Abstract:
BACKGROUND:To explore the correlation between recurrent risk and CYP2C19 gene polymorphisms in patients with ischemic stroke (IS) treated with clopidogrel for prevention. METHODS:A total of 289 patients with IS treated with clopidogrel regularly were enrolled in this study, and stroke recurrence of all patients were recorded by follow-up. The correlation between CYP2C19 gene polymorphism and stroke recurrence in patients taking clopidogrel regularly was analyzed. RESULTS:After a mean follow-up period of 6 months, there were 289 patients who took clopidogrel regularly, and 41 of which occurred recurrent stroke. Patients of poor metabolizer and intermediate metabolizer had higher risk of recurrent stroke comparing with patients of extensive metabolize, and the odds ratios were 2.88 (95% confidence interval [CI] 1.31-6.33, P = .068) and 3.00 (95% CI 1.09-8.22, P = .027), respectively. The recurrence risk of *2 (G681A)A allele carriers was 3.30 times that of G allele carriers (P = .0065). The recurrence rate of stroke in patients carrying heterozygous and homozygous *2 allele mutant was 1.96 times (P = .071) and 3.30 times (P = .012) that of patients with wild-type genes. Multifactor logistic regression analysis result indicated carrying loss of function (LOF) allele was an independent risk factor of stroke recurrence. CONCLUSION:For patients with IS treated with clopidogrel regularly for secondary prevention, poor metabolizer, and intermediate metabolizer patients had higher risk of recurrent stroke comparing with extensive metabolize ones. Carrying CYP2C19 LOF allele is an independent risk factor of stroke recurrence in patients with IS.
journal_name
Medicine (Baltimore)journal_title
Medicineauthors
Liu G,Yang S,Chen Sdoi
10.1097/MD.0000000000019143subject
Has Abstractpub_date
2020-03-01 00:00:00pages
e19143issue
11eissn
0025-7974issn
1536-5964pii
00005792-202003130-00017journal_volume
99pub_type
杂志文章相关文献
MEDICINE文献大全abstract:BACKGROUND:Allergic rhinitis is a major chronic inflammatory disease of the respiratory tract. A large number of epidemiological investigations have shown that the prevalence of allergic rhinitis (AR) is increasing, resulting in a large burden of disease. Desensitizing drugs such as nasal glucocorticoids and antihistam...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000013772
更新日期:2018-12-01 00:00:00
abstract::The aim of the present study was to assess the effect of Endostar and temozolomide or dacarbazine plus 5-fluorouracil (5-FU) in patients with advanced pancreatic neuroendocrine tumors (pNETs).Phase II study of 14 patients with locally advanced or metastatic well-differentiated pNETs treated between April 2013 and Sept...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000012750
更新日期:2018-11-01 00:00:00
abstract::Most of recurrent bladder carcinoma after partial cystectomy did not cause diagnostic difficulties for urologists, because of the appearance of typical papillary in ultrasonography or cystoscopy, and could be easily confirmed by tumor biopsy. Three patients, ages from 35 to 62 years, had undergone bladder sparing trea...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000000898
更新日期:2015-06-01 00:00:00
abstract:INTRODUCTION:Chimeric antigen receptor T cells (CAR-T) targeting CD19 have shown great potential for treatment of B-cell malignancies. For those patients who can not achieve complete remission (CR) or suffer from relapse after CAR-T therapy, further therapeutic strategies still remain elusive. Whether existing CAR-T ce...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000022510
更新日期:2020-10-23 00:00:00
abstract::The aim of this study was to compare the effectiveness and safety of 2 surgical techniques that are used to treat proximal femoral fractures.A systematic literature search (up to December 2014) was conducted in Medline, Embase, PubMed, and The Cochrane Central Register of Controlled Trials to screen for studies compar...
journal_title:Medicine
pub_type: 杂志文章,meta分析
doi:10.1097/MD.0000000000003168
更新日期:2016-04-01 00:00:00
abstract:RATIONALE:Infantile-onset Pompe disease, also known as glycogen storage disease type II, is a progressive and fatal disorder without treatment. Enzyme replacement therapy with recombinant human acid alpha-glucosidase (GAA) enhances survival; however, the best outcomes have been achieved with early treatment. PATIENT C...
