Diagnostic accuracy of serum alanine aminotransferase as biomarker for nonalcoholic fatty liver disease and insulin resistance in healthy subjects, using 3T MR spectroscopy.


:Recognition of the close relationship of nonalcoholic fatty liver disease (NAFLD) with diabetes mellitus 2, obesity, metabolic syndrome, and cardiovascular disease has stimulated growing interest in NAFLD as a public health problem. Serum alanine aminotransferase (ALT) has been proposed as a marker of NAFLD, but levels are within the range currently considered "normal" in a large proportion of NAFLD subjects.The aim of the study was to determine the diagnostic accuracy of serum ALT for identifying individuals with NAFLD, using 3-Tesla (T) magnetic resonance spectroscopy (H-MRS).A cross-sectional study was conducted in 129 healthy subjects. Liver triglyceride content was quantified by H-MRS. NAFLD was defined as liver triglyceride content greater than 5.56%.Liver triglyceride content was >5.56% in 79 participants (NAFLD) and lower in the remaining 50 (normal). Serum ALT levels correlated positively with liver triglyceride content (r = 0.58, P < .001), Homeostatic Model Assessment for Insulin Resistance (r = 0.32, P < .01), and fasting insulin (r = 0.31, P < .01), and inversely correlated with adiponectin (r = 0.35, P < .01) and high-density lipoprotein cholesterol (r = 0.32, P < .01). Regression analysis showed that serum ALT was the best predictor of NAFLD (P < .01). Optimal serum ALT cut-off to predict NAFLD was 23 IU/L (area under receiver-operating characteristic curve: 0.93; sensitivity: 0.94; specificity: 0.72).This study shows that serum ALT is a sensitive and accurate biomarker of NAFLD if the "normal" ALT value is revised and established at a lower level. An ALT threshold of 23 IU/L identified 94% of individuals with NAFLD in the present series, using 3-T H-MRS for liver triglyceride quantification.


Medicine (Baltimore)




Martin-Rodriguez JL,Gonzalez-Cantero J,Gonzalez-Cantero A,Arrebola JP,Gonzalez-Calvin JL




Has Abstract


2017-04-01 00:00:00
















  • Miller-Fisher syndrome complicated by Bickerstaff brainstem encephalitis: A case report.

    abstract:RATIONALE:Bickerstaff brainstem encephalitis (BBE) and Miller-Fisher syndrome (MFS) might be a pedigree disease. Herein, we report a rare case that fits the diagnoses of both MFS and BBE. PATIENT CONCERNS:A 48-year-old woman was hospitalized due to blurred vision and unsteady gait lasting for 9 days, and numbness of t...


    pub_type: 杂志文章


    authors: Jing C,Wang Z,Chu C,Dong M,Lin W

    更新日期:2018-03-01 00:00:00

  • Acute rib fracture caused by preoperative positioning for direct lateral interbody fusion: A case report.

    abstract:RATIONALE:Degenerative spondylolisthesis is defined as forward slippage of a vertebra with respect to the underlying vertebra and is associated with the induction of lumbar canal stenosis. The use of anterior column support for degenerative lumbar conditions has been well documented. Direct lateral interbody fusion (DL...


    pub_type: 杂志文章


    authors: Hong CH,Jung KJ,Soh JW,Won SH,Hong SJ,Kim CH,Lee HS,Wang SD,Lee WS,Kim WJ

    更新日期:2019-02-01 00:00:00

  • Association between the IL-10 rs1800872 polymorphisms and periodontitis susceptibility: A meta-analysis.

    abstract:BACKGROUND:Periodontitis is a common disease with an unclear pathological mechanism. No precise consensus has been reached to evaluate the association between the IL-10 rs1800872 (- 592, -590, -597 C>A) polymorphism and periodontal disease. Thus, we performed this meta-analysis to collect more evidence-based informatio...


    pub_type: 杂志文章,meta分析


    authors: Wang Z,Li Y,Zhou Y,Qiao Y

    更新日期:2019-10-01 00:00:00

  • Nuclear factor κB -inducing kinase is a diagnostic marker of gastric cancer.

