diagnosed with lumbar ...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000007056
更新日期:2017-06-01 00:00:00
abstract::Rapid response teams have been adopted to prevent unexpected in-ward cardiac arrest. However, there is no convincing evidence of optimal operation with rapid response team. Our aim was to address the impact of focused rapid response team on the safety of patients in wards. Comparison of focused with extended rapid res...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000019032
更新日期:2020-03-01 00:00:00
abstract::Periodontitis is a systemic and chronic inflammatory disease associated with multiple physical conditions. Distress and depression are other problems affecting the progression of periodontitis. However, the causal relationship between depression and periodontitis has not been adequately investigated. This aim of this ...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000002347
更新日期:2015-12-01 00:00:00
abstract::Aortoiliac occlusive disease (AIOD) affects the systemic vascular resistance and increases the afterload because the left ventricle (LV) must work harder to eject blood into a smaller vascular bed. This study was to determine whether successful revascularization of AIOD is associated with improvement of left ventricul...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000012339
更新日期:2018-09-01 00:00:00
abstract:BACKGROUND:Many studies were performed to explore the correlation between taxane-based chemotherapy and the risk of breast cancer-related lymphedema (BCRL), however, with inconsistent results. Hence, the purpose of this study is to evaluate whether taxane-based chemotherapy is a risk factor for BCRL. METHODS:A compreh...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000016563
更新日期:2019-07-01 00:00:00
abstract:OBJECTIVES:The primary objective of this study was to investigate whether dexmedetomidine could potentiate the analgesic efficacy of ropivacaine, when added to ropivacaine for wound infiltration in patients undergoing open gastrectomy. METHODS:Fifty patients scheduled for open gastrectomy were divided into 2 equal gro...
journal_title:Medicine
pub_type: 杂志文章,随机对照试验
doi:10.1097/MD.0000000000007950
更新日期:2017-09-01 00:00:00
abstract:BACKGROUND:Presently, hip arthroscopy is a widely adopted surgical intervention for the treatment of femoroacetabular impingement (FAI). However, there is insufficient evidence regarding which between arthroscopy and nonoperative treatment is more optimal for symptomatic FAI. METHODS:MEDLINE, Embase, Web of Science, a...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000023247
更新日期:2020-12-04 00:00:00
abstract:BACKGROUND:Glioblastomas are malignant brain tumors associated with high mortality and poor prognosis. Evidence from preclinical studies suggests that statins have an antitumor role, but their effects on the survival of patients with glioblastoma remain controversial. This meta-analysis attempts to assess the associati...
journal_title:Medicine
pub_type: 杂志文章,meta分析
doi:10.1097/MD.0000000000018997
更新日期:2020-02-01 00:00:00
abstract::The associations of tea consumption with risk of oral cancer remain not clear. The present meta-analysis aims to clarify the real relationship between tea intake and the risk of oral cancer and quantifies the potential dose-response relationship between them.A Web search was performed within Pubmed, Embase, and Web of...
journal_title:Medicine
pub_type: 杂志文章,meta分析
doi:10.1097/MD.0000000000013611
更新日期:2018-12-01 00:00:00
abstract::The remarkable success of trastuzumab and other newly developed anti-HER2 (human epidermal growth factor receptor 2) therapies in breast, gastric, or gastroesophageal junction cancer patients has supported us to investigate the HER2 status and its possible therapeutic implication in mucinous epithelial ovarian cancer ...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000000171
更新日期:2014-12-01 00:00:00
abstract::The evaluation of the electrically induced bulbocavernosus reflex (BCR) using electromyography (EMG) is a useful tool for evaluating the integrity of sacral spinal segments 2 to 4, and that of their afferent and efferent connections in the urogenital region. In the current retrospective study, the value of this techni...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000007014
更新日期:2017-05-01 00:00:00
abstract::Critical illness insurance to reduce the incidence of catastrophic health expenditure was implemented in China in 2012. The aim of this study is to explore the implementation status and medical guarantee effect of critical illness insurance in various cities.We extracted insurance reimbursement data for 2014 from the ...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000011362
更新日期:2018-07-01 00:00:00
abstract::There is little information about the management and clinical outcomes of the periprosthetic fracture after total knee arthroplasty (TKA) with a stem extension. The purposes of this study were to demonstrate management of the periprosthetic fractures after TKA with a stem extension, to report treatment outcomes, and t...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000016088
更新日期:2019-06-01 00:00:00