journal_title:Medicine
pub_type: 杂志文章,评审
doi:10.1097/MD.0000000000009186
更新日期:2017-12-01 00:00:00
abstract::The purpose of the current study was to investigate the characteristics of patients with diabetic nephropathy (DN) without diabetic retinopathy (DR).One hundred four patients with biopsy-proven DN, and 52 patients with diabetes mellitus (DM) without DR who were diagnosed as membranous nephropathy by renal biopsy were ...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000006805
更新日期:2017-05-01 00:00:00
abstract::The aim of this study was to evaluate the correlation between radionuclide salivagram findings and clinical characteristics in stroke patient with swallowing difficulty.In this study, dysphagic stroke patients who had undergone both a radionuclide salivagram and videofluoroscopic swallowing study (VFSS) were included ...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000014977
更新日期:2019-03-01 00:00:00
abstract:BACKGROUND:Since the COVID-19 outbreak in 2020, more than 20 million people worldwide have been diagnosed with COVID-19, and all health care workers are looking for ways to improve the cure rate of the disease. As an important method of rehabilitation therapy, exercise therapy has been proved to improve the level of hu...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000023762
更新日期:2020-12-18 00:00:00
abstract::Sleep disturbance is a common comorbidity among patients with acromegaly [patients with growth hormone (GH)-secreting tumor] due to somatotropic axis change and sleep apnea. However, no previous studies exist concerning sleep disturbance and delirium in the early postoperative period in patients with acromegaly underg...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000023157
更新日期:2020-11-06 00:00:00
abstract:RATIONALE:Supernumerary teeth are those that teeth in excess number than the normal count. It is usually associated with genetic syndromes when present in more numbers. Several causal genes, such as APC, NHS, TRPS1, EVC and RUNX2, have been identified. However, etiology of supernumerary teeth remains largely unclear. ...
journal_title:Medicine
pub_type: 杂志文章,评审
doi:10.1097/MD.0000000000011328
更新日期:2018-08-01 00:00:00
abstract:RATIONALE:Foreign-body ingestion is a common phenomenon and foreign bodies are mostly excreted in stool. Once sharp bodies are ingested without being realized, perforation of intestine is possible and misdiagnosis may be made. We report 2 toothpick ingestion cases that were both diagnosed accurately. PATIENT CONCERNS:...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000009710
更新日期:2018-02-01 00:00:00
abstract:BACKGROUND:Alpha-fetoprotein (AFP) is an important marker for hepatocellular carcinoma, and the detection of serum AFP is currently the principle method for the diagnosis of hepatocellular carcinoma. The prevalence of gastric cancer (GC) with high level of serum AFP is extremely rare, but has unique clinical features. ...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000004610
更新日期:2016-09-01 00:00:00
abstract:RATIONALE:Patients who undergo hilar cholangiocarcinoma (HCAC) resection with concomitant hepatectomy have a high risk of postoperative morbidity and mortality due to surgical trauma to the hepatic and biliary vasculature. PATIENT CONCERNS:A 58-year-old Chinese man with yellowing skin and sclera, abdominal distension,...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000008083
更新日期:2017-09-01 00:00:00
abstract:RATIONALE:Conjunctival lymphoproliferative lesions constitute a significant diagnostic challenge and it is essential to exclude neoplastic lesions. Histopathological and immunohistochemical tests are very useful in establishing the correct diagnosis. Reactive lymphoid hyperplasia (RLH) is part of a spectrum of lymphocy...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000008656
更新日期:2017-11-01 00:00:00
abstract::Significant changes in body composition are known to occur with aging. The aim of the present study was to provide a normative reference of body composition and to investigate age and sex-related differences in healthy subjects by multifrequency bioelectrical impedance analyzer (BIA).A cross-sectional study was conduc...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000011152
更新日期:2018-06-01 00:00:00
abstract::Time resolved magnetic resonance angiography with interleaved stochastic trajectories (TWIST) allows for identification of tumor feeding arteries and arteriovenous shunt (AVS). We used TWIST to obtain number of feeding arteries (NFA) and detect AVS for 43 cases of pathology-confirmed soft tissue tumors. We compared no...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000016346
更新日期:2019-07-01 00:00:00
abstract:RATIONALE:Tibial nerve injury is a sustainable but rare complication during total-ankle arthroplasty (TAA). We outlined 2 previously unreported cases of tibial nerve injury in TAA, including the prognoses and possible causes. PATIENT CONCERNS:First, a 63-year-old woman complained of a 5-month history of persistent tin...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000021474