    abstract::Nuclear factor-κB-inducing kinase (NIK) is a new regulator of nuclear factor-κB signaling, which plays an important role in tumorigenesis. This study aimed to examine the expression of NIK in gastric cancer and investigate its clinical significance.Tumor issues were collected from 80 gastric cancer patients who receiv...


    pub_type: 杂志文章


    authors: Teng H,Xue L,Wang Y,Ding X,Li J

    更新日期:2020-01-01 00:00:00

  • The efficacy and safety of qiming granule in dry eye disease: Protocol for systematic review and meta-analysis.

    abstract:BACKGROUND:Dry eye disease is a common eye disease mainly manifests with eye fatigue, foreign body sensation, dry and astringent eyes and other symptoms. Growing evidence shows that qiming granule may have beneficial effects on the clinical treatment of dry eye disease. However, no systematic review and meta-analysis c...


    pub_type: 杂志文章,meta分析


    authors: Yang M,Hu Z,Yue R,Yang L,Zhang B,Chen Y

    更新日期:2019-09-01 00:00:00

  • Clinico-radiologic features of molar-incisor malformation in a case series of 38 patients: A retrospective observational study.

    abstract::Molar-incisor malformation (MIM) is a recently defined dental abnormality of molar root and incisors, and introduced as one of the causes of periapical and periodontal abscess. The purpose of this study was to investigate the clinical and radiological features of MIM, with special emphasis on various medical history. ...


    pub_type: 杂志文章


    authors: Kim JE,Hong JK,Yi WJ,Heo MS,Lee SS,Choi SC,Huh KH

    更新日期:2019-10-01 00:00:00

  • Association between KRAS G13D mutations and anastomotic recurrence in colorectal cancer: Two case reports.

    abstract:RATIONALE:The prevalence of anastomotic recurrence (AR) in colorectal cancer (CRC) after resection of the primary tumor (PT) is 5% to 14%. However, no association has been observed between specific somatic genetic alterations and AR. Such associations may shed light on the mechanism of AR. PATIENT CONCERNS:We experien...


    pub_type: 杂志文章


    authors: Okada S,Hata K,Kawai K,Yamamoto Y,Tanaka T,Nishikawa T,Sasaki K,Kaneko M,Emoto S,Murono K,Nozawa H

    更新日期:2019-03-01 00:00:00

  • Lower circulating angiotensin II levels are related to the severity of preeclampsia and its risk as disclosed by a specific bioassay.

    abstract::Preeclampsia is characterized by an increased sensitivity to angiotensin II (Ang II). We herein assessed whether serum Ang II levels measured by a new developed bioassay are associated with preeclampsia, its severity, and the risk for developing this disease.Using a cross-sectional design, we studied 90 pregnant women...


    pub_type: 杂志文章


    authors: Leaños-Miranda A,Inova Campos-Galicia,Méndez-Aguilar F,Molina-Pérez CJ,Ramírez-Valenzuela KL,Sillas-Pardo LJ,Uraga-Camacho NC,Isordia-Salas I,Berumen-Lechuga MG

    更新日期:2018-09-01 00:00:00

  • Effect of shikonin on the proliferation and apoptosis of human ovarian cancer cell SKOV3: A protocol of systematic review and meta-analysis.

    abstract:BACKGROUND:This study will investigate the effect of shikonin on the proliferation and apoptosis of human ovarian cancer cell SKOV3 (HOCC-SKOV3). METHODS:We will retrieve potential studies from inception to the March 1, 2020 in Cochrane Library, MEDLINE, EMBASE, Scopus, Cumulative Index to Nursing and Allied Health Li...


    pub_type: 杂志文章


    authors: Zhang DF,Zhao DX,Liu XZ,Li J,Hu YH,Dou PH

    更新日期:2020-05-29 00:00:00

  • Case report: Takayasu arteritis in a 3-month-old Chinese girl.

    abstract:RATIONALE:Takayasu arteritis is a rare large vessel systemic vasculitis that predominantly affects the aorta and its main branches in women of childbearing age. Due to nonspecific symptoms during the acute phase of disease, early diagnosis is still a challenge for pediatricians. PATIENT CONCERNS:We reported a 3-month-...


    pub_type: 杂志文章


    authors: Liu H,Sun L,Upadhyaya RS,Chen Y,Ajoje OO

    更新日期:2018-10-01 00:00:00

  • Gatekeeping and the utilization of community health services in Shenzhen, China: A cross-sectional study.

    abstract::To assess the effects of the gatekeeper policy implemented in Shenzhen, China, in conjunction with a labor health insurance program, on channeling patients toward community health centers (CHCs).Eight thousand patients who visited 8 CHCs in Shenzhen were surveyed between May 1, 2013 and July 28, 2013. Half of the pati...


    pub_type: 杂志文章


    authors: Li W,Gan Y,Dong X,Zhou Y,Cao S,Kkandawire N,Cong Y,Sun H,Lu Z

    更新日期:2017-09-01 00:00:00

  • Impact of Age on Stent Strut Coverage and Neointimal Remodeling as Assessed by Optical Coherence Tomography.

    abstract::While older age associates with adverse percutaneous coronary intervention (PCI) outcomes, detailed information relating age to stent strut coverage and neointimal characteristics is lacking. One hundred nineteen patients with 123 sirolimus-eluting stents (SESs) were divided into 3 groups: group A (≤55 years), group B...


    pub_type: 杂志文章


    authors: Han Z,Feng L,Du H,Sun Z,Hu S,Dai J,Sun M,Xing L,Hou J,Zhang S,Yu B

    更新日期:2015-12-01 00:00:00

  • Sensory-motor and cardiorespiratory sensory rehabilitation associated with transcranial photobiomodulation in patients with central nervous system injury: Trial protocol for a single-center, randomized, double-blind, and controlled clinical trial.

    abstract:BACKGROUND:Central nervous system diseases such as stroke, spinal cord injury, traumatic brain injury, and multiple sclerosis can be fatal or cause sequelae, affecting sensorimotor and cardiorespiratory systems and quality of life. These subjects present a low response to aerobic and resistance exercise, due to decreas...


    pub_type: 杂志文章


    authors: Pinto AP,Guimarães CL,Souza GADS,Leonardo PS,Neves MFD,Lima FPS,Lima MO,Lopes-Martins RAB

    更新日期:2019-06-01 00:00:00

  • Bullying, Depression, and Suicidal Ideation Among Adolescents in the Fujian Province of China: A Cross-sectional Study.

    abstract::The relationship of bullying with suicidal ideation among adolescents is controversial. Although depression has been related to bullying and suicidal ideation, little is known about the combined impacts of depression and bullying on suicidal ideation.A sample of 20,509 high school students from Fujian Province were se...


    pub_type: 杂志文章


    authors: Hong L,Guo L,Wu H,Li P,Xu Y,Gao X,Deng J,Huang G,Huang J,Lu C

    更新日期:2016-02-01 00:00:00

  • A Comparative Study of Daily 3-Gy Hypofractionated and 1.8-Gy Conventional Breast Irradiation in Early-Stage Breast Cancer.

    abstract::We retrospectively compared accelerated hypofractionation (AHF) with conventional fractionation (CF) in the radiation therapy (RT) for early-stage breast cancer patients.Three hundred seventy-nine early-stage (pT1-2 and pN0-1a) breast cancer patients who received RT with AHF after breast-conserving surgery (BCS) were ...


    pub_type: 杂志文章


    authors: Lee SW,Kim YJ,Shin KH,Kim K,Chie EK,Han W,Im SA,Jung SY,Lee KS,Lee ES

    更新日期:2016-05-01 00:00:00

  • Effects of cinnamaldehyde on anti-respiratory syncytial virus: A protocol of systematic review and meta-analysis.

    abstract:BACKGROUND:Previous reports found that cinnamaldehyde has effects on anti-respiratory syncytial virus (ARSV). However, their results are still contradictory. Therefore, this study will systematically address the effects of cinnamaldehyde on ARSV. METHODS:The following electronic bibliographic databases will be retriev...


    pub_type: 杂志文章,meta分析


    authors: Feng L,Li J,Yu HB,Xue Q,Dai LJ

    更新日期:2020-05-01 00:00:00

  • Treatment of atypical gouty arthritis of the hip using total hip arthroplasty: A case report.