更新日期:2020-07-31 00:00:00
abstract::Mastocytosis is a rare disease characterized by clonal neoplastic proliferation of mast cells (MCs). It ranges from skin lesions as cutaneous mastocytosis (CM) which may spontaneously regress to highly aggressive neoplasms with multiorgan involvement corresponding to some aggressive systemic mastocytosis (ASM), mast c...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000010642
更新日期:2018-05-01 00:00:00
abstract::Although percutaneous nephrolithotomy is minimally invasive, it is associated with several complications, including extravasation of fluid and urine, the need for a blood transfusion, and septicemia. However, little is known about pulmonary complications after this procedure. Therefore, we aimed to evaluate the risk f...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000004513
更新日期:2016-08-01 00:00:00
abstract:RATIONALE:Henoch-Schönlein purpura (HSP) is a small-vessel vasculitis that has been extensively studied in children, but little is known about its natural history in adults. There is no consensus regarding the treatment of glucocorticosteroids use for HSP. The efficacy of glucocorticoid for preventing from severe compl...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000018602
更新日期:2020-01-01 00:00:00
abstract::While salmonellosis is often considered to affect primarily the gastrointestinal tract, infection at other sites may occur, producing characteristic clinical syndromes. We reviewed cases from our institutions and the literature on focal manifestations of salmonella infections. In the past, most extra-intestinal salmon...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/00005792-198709000-00003
更新日期:1987-09-01 00:00:00
abstract::Semantic and verbal fluency tasks are widely used as a measure of frontal capacities. It has been well described in literature that patients affected by schizophrenic and bipolar disorders present a worse execution in these tasks. Some authors have also noted the importance of educational years. Our objective is to an...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000001596
更新日期:2015-09-01 00:00:00
abstract:BACKGROUND:Tianqi Jiangtang Capsule is a commonly used Chinese patent medicine for the treatment of type 2 diabetes mellitus (T2DM) in China. The purpose of this study is to systematically evaluate the clinical efficacy and safety of Tianqi Jiangtang Capsule in the treatment of type 2 diabetes mellitus. METHODS:Random...
journal_title:Medicine
pub_type: 杂志文章,meta分析
doi:10.1097/MD.0000000000019702
更新日期:2020-05-22 00:00:00
abstract:RATIONALE:Although several studies have described the involvement pattern of myotonic dystrophy type 1 (DM1) using muscle MRI, most of these studies have limitations as cross-sectional studies. To the best of our knowledge, there have been no reports of longitudinal studies describing muscle involvement patterns in pat...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000009379
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:Diabetic peripheral neuropathy (DPN) is one of the most common causes of disability in diabetic population, and its pathogenesis is related to a variety of factors. There is currently no effective treatment for such chronic disease. Traditional Chinese medicine has a long clinical history for the prevention ...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000016696
更新日期:2019-08-01 00:00:00
abstract::The free antiretroviral therapy (ART) program in India has scaled up to register second largest number of people living with HIV/AIDS across the globe. To assess the effectiveness of current first-line regimen we estimated virological suppression on completion of 1 year of ART. The study describes the correlates of vi...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000004886
更新日期:2016-09-01 00:00:00
abstract::The authors propose to encompass under the designation of "fasciitis-panniculitis syndromes" (FPS) a group of disorders characterized by induration of the skin due to chronic inflammation and fibrosis of the subcutaneous septa and muscular fascia. The prototype of the FPS is eosinophilic fasciitis. Thirty-two consecut...
journal_title:Medicine
pub_type: 杂志文章,评审
doi:10.1097/00005792-199601000-00002
更新日期:1996-01-01 00:00:00
abstract::Acute myocardial infarction (AMI) is recognized as being a life-threatening event. Both microvascular obstruction (MVO) and intramyocardial hemorrhage (IMH) have been recognized as poor prognostic factors in myocardial infarct (MI) since they adversely affect left ventricular remodeling. MVO refers to small vessels ch...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000011617
更新日期:2018-07-01 00:00:00
abstract::Coronary heart disease (CHD), one of the leading causes of death in the world, is a complex metabolic disorder due to genetic and environmental interactions. The potential mechanisms and diagnostic biomarkers for different types of coronary heart disease remain unclear. Metabolomics is increasingly considered to be a ...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000014309
更新日期:2019-02-01 00:00:00