    abstract:RATIONALE:Gout and gouty arthritis typically involve peripheral and monoarticular joints, especially the first metatarsophalangeal joint and knees. Hip involvement in patients with gout is rare, and its diagnosis is very difficult, especially in the late stages of the disease. Total hip arthroplasty could be a surgical...


    pub_type: 杂志文章


    authors: Huang Y,Huang J,Luo C,Chen L,Huang B

    更新日期:2020-10-30 00:00:00

  • Neutropenia following intravenous immunoglobulin therapy in adult patients with immune thrombocytopenic purpura: A single center experience and literature review.

    abstract::The purpose of this study was to evaluate neutropenia following intravenous immunoglobulin (IVIG) therapy in adults with immune thrombocytopenic purpura (ITP).Our analysis included 88 patients with ITP, who received IVIG from January 2006 to March 2016, at Pusan National University Hospital in Korea. Their white blood...


    pub_type: 杂志文章


    authors: Oh SB,Shin HJ

    更新日期:2020-01-01 00:00:00

  • Clinical utilization of serum- or plasma-based miRNAs as early detection biomarkers for pancreatic cancer: A meta-analysis up to now.

    abstract:BACKGROUND:Pancreatic cancer (PC) is a lethal disease, however current screening methods unable to achieve early diagnosis. Blood-based microRNAs (miRNAs) are promising molecular biomarkers for detecting PC. This meta-analysis summaries studies identifying serum- or plasma-based miRNAs dysregulated in PC patients compa...


    pub_type: 杂志文章,meta分析,评审


    authors: Wei L,Yao K,Gan S,Suo Z

    更新日期:2018-08-01 00:00:00

  • Bilateral subthalamic deep brain stimulation initial impact on nonmotor and motor symptoms in Parkinson's disease: An open prospective single institution study.

    abstract::Numerous studies document significant improvement in motor symptoms in patients with Parkinson's disease (PD) after deep brain stimulation of the subthalamic nucleus (STN-DBS). However, little is known about the initial effects of STN-DBS on nonmotor domains.Our objective was to elucidate the initial effects of STN-DB...


    pub_type: 杂志文章


    authors: Kurcova S,Bardon J,Vastik M,Vecerkova M,Frolova M,Hvizdosova L,Nevrly M,Mensikova K,Otruba P,Krahulik D,Kurca E,Sivak S,Zapletalova J,Kanovsky P

    更新日期:2018-02-01 00:00:00

  • Identification of a novel mutation of RUNX2 in a family with supernumerary teeth and craniofacial dysplasia by whole-exome sequencing: A case report and literature review.

    abstract:RATIONALE:Supernumerary teeth are those that teeth in excess number than the normal count. It is usually associated with genetic syndromes when present in more numbers. Several causal genes, such as APC, NHS, TRPS1, EVC and RUNX2, have been identified. However, etiology of supernumerary teeth remains largely unclear. ...


    pub_type: 杂志文章,评审


    authors: Ma D,Wang X,Guo J,Zhang J,Cai T

    更新日期:2018-08-01 00:00:00

  • A case report of mixed acinar-endocrine carcinoma of the pancreas treated with S-1 chemotherapy: Does it work or induce endocrine differentiation?

    abstract:RATIONALE:Acinar cell carcinomas (ACCs) and mixed acinar-endocrine carcinomas (MAECs) of the pancreas are rare, accounting for only 1% of pancreatic tumors. Although both typically present at an advanced stage, chemotherapeutic regimes have not yet been standardized. PATIENT CONCERNS:A 65-year-old man presented with a...


    pub_type: 杂志文章


    authors: Yokode M,Itai R,Yamashita Y,Zen Y

    更新日期:2017-11-01 00:00:00

  • Acute cerebral infarction following a Trimeresurus stejnegeri snakebite: A case report.

    abstract:RATIONALE:Acute cerebral infarction after snake bites is rare. The underlying mechanism causing the thrombotic process remains complex and unknown. PATIENT CONCERNS:We herein describe a 49-year-old female who was bitten by a Trimeresurus stejnegeri. After 4 days of biting, she developed acute ischemic infarct. DIAGNO...


    pub_type: 杂志文章


    authors: Zeng X,Hu J,Liang X,Wu Y,Yan M,Zhu M,Fu Y

    更新日期:2019-06-01 00:00:00

  • Starting of biological disease modifying antirheumatic drugs may be postponed in rheumatoid arthritis patients with multimorbidity: Single center real life results.

    abstract::The objective of this study was to assess the frequency of comorbidities and multimorbidities in rheumatoid arthritis (RA) patients under biologic therapy and their effects on biological disease modifying antirheumatic drugs (DMARDs) choice, timing, and response.Hacettepe University Biologic Registry (HUR-BIO) is sing...


    pub_type: 杂志文章


    authors: Armagan B,Sari A,Erden A,Kilic L,Erdat EC,Kilickap S,Kiraz S,Bilgen SA,Karadag O,Akdogan A,Ertenli I,Kalyoncu U

    更新日期:2018-03-01 00:00:00

  • Sexual dream and family relationships in frequent sexual dreamers and healthy volunteers.

    abstract::Early life family relationships affect the sexuality in adulthood, and these influences might be reflected in sexual dreams. The present study was designed to investigate the exact associations between family relationships and sexual dream experience. We therefore invited 62 frequent sexual dreamers (dreamers) and 104...


    pub_type: 杂志文章


    authors: Shao X,Wang C,Jia Y,Wang W

    更新日期:2020-09-04 00:00:00

  • Coinfection with cryptococcus and aspergillus in an immunocompetent adult: A case report.

    abstract:RATIONALE:Aspergillus and Cryptococcus exposure can cause serious secondary infections in human lungs, especially in immunocompromised patients or in conjunction with a chronic disease caused by low disease resistance. Primary invasive fungal infections are clinically rare; therefore, coexistence of 2 fungi at an infec...


    pub_type: 杂志文章


    authors: Wang Q,Wang Z,Hao Y,Li W,Xin T,Chen M,Gao P

    更新日期:2018-09-01 00:00:00

  • Patient outcomes following surgical management of multinodular goiter: Does multinodularity increase the risk of thyroid malignancy?

    abstract:BACKGROUND:the difference in the risk of thyroid malignancy for patients with multinodular goiter (MNG) and solitary nodular goiter (SNG) remains controversial. Although total thyroidectomy (TT) is the current preferred surgical option for MNG, permanent hypothyroidism in these patients may be a concern. Therefore, we ...


    pub_type: 杂志文章


    authors: Lin YS,Wu HY,Yu MC,Hsu CC,Chao TC

    更新日期:2016-07-01 00:00:00

  • Efficacy and safety of tripterygium glycosides for Graves ophthalmopathy: A systematic review and meta-analysis.

    abstract:BACKGROUND:Graves ophthalmopathy (GO) is one of the remaining enigmas in thyroidology. Glucocorticoids (GCs) are strongly recommended but their effects are not completely satisfactory and adverse reactions can occur. Tripterygium glycosides (TG) is a promising component extracted from Tripterygium wilfordii Hook F (TwH...


    pub_type: 杂志文章,meta分析


    authors: Liu X,Gao C,Liu X,Gao T

    更新日期:2019-12-01 00:00:00

  • Associations of daily sleep duration and dietary macronutrient consumption with obesity and dyslipidemia in Koreans: A cross-sectional study.

    abstract::Daily sleep duration is known to be associated with obesity and dyslipidemia.This study was performed to examine the interactions between daily sleep duration and the risks of obesity and dyslipidemia according to dietary macronutrient consumption in 14,680 Korean adults using the 5th Korean National Health and Nutrit...


    pub_type: 杂志文章


    authors: Doo H,Chun H,Doo M

    更新日期:2016-11-01 00:00:00

  • Multiple ectopic hepatocellular carcinomas in the pancreas: A case report.

    abstract:RATIONALE:Ectopic liver tissue can develop at various sites near the liver. Ectopic hepatocellular carcinomas (HCCs) arising from ectopic liver tissue have a rare clinical incidence. A very rare case has been observed to have metastasis after operation. PATIENT CONCERNS:We report an extremely rare case with multiple m...


    pub_type: 杂志文章


    authors: Li Z,Wu X,Wen T,Li C,Peng W

    更新日期:2017-07-01 00:00